• Proceedings of the KSRS Conference
• /
• 2009.03a
• /
• pp.151-154
• /
• 2009

MODIS Aqua에 의한 한반도 주변 해역의 관측은 엽록소의 변동을 관측하여 해양환경변화를 관측하는데 주로 연구되었다. 그러나 황해는 Case II 해역으로 해양의 엽록소 관측에 오차가 크기 때문에 동해와 남해, 동중국해역을 관측한 연구가 발표되어 왔다. 특히 적조와 같은 이상변동을 관측하는데 해색자료의 활용은 매우 활발한 연구가 이루어졌다. 하지만 K490(Diffuse attenuation coefficient for downwelling irradiance at 490nm)은 OCTS, SeaWiFS, MODIS, MERIS 등의 해색자료에 의해 많은 자료가 생산되고 있으나 이를 이용한 한반도 주변 해역의 해양환경변동에 관한 연구는 부족한 실정이다. 본 연구에서는 2008년 한반도 주변해역에서 관측된 MODIS 자료를 처리하여 K490에 의한 시-공간적 변화를 분석하였다. 특히 K490에 의한 월 변화(monthly)와 통계처리 결과를 분석하여 기후변화의 주요 분석인자인 해양의 일차생산력을 판단하는데 중요한 영향을 미치는 K490의 공간 특성을 제시하였다. 한반도 주변 해역의 K490에 의한 시-공간적 특성은 육상의 주요 하천에서 기인하는 부유사와 서남해역의 재부유 물질에 의한 영향이 시-공간적으로 뚜렷하게 나타나는 것을 파악할 수 있었다.

• Fire Science and Engineering
• /
• v.28 no.5
• /
• pp.52-57
• /
• 2014

When structural elements of steel framed structures are exposed to fire situations, the structural stability begins to decrease due to dislocation of substantial. The increase of the beam length causes an additional stress and deflection. These can be serious factors to cause a severe failure of structures. To improve the fire resistance of beams, prevention of the heat from a fire by coating with fire protection material is essential for beams. The FR 490 was developed to enhance fire resistance compared with SM 490 steel. However, the fire resistance of FR 490 H-beams has not been evaluated by analysis method since it was developed. In this paper, materials properties in high temperature and a heat transfer and thermal stress theory were used in the evaluation of the fire resistance of FR490 H-beams. The fire resistance of FR490 steel beams was compared with that of SM490 beams. The comparison verified that the structural stability of FR490 beams at high temperature was superior to that of SM490 beams.

• Korean Journal of Optics and Photonics
• /
• v.10 no.2
• /
• pp.157-161
• /
• 1999

A Ti:Sapphire laser pumped by the HCP has been designed and fabricated to study the optimal pumping conditions for lasing. The fluorescence energy converter LD-490 has been used. The result showed that the threshold energy of Ti:Sapphire laser is 1.39 KJ and the best efficiency is $7.13{\times}10^{-3}$% at the concentration $1.0{times}10^{-3}$ Mol/l of LD-490 dye. However, the efficiencies were decreased with the decrease of dye concentrations. The maximum output energy was obtained at 50 Torr Ar pressure, when the input voltage was 15 kV. As a convert dye, BBQ, was added to LD-490 with the rate of 1:1, the output energy was increased, whereas the thereshold energy was decreased as 1.17 kJ.

• IMMUNE NETWORK
• /
• v.5 no.2
• /
• pp.99-104
• /
• 2005

Background: Malignant gliomas are the most common primary tumors in the central nervous system. Methods: We investigated the combined effect of PG490 and LPS on the induction of the apoptotic pathway in human astroglioma cells. Results: Treatment of U87 cells with combination of 50nM of PG490 and $50{\mu}g/ml$ of LPS resulted in increased internucleosomal DNA fragmentation, cleavage of PLC-${\gamma}1$, and downregulation of cIAP1 and XIAP. The combination of LPS and PG490 treatment-induced apoptosis is mediated through the activation of caspase, which is inhibited by the caspase inhibitor, z-VAD-fmk. Also, release of cytochrome c was found in PG490 and LPS-cotreated U87 cell. Conclusion: Taken together, combination of PG490 and LPS appears to be a potent inducer of apoptosis in astrogliaoma cells, and might have some benefit in the treatment of glioma patients.

• Journal of Korean Society of Steel Construction
• /
• v.28 no.5
• /
• pp.313-323
• /
• 2016

Seven types of tests were conducted to experimentally evaluate the material properties of ultral-thick (or 120mm-thick) SM490TMC plate. The investigation of through-thickness properties was among the most significant considerations. All chemical and mechanical test results showed the through-thickness homogeneity as required and conformed to the KS(Korean industrial Standards), although the thickness was 1.5 times thicker than the thickness limit (80mm) imposed by Steel Structure Design Code. No reduction in the yield strength of 120mm-thick SM490TMC plate is recommended for design.

• The Korean Journal of Physiology and Pharmacology
• /
• v.13 no.2
• /
• pp.131-138
• /
• 2009

The binding of interleukin-6 (IL-6) cytokine family ligands to the gp130 receptor complex activates the Janus kinase (JAK)/ signal transducer and activator of transcription 3 (STAT3) signal transduction pathway, where STA T3 plays an important role in cell survival and tumorigenesis. Constitutive activation of STAT3 has been frequently observed in many cancer tissues, and thus, blocking of the gp130 signaling pathway, at the JAK level, might be a useful therapeutic approach for the suppression of STAT3 activity, as anticancer therapy. AG490 is a tyrphostin tyrosine kinase inhibitor that has been extensively used for inhibiting JAK2 in vitro and in vivo. In this study, we demonstrate a novel mechanism associated with AG490 that inhibits the JAK/STAT3 pathway. AG490 induced downregulation of gp130, a common receptor for the IL-6 cytokine family compounds, but not JAK2 or STAT3, within three hours of exposure. The downregulation of gp130 was not caused by enhanced degradation of gp130 or by inhibition of mRNA transcription. It most likely occurred by translation inhibition of gp130 in association with phosphorylation of the eukaryotic initiation factor-2 a. The inhibition of protein synthesis of gp130 by AG490 led to immediate loss of mature gp130 in cell membranes, due to its short half-life, thereby resulting in reduction in the STAT3 response to IL-6. Taken together, these results suggest that AG490 blocks the STAT3 activation pathway via a novel pathway.

• Proceedings of the Korean Operations and Management Science Society Conference
• /
• 1995.04a
• /
• pp.490-490
• /
• 1995

• Journal of Welding and Joining
• /
• v.28 no.1
• /
• pp.60-65
• /
• 2010

This paper is concerned with effects of Al, Mn and Si contents on spatter, fume, microstructure and mechanical property with 490MPa Grade Flux Core Wire(FCW). Ten kinds of FCW were fabricated by varying Mn, Si and Al contents and each FCW was weld for check the amount of spatter and fume generations, microstructures and mechanical property. Amount of spatter and fume generations was decreased with the increasing Si contents and decreasing by Al contents in FCW. And, their microstructure of weld metal were changed by Mn, Al and Si contents in FCW. With increasing of Al and Si, acicular ferrite was fine and volume fraction of acicula ferrite was increased. Thereby leading to improvement of Charpy impact property and strength.

• Journal of Korean Society of Steel Construction
• /
• v.30 no.1
• /
• pp.13-23
• /
• 2018

The use of a built-up H-beam (BH) that can easily manufacture a section is increasing. This is a basic study on standardization of BH. It confirmed the material properties of SM490 and SM520 steel such as yield strength, tensile strength, elongation, charpy absorbed energy, and else. The six BH specimens were manufactured with single-SAW or tandem-SAW. The welding performance was confirmed by collecting the macroscopic specimen and T-bar tensile specimen form the BH. As a result of the material property test, the properties of SM490 and SM520 which are made in Korea both satisfied the KS. As a result of the welding performance experiment, it is determined that the weld zone of BH has sufficient welding performance. Therefore, they are determined that the SM490 and SM520 steel are a proper material of BH, and the single-SAW and the tandem-SAW show a sufficient welding performance.

• Journal of the Korean Association of Geographic Information Studies
• /
• v.16 no.1
• /
• pp.59-66
• /
• 2013

When the typhoons are passing over the ocean, the ocean environment has both physical and biological impacts on the East, South sea and Yellow sea of Korea. As a result of typhoon path, vertical mixing and upwelling injured colder subsurface water, and leaded to phytoplankton blooming along the typhoons. The ocean environment before and after a typhoon played an important role in the biological effect of sea surface. Although the magnitude of sea surface temperature (SST) gets cooler because of typhoon path, other physical and biophysical responses are quite different such as chlorophyll, K490 and SST. The purpose of this study is to compare with the typhoon path that influenced the Korean Peninsula and ocean environment parameters which were observed by ocean color remotely-sensed data. The MODIS data were used to assess the parameters of ocean environments such as K490 and chlorophyll data from 2002 to 2005. Mean chlorophyll from MODIS data increased by about 1-4% in the East sea after the typhoon. Mean concentration of MODIS chlorophyll in the post-typhoon period increased along the typhoon passage. However, Jeju coastal area has different patterns from those of the East sea.