• Title/Summary/Keyword: K3

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Analysis of 3-MCPD and 1,3-DCP in Various Foodstuffs Using GC-MS

  • Kim, Wooseok;Jeong, Yun A;On, Jiwon;Choi, Ari;Lee, Jee-yeon;Lee, Joon Goo;Lee, Kwang-Geun;Pyo, Heesoo
    • Toxicological Research
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    • v.31 no.3
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    • pp.313-319
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    • 2015
  • 3-Monochloro-1,2-propanediol (3-MCPD) and 1,3-dichloro-2-propanol (1,3-DCP) are not only produced in the manufacturing process of foodstuffs such as hydrolyzed vegetable proteins and soy sauce but are also formed by heat processing in the presence of fat and low water activity. 3-MCPD exists both in free and ester forms, and the ester form has been also detected in various foods. Free 3-MCPD and 1,3-DCP are classified as Group 2B by the International Agency for Research on Cancer. Although there is no data confirming the toxicity of either compound in humans, their toxicity was evidenced in animal experimentation or in vitro. Although few studies have been conducted, free 3-MCPD has been shown to have neurotoxicity, reproductive toxicity, and carcinogenicity. In contrast, 1,3-DCP only has mutagenic activity. The purpose of this study was to analyze 3-MCPD and 1,3-DCP in various foods using gas chromatography-mass spectrometry. 3-MCPD and 1,3-DCP were analyzed using phenyl boronic acid derivatization and the liquid-liquid extraction method, respectively. The analytical method for 3-MCPD and 1,3-DCP was validated in terms of linearity, limit of detection (LOD), limit of quantitation, accuracy and precision. Consequently, the LODs of 3-MCPD and 1,3-DCP in various matrices were identified to be in the ranges of 4.18~10.56 ng/g and 1.06~3.15 ng/g, respectively.

Expression and characterization of transmembrane and coiled-coil domain family 3

  • Sohn, Wern-Joo;Kim, Jae-Young;Kim, Dongbum;Park, Jeong-A;Lee, Younghee;Kwon, Hyung-Joo
    • BMB Reports
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    • v.49 no.11
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    • pp.629-634
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    • 2016
  • Transmembrane and coiled-coil domain family 3 (TMCC3) has been reported to be expressed in the human brain; however, its function is still unknown. Here, we found that expression of TMCC3 is higher in human whole brain, testis and spinal cord compared to other human tissues. TMCC3 was expressed in mouse developing hind brain, lung, kidney and somites, with strongest expression in the mesenchyme of developing tongue. By expression of recombinant TMCC3 and its deletion mutants, we found that TMCC3 proteins self-assemble to oligomerize. Immunostaining and confocal microscopy data revealed that TMCC3 proteins are localized in endoplasmic reticulum through transmembrane domains. Based on immunoprecipitation and mass spectroscopy data, TMCC3 proteins associate with TMCC3 and 14-3-3 proteins. This supports the idea that TMCC3 proteins form oligomers and that 14-3-3 may be involved in the function of TMCC3. Taken together, these results may be useful for better understanding of uncharacterized function of TMCC3.

Sintering behavior and characterization of Ln0.7Ca0.3MnO3 (Ln=Nd, Sm, La) (Ln0.7Ca0.3MnO3 (Ln=Nd, Sm, La)의 소결 거동 및 특성)

  • Chon, Gom-Bai;Koo, Bon-Heun;Lee, Chan-Gyu
    • Korean Journal of Materials Research
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    • v.16 no.1
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    • pp.44-49
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    • 2006
  • Effects of doping rare earth element on Ln site of $Ln_{0.7}Ca_{0.3}MnO_3$ (Ln=Nd, Sm and La) were examined from sintering behavior, structure and magnetic properties. Sintering reactions proceeded rapidly in order of $La_{0.7}Ca_{0.3}MnO_3>Nd_{0.7}Ca_{0.3}MnO_3>Sm_{0.7}Ca_{0.3}MnO_3$. This result can be explained by diffusivity of metal cation. Size of a-axis increased as following order of La$Nd_{0.7}Ca_{0.3}MnO_3$, 93K for $Sm_{0.7}Ca_{0.3}MnO_3$ and 225K for $La_{0.7}Ca_{0.3}MnO_3$ were obtained. This result coincides with change of Mn-O bond length causing by a-axis lattice constant.

Anti-diabetic Activity of Constituents of Lycii Fructus (구기자 성분의 혈당강하작용)

  • Kim, Kyoung-Soon;Shim, Sang-Hee;Jeong, Gi-Hwa;Cheong, Chun-Sik;Ko, Kwang-Ho;Park, Jeong-Hill;Huh, Hoon;Lee, Bong-Jin;Kim, Bak-Kwang
    • Biomolecules & Therapeutics
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    • v.6 no.4
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    • pp.378-382
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    • 1998
  • In the previous screening on antidiabetic effect of Lycii fructus by glucose transport method using $N_2$-STZ diabeted rat model, each extracts showed the potent antidiabetic activity. We obtained three compounds isolated from the water fraction, EtOAc fraction and n-BuOH fraction of Lycii fructus in the present work and their structures were identified as 1-carboxy-N,N,N-trimethylmethanaminium hydroxide inner salt, 2,4(1H,3H)-pyrimidinedione and 3,3',4',5,7-pentahydroxyflavone-3-rutinoside . Among the constituents separated from Lycii fructus, 2,4(IH,3H)-pyrimidinedione, 3,3',4',5,7-pentahydroxyflavone-3-rutinoside and ascorbic acid were shown a remarkable antidiabetic effect.

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A Study on the Piezoelectric Characteristics of Ca-Substituded $PbTiO_3$ Ceramics (Ca가 치환된 $PbTiO_3$계 세라믹스의 압전 특성에 관한 연구)

  • Park, J.H.;Yoon, S.J.;Lee, D.H.;Paik, D.S.;Park, C.Y.
    • Proceedings of the KIEE Conference
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    • 1992.07b
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    • pp.744-746
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    • 1992
  • In this study, we investigated structural, electrical characteristics and studied the conditions which improved hydrostatic constants in hydrophones as we changed x = 0.1, 0.25, 0.35, 0.4 and y = 0.04, 0.08, 0.12, 0.16 in $(Pb_{1-x}Ca_x)[(Mg_{1/3}Nb_{2/3})_yTi_{1-0.01}Mn_{0.01}]O_3$ ceramics in which Ca was substituted with Pb and $Pb(Mg_{1/3}Nb_{2/3})O_3$ was added to decrease sintering temperature in $PbTiO_3$. When Ca was substituted 0.25[mol], the largest electro-mechanical anisotropy ($k_t/k_p$) was found ($k_t{\fallingdotseq}50,k_p{\fallingdotseq}4$), and the less $Pb(Mg_{1/3}Nb_{2/3})O_3$ and the stronger poling field, the larger this anisotropy was. When Ca=0.25[mol], $Pb(Mg_{1/3}Nb_{2/3})O_3=0.08[mol]$ were substituted, ($k_t/k_p$)(=12, 3) was large, permittivity was low and hydrostatic constants were high. Therefore, this composition is promising as wide band ultrasonic devices in water.

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The Optimal Design of Field Ring for Reliability and Realization of 3.3 kV Power Devices (3.3 kV 이상의 전력반도체 소자 구현 및 신뢰성 향상을 위한 필드링 최적 설계에 관한 연구)

  • Kang, Ey Goo
    • Journal of the Korean Institute of Electrical and Electronic Material Engineers
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    • v.30 no.3
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    • pp.148-151
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    • 2017
  • This research concerns field rings for 3.3kV planar gate power insulated-gate bipolar transistors (IGBTs). We design an optimal field ring for a 3.3kV power IGBT and analyze its electrical characteristics according to field ring parameters. Based on this background, we obtained 3.3kV high breakdown voltage and a 2.9V on state voltage drop. To obtain high breakdown voltage, we confirmed that the field ring count was 23, and we obtained optimal parameters. The gap distance between field rings $13{\mu}m$ and the field ring width was $5{\mu}m$. This design technology will be adapted to field stop IGBTs and super junction IGBTs. The thyristor device for a power conversion switch will be replaced with a super high voltage power IGBT.

Operation and Performance Analysis of 3-Phase 3300/220V 6kVA Bidirectional Intelligent Semiconductor Transformer (3상 3300/220V 6kVA 양방향 지능형 반도체 변압기의 동작과 성능 분석)

  • Kim, Do-Hyun;Kim, Jae-Hyuk;Han, Byung-Moon
    • Proceedings of the KIPE Conference
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    • 2013.11a
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    • pp.58-59
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    • 2013
  • 본 과제에서는 3.3kV/220V, 6kVA 용량의 양방향 지능형 반도체 변압기의 새로운 회로 구성을 제안하고 그 동작과 성능을 분석하였다. 제안하는 3상 반도체변압기는 1.9kV/127V 단상 반도체 변압기 모듈 3대를 Y-결선으로 구성하였으며, 각 단상 반도체 변압기는 고압 고주파 AC-DC 정류기와 저압 양방향 DC-DC-AC 컨버터로 구성되어 있다. 제안하는 3.3kV/220V, 6kVA 3상 반도체변압기를 제작하고 실험을 통해 그 동작과 성능을 검증하였다. 먼저 1차적으로는 3상 반도체변압기의 정상동작에 대해 실험을 실시하고 그 후에는 3상 입력전압에 외란이 발생하였을 때 보상성능을 순방향 조류와 역방향 조류 2가지 경우로 나누어 실험을 실시하고 그 결과를 분석하였다. 분석한 결과 제안하는 반도체변압기는 양방향 전력흐름이 가능하고 입력전압에 Sag가 발생한 경우에도 이를 보상하여 수전단이나 부하에 전력공급이 가능함을 알 수 있었다.

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