• 순환기질환의공학회:학술대회논문집
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• 순환기질환의공학회 2006년도 제6회 학술대회
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• pp.10-13
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• 2006

Inflammation plays an important role in the progression of atherosclerosis and plaque destabilization converting a chronic process into an acute disorder with ensuing thromboembolism. Current therapeutic effective in preventing atherosclerosis and stroke such as statins, ASS and RAS inhibitors my exert part of their effects by modulating inflammatory responses in the vessel walls. As alternative approaches, discovery to find having inhibitory action of MMP activity, COX-2, macrophage infiltration, such as APE1/ref-1 and fusion technology for cell permeable protein may provide a new antiatherosclerotic therapy in the future.

• Journal of Astronomy and Space Sciences
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• 제15권1호
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• pp.229-234
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• 1998

We study on a terrain contour matching algorithm using Radial Basis Functions(RBFs) for aided inertial navigation system for position fixing aircraft, cruise missiles or re-entry vehicles. The parameter optimization technique is used for updating the parameters describing the characteristics of an area with modified Gaussian least square differential correction algorithm and the step size limitation filter according to the amount of updates. We have applied the algorithm for matching a sampled area with a target area supposed that the area data are available from Radar Terrain Sensor(RTS) and Reference Altitude Sensor(RAS)

• 자원리싸이클링
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• 제13권1호
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• pp.59-67
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• 2004

A universal plasma-chemical module (PChM) for the industrial processing of different hydrocarbon raw material pyrolysis was designed and tested. Laboratory investigations for the plasma-chemical method of acetylene production from natural gas and different coals were made. Similar laboratory tests on the industrial production of acetylene as a raw material for organic syn-thesis were developed using the PChM. A comparison of the suggested plasma-chemical method with the traditional process of acetylene production were carried out. The outlook of the plasma-chemical method was shown.

• 대한약학회:학술대회논문집
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• 대한약학회 2000년도 춘계총회 및 학술대회
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• pp.115.1-115.1
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• 2000

• 한국습지학회지
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• 제17권3호
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• pp.209-220
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• 2015

본 연구에서는 기존의 물리적 하천교란 평가방법을 개선하고 적용성을 분석하였다. 개선한 교란평가 기법은 정성적 항목을 정량적인 항목으로 제시하고 이의 근거와 평가 산정식을 제시하였고, 이에 상응하는 평가영역 내 점수를 보다 세분화 하고 수리특성과 지형 변화를 수치모의에 의한 결과를 이용할 수 있도록 개선하였다. 개선된 교란평가방법은 적용성을 확인하기 위해 비정비하천, 도시관류하천, 산지계류하천의 특성을 가지는 6개의 하천에 적용하여 기존의 평가방법과 개선된 평가방법의 결과를 비교 분석하였다. 하상서식환경과 하상재료를 제외한 8가지 평가항목은 HEC-RAS 수치모의 결과를 직접 입력하여 간편하게 수행할 수 있었다. 또한 정량적 평가방법의 적용 결과 기존의 평가방법보다 민감한 평가 결과를 나타냈으나, 전반적으로 기존의 평가방법과 비슷한 결과를 나타내어 적용성이 있음을 확인하였다.

• 한국정보통신학회논문지
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• 제19권5호
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• pp.1131-1136
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• 2015

VoIP(Voice over Internet Protocol)와 IP Telephony 기술이 발전함에 따라 기존 회선이 아닌 인터넷 망을 사용하여 전화를 사용하는 IP-PBX(Internet Protocol Private Branch Exchange)의 사용이 증가하고 있다. IP-PBX는 전화회선을 사용하지 않아 전화 업무가 많은 기업들과 기관들의 경영비용을 절감할 수 있으며 일반전화 회선과 유사한 품질을 제공한다. 하지만 IP-PBX를 도입하기 위해선 고가의 하드웨어 장비나 상용 소프트웨어를 구매해야 하는 초기 비용이 필요하다. 본 논문에서는 고가의 하드웨어 장비나 상용 소프트웨어를 구매하지 않고 IP-PBX를 도입할 수 있는 방안을 제안한다. 제안하는 IP-PBX는 Raspberry Pi와 Asterisk를 사용하여 IP-PBX 서버를 설계하고 구현한다. 그리고 구현된 IP-PBX 기반으로 PC와 스마트 폰 간의 음성 통화를 실시하여 논문의 적합성을 검증한다.

• 농촌계획
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• 제21권2호
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• pp.23-32
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• 2015

The objective of this study is to analyze how much economic impact is changed before and after the designation as biosphere reserve area by tourism. The subject region of this study is Hajun mud village which is the famous place to experience eco-tourism located in Gochang-gun. This region has been designated as a UNESCO biosphere reserve in 2013. In order to estimate the regional economic effects, we employ a regional input-output model which is derived by a RAS method. Using regional input-output model analysis, this study estimates direct and indirect effects of tourist's expenditure on experience of Hajun mud village in Gochang-gun across associated industries between 2011 and 2013. Also, we tried to calculate a net increase in number of visitors in 2013 with considering the trend of tourist in this region and estimate a net regional economic effect after the designation as a biosphere reserve area by tourism. The empirical result could be summarized as follows : (1) the change of production inducement effect shows that regional outputs is approximately increased by 386 million won between 2011 and 2013, (2) regional value-added is increased by 223 million won during the same period, (3) regional employment is approximately increased by 20 according to the labor inducement effects of expanding tourist's expenditure in biosphere reserve area. (4) social service industry has highly been benefited by increase in experience tourist after Gochang-gun was designated as the biosphere reserve area. (5) estimated net increase in number of visitors after the designation as biosphere reserve area is about 37,364 which is 93.4% of the absolute increase in number of visitors amounting 40,011 between 2011 and 2013.

• Biomolecules & Therapeutics
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• 제22권5호
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• pp.371-383
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• 2014

The nematode Caenorhabditis elegans (C. elegans) offers a unique opportunity for biological and basic medical researches due to its genetic tractability and well-defined developmental lineage. It also provides an exceptional model for genetic, molecular, and cellular analysis of human disease-related genes. Recently, C. elegans has been used as an ideal model for the identification and functional analysis of drugs (or small-molecules) in vivo. In this review, we describe conserved oncogenic signaling pathways (Wnt, Notch, and Ras) and their potential roles in the development of cancer stem cells. During C. elegans germline development, these signaling pathways regulate multiple cellular processes such as germline stem cell niche specification, germline stem cell maintenance, and germ cell fate specification. Therefore, the aberrant regulations of these signaling pathways can cause either loss of germline stem cells or overproliferation of a specific cell type, resulting in sterility. This sterility phenotype allows us to identify drugs that can modulate the oncogenic signaling pathways directly or indirectly through a high-throughput screening. Current in vivo or in vitro screening methods are largely focused on the specific core signaling components. However, this phenotype-based screening will identify drugs that possibly target upstream or downstream of core signaling pathways as well as exclude toxic effects. Although phenotype-based drug screening is ideal, the identification of drug targets is a major challenge. We here introduce a new technique, called Drug Affinity Responsive Target Stability (DARTS). This innovative method is able to identify the target of the identified drug. Importantly, signaling pathways and their regulators in C. elegans are highly conserved in most vertebrates, including humans. Therefore, C. elegans will provide a great opportunity to identify therapeutic drugs and their targets, as well as to understand mechanisms underlying the formation of cancer.

• Asian Pacific Journal of Cancer Prevention
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• 제17권4호
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• pp.1729-1732
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• 2016

In the patients with metastatic colorectal cancer (mCRC), RAS testing is the first step to identify those that could benefit from anti-EGFR therapy. This study examined associations between KRAS mutations and clinicopathological and survival data in Iranian patients with mCRC. Between 2008 to2015 in a retrospective study, 83 cases of mCRC were referred to the Clinic of Medical Oncology. The mean follow-up was 45 months that there were 27 deaths. The 3 patients that did not complete follow-up were censored from the study. KRAS and NRAS were analyzed using allele-specific PCR primers and pyrosequencing in exons 2, 3 and 4. Multivariate survival analysis using Cox's regression model was used for affecting of variables on overall survival (OS). The mean age at diagnosis for patients was 57.7 (range, 18 to 80 years) and 61.4% were male. There was no significant different between prognostic factors and KRAS mutation with wild-type. Also, There was no significant different between KRAS mutation and KRAS wild-type for survival, but there was a significant different between KRAS 12 and 13 mutations for survival (HR 0.13, 95% CI 0.03-0.66, P=0.01). In conclusion, the prevalence of KRAS mutations in CRC patients was below 50% but higher than in other studies in Iran. As in many studies, patients with KRAS 12 mutations had better OS thn those with KRAS 13 mutation. In addition to KRAS testing, other biomarkers are needed to determine the best treatment for patients with mCRC.

• Corrosion Science and Technology
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• 제2권2호
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• pp.88-92
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• 2003

The technique for in situ simultaneous measurements of IR-RAS and QCM, which has been developed for investigation of corrosion in gaseous environments, was employed to study the effects of an extremely thin water layer on the corrosion rate. An evaporated copper film on a QCM element was exposed to air containing water vapor and $SO_2$, and time-resolved IR-RAS spectra were measured and mass gains were simultaneously followed with QCM. The tested ranges of relative humidity (RH) and concentration of $SO_2$ were 60% - 90% and 1 - 20 ppm, respectively. On the basis of 2D-IR analysis, the corrosion products were determined to be Chevreul's salt ($CuSO_3Cu_2SO_3{\cdot}2H_2O$) and $CuSO_4{\cdot}5H_2O$. By constructing curves of the relations between band intensities of IR spectra and mass gains of QCM for the corrosion products, the time variations in each product were determined from spectral experiments on copper plates. The thicknesses of physically adsorbed water layers in course of the corrosion process were also determined from water band intensities. The results showed that the thickness of the physically adsorbed water layer increased with increase in RH, and it also increased with increase in accumulation of corrosion products. The latter is probably due to the capillary effect of the corrosion products.