• Proceedings of the Korea Contents Association Conference
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• 한국콘텐츠학회 2016년도 춘계 종합학술대회 논문집
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• pp.463-464
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• 2016

본 연구에서는 하나의 도시유역 중소하천에 대하여 수리 수문 분석을 바탕으로 홍수예경보 발령을 위한 일련의 분석 체계를 수립하였다. 이를 통해 산정된 결과물은 강우지속기간별 경보발령 기준 강우량 수치이다. 이것은 해당 하천이 합류하는 본류 하천의 배수위 영향에 따라 달라질 수 있다. 경보발령 기준 강우량 산정을 위한 도시유역 중소하천의 수리 수문 분석은 가장 일반적인 해석 모형인 HEC-HMS 및 HEC-RAS 모형들을 상호 연계하여 이루어졌으며, 경보발령 기준 강우량 산정에 있어서는 상 하류의 다양한 관측수위 조건을 고려하였다.

• Bulletin of the Korean Chemical Society
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• 제27권4호
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• pp.529-534
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• 2006

Chemical modification of the S. cerevisiae farnesyl protein transferase (FPT) with CMC, phenylglyoxal and DEPC resulted in enzyme inactivation, depending upon the reagent concentration. The peptide substrate GST-PEP-I, a GST-fused undecapeptide mimicking the C-terminus of $p21^{Ki-ras}$, protected the enzyme against inactivation by CMC which is specific to either aspartate or glutamate, while the other substrate farnesyl pyrophosphate (FPP) showed protection against phenylglyoxal which is the specific modifier of arginine residues, dependent on the substrate concentrations. Neither of the two substrates protected the enzyme against histidine inactivation by DEPC. It is suggested that there is at least one aspartate or glutamate residue at the peptide substrate binding site, and that at least one arginine residue is located at the binding site of FPP. There also seems to be at least one histidine residue which is critical for enzymic activity and is exposed toward the bulk solution, excluded from the substrate binding sites.

• Proceedings of the Korea Information Processing Society Conference
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• 한국정보처리학회 2003년도 춘계학술발표논문집 (하)
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• pp.1925-1928
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• 2003

음성과 데이터가 같이 사용될 수 없는 2.5G의 통신형 PDA를 위한 PUSH 서비스를 제안하였고, 이 PUSH 서비스와 이동 단말기의 특성을 고려한 보안 프로토콜을 현재 상용화된 알고리즘을 적절히 적용하여 구현하였다. 제안한 PUSH 서비스는 유선 인터넷 망과는 오프라인 상태인 음성 대기용 클라이언트 단말기와 망 접속 방식으로 SMS(short message service)를 이용하였으며, SMS 메시지 수신 후에는 단말기 상에서 SMS의 데이터를 분석하여 RAS(remote access service)를 통해 데이터 채널을 생성하여 서버측의 데이터가 PUSH 되도록 구현하였다. 보안 프로토콜은 통신횟수를 줄이기 위하여 비표 형식을 취했으며, SMS와 데이터의 2개의 채널을 가지는 2중 통신 방법을 이용하였다. 이를 위하여 보안 알고리즘 중 처리속도가 빠르고 적은 메모리 공간을 사용하는 SEED와 MD5 알고리즘을 사용하였으며, 더욱더 안전한 키 분배를 위하여 인증과 보안의 효과를 가지는 RSA알고리즘도 이용하였다.

• Journal of Korean Society of Industrial and Systems Engineering
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• 제31권4호
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• pp.168-176
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• 2008

In an environment where manufacturing conditions such as product lines keep changing, manufacturing control systems need to be continually maintained and upgraded according to the change. This requires an effective system implementation methodology. In this paper, a methodology based on the multi-criteria similarity comparison of manufacturing processes is proposed. A newly introduced process is compared with existing ones based on the multi-criteria similarity, and candidates for software reuse are selected from stored modules according to the overall process characteristics. The proposed methodology has been tested for an electronics manufacturing company's manufacturing control system, and the result has been satisfactory in that it can save time and efforts for system implementation.

• Applied Microscopy
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• 제39권2호
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• pp.81-87
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• 2009

Diabetic retinopathy is one of major complications of diabetes mellitus, which is associated with the dysfunction of retina. It has been reported that the onset of diabetic retinopathy is related to the activation of renin-angiotensin system (RAS). Angiotensin converting enzyme (ACE), which converts angiotensin I into angiotensin II, is a key component of RAS. Among many growth factors, vascualr endothelial growth factor (VEGF) is an important cytokine in the neovasculization of retina, which is a characteristics of diabetic retinopathy. However, the relationship between ACE and VEGF was not elucidated in diabetic retinopathy. Thus, this study was conducted to examine the protective effect of captopril, an ACE inhibitor, in the retina of streptozotocin (STZ)-treated diabetic rats. In present study, STZ-treated diabetic rats exhibited the increase of VEGF levels in serum and retina. The serum levels of VEGF in STZ-treated diabetic rats was not blocked by the treatment of captopril. However, the retina levels of VEGF in STZ-treated diabetic rats was blocked by the treatment of captopril, suggesting the local action of captopril in retina. Immunohistochemical analysis also revealed that the retina of STZ-treated diabetic rats manifested the increase of ganglion cell layers, outer nuclear layers, and inner nuclear layers, which were also prevented by the treatment of captopril. In conclusion, captopril prevented the expression of VEGF in the retina of STZ-treated diabetic rats.

• Journal of the Korean Association of Geographic Information Studies
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• 제19권1호
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• pp.106-119
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• 2016

Flood risk map, flood damage map, disaster information map, inundation trace map are involved with the cartographic analysis of flood inundation based on prevention, preparation, restoration, response from natural disasters such as flood, flooding, etc. In this study, the analysis for channel and basin characteristics Chungju dam to Paldang dam of South han river after four river project. Flood scenario is selected to take advantage of design flood level of schematic design for river. Flood inundation of one dimensional non-uniform flow by using HEC-RAS with basin characteristics is accomplished and two dimensional unsteady flow was interpreted by using FLUMEN. Frequency analysis is carried out about each abundance of South han river for 100 year period, 200 year period and 500 year period. Flooding disaster area of 100 year period on 0.5m damage functions is 2378.8ha, 200 year period on 0.5m damage functions is 3155.2ha, 500 year period on 0.5m damage functions is 3995.3ha respectively. It will be significant data for decision making to establish inundation trace map for providing basic plan for river maintenance, land use plan, flood protection plan, application plan and getting information of flood expectation area.

• Asian Pacific Journal of Cancer Prevention
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• 제15권13호
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• pp.5239-5243
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• 2014

Background: The prognosis of young colorectal cancer (CRC) patients has been addressed by several studies but with contradictory results. The aim of the present study was to evaluate the clinico-pathological features of young Saudi patients with CRC in addition to displaying their survival outcome. Materials and Methods: In this retrospective study, young CRC patients (${\leq}40$ years) diagnosed between 2007 and 2011 from 4 centres in western Saudi Arabia, were included. Clinico-pathological features, tumor markers, dates of disease relapse and death were collected. Survival parameters were compared with those of older Saudi patients, reported in previous studies. Results: One hundred and sixteen young patients with CRC were identified (32.2% rectal, 67.8% colon). Some 44% were metastatic while 32.7% had stage III at diagnosis. Patients with grade 3 tumors made up 29.4% of the total while 49.5% had positive lymphovascular invasion (LVI), 56% had a lymph node (LN) ratio ${\geq}0.2$ and 40.2% were K-ras mutant. Median disease-free survival (DFS) and overall survival (OS) in non-metastatic cases were 22.8 and 49.6 months respectively with better median DFS in K-ras wild compared to mutant patients (28.5 vs 20.9 months, p=0.005). In metastatic cases, median OS was 19.5 months. These survival outcomes are inferior compared to those of older Saudi patients reported in prior studies. Conclusions: Young CRC patients present more commonly with advanced stage and a high incidence of adverse prognostic factors such as LVI and high LN ratio. Young CRC patients seem to have worse survival compared to older Saudi patients.

• Proceedings of the Korean Society of Toxicology Conference
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• 한국독성학회 1998년도 국제심포지움 및 추계학술대회
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• pp.36-36
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• 1998

Tumorigenicity of benzo(a)pyrene (BP) and benzo(a)pyrene diol epoxides ((+)BPDE-1, (-)BPDE-1) was investigated in transgenic TG-AC mice carrying v-Ha-ras oncogene fused to the promoter of the mouse embryonic a-like, z-globin gene. Animals were topically treated twice per week for 25weeks with BPDE (10$\mu$g/mouse) and BP (10, 20, 40$\mu$g/mouse). In addition, animals were treated with BPDE or BP (initiated) followed by TPA (2$\times$2.5$\mu$g/week, for 4 weeks) for promotion study. In the continuous treatment of BPDE or BP, animals treated with 40$\mu$g BP showed $100\%$ tumor response after 20 weeks, $40\%$ of mice for 20$\mu$g BP, and $20\%$ for (+)BPDE-1, but (-)BPDE-1 and 10$\mu$g BP did not show any tumor response. After 25 weeks, most tumors turned out to be carcinomas in animals treated with 40$\mu$g BP. In BPDE or BP/TPA Initiation-promotion study, papilloma response occurred earlier (6 weeks after TPA treatment) than in continuously treated animals with BPDE or BP. RT-PCR assay for transgene expression showed that BP or BPOE was not transgene dependent in its tumorigenicity, but TPA was. Several Cytokine genes(TGF-a, TNF-a) and c-myc gene expressions were monitored in skin tissues during BP carcinogenesis. In early stage of BP treatment, the gene expressions were elevated(c-myc,TGF-a) or unchanged(TNF-a) compared to control, but the levels were gradually decreased during both middle and late stages of cacinogenesis, Gene expression levels of skin papillomas in acetone initiated-TPA promoted animals were close to those of middle stage or between middle and late stages. i-NOS was also highly expressed in carcinoma and papilloma, These data suggest that transgene expressions of TG-AC mice were not dependent on BP carcinogenesis and that TG-AC mice were more sensitive to TPA regardless of types of initiators. In addition, genes(TGF-a, c-myc, TNF-a, i-NOS) were modulated in the skin during BP cacinogenesis or TPA promotion.

• Asian Pacific Journal of Cancer Prevention
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• 제15권13호
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• pp.5437-5442
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• 2014

Esophageal squamous cell carcinoma (ESCC) is one of the most malignancies with a poor prognosis. The phospholipase $C{\varepsilon}$ gene (PLCE1) encodes a novel ras-related protein effector mediating the effects of R-Ras on the actin cytoskeleton and membrane protrusion. However, molecular mechanisms pertinent to ESCC are unclear. We therefore designed PLCE1-special small interfering RNA and transfected to esophageal squamous cell (EC) 9706 cells to investigat the effects of PLCE1 gene silencing on the cell cycle and apoptosis of ESCC and indicate its important role in the development of ESCC. Esophageal cancer tissue specimens and normal esophageal mucosa were obtained and assayed by immunohistochemical staining to confirm overexpression of PLCE1 in neoplasias. Fluorescence microscopy was used to examine transfection efficiency, while the result of PLCE1 silencing was examined by reverse transcription (RT-PCR). Flow cytometry and annexin V apoptosis assays were used to assess the cell cycle and apoptosis, respectively. Expression of cyclin D1 and caspase-3 was detected by Western-blotting. The level of PLCE1 protein in esophageal cancer tissue was significantly higher than that in normal tissue. After transfection, the expression of PLCE1 mRNA in EC 9706 was significantly reduced, compared with the control group. Furthermore, flow cytometry results suggested that the PLCE1 gene silencing arrested the cell cycle in the G0/G1 phase; apoptosis was significantly higher than in the negative control group and mock group. PLCE1 gene silencing by RNAi resulted in decreased expression of cyclin D1 and increased expression of caspase-3. Our study suggests that PLCE1 may be an oncogene and play an important role in esophageal carcinogenesis through regulating proteins which control cell cycling and apoptosis.

• Journal of Life Science
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• 제19권7호
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• pp.905-916
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• 2009

Pinelliae rhizoma (Pr, 半夏) is a traditional medicine used in the treatment of incipient stroke. We investigated the effects of Pr on gene expression in a hypoxic model using cultured rat cortical cells. Pr (2.5 $\mu$g/ml) was added to the culture medium on DIV 12. A hypoxic shock (2% 0$_2$/5% CO$_2$, 37$^{\circ}$C, 3 hr) was given two days later (on DIV 14), and total mRNAs were isolated at 24 hr post-shock from both Pr-treated samples and untreated control cultures. Microarray using TwinChip $^{TM}$ Rat-5K (Digital Genomics, Seoul) indicated that Pr upregulated genes for cell growth and differentiation (tubb5, tgfa, ptpn11, n-ras, pdgfa) and antiapoptosis (mcl-1), while downregulating the apoptosis-induced gene (tieg). Therefore, it is interpreted that Pr protects neurons from hypxoic shock by maintaining cell growth and differentiation and by preventing apoptosis.