• 순환기질환의공학회:학술대회논문집
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• 2006.10a
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• pp.10-13
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• 2006

Inflammation plays an important role in the progression of atherosclerosis and plaque destabilization converting a chronic process into an acute disorder with ensuing thromboembolism. Current therapeutic effective in preventing atherosclerosis and stroke such as statins, ASS and RAS inhibitors my exert part of their effects by modulating inflammatory responses in the vessel walls. As alternative approaches, discovery to find having inhibitory action of MMP activity, COX-2, macrophage infiltration, such as APE1/ref-1 and fusion technology for cell permeable protein may provide a new antiatherosclerotic therapy in the future.

• Journal of Astronomy and Space Sciences
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• v.15 no.1
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• pp.229-234
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• 1998

We study on a terrain contour matching algorithm using Radial Basis Functions(RBFs) for aided inertial navigation system for position fixing aircraft, cruise missiles or re-entry vehicles. The parameter optimization technique is used for updating the parameters describing the characteristics of an area with modified Gaussian least square differential correction algorithm and the step size limitation filter according to the amount of updates. We have applied the algorithm for matching a sampled area with a target area supposed that the area data are available from Radar Terrain Sensor(RTS) and Reference Altitude Sensor(RAS)

• Resources Recycling
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• v.13 no.1
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• pp.59-67
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• 2004

A universal plasma-chemical module (PChM) for the industrial processing of different hydrocarbon raw material pyrolysis was designed and tested. Laboratory investigations for the plasma-chemical method of acetylene production from natural gas and different coals were made. Similar laboratory tests on the industrial production of acetylene as a raw material for organic syn-thesis were developed using the PChM. A comparison of the suggested plasma-chemical method with the traditional process of acetylene production were carried out. The outlook of the plasma-chemical method was shown.

• Proceedings of the PSK Conference
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• 2000.04a
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• pp.115.1-115.1
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• 2000

• Journal of Wetlands Research
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• v.17 no.3
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• pp.209-220
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• 2015

This study has improved the existed physical disturbance evaluation assessment technique in a river and analysed its applicability. The improvements are the quantitative evaluation items instead of qualitative one by providing the background and their evaluation equations, corresponding detailed itemization of evaluation score, and the direct input of hydraulic characteristics and geometrical changes by numerical simulation. In order to confirm the applicability of improved disturbance evaluation technique, the comparison and analysis between the evaluation results of existed and improved techniques have been carried out by applying to the 6 cases of natural, urban, and mountainous streams. Direct input of numerical simulation results of HEC-RAS enables the evaluation simple for 8 evaluation items excluding the items of habitat environment and bottom substrate. The improved disturbance evaluation technique, which evaluates the degree of disturbance sensitively by the quantitative and detailed itemized evaluations, has been confirmed the appropriate applicability by applying to river systems.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.19 no.5
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• pp.1131-1136
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• 2015

VoIP and IP Telephony telephony technology development is a growing by easy to using IP-PBX by using phone from using existing lines rather than the internet. IP-PBX do not use the phone line from phone work for many companies and institutions of management costs reduce as provides similar to regular phone line quality. But IP-PBX to introduce for need to be the initial cost on is should buy for expensive hardware equipment or commercial software. In this paper, suggest way to introduce IP-PBX do not buy expensive hardware equipment or commercial software. Suggest IP-PBX on designed and implement for IP-PBX server using Raspberry Pi and Asterisk. And verification treatise on the suitability of conducted by voice calls based on IP-PBX between PC and a Smartphone

• Journal of Korean Society of Rural Planning
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• v.21 no.2
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• pp.23-32
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• 2015

The objective of this study is to analyze how much economic impact is changed before and after the designation as biosphere reserve area by tourism. The subject region of this study is Hajun mud village which is the famous place to experience eco-tourism located in Gochang-gun. This region has been designated as a UNESCO biosphere reserve in 2013. In order to estimate the regional economic effects, we employ a regional input-output model which is derived by a RAS method. Using regional input-output model analysis, this study estimates direct and indirect effects of tourist's expenditure on experience of Hajun mud village in Gochang-gun across associated industries between 2011 and 2013. Also, we tried to calculate a net increase in number of visitors in 2013 with considering the trend of tourist in this region and estimate a net regional economic effect after the designation as a biosphere reserve area by tourism. The empirical result could be summarized as follows : (1) the change of production inducement effect shows that regional outputs is approximately increased by 386 million won between 2011 and 2013, (2) regional value-added is increased by 223 million won during the same period, (3) regional employment is approximately increased by 20 according to the labor inducement effects of expanding tourist's expenditure in biosphere reserve area. (4) social service industry has highly been benefited by increase in experience tourist after Gochang-gun was designated as the biosphere reserve area. (5) estimated net increase in number of visitors after the designation as biosphere reserve area is about 37,364 which is 93.4% of the absolute increase in number of visitors amounting 40,011 between 2011 and 2013.

• Biomolecules & Therapeutics
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• v.22 no.5
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• pp.371-383
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• 2014

The nematode Caenorhabditis elegans (C. elegans) offers a unique opportunity for biological and basic medical researches due to its genetic tractability and well-defined developmental lineage. It also provides an exceptional model for genetic, molecular, and cellular analysis of human disease-related genes. Recently, C. elegans has been used as an ideal model for the identification and functional analysis of drugs (or small-molecules) in vivo. In this review, we describe conserved oncogenic signaling pathways (Wnt, Notch, and Ras) and their potential roles in the development of cancer stem cells. During C. elegans germline development, these signaling pathways regulate multiple cellular processes such as germline stem cell niche specification, germline stem cell maintenance, and germ cell fate specification. Therefore, the aberrant regulations of these signaling pathways can cause either loss of germline stem cells or overproliferation of a specific cell type, resulting in sterility. This sterility phenotype allows us to identify drugs that can modulate the oncogenic signaling pathways directly or indirectly through a high-throughput screening. Current in vivo or in vitro screening methods are largely focused on the specific core signaling components. However, this phenotype-based screening will identify drugs that possibly target upstream or downstream of core signaling pathways as well as exclude toxic effects. Although phenotype-based drug screening is ideal, the identification of drug targets is a major challenge. We here introduce a new technique, called Drug Affinity Responsive Target Stability (DARTS). This innovative method is able to identify the target of the identified drug. Importantly, signaling pathways and their regulators in C. elegans are highly conserved in most vertebrates, including humans. Therefore, C. elegans will provide a great opportunity to identify therapeutic drugs and their targets, as well as to understand mechanisms underlying the formation of cancer.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.4
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• pp.1729-1732
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• 2016

In the patients with metastatic colorectal cancer (mCRC), RAS testing is the first step to identify those that could benefit from anti-EGFR therapy. This study examined associations between KRAS mutations and clinicopathological and survival data in Iranian patients with mCRC. Between 2008 to2015 in a retrospective study, 83 cases of mCRC were referred to the Clinic of Medical Oncology. The mean follow-up was 45 months that there were 27 deaths. The 3 patients that did not complete follow-up were censored from the study. KRAS and NRAS were analyzed using allele-specific PCR primers and pyrosequencing in exons 2, 3 and 4. Multivariate survival analysis using Cox's regression model was used for affecting of variables on overall survival (OS). The mean age at diagnosis for patients was 57.7 (range, 18 to 80 years) and 61.4% were male. There was no significant different between prognostic factors and KRAS mutation with wild-type. Also, There was no significant different between KRAS mutation and KRAS wild-type for survival, but there was a significant different between KRAS 12 and 13 mutations for survival (HR 0.13, 95% CI 0.03-0.66, P=0.01). In conclusion, the prevalence of KRAS mutations in CRC patients was below 50% but higher than in other studies in Iran. As in many studies, patients with KRAS 12 mutations had better OS thn those with KRAS 13 mutation. In addition to KRAS testing, other biomarkers are needed to determine the best treatment for patients with mCRC.

• Corrosion Science and Technology
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• v.2 no.2
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• pp.88-92
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• 2003

The technique for in situ simultaneous measurements of IR-RAS and QCM, which has been developed for investigation of corrosion in gaseous environments, was employed to study the effects of an extremely thin water layer on the corrosion rate. An evaporated copper film on a QCM element was exposed to air containing water vapor and $SO_2$, and time-resolved IR-RAS spectra were measured and mass gains were simultaneously followed with QCM. The tested ranges of relative humidity (RH) and concentration of $SO_2$ were 60% - 90% and 1 - 20 ppm, respectively. On the basis of 2D-IR analysis, the corrosion products were determined to be Chevreul's salt ($CuSO_3Cu_2SO_3{\cdot}2H_2O$) and $CuSO_4{\cdot}5H_2O$. By constructing curves of the relations between band intensities of IR spectra and mass gains of QCM for the corrosion products, the time variations in each product were determined from spectral experiments on copper plates. The thicknesses of physically adsorbed water layers in course of the corrosion process were also determined from water band intensities. The results showed that the thickness of the physically adsorbed water layer increased with increase in RH, and it also increased with increase in accumulation of corrosion products. The latter is probably due to the capillary effect of the corrosion products.