• 한국환경복원기술학회지
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• 제20권2호
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• pp.13-35
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• 2017

This study was carried out to analyze vegetation structure and change of the disturbed area in forest ecosystem(FE), riparian ecosystem(RE) and coastal ecosystem(CE) related to Regional Ecological Network at Chungnam province through constancy and dominance analysis, species diversity index, similarity index and canonical correlation analysis. Data were collected from April to October in 2015. As a result of constancy and dominance analysis of forest disturbed area, non-effective species(NES) was 30 species(17.0%), exported species(ES) was 98 species(55.7%) and imported species(IS) was 48 species(27.3%) among the total 176 species, respectively. In riparian disturbed area with total 139 species, there were 16 NES(11.5%), 98 ES(70.5%) and 25 IS(18.0%) respectively. In coastal disturbed area with 140 species, there were 20 NES(14.3%), 88 ES(62.9%) and 32 IS(22.9%) respectively. In all types of disturbed areas, the ratio of ES was higher than IS. As a result of species diversity, species richness and shannon's diversity index of disturbed area decreased in all kinds of crown strata such as tree, subtree, shrub and herb layer compared to the control area. As a result of similarity index, that of each type between control site and disturbed site was 0.374 in FE, 0.329 in CE and 0.259 in RE in the order. As a result of the CCA analysis, the number of present species, vine plants ratio and exported species ratio in disturbed area of FE and RE were decreased, and the naturalized plant ratio, imported species ratio and herb ratio were increased. But environmental factors of CE were not shown any clear tendency. In conclusion, many species occupied in control site disappeared into the disturbed area, and the naturalized plants and herb species were abundantly imported in the area. Therefore, it was considered that this study could be applied to the development of long-term and short-term ecological restoration techniques in view of vegetation changes.

• Journal of Evidence-Based Herbal Medicine
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• 제1권2호
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• pp.1-6
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• 2008

The internet is closely related to the lives of modern people in the 21st Century. Exchanging information with others over the internet in any place through is possible nowadays and such exchanging information has been developed at rapid speed also in the areas of medical care. The internet is an important and rapidly-evolving source of health-related information, and many patients with atopy dermatitis attempt to find information from the internet. This study was performed to investigate the current information available in atopy dermatitis on the internet in Korea. We chose three portal sites and two network communities to analyze the information in which the topic of 'atopy' could be found. Among the 2,024 web sites and 5,613 network communities, 98.2% of the web sites and 71.7% of the communities were related products or service advertisements, and some of them provided incorrect of exaggerated information. There were only 42 web sites and 75 available communities with genuine information, and most of these also presented unattested treatment methods, including alternative therapies. It is quite understandable that patients with atopy dermatitis want to seek information related to their disease and the internet has the potential to be a useful source of information. However, there are no regulations to control the accuracy and quality of information on the internet. We should take an active role in identifying the accuracy and evaluating the quality.

• 한국의사학회지
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• 제32권2호
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• pp.1-17
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• 2019

The purpose of this study is analyzing how Kim Young-hun treated menstrual diseases-by utilizing the Cheonggang medical records DB. The term "Hyeoljunggiche (血中氣滯)" has been used as an etiological factor of menstrual diseases. Hyeoljunggiche mostly described menstrual diseases of females in the reproductive ages. Four of the most popular prescription were Jeungsonojeok-san (增損五積散), Hyeonbuigyeong-tang (玄附理經湯), Hyeonbuiyeong-jeon (玄附理營煎), and Hyeonbuohwa-eum (玄附五和飮). By writing a medicinal herb network of the four prescriptions, It was found that Kim Young-hun preferred to use three clusters of regulating qi and move blood medicinal (理氣行血藥), sānwù-tāng (三物湯), and píngchén-tāng (平陳湯) with some adjustment of heat-clearing medicinal (淸熱藥) and cold-dispelling medicinal (溫裏藥).

• 대한한의학방제학회지
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• 제26권3호
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• pp.237-250
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• 2018

Objectives : This study is a pharmacological network approach, aimed to identify the potential active compounds contained in Curcumae Radix, and their associated targets, to predict the various bio-reactions involved, and finally to establish the cornerstone for the deep-depth study of the representative mechanisms. Methods : The active compounds of Curcumae Radix have been identified using Traditional Chinese Medicine System Pharmacology Database and Analysis Platform. The UniProt database was used to collect each of information of all target proteins associated with the active compounds. To find the bio-metabolic processes associated with each target, the DAVID6.8 Gene Functional classifier tool was used. Compound-Target and Target-Pathway networks were analyzed via Cytoscape 3.40. Results : The target information from 32 potential active compounds of Curcumae Radix was collected through TCMSP analysis. The active compounds interact with 133 target genes engaging in total of 885 biological pathways. The most relevant pathway was the lipid-related metabolism, in which 3 representative active compounds were naringenin, oleic acid, and ${\beta}-sitosterol$. The mostly targeted proteins in the lipid pathway were ApoB, AKT1 and PPAR. Conclusions : The pharmacological network analysis is convenient approach to predict the overall metabolic mechanisms in medicinal herb research, which can reduce the processes of various experimental trial and error and provide key clues that can be used to validate and experimentally verify the core compounds.

• 전자공학회논문지
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• 제51권12호
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• pp.99-108
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• 2014

WBAN(Wireless Body Area Network)은 의료 및 비의료 서비스를 지원하는 네트워크로, 데이터의 지연과 손실에 민감한 특성이 있다. 다양한 서비스를 제공하기 위해 다양한 전송률, 데이터의 우선순위 등의 요구사항들을 만족해야 한다. 본 논문에서는 WBAN의 서비스 품질을 향상시키기 위하여 데이터의 우선순위와 전송 지연 시간을 고려한 스케줄링 알고리즘을 제안한다. 이 알고리즘은 데이터의 지연 시간이 긴 플로우에 채널을 우선적으로 할당하여 동작하다가, 패킷이 큐에 일정시간이상 머물면 데이터의 우선순위에 따라 채널을 할당하여 서비스한다. 기존의 알고리즘과의 비교를 통해 제안한 알고리즘의 의료 데이터의 수신률이 높아지고 전체 서비스의 품질이 향상된 것을 확인할 수 있었다.

• 대한예방한의학회지
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• 제19권2호
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• pp.145-157
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• 2015

Objective : This study aimed to analyze a comprehensive feature of experimental research on Insamyangyoungtang and develop a strategy that can be used for experimental studies on Insamyangyoung-tang in the future. Method : The journal search was performed using six databases : PubMed, Chinese database (China Network Knowledge Infrastructure, [CNKI]), Japan database (Japan Science and Technology Information Aggregator, Electronic, [J-STAGE]) and three Korean databases (Oriental Medicine Advanced Searching Integrated System [OASIS], Research Information Service System [RISS], and Korean Studies Information Service System [KISS]). We used limited keywords and analyzed studies by publication year, experimental models, and the subjects of biological activities. The mechanism of pharmacological activity in accordance with the therapeutic effects of Insamyangyoung-tang was noted. Results and Conclusion : A total of 43 studies (6 domestic studies and 37 foreign ones) were examined according to the inclusion criteria of the experimental study. Research on the pharmacological activities of Insamyangyoung-tang showed its therapeutic effects on the nervous and immune systems, as well as its anti-aging, anti-fatigue, and hematopoietic effects. Additional efficacy and safety assessments and experimental and clinical studies should be performed to evaluate the mechanism of Insamyangyoung-tang. The present review has provided preliminary information for further studies on Insamyangyoung-tang.

• 대한한방내과학회지
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• 제22권4호
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• pp.639-645
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• 2001

Angiogenesis is a fundamental process in reproduction and wound healing. Under these condition, neovascularization is tightly regulated. Unregulated angiogenesis may lead to several angiogenic diseases, and is thought to be indispensible for solid tumor growth and metastsis. The construction of new vascular network is a multistep cascade involving basement membrane degradation, endothelial cell proliferation, endothelial cell migration, and tube formation. Newly reported anti-angiogenic agents in oriental medical field have targeted both specific and multistep stages in the angiogenic process. From recent approach in oriental medical field with several herb medicines including activating blood flow and removing blood stasis medicine(活血化瘀藥), it may be possible in the future to develope specific anti-angiogenic agents that offer a less toxic potential therapy for cancer and angiogenic disease.

• IMMUNE NETWORK
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• 제8권1호
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• pp.13-20
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• 2008

Background: Coptis chinensis rhizome has been used as a medicinal herb in traditional Oriental medicine. We investigated the effects of Coptis chinensis extract on inflammatory mediators and delayed type hypersensitivity in mice. Methods: The inhibitory effect of ethanolic extract of Coptis chinensis (CCE) on cell proliferation was evaluated using MTS assay. The lipopolysaccharide (LPS)-stimulated RAW264.7 macrophages and the Con A-activated mouse splenocytes were cultured with various concentrations of CCE. Total nitric oxide (NO) production was determined by Griess reaction. The amounts of secreted prostaglandine E2 ($PGE_2$), interleukin (IL)-2 and IFN-${\gamma}$ were measured by ELISA. To investigate the in vivo anti-inflammatory effect of CCE, oxazolone-induced delayed type hypersensitivity (DTH) model was used. Results: The CCE at $100{\mu}g/ml$ significantly blocked the LPS-induced production of pro-inflammatory mediators (NO and PGE) in RAW264.7 macrophages. Also, it significantly inhibited cell proliferation and cytokine (IL-2 and IFN-${\gamma}$) production in splenocytes. Furthermore, when splenocytes from CCE fed mice (200 mg/kg for 2 weeks) were activated with Con A, cell proliferation and cytokine production were significantly inhibited. In addition, CCE decreased in vivo inflammation in oxazolone-induced DTH model mice. Conclusion: We suggest that Coptis chinensis can be used as an anti-inflammatory drug by exerting an inhibitory effect in inflammatory mediator- and cell-mediated inflammation.

• 대한한의학방제학회지
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• 제18권2호
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• pp.227-239
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• 2010

Objective : The purpose of this study was to develop the simulator which can analyze the anti-inflammatory effects of herbs based on e-cell, or the virtual cell. Method : We have ensured the medical herbs and its active compounds by investigating the oriental medicine records and NBCI(Biomedicine database). Also we have developed the web-based search system for confirming database related to anti-inflammation. We have researched the cell signal pathway related with inflammatory response control and established the mathematical model of herb interaction on selected signal pathway in e-cell. Finally we have developed the prototype which can confirm the result of this model visibly. Results : We constructed the database of 62 cases of anti-inflammatory active compounds in 61 cases of medical herbs which have been known anti-inflammation effects in the paper, 16 cases of inflammatory factors, 10 cases of signal pathways related with inflammatory response and 6,834 cases of URL(Uniform Resource Locator) of referenced papers. And we embodied the web-based research system, which can research this database. User can search basic and detailed information of medical plants related with anti-inflammatory by using information system. And user can acquire information on an active compounds, a signal pathway and a link URL of related paper. Among investigated ten pathways, we selected NF-${\kappa}B$, which plays important role in activation of immune system, and we searched the mechanisms of actions of proteins which could be components of this pathway. We reduced total network into IKK-$I{\kappa}B$ - NF-${\kappa}B$, and completed mathematic modeling by using ordinary differential equations and response variables of $I{\kappa}B-NF-{\kappa}B$ signaling model network which is suggested by Baltimore Group. We designed OED(Ordinary Differential Equation) for response of IKK, $I{\kappa}B$, $NF-{\kappa}B$ in e-cell's cytoplasm and nucleus, and measured whether an active compound of medicinal plants which is inputted by an user would have a anti-inflammation effects in obedience to change in concentration over time. The proposed model was verified by using experimental results of the papers which are listed on NCBI.

• IMMUNE NETWORK
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• 제4권2호
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• pp.100-107
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• 2004

Background: The fruit of Rubus coreanus (RC), a perennial herb, has been cultivated for a long time as a popular vegetable. The anti-allergy mechanism of RC is unknown. The purpose of this study is to investigate the inhibitory effect of RC on compound 48/80- or anti-DNP IgE-induced mast cell activation. Methods: For this, influences of RC on the compound 48/80-induced degranulation, histamine release, calcium influx and the change of the intracellular cAMP (cyclic adenosine-3',5' monophosphate) levels of rat peritoneal mast cells (RPMC) and on the anti-DNP IgE-induced histamine release of RPMC were observed. Results: The pretreatment of RC inhibited compound 48/80-induced degranulation, histamine release and intracelluar calcium uptake of RPMC. The anti-DNP IgE-induced histamine release of RPMC was significantly inhibited by pretreatment of RC. The RC increased the level of intracellular cAMP of RPMC, and the pretreatment of RC inhibited compound 48/80-induced decrement of intracellular cAMP of RPMC. Conclusion: These results suggest that RC contains some substances with an activity to inhibit the compound 48/80- or anti-DNP IgE-induced mast cell activitation. The inhibitory effects of RC are likely due to the stabilization of mast cells by blocking the calcium uptake and enhancing the level of intracellular cAMP.