• Title/Summary/Keyword: K-40

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Disaggregation Simulation Analysis on Distinct Aβ40 Fibril Models

  • Cho, Tony;Yu, Youngjae;Shin, Seokmin
    • Proceeding of EDISON Challenge
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    • 2016.03a
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    • pp.55-61
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    • 2016
  • $A{\beta}_{40}$ peptides form oligomers that later aggregate into a plaque, which is deemed to be a leading cause of Alzheimer's Disease. Its non-crystalline morphology has limited an understanding of comprehensive structural study. In this research, computational biomolecular simulations were performed in the following order: solvent and ion addition in a box, energy minimization of protein, equilibration, and periodic boundary condition disaggregation of a monomer from fibril. The result founded the two-fold model is 25% more stable in the simulation environment, and the steric zippers held on most tightly until 220 ps of simulation. The study supports the previous findings that two-fold aggregate $A{\beta}_{40}$ is more stable at 310 K and discusses further how much contribution steric-zipper and hydrogen bonding are making.

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Optimization of 40 Gb/s WDM Systems Using Super-Gaussian RZ Pulses

  • Lee, Jong-Hyung;Han, Dae-Hyun;Lee, Yong-Jae;Choi, Byeong-Yoon
    • Journal of the Optical Society of Korea
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    • v.12 no.4
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    • pp.226-231
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    • 2008
  • 40 Gbps WDM Systems using super-Gaussian RZ pulses have been studied by numerical simulation to optimize their performance. The assumption of standard single mode fiber is valid when existing WDM systems are required to upgrade their performance to 40Gbps. It is shown that the standard single mode fiber can transmit optical signals over 720 km (Q > 10) by optimizing optical and electrical filter characteristics at the receiver and by compensation of dispersion. However, it is also shown that ${\pm}0.3%$ dispersion compensation tolerance per span (80 km) could prohibit transmitting over 320km (Q > 10). In addition, a duty cycle of less than 0.4 degrades system performance significantly.

The Effect of Lotus Root Powder on the Quality of Dasik (연근가루 첨가가 다식의 품질특성에 미치는 영향)

  • Yoon, Sook-Ja;Noh, Kwang-Seok;Jung, Sang-Eun
    • Korean journal of food and cookery science
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    • v.25 no.2
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    • pp.143-149
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    • 2009
  • The objective of this study was to evaluate the quality characteristics of lotus root Dasik prepared by different additions of lotus root powder (0%, 20%, 40%, 60%, 80%). As the level of lotus root powder in the formulation increased, the moisture contents of samples increased. Also, the L-, a-, and b-values of samples significantly decreased as the amount of lotus root powder increased. According to the results for mechanical characteristics, hardness, gumminess, springiness, cohesiveness, and chewiness decreased, whereas adhesiveness increased, as the amount of lotus root powder increased. The sensory evaluation results showed that the 40% lotus root sample received the highest preference scores; therefore, the 40% lotus root Dasik prepared with 60 g of flour, 40 g of lotus root powder, and 80 g of honey was chosen as the superior product.

Effects of Liquid Culture of Agaricus blazei Murill on Protein, Mineral Levels and Enzyme Activities in Rats

  • Koh, Jin-Bog;Kim, Jai-Young
    • Biomedical Science Letters
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    • v.10 no.2
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    • pp.171-177
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    • 2004
  • This study was performed to investigate the effects of liquid culture of Agaricus blazei Murill on the weight gains, food efficiency ratios, serum protein and mineral levels, and serum enzyme activities in growing male rats. Sprague-Dawley rats (7 weeks old) were given four different types of diets for a succeeding period of 6 weeks, respectively: a normal diet group, a control diet group (normal diet + 15% lard + 0.5% cholesterol), a 30% or 40% A. blazei diet groups (control diet + 30% or 40% A. blazei in water) according to the levels of A. blazei supplementation. The body weight gains, food efficiency ratios, and the liver of the rats fed control diet, 30% or 40% A. blazei diets were significantly increased compared to rats fed the normal diet, but those of rats fed the 30% and 40% A. blazei diets were similar to those of rats fed the control diet. The concentrations of total protein, albumin, glucose, and hematocrit value in serum of rats fed the control diet, 30% or 40% A. blazei diets were similar to those of rats fed the normal diet. The concentrations of urea and creatinine in serum of rats fed the 30% or 40% A. blazei diets were similar to those of rats fed the control diet. but the urea of rats fed the 30% and 40% A. blazei diets were significantly decreased compared to rats fed the normal diet. The concentrations of Ca, P, Fe and Mg, and $Ca^{++}$, $K^+$, $Na^+$ and $Cl^-$ of rats fed the control diet, 30% or 40% A. blazei diets were similar to those of rats fed the normal diet. There were no differences in the activities of aspartate aminotransferase, alanine aminotransferase, $\gamma$-glutamyltranspeptidase and alkaline phosphatase in the serum among the experimental groups. In conclusion, the rats fed the A. blazei maintained normal protein and mineral levels, and enzyme activities of serum. But the A. blazei feeding could not decrease the body and liver weights in the rats fed high cholesterol diets.

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Effects of the Dietary Microbial Phytase Supplementation on Bioavailability of Phosphorus in Juvenile Olive Flounder Paralichthys olivaceus Fed Soybean Meal based Diets

  • Yoo, Gwangyeol;Bai, Sungchul C.
    • Fisheries and Aquatic Sciences
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    • v.17 no.3
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    • pp.319-324
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    • 2014
  • An 8 weeks feeding trial was carried out to evaluate the effects of dietary microbial phytase (P) supplementation on nutrient digestibility, and body composition in juvenile olive flounder Paralichthys olivaceus fed soybean meal-based diets. Seven experimental diets were formulated to be isonitrogenous and isocaloric to contain 50.0% crude protein (CP) and 16.7 kJ of available energy/g with or without dietary phytase supplementation. White fish meal (FM) provided 92.4% of the total protein in the basal diet ($S_0$), in the other 6 diets, 30% or 40% FM protein was replaced by soybean meal: 70% FM + 30% soybean meal ($S_{30}$); 70% FM + 30% SM + 1000 U phytase/kg diet ($S_{30}P_{1000}$); 70% FM + 30% SM + 2000 U phytase/kg diet ($S_{30}P_{2000}$); 60% FM + 40% SM ($S_{40}$); 60% FM + 40% SM + 1000 U phytase/kg diet ($S_{40}P_{1000}$); and 60% FM + 40% SM + 2000 U phytase/kg diet ($S_{40}P_{2000}$). After two weeks of the conditioning period, triplicate groups of 25 fish initially averaging $6.15{\pm}0.04g$ ($mean{\pm}S.D.$) were randomly distributed into the aquarium and were fed one of the experimental diets for 8 weeks. After feeding trial, supplementation of phytase significantly improved the apparent digestibility coefficients of phosphorus in flounder diets (P<0.05) containing 30% and 40% soybean meal regardless the levels. However, phytase had no significant influence on growth performance and whole body composition of fish. Based on the experimental results, we conclude that dietary supplementation of phytase could improve the apparent digestibility coefficient of phosphorus in olive flounder.

Radioactive Concentrations in Chemical Fertilizers

  • Gwang-Ho Kim;Jae-Hwan Cho
    • Journal of Radiation Protection and Research
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    • v.47 no.4
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    • pp.195-203
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    • 2022
  • Background: The aim of the present study was to determine radioactive concentrations in fertilizers known to contain essential nutrients. Results of this study could be used as basic data to monitor the impact of chemical fertilizers on the environment and public health. Nitrogen fertilizers, calcium fertilizers, sulfur fertilizers, phosphate acid fertilizers, and potassium chloride fertilizers were used in this study. Materials and Methods: Five chemical fertilizers were pulverized, placed in polyethylene containers, and weighed. The time to measure each specimen was set to be 3,600 seconds for a scintillator-based gamma-ray spectroscopy system. Concentration of gamma radionuclide was analyzed based on obtained spectra. At the end of the measurement, the spectrum file was stored and used to calculate radioactive concentrations using a gamma-ray spectrometer software. Results and Discussion: In the nitrogen fertilizer, 3.49 ± 5.71 Bq/kg of 137Cs, 34.43 ± 7.61 Bq/kg of 134Cs, and 569.16 ± 91.15 of 40K were detected whereas 131I was not detected. In the calcium fertilizer, 5.74 ± 4.40 Bq/kg of 137Cs (the highest concentration among all fertilizers), 22.37 ± 5.39 Bq/kg of 134Cs, and 433.67 ± 64.24 Bq/kg of 40K were detected whereas 131I was not detected. In the sulfur fertilizer, 347.31 ± 55.73 Bq/kg of 40K, 19.42 ± 4.53 Bq/kg of 134Cs, 2.21 ± 3.49 of 137Cs, and 0.04 ± 0.22 Bq/Kg of 131I were detected. In the phosphoric acid fertilizer, 70,007.34 ± 844.18 Bq/kg of 40K (the highest concentration among all fertilizers) and 46.07 ± 70.40 Bq/kg of 134Cs were detected whereas neither 137Cs nor 131I was detected. In the potassium chloride fertilizer, 12,827.92 ± 1542.19 Bq/kg of 40K was and 94.76 ± 128.79 Bq/kg of 134Cs were detected whereas neither 137Cs nor 131I was detected. The present study examined inorganic fertilizers produced by a single manufacturer. There might be different results according to the country and area from which fertilizers are imported. Further studies about inorganic fertilizers in more detail are needed to create measures to reduce 40K. Conclusion: Measures are needed to reduce radiation exposure to 40K contained in fertilizers including phosphoric acid and potassium chloride fertilizers.

Characteristics of Equilibrium, Kinetic and Thermodynamic for Adsorption of Acid Blue 40 by Activated Carbon (활성탄에 의한 Acid Blue 40 흡착에 있어서 평형, 동력학 및 열역학적 특성)

  • Lee, Jong Jib
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.19 no.12
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    • pp.592-599
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    • 2018
  • The kinetics and thermodynamics of the adsorption of acid blue 40 from an aqueous solution by activated carbon were examined as a function of the activated carbon dose, pH, temperature, contact time, and initial concentration. The adsorption efficiency in a bathtub was increased at pH 3 and pH 11 due to the presence of sufonate ions ($SO_3{^-}$) and amine ions ($NH_2{^+}$). The equilibrium adsorption data were fitted to the Langmuir, Freundlich and Temkin isotherms. The results indicated that the Langmuir model provides the best correlation of the experimental data. The separation factor of the Langmuir and Freundlich model showed that the adsorption treatment of acid blue 40 by activated carbon could be an effective adsorption process. The adsorption energy determined by the Temkin equation showed that the adsorption step is a physical adsorption process. Kinetics analysis of the adsorption process of acid blue 40 on activated carbon showed that a pseudo second order kinetic model is more consistent than a pseudo second order kinetic model. The estimated activation energy was 42.308 kJ/mol. The enthalpy change (80.088 J/mol) indicated an endothermic process. The free energy change (-0.0553 ~ -5.5855 kJ/mol) showed that the spontaneity of the process increased with increasing adsorption temperature.

Impact of SV40 T antigen on two multiple fission microalgae species Scenedesmus quadricauda and Chlorella vulgaris

  • Gomaa, Ahmed E.;Yang, Seung Hwan
    • International journal of advanced smart convergence
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    • v.7 no.1
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    • pp.48-63
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    • 2018
  • The combination of Simian Virus40 (SV40)'s large T antigen with its replication origin is commonly used in molecular studies to enhance the expression of heterogeneous genes through multiplying the plasmid copy number. There are no reports related to the impact of the SV40 T antigen on plant, multiple fissional, cell-type. This study explores the response of two multiple-fission microalgal cells, Scenedesmus quadricauda and Chlorella vulgaris, to the expression of the T-antigen, with aim of applying SV40 T-antigen to increase the expression efficiency of foreign genes in the two species. Different levels of low-expression have been constructed to control the expression of SV40 T antigen using three heterogenous promoters (NOS, CaMV35S, and CMV). Chlorella cultures showed slowdown in the growth rate for samples harboring the T antigen under the control of CaMV35S and CMV promoters, unlike Scenedesmus cultures which showed no significant difference between samples and could have silenced the expression.