• Journal of computational fluids engineering
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• v.20 no.1
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• pp.47-56
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• 2015

In this paper, we study the effect of various turbulence models by comparing the aerodynamic characteristics and the flow patterns computed for aircraft models. An in-house CFD solver, MSAPv, that solves the three dimensional RANS equations with the turbulence model equations is used. The turbulence models used in this study are the Spalart-Allmaras model, Menter's $k-{\omega}$ SST model, Coakley's $q-{\omega}$ model, and Huang and Coakley's $k-{\varepsilon}$ model. DLR-F6 WB and WBNP configurations are selected for the study. We concentrate on the separated flow pattern variations with the turbulence models at the wing-body junction and the wing-pylon junction as well as drag polar curves.

• Proceedings of the PSK Conference
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• 2000.04a
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• pp.70-81
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• 2000

DA-5018 is a synthetic capsaicin derivative under development as a non-narcotic a analgesic ag$\varepsilon$nt. DA-50 18 showed a potent analgesic activity against acute and chronic pain m model(Tablel, 2.), but it had a narrow margin of safety. DA-5018 did not bind to opioid(${\kappa}, {\delta}, {\mu}$), NKl, CGRP receptors in vitro and its analgesic effect was not antagonized by naloxone, a and it did not develop analgesic tolerance. In addition DA-5018 had no inhibitory effects against c cyclooxygenase and 5-lipooxygenase activities. DA-5018 significantly increased the relcase of substance P from the slices of the rat spinal cord. These results suggest that DA-50 18 is not a narcotic nor aspirin-like analgesic and the release of substance P is one of analgesic mechanism of action of DA-5018. We found that DA-5018 was almost ten times more potent and was at l least IOO-times less irritable compared to capsaicin. Accordingly development of topical formula was adopted. Topical formula was desiged and screened by flux test of DA-5018 using hairless mouse skin and several formulas were selected. With these topical formulas we a assessed the analgesic efficacy and carried out the toxicity, skin irritation and pharmacokinetic studies. In streptozotocin-induced hyperalgesic rat and 50 % galactose-fed hyperalgesic rat as diabetic pain models, DA-5018 cream increased the pain thresh이ds up to 77.0% and 24.4% respectively, while Zostrix-HP(capsaicin cream) incr$\varepsilon$as cd by 65.9% and 21.0%. DA-5018 c cream showed a good analgesic effect as welI in FCA-induced arthritic rat. DA-5018 cream did not show any toxicological signs in acute and chronic toxicity test and had little skin irritation in car swclIing and scratching t$\varepsilon$st. Pharmacokinetics of DA-50 18 were studied after topical application of ${14}^C$-Iabelled or unlabelIed DA-5018 cream. Plasma and skin concentrations c except applied skin wcre below the dctection limit and after 7-day cummulative application, plasma concentrations were also below detection limit DA-50 18 may have an advantag$\varepsilon$ ov$\varepsilon$r c capsaicin and is now being developed as a topical agent for the treatment of pains. DA-50 18 cream was approved for Korean IND and is now under a Phase II clinical study for arthritic pain a after finising Phase I study. DA-50 18 was also liscensed out to Stiefel Company in America in

• Journal of the Korean Society of Food Science and Nutrition
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• v.43 no.3
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• pp.349-354
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• 2014

Elevation of intracellular calcium ($Ca^{{+}{+}}$) triggers degranulation of mast cells by bypassing receptor activation. Flos Sophora japonica L. has been used as a natural dying source and has been reported to have biological activities such as anti-inflammatory and anti-allergic effects through $Fc{\varepsilon}RI$ and IgE crosslinking. In the present investigation, we report the regulatory effect of ethanolic extract of Flos Sophora japonica L. (S.F) on allergic mediators produced by $Ca^{{+}{+}}$ ionophore activation in mast cells. S.F significantly inhibited calcium ionophore (A23187)-induced interleukin (IL)-4 and tumor necrosis factor (TNF)-${\alpha}$ production as well as mast cell degranulation. Furthermore, administration of S.F suppressed allergic reactions in a 2,4-dinitrofluorobenzene (DNFB)-induced allergic dermatitis mouse model. Both oral administration and ear painting using 50 mg/kg of S.F significantly reduced levels of cytokines such as IL-4, TNF, and interferon-${\gamma}$ in ear tissues compared to the DNFB alone-treated group. Serum IgE level in the S.F-treated group also decreased compared to the DNFB alone-treated group. Weights of spleens and lymph nodes in the S.F-treated groups also decreased compared to the control group. Considering the data, we conclude that S.F mediates its anti-allergic effects not only through $Fc{\varepsilon}RI$ stimulation but also $Ca^{{+}{+}}$ influx in mast cells.

• Journal of computational fluids engineering
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• v.11 no.3 s.34
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• pp.59-63
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• 2006

Accurate prediction of a supersonic missile base drag continues to defy even well-rounded CFD codes. In an effort to address the accuracy and predictability of the base drags, the influence of grid system and competitive turbulence models on the base drag is analyzed. Characteristics of some turbulence models is reviewed through incompressible turbulent flow over a flat plate, and performance for the base drag prediction of several turbulence models such as Baldwin-Loman(B-L), Spalart-Allmaras(S-A), k-$\varepsilon$, k-$\omega$ model is assessed. When compressibility correction is injected into the S-A model, prediction accuracy of the base drag is enhanced. The NSWC wind tunnel test data are utilized for comparison of CFD and semi-empirical codes on the accuracy of base drag predictability: they are about equal, but CFD tends to perform better. It is also found that, as angle of attack of a missile with control fins increases, even the best CFD analysis tool we have lacks the accuracy needed for the base drag prediction.

• International Journal of Naval Architecture and Ocean Engineering
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• v.9 no.2
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• pp.149-159
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• 2017

In this study, the numerical investigation of ship motions and added resistance at constant forward velocity of KVLCC2 model is presented. Finite volume CFD code is used to calculate three dimensional, incompressible, unsteady RANS equations. Numerical computations show that reliable numerical results can be obtained in head waves. In the numerical analyses, body attached mesh method is used to simulate the ship motions. Free surface is simulated by using VOF method. The relationship between the turbulence viscosity and the velocities are obtained through the standard ${\kappa}-{\varepsilon}$ turbulence model. The numerical results are examined in terms of ship resistance, ship motions and added resistance. The validation studies are carried out by comparing the present results obtained for the KVLCC2 hull from the literature. It is shown that, ship resistance, pitch and heave motions in regular head waves can be estimated accurately, although, added resistance can be predicted with some error.

• Solar Energy
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• v.17 no.3
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• pp.3-11
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• 1997

Recently the construction of atrium buildings has increased but along with it many problems in thermal environment have arised. since the exterior wall of glass, indoor temperature is greatly influenced by weather conditions and since the space volume is very large, the vertical air temperature is not uniform. So, in this study, a Vertical Temperature Distribution Model was developed to predict the vertical air temperature of an atrium and evaluate the effects of the design parameters on the air temperature distribution of an atrium. To consider the characteristics of the vertical air temperature distribution in an atrium, the Satosh Togari's Macroscopic Model was used basically for the calculation of the vertical air temperature distribution in large space and the solar radiation analysis model and natural ventilation analysis model in atrium. And to calculate the unsteady-state inside wall surface temperature(boundary condition), the finite difference method was used. For the verification of the developed temperature distribution program, numerical evaluation of air flow by the ${\kappa}-{\varepsilon}$ turbulence model and in-situ test was conducted in parallel. The results of this study, the developed temperature distribution program was seen to predict the thermal condition of the atrium very accurately.

• Wind and Structures
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• v.25 no.6
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• pp.537-549
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• 2017

In this study, the turbulent flow around a bluff body for different wind velocities was investigated numerically by using its two- and three-dimensional models. These models were tested to verify the validity of the simulation by being compared with experimental results which were taken from the literature. Variations of non-dimensional velocities in different positions according to the bluff body height were analysed and illustrated graphically. When the velocity distributions were examined, it was seen that the results of both two- and three-dimensional models agree with the experimental data. It was also seen that the velocities obtained from two-dimensional model matched up with the experimental data from the ground to the top of the bluff body. Particularly, compared to the front part of the bluff body, results of the upper and back part of the bluff body are better. Moreover, after comparing the results from calculations by using different models with experimental data, the effect of multidimensional models on the obtained results have been analysed for different inlet velocities. The calculation results from the two-dimensional (2D) model are in satisfactory agreement with the calculation results of the three-dimensional model (3D) for various flow situations when comparing with the experimental data from the literature even though the 3D model gives better solutions.

• Proceedings of the Korean Society of Tribologists and Lubrication Engineers Conference
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• 1990.06a
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• pp.73-91
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• 1990

Incompressible turbulent flow in a single cavity of the stepped multi-cavity labyrinth seal is numerically analyzed to investigate an effect of the shaft speed on the leakage. SIMPLER algorithm is used to solve governing equations, and low-Reynolds k-$\varepsilon$ turbulence model as outlined by Launder and Sharma is adopted to predict turbulent flow. Pressure drops for the cavity with and without the groove are evaluated for four different Reynolds numbersand three different shaft speeds.

• Tribology and Lubricants
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• v.6 no.2
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• pp.27-33
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• 1990

Incompressible turbulent flow in a single cavity of the stepped multi-cavity labyrinth seal is numerically analyzed to investigate an effect of the shaft speed on the leakage. SIMPLER algorithm is used to solve governing equations, and low-Reynolds k-$\varepsilon$ turbulence model as outlined by Launder and Sharma is adopted to predict turbulent flow. Pressure drops for the cavity with and without the groove are evaluated for four different Reynolds numbers and three different shaft speeds.

• Korean Journal of Air-Conditioning and Refrigeration Engineering
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• v.12 no.6
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• pp.616-622
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• 2000

This paper concerns the application of smoke and fire spread to road tunnel fire problems. When a road tunnel is on fire. a fire protection system of road tunnel have to offer an adequate escape space to human. Therefore, this study carried out a simulation for predicting a spreading path of smoke and fire. The evolution of the flow field is simulated with the low Reynolds number k-$\varepsilon$ turbulent model and SIMPLE algorithm based on the finite volume method.