• Title/Summary/Keyword: K/r Hypothesis

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Plasma Phospholipids, including Plasmalogens, after Consumption of Diets Enriched in Long-chain n-3 Fatty Acids

  • Yeo, Young-K.;Kim, Jong-S.;Lee, Jong-R.;Lee, Ji-Y.;Chung, Sang-W.;Kim, Hyo-J.;Horrocks, Lloyd A.;Park, Young-S.
    • BMB Reports
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    • v.33 no.6
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    • pp.499-505
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    • 2000
  • The level of long-chain n-3 fatty acids in chicken and pork can be increased by changing the diet of the animals. Increased levels of these essential fatty acids improve cardiovascular health in humans. The purpose of this study was to study the effects of the consumption of pork and chicken enriched in docosahexaenoic acid (DHA) on plasma lipids. The consumption of these products decreased the levels of two cardiovascular risk factors, LDL-cholesterol and triacylglycerols, in the plasma of female college students. The effect on LDL-cholesterol differed from that of fish oil, which does not affect the level of LDL-cholesterol. The proportions of DHA in the triacylglycerols and the glycerophospholipids were increased markedly. The greatest changes in the glycerophospholipids were in the ether types of the ethanolamine glycerophospholipids. Dietary DHA appears to be incorporated preferentially into the plasma ethanolamine plasmalogens, which can act as antioxidants. This agrees with our hypothesis that DHA stimulated the transcription of the genes for peroxisomal enzymes that are required for plasmalogen synthesis.

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Astragaloside IV Prevents Obesity-Associated Hypertension by Improving Pro-Inflammatory Reaction and Leptin Resistance

  • Jiang, Ping;Ma, Dufang;Wang, Xue;Wang, Yongcheng;Bi, Yuxin;Yang, Jinlong;Wang, Xuebing;Li, Xiao
    • Molecules and Cells
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    • v.41 no.3
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    • pp.244-255
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    • 2018
  • Low-grade pro-inflammatory state and leptin resistance are important underlying mechanisms that contribute to obesity-associated hypertension. We tested the hypothesis that Astragaloside IV (As IV), known to counteract obesity and hypertension, could prevent obesity-associated hypertension by inhibiting pro-inflammatory reaction and leptin resistance. High-fat diet (HFD) induced obese rats were randomly assigned to three groups: the HFD control group (HF con group), As IV group, and the As IV + ${\alpha}$-bungaratoxin (${\alpha}-BGT$) group (As IV+${\alpha}-BGT$ group). As IV ($20mg{\cdot}Kg^{-1}{\cdot}d^{-1}$) was administrated to rats for 6 weeks via daily oral gavage. Body weight and blood pressure were continuously measured, and NE levels in the plasma and renal cortex was evaluated to reflect the sympathetic activity. The expressions of leptin receptor (LepRb) mRNA, phosphorylated signal transducer and activator of transcription-3 (p-STAT3), phosphorylated phosphatidylinositol 3-kinase (p-PI3K), suppressor of cytokine signaling 3 (SOCS3) mRNA, and protein-tyrosine phosphatase 1B (PTP1B) mRNA, pro-opiomelanocortin (POMC) mRNA and neuropeptide Y (NPY) mRNA were measured by Western blot or qRT-PCR to evaluate the hypothalamic leptin sensitivity. Additionally, we measured the protein or mRNA levels of ${\alpha}7nAChR$, inhibitor of nuclear factor ${\kappa}B$ kinase subunit ${\beta}/nuclear$ factor ${\kappa}B$ ($IKK{\beta}/NF-KB$) and pro-inflammatory cytokines ($IL-1{\beta}$ and $TNF-{\alpha}$) in hypothalamus and adipose tissue to reflect the anti-inflammatory effects of As IV through upregulating expression of ${\alpha}7nAChR$. We found that As IV prevented body weight gain and adipose accumulation, and also improved metabolic disorders in HFD rats. Furthermore, As IV decreased BP and HR, as well as NE levels in blood and renal tissue. In the hypothalamus, As IV alleviated leptin resistance as evidenced by the increased p-STAT3, LepRb mRNA and POMC mRNA, and decreased p-PI3K, SOCS3 mRNA, and PTP1B mRNA. The effects of As IV on leptin sensitivity were related in part to the up-regulated ${\alpha}7nAchR$ and suppressed $IKK{\beta}/NF-KB$ signaling and pro-inflammatory cytokines in the hypothalamus and adipose tissue, since co-administration of ${\alpha}7nAChR$ selective antagonist ${\alpha}-BGT$ could weaken the improved effect of As IV on central leptin resistance. Our study suggested that As IV could efficiently prevent obesityassociated hypertension through inhibiting inflammatory reaction and improving leptin resistance; furthermore, these effects of As IV was partly related to the increased ${\alpha}7nAchR$ expression.

The Relationships between Sports Ability Beliefs, Achievement Goal Orientation, Exercise Flow, and Perceived Performance in College Golf Athletes (대학 골프선수들의 운동능력믿음, 성취목표성향, 운동몰입 및 인지된 경기력의 관계)

  • Bum, Chul-Ho
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.18 no.2
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    • pp.268-276
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    • 2017
  • The aim of this study was to verify the theoretical relationship between sports ability beliefs, achievement goal orientation, exercise flow, and athletic performance in college golf athletes. The results of the Statistical Package for Social Sciences (SPSS) 18.0 and Analysis of MOment Structures (AMOS) 18.0 performed on the data collected from 211 participants are as follows. First, hypothesis testing showed that college golf athletes with incremental beliefs set task-oriented goals (C.R.=3.780, p<.001). Second, the task-oriented goals (C.R.=4,082, p<.001) and ego-oriented goals (C.R.=3.819, p<.001) in achievement goal orientation raised the level of flow during golf. Third, in achieving goal orientation, only task orientation led to a higher perceived level of golf performance (C.R.=3.020, p<.01). Fourth, a higher level of flow led to higher levels of golf performance (C.R.=4.642, p<.001). Other sub-factors were not statistically significant in the current study. These results could be applied in the field of sports as they show what results can be achieved depending on the athlete's belief in their sports ability.

Grazing Soybean to Increase Voluntary Cow Traffic in a Pasture-based Automatic Milking System

  • Clark, C.E.F.;Horadagoda, A.;Kerrisk, K.L.;Scott, V.;Islam, M.R.;Kaur, R.;Garcia, S.C.
    • Asian-Australasian Journal of Animal Sciences
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    • v.27 no.3
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    • pp.422-430
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    • 2014
  • Pasture-based automatic milking systems (AMS) require cow traffic to enable cows to be milked. The interval between milkings can be manipulated by strategically allocating pasture. The current experiment investigated the effect of replacing an allocation of grazed pasture with grazed soybean (Glycine max) with the hypothesis that incorporating soybean would increase voluntary cow traffic and milk production. One hundred and eighty mixed age, primiparous and multiparous Holstein-Friesian/Illawarra cows were randomly assigned to two treatment groups (n = 90/group) with a $2{\times}2$ Latin square design. Each group was either offered treatments of kikuyu grass (Pennisetum clandestinum Hoach ex Chiov.) pasture (pasture) or soybean from 0900 h to 1500 h during the experimental period which consisted of 2 periods of 3 days following 5 days of training and adaptation in each period with groups crossing over treatments after the first period. The number of cows trafficking to each treatment was similar together with milk yield (mean ${\approx}18$ L/cow/d) in this experiment. For the cows that arrived at soybean or pasture there were significant differences in their behaviour and consequently the number of cows exiting each treatment paddock. There was greater cow traffic (more cows and sooner) exiting pasture allocations. Cows that arrived at soybean stayed on the allocation for 25% more time and ate more forage (8.5 kg/cow/d/allocation) relative to pasture (4.7 kg/cow/d/allocation). Pasture cows predominantly replaced eating time with rumination. These findings suggest that replacing pasture with alternative grazeable forages provides no additional incentive to increase voluntary cow traffic to an allocation of feed in AMS. This work highlights the opportunity to increase forage intakes in AMS through the incorporation of alternative forages.

Value-Relevance of R&D and Ad expenditures in the Medical Industry : Medical Precision and Medicine Industry Case (의료관련 산업의 연구개발비와 광고선전비 지출이 기업가치에 미치는 영향 (의료정밀과 의약품 산업을 중심으로))

  • Cho, Duk-Young;Choi, Soo-Hyung
    • Korea Journal of Hospital Management
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    • v.11 no.3
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    • pp.1-18
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    • 2006
  • The purpose of this study is to analyze the relationship between intangible asset items and company value by empirical research in the medical industry, which may enhance usefulness of the results of other empirical research on intangible asset and company value. In order to attain the purpose of this study, the stock price is taken as the independent variable and all of intangible asset items reported to a balance sheet except the development expenditures and other development expenditures, and advertisement expenses, ordinary research & development expenditures reported on the income statement are taken as the dependent variables. In the following, I carried out four meaningful results from the analysis. First, research hypothesis 1; Book value of intangible asset reported in balance sheet bears positive relationship with company value shows that development expenditures 1 variable gives positive association in a significant level while a group of \10,000-above-company shows no relationship with company value, the other group of below-\10,000-company supports a consistently significant association. All this considering, we have to keep in mind that lack of prudence may leads to wrong results when we try to analyze. Second, research hypothesis 2; Intangible asset and other intangible asset expenditures reported on the income statement gives positive effect on company value shows that R&D accounts variables give insignificance in a statistical level to all company, including entire group, \10,000-above and below consistently. These results testify that current accounting system is valid. Third, in the case of other intangible asset, it requires further examination of current KAS because statistical results show negatively significant value or insignificant value in a statistical level. That means the more intangible assets, the less company value or nothing. Last, in the case of advertisement expenditure variables of above-\10,000 and entire company shows insignificances in a statistical level consistently while below-\10,000-company shows significant result coherently. We should regard accounting information on the advertisement expenditures of \10,000-below-company with caution. The results of this study provide controversial points whether intangible asset items reported on B/S, excluding development expenditures, should be regarded as asset. To facilitate the utility of accounting information on intangible asset, it seems necessary to regard advertisement expenditures reported on I/S as asset accounts. There are further arguments on the way of dealing with intangible asset under KAS that might be considered.

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An Analysis of Factors Affecting Industry-Public Research Institutes Cooperation and Firm Performance in Korea (기업-정부출연(연) 간 협력과 기업성과에 영향을 미치는 요인)

  • Hwang, Kyung-Yun;Sung, Eul-Hyun
    • Management & Information Systems Review
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    • v.37 no.3
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    • pp.147-171
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    • 2018
  • The purpose of this study is to analyze the factors affecting cooperation between industry and public research institutes, in addition to the effects of cooperation between them; on technological and economic performance of firms. Based on existing research relating to the factors affecting industry-university-research institutes cooperation and the relationship between them and firm performance, this study selected the competence of government-funded research institutes, R&D capabilities and organizational characteristics of firms, and support of government and local governments; as factors influencing cooperation between industry and public research institutes. This study sets seven hypotheses on the relationship between the factors promoting industry-public research institute cooperation, technological performance and economic performance. A questionnaire survey was used to collect data for hypothesis testing and 116 questionnaires were completed and used in this research. The PLS-MGA was used as a method for hypothesis testing. In the analysis results, we found that the competence of government-funded research institutes, organizational characteristics of firms, and the support of government and local governments have a positive impact on cooperation between industry and public research institutes. We also found that the collaboration between industry and public research institutes, positively affects firms' technological performance. In addition, we found that the technological performance of a firm, positively affects a firms' economic performance. On the other hand, firms' R&D capabilities have no significant effect on cooperation between industry and public research institutes, and industry-public research institute cooperation does not directly affect the economic performance of firms.

β-Glucanase-assisted extraction of starch from glutinous barley (찰보리 전분 추출에 있어서 β-Glucanase 처리 효과)

  • Bae, Jae-Seok;Lee, Eui-Suk;Jeong, Yong-Sun;Kim, Jeong-Won;Lee, Mi-Ja;Hong, Soon-Taek
    • Korean Journal of Agricultural Science
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    • v.39 no.3
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    • pp.387-393
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    • 2012
  • In the present study, ${\beta}$-glucanase-assisted extraction of starch from glutinous barley(Hinchal ssalbory) was investigated. ${\beta}$-glucanase was added to a coarse starch suspension obtained after wet milling in the starch extraction process. It was found that in the isolated starch with enzyme treatment, protein content was lower by 0.03%, compared to that with non-enzyme treatment. More importantly it was observed that the extraction yield of starch from enzyme treatment was found to be about 12% higher than the one from non-enzyme treatment (enzyme treated: 90.56%, non-enzyme treated: 78.46%). In order to elucidate this finding, the mass-balance determination of starch in each extraction step was carried out and found that the enzyme treatment might influence on the insoluble residues(R3 and R4 fractions) to hydrolyze ${\beta}$-glucan and other materials (e.g., mucilages etc.), thereby facilitated the separation of starch from it and a next filtration process. With a phase-contrast microscope it was observed that the isolated starch with enzyme treatment contained small starch granules more than the one with non-enzyme treatment and this might result in higher extraction yield observed with the former. In order to confirm this hypothesis, further experiments would be necessary.

Rheological and mechanical properties of ABS/PC blends

  • Khan M.M.K.;Liang R.F.;Gupta R.K.;Agarwal S.
    • Korea-Australia Rheology Journal
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    • v.17 no.1
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    • pp.1-7
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    • 2005
  • Acrylonitrile-Butadiene-Styrene (ABS), polycarbonate (PC) and their alloys are an important class of engineering thermoplastics that are widely used for automotive industry, computer and equipment housings. For the process of recycling mixtures of ABS and PC, it is desirable to know how sensitive the blend properties are to changes in compositions. It was for this reason that blends of virgin ABS and virgin PC at five different compositions, namely, $15\%,\;30\%,\;50\%,\;70%$ and $85\%$ by weight of ABS were prepared and characterised by rheological and mechanical measurements. Rheological properties of these blends in steady, oscillatory and transient step shear and mechanical properties, namely, tensile strength, elongation-at-break and Izod impact strength are reported. The results show that PC behaves in a relatively Newtonian manner, but ABS exhibits significant shear thinning. The ABS-rich blends show a trend that is similar to that of ABS, while PC-rich blends, namely $0\%$ and $15\%$, exhibit a nearly Newtonian behaviour. However, at a fixed shear rate or frequency, the steady shear or the dynamic viscosity varied respectively in a non-mono-tonic manner with composition. Except for $15\%$ blend, the viscosities of other blends fall into a narrow band indicating a wide-operation window of varying blend ratio. The blends exhibited a lower viscosity than either of the two pure components. The other noticeable feature was that the blends at $70\%$ and $85\%$ ABS content had a higher G' than pure ABS, indicating an enhancement of elastic effect. The tensile yield strength of the blends followed the 'rule of mixtures' showing a decreasing value with the increase of ABS content in PC. However, the elongation-at-break and the impact strength did not appear to obey this 'rule of mixtures,' which suggests that morphology of the blends also plays a significant role in determining the properties. Indeed, scanning electron micrographs of the fracture surfaces of the different blends validate this hypothesis, and the $15\%$ blend is seen to have the most distinct morphology and correspondingly different behaviour and properties.

Correlation between lateral abdominal, rectus femoris, and triceps brachii muscle thickness and endurance during prone bridge exercise in healthy young adults

  • Lee, Kyeong Bong;Kim, Jong Geun;Park, Han Gi;Kim, Ji Eun;Kim, Hye Sun;Lee, Wan Hee
    • Physical Therapy Rehabilitation Science
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    • v.4 no.1
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    • pp.11-16
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    • 2015
  • Objective: Prone bridge exercise is one of the core strengthening exercise for improving abdominal, lower and upper extremity muscles. In addition, coactivation of the trunk muscles and extremities is important for treatment of low back pain. This study aimed to investigate the correlation between the thickness, cross-sectional area of the target muscle, and endurance during prone bridge exercise. Our hypothesis was that an increase in muscle thickness is positively related to the hold time for the static prone bridge exercise. Design: Cross-sectional study. Methods: Fourteen healthy university students (8 men and 6 women) voluntarily participated in the study at Sahmyook University. Hold time for the prone bridge with one and both legs was measured. The resting and contracted thickness of the lateral abdominal, rectus femoris, and triceps muscles was measured using rehabilitative ultrasound imaging. The correlation between muscle thickness and endurance for maintenance time was evaluated. Results: The prone bridge with both legs and the contraction thickness of the triceps muscle showed a positive correlation (r=0.692, p<0.05); the prone bridge with one leg and the contraction thickness of the internal oblique and transversus abdominis muscles showed a positive correlation (r=0.545, 0.574, p<0.05, 0.05, respectively). Conclusions: Endurance for the prone bridge exercise with a stable support surface is correlated with the contraction thickness of arm muscles; the prone bridge exercise with an unstable support surface is correlated with the contraction thickness of the deep abdominal muscles.

The Validity and Reliability of the Korean Version of Readiness for Practice Survey for Nursing Students (한국어판 간호학생 간호실무준비도 측정도구의 타당도와 신뢰도)

  • Lee, Tae Wha;Ji, Yoonjung;Yoon, Yea Seul
    • Journal of Korean Academy of Nursing
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    • v.52 no.6
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    • pp.564-581
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    • 2022
  • Purpose: This study aimed to evaluate the validity and reliability of the Korean version of the Readiness for Practice Survey (K-RPS). Method: The English Readiness for Practice Survey was translated into Korean using the Translation, Review, Adjudication, Pretesting, and Documentation (TRAPD) method. Secondary data analysis was performed using the dataset from the New Nurse e-Cohort study (Panel 2020) in South Korea. This study used a nationally representative sample of 812 senior nursing students. Exploratory and confirmatory factor analyses were also conducted. Convergent validity within the items and discriminant validity between factors were assessed to evaluate construct validity. Construct validity for hypothesis testing was evaluated using convergent and discriminant validity. Ordinary α was used to assess reliability. Results: The K-RPS comprises 20 items examining four factors: clinical problem solving, learning experience, professional responsibilities, and professional preparation. Although the convergent validity of the items was successfully verified, discriminant validity between the factors was not. The K-RPS construct validity was verified using a bi-factor model (CMIN/DF 2.20, RMSEA .06, TLI .97, CFI .97, and PGFI .59). The K-RPS was significantly correlated with self-esteem (r = .43, p < .001) and anxiety about clinical practicum (r = - .50, p < .001). Internal consistency was reliable based on an ordinary α of .88. Conclusion: The K-RPS is both valid and reliable and can be used as a standardized Korean version of the Readiness for Practice measurement tool.