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CT Based 3-Dimensional Treatment Planning of Intracavitary Brachytherapy for Cancer of the Cervix : Comparison between Dose-Volume Histograms and ICRU Point Doses to the Rectum and Bladder

  • Hashim, Natasha;Jamalludin, Zulaikha;Ung, Ngie Min;Ho, Gwo Fuang;Malik, Rozita Abdul;Ee Phua, Vincent Chee
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.13
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    • pp.5259-5264
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    • 2014
  • Background: CT based brachytherapy allows 3-dimensional (3D) assessment of organs at risk (OAR) doses with dose volume histograms (DVHs). The purpose of this study was to compare computed tomography (CT) based volumetric calculations and International Commission on Radiation Units and Measurements (ICRU) reference-point estimates of radiation doses to the bladder and rectum in patients with carcinoma of the cervix treated with high-dose-rate (HDR) intracavitary brachytherapy (ICBT). Materials and Methods: Between March 2011 and May 2012, 20 patients were treated with 55 fractions of brachytherapy using tandem and ovoids and underwent post-implant CT scans. The external beam radiotherapy (EBRT) dose was 48.6Gy in 27 fractions. HDR brachytherapy was delivered to a dose of 21 Gy in three fractions. The ICRU bladder and rectum point doses along with 4 additional rectal points were recorded. The maximum dose ($D_{Max}$) to rectum was the highest recorded dose at one of these five points. Using the HDRplus 2.6 brachyhtherapy treatment planning system, the bladder and rectum were retrospectively contoured on the 55 CT datasets. The DVHs for rectum and bladder were calculated and the minimum doses to the highest irradiated 2cc area of rectum and bladder were recorded ($D_{2cc}$) for all individual fractions. The mean $D_{2cc}$ of rectum was compared to the means of ICRU rectal point and rectal $D_{Max}$ using the Student's t-test. The mean $D_{2cc}$ of bladder was compared with the mean ICRU bladder point using the same statistical test. The total dose, combining EBRT and HDR brachytherapy, were biologically normalized to the conventional 2 Gy/fraction using the linear-quadratic model. (${\alpha}/{\beta}$ value of 10 Gy for target, 3 Gy for organs at risk). Results: The total prescribed dose was $77.5Gy{\alpha}/{\beta}10$. The mean dose to the rectum was $4.58{\pm}1.22Gy$ for $D_{2cc}$, $3.76{\pm}0.65Gy$ at $D_{ICRU}$ and $4.75{\pm}1.01Gy$ at $D_{Max}$. The mean rectal $D_{2cc}$ dose differed significantly from the mean dose calculated at the ICRU reference point (p<0.005); the mean difference was 0.82 Gy (0.48-1.19Gy). The mean EQD2 was $68.52{\pm}7.24Gy_{{\alpha}/{\beta}3}$ for $D_{2cc}$, $61.71{\pm}2.77Gy_{{\alpha}/{\beta}3}$ at $D_{ICRU}$ and $69.24{\pm}6.02Gy_{{\alpha}/{\beta}3}$ at $D_{Max}$. The mean ratio of $D_{2cc}$ rectum to $D_{ICRU}$ rectum was 1.25 and the mean ratio of $D_{2cc}$ rectum to $D_{Max}$ rectum was 0.98 for all individual fractions. The mean dose to the bladder was $6.00{\pm}1.90Gy$ for $D_{2cc}$ and $5.10{\pm}2.03Gy$ at $D_{ICRU}$. However, the mean $D_{2cc}$ dose did not differ significantly from the mean dose calculated at the ICRU reference point (p=0.307); the mean difference was 0.90 Gy (0.49-1.25Gy). The mean EQD2 was $81.85{\pm}13.03Gy_{{\alpha}/{\beta}3}$ for $D_{2cc}$ and $74.11{\pm}19.39Gy_{{\alpha}/{\beta}3}$ at $D_{ICRU}$. The mean ratio of $D_{2cc}$ bladder to $D_{ICRU}$ bladder was 1.24. In the majority of applications, the maximum dose point was not the ICRU point. On average, the rectum received 77% and bladder received 92% of the prescribed dose. Conclusions: OARs doses assessed by DVH criteria were higher than ICRU point doses. Our data suggest that the estimated dose to the ICRU bladder point may be a reasonable surrogate for the $D_{2cc}$ and rectal $D_{Max}$ for $D_{2cc}$. However, the dose to the ICRU rectal point does not appear to be a reasonable surrogate for the $D_{2cc}$.

A Study of The Correlation of The Area Dose with Residual CT Contrast Media and MRI Contrast Media during The Use of General Imaging Automatic Exposure Control System (일반촬영 자동노출제어장치 사용 시 잔존 CT 조영제와 MRI 조영제에 따른 면적선량의 상관성 연구)

  • Hong, Chan-Woo;Park, Jin-Hun;Lee, Jung-Min;Seo, Young-Deuk
    • Journal of the Korean Society of Radiology
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    • v.10 no.8
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    • pp.619-627
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    • 2016
  • The purpose of this study is to investigate the effect of CT contrast agent and MRI contrast agent on the area dose in the body when using automatic exposure control system in general radiography. After making rectangular holes in the center of the abdominal thickness paraffin phantom, CT contrast agent and MRI contrast agent were respectively diluted with physiological saline solution for contrast medium dilution ratio of 10:0, 9:1, 8:2, 7:3, 6:4, 5:5, 4:6, 3:7, 2:8, 1:9, 0:10%. Each experiment was set to 78 kVp, 320 mA, which is the proper condition for KUB photography, and thereafter a total of 30 inspections were made for each dilution ratio using an automatic exposure control device, and the area dose corresponding to the dilution ratio of each contrast agent, Average comparison and correlation analysis were performed on the exposure index. As a result, the CT contrast agent and the MRI contrast agent appeared different in area dose according to the dilution ratio(p<0.05), and as the dilution ratio increased, the area dose increased for CT contrast agent and MRI contrast agent(P<0.05). In each test, the exposure index showed the manufacturer's recommendation of 200-800 EI value, and the exposure index and area dose increased as the area dose increased(p<0.05). In conclusion, CT contrast agent and MRI contrast agent confirmed to increase the area dose by general imaging test using all automatic exposure control device. Therefore, it is considered that it is necessary to perform it after the contrast medium has been excreted sufficiently when using usual imaging test after using the contrast agent in CT and MRI examination.

Radiopharmceutical Factors in the Prepartion of $^{99m}Tc-HMPAO$ Images of the Brain (뇌스캔용 $^{99m}Tc-HM-PAO$의 방사성 동위원소표지에 영향을 미치는 인자에 대한 연구)

  • Yeom, Mi-Kyoung;Kim, Sang-Eun;Lee, Dong-Soo;Chung, June-Key;Lee, Myung-Chul;Koh, Chang-Soon
    • The Korean Journal of Nuclear Medicine
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    • v.25 no.1
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    • pp.117-121
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    • 1991
  • Technetium-99m-hexamethylpropyleneamine oxime $(^{99m}Tc-HM-PAO)$ is a neutral-lipophilic chelate which is used for scanning cerebral blood flow. The labeling efficiencies of $^{99m}Tc-HM-PAO$ is known to be sensitive to the amount of pertechnetate added and the quality of the pertechnetate. Because of these factors, the manufacture recommends that HM-PAO kits be reconstituted with a maximum of 30 mCi pertechnetate which was eluted <4 hr earlier from a generator which had been eluted < 24 hr previously. So we measured the labelling efficiencies and the decomposition rate constant according to the amount of pertechnetate added, the volume of pertechnette added, and generator in-growth time. We used the 3-system chromatographic methods (paper & ITLC-SG chromatography) which analyzed the labelling efficiencies of the $^{99m}Tc-HM-PAO$. There was no significant difference in labelling efficiencies between variable pertechnetate acitvities added. ($39.9{\pm}4.9\;mCi:\;87.8{\pm}5.1\;(%)$, $60.8{\pm}5.0\;mCi:\;90.7{\pm}2.2\;(%)$, $79.0{\pm}6.0\;mCi:\;86.8{\pm}3.9\;(%)$, $106.6{\pm}11.6\;mCi:\;87.7{\pm}1.2\;(%)$, p>0.05) No significant difference in labelling efficiencies were found between pertechnetate of 4ml and 5ml. (4ml : $89.1{\pm}3.2(%)$, 5ml: $87.3{\pm}4.0(%)$, p>0.05). There was no difference between 1-6 and 10-48 hr of generator in-growth time. (1-6 hr: $87.8{\pm}4.0(%)$, 10-48 hr: $89.6{\pm}1.6(%)$, p>0.05) The mean value of decomposition rate constant was $0.196{\pm}0.097\;(hr^{-1})$, and there were no difference according to the amount of pertecnetate added and the volume of pertecnetate added, ($39.9{\pm}4.9\;mCi:\;0.208{\pm}0.059\;(hr^{-1})$, $60.8{\pm}5.0\;mCi:\;0.191{\pm}0.100\;(hr^{-1})$ $79.0{\pm}6.0\;mCi:\;0.192{\pm}0.118\;(hr^{-1})$, $106.6{\pm}11.6\;mCi:\;0.212{\pm}0.030\;(hr^{-1})$, p>0.05, 4 ml: $0.200{\pm}0.074\;(hr^{-1})$, Sml: $0.193{\pm}0.115\;(hr^{-1})$, p>0.05). In the case of using the first eluate, the labelling efficiency of $^{99m}Tc-HM-PAO$ W3S 82.1%. These data suggest that there were no significant alteration in labelling efficiency of $^{99m}Tc-HM-PAO$ according to the considerable range of pertechnetate activities and volume added, and generator in-growth time. Also, it was shown that one vial of HM-PAO kit supplied the $^{99m}Tc-HM-PAO$ which was used for 3-4 patients.

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A Study on Seasonal Pollutant Distribution Characteristics of Contaminated Tributaries in Nakdong River Basin (낙동강 중점관리지류·지천의 계절적 오염발생특성 분석)

  • Na, Seungmin;Kwon, Heongak;Shin, Sang Min;Son, YoungGyu;Shin, Dongseok;Im, Tae Hyo
    • Journal of Wetlands Research
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    • v.18 no.3
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    • pp.301-312
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    • 2016
  • This study has performed comparative analysis on characteristics of contaminated 35 tributaries on seasonal variation/point discharge load/pollutant distribution of water quality factors(8) in order to understand the effect of the watershed in Nakdong River Basin. As a results, the water quality of $BOD_5$(Biochemical Oxygen Demand), Chl-a(Chlorophyll a) and Fecal E. Coli shows II grade at tributaries of more than 50% without COD(Chemical Oxygen Demand), TP(Total Phosphate), TOC(Total Oxygen Carbon) and TN(Total Nitrogen) factors. The specific discharge(Q) were occupied about 54.4% (19 sites) as $0.05m^3/sec/km^2$ value. Among these results, the contaminant level of Dalseocheon, Hyeonjicheon, Seokkyocheon 1, Uriyeongcheon and Dasancheon was also high, which has to consider a discharged pollutant load(kg/day). The 35 major tributaries of Nakdong River were included in 7 mid-watershed, such as Nakdong Waegwan, Geumho River, Nakdong Goryung, Nakdong Changnyung, Nam River, Nakdong Milyang, Nakdong River Hagueon. Especially, the discharged pollutant load of Nam River and Geumho River also was high according to the amount of discharge such as Kachang dam, Gongsan dam and Nam river dam. Seasonal difference of the water quality factors such as $BOD_5$, TN, SS and Q was observed largely, on the other hand the TP and Chl-a was not. This is guessed due to the precipitation effect of site, biological and physicochemical degradation properties of pollutant and etc. The co-relationship between the seasonal difference and water quality factors was observed using a Pearson correlation coefficients. Besides, the Multiple Regression analysis using a Stepwise Regression method was conducted to understand the effect between seasonal difference and water quality factors/regression equations. As a result, the Multiple Regression analysis was adapted in the spring, summer and autumn without the winter, which was observed high at spring, summer and autumn in the order COD/TP, Chl-a/TOC, TOC/COD/$BOD_5$ water quality factors, respectively.

Studies on Improving the nutritive value of Rice straw by Fermentation with Lyophyllum decastes -II. Effect of $H_2O_2\;and\;2Na_2CO_3{\cdot}3H_2O_2$ treatments- (Lyophyllum decastes를 이용(利用)한 볏짚의 발효사료(醱酵飼料)에 관한 연구(硏究) -ll. 과산화수소(過酸化水素) 및 과탄산(過炭酸)소다 처리(處理)의 영향(影響)-)

  • Hong, Jae-Sik;Kim, Dong-Han;Lee, Keug-Ro;Kim, Myung-Kon;Kim, Young-Soo;Yeo, Kyu-Young
    • The Korean Journal of Mycology
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    • v.16 no.3
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    • pp.135-143
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    • 1988
  • The treatments of $H_2O_2$ were more effective on the degradation of difficult digestible materials by increasing the treatment concentration and adjusting the pH to alkaline. The smaller particle size of rice straw was, the more these effect. $2N_2CO_3{\cdot}3H_2O_2$, didn't need to adjust on pH, but the effect of treatment was lower than $H_2O_2$(pH 11.5) treatment. Lignin and hemicellulose content were decreased by the alkaline peroxide treatments. The fermentation of rice straw which pretreated with alkaline peroxide, the content of total nitrogen and ash increased. And NDF, hemicellulose and lignin were decreased, and ADF and cellulose decreased as the lower concentra­tion of treatment. The digestibility of rice straw which treated alkaline peroxide was increased with increasing the treatment concentration. The treatment of 12% $H_2O_2$(pH 11.5) and 12% $2Na_2^-CO_3{\cdot}3H_2O_2$ increased the digestibility from 31.1% to 89.4% and 76.8% compared with nontreated rice straw, respectively. The digestibility of fermented rice straw which pretreated with alkaline peroxide was effectively increased as the pretreatment concentration was low. Semi-dry treat­ment of $H_2O_2$ decreased the ADF and cellulose, and exhibited the 57.5% of digestjbility. Fer­mentation of rice straw which semi-dry treated with 4% $H_2O_2$, increased the digestibility from 33.4% to 63.4% compared with control.

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Influences of Worm Casting Organic Fertilizer on Weed Invasion on the Creeping Bentgrass Sward (지렁이분 시비가 잡초의 침입과 벤트그라스 잔디초지에 미치는 영향)

  • Park Sung-Jun;Cho Nam-Ki;Kang Young-Kil;Song Chang-Khil;Hyun Hae Nam;Cho Young-Il
    • Journal of The Korean Society of Grassland and Forage Science
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    • v.25 no.3
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    • pp.211-216
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    • 2005
  • This study was conducted from March 21 to July 10 in 2004 at JeJu to investigate the influences of worm casting organic fertilizer rates (0, 150, 300, 450, 600 kg/10a) on creeping bentgrass sward. The result obtained were summarized as follows; plant height was getting longer as organic fertilizer increased from 0 to 600 kg/10a. But it was no significance from 450 to 600kg/10a. Root length, SPAD reading value, leave and root weight were the same trend with plant height response. Percentage of land cover and density of creeping bentgrass increased as fertilizer rate increased from 0 to 600 kg/10a. But percentage of land cover and density of weed decreased. Number of weed species were decreased as increasing of organic fertilizers. Then ranking of the dominant weeds were Chenopodium album var. cetrorubrum and Digitaria adscendens, Polygonum hydropiper (at 0kg/10a), Portulaca oleracea and Digitaria adscendens, Polygonum hydropiper (at 150kg/10a), Polygonum hydropiper and Poa annua, Digitaria adscendens (at 450 kg/10a), Polygonum hydropipr and Digitaria adscendens, Portulaca oleracea (at 600 kg/10a).

Response of Early-season Asian Pear 'Hanareum' Treated with GA4+7 to Postharvest Application of 1-methylcyclopropene (1-MCP) (조생종 배 '한아름'에 대한 GA4+7 및 1-methylcyclopropene(1-MCP) 처리 반응)

  • Lee, Ug-Yong;Oh, Kwang-Suk;Lim, Byung-Sun;Wang, Mao-Hua;Hwang, Yong-Soo;Chun, Jong-Pil
    • Horticultural Science & Technology
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    • v.32 no.5
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    • pp.645-654
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    • 2014
  • This study was conducted to investigate the effect of 1-methylcyclopropene (1-MCP, $1.0{\mu}L{\cdot}L^{-1}$), a known ethylene action inhibitor, on fruit quality and incidence of physiological disorders during a simulated marketing period at $25^{\circ}C$ for 20 days in early-season Asian pear (Pyrus pyrifolia Nakai) 'Hanareum' that had been treated with 0, 0.5, 1.2 or 2.4% $GA_{4+7}$. Weight loss of stored fruits increased with $GA_{4+7}$ concentration, and the 1-MCP treatment slightly reduced the weight loss rates during the marketing period. Flesh firmness decreased abruptly in all 1-MCP-untreated fruits as the storage period extended to 10 d, whereas the firmness of 1-MCP-treated fruits remained high (> 30 N) during 15 days shelf-life. The effect of 1-MCP was significantly reduced when fruits were subjected to increased GA concentration. Higher soluble solids content and acidity during extended shelf-life were also apparent in 1-MCP-treated 'Hanareum' pears. The L-values (lightness) and hue angles of 1-MCP treated samples were higher than those of controls during 20 days shelf-life, but the a-value (redness) was lower in 1-MCP treated fruits. 1-MCP treatment did not decrease the level of ethylene evolution regardless of $GA_{4+7}$ concentration during shelf-life in early-season Asian pear 'Hanareum'. By contrast, 1-MCP treatment decreased the respiration rate significantly during shelf-life. The efficacy of 1-MCP was greatest in the GA-untreated fruit and was reduced as the $GA_{4+7}$ concentration increased. 1-MCP treatment influenced the severity of physiological disorders including core browning and mealiness: 1-MCP treatment completely blocked the incidence of core browning of during 15 days shelf-life, and reduced the severity of mealiness during 20 days shelf-life regardless of $GA_{4+7}$ concentration. Based on our results, we conclude that the use of $1{\mu}L{\cdot}L^{-1}$ 1-MCP can be of great benefit for maintaining quality and preventing physiological disorders in early-season pear cultivar 'Hanareum' pear, whereas its efficacy decreases with the concentration of $GA_{4+7}$ whereas its efficacy gradually decreases when the concentration of $GA_{4+7}$ paste increased.

Effect of working time on the film thickness of dental resin cements (레진 시멘트의 혼합 후 시간에 따른 피막도의 변화)

  • Yi, Yu-Seung;Kim, Sung-Hun;Lee, Jai-Bong;Han, Jung-Suk;Yeo, In-Sung;Ha, Seung-Ryong;Kim, Hee-Kyung
    • The Journal of Korean Academy of Prosthodontics
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    • v.53 no.4
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    • pp.325-329
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    • 2015
  • Purpose: The aim of this study was to compare the film thicknesses of several resin cements as a function of time after mixing and to examine the effect of working time on the film thicknesses. Materials and methods: The film thickness (${\mu}m$) of 4 resin cements (n=10), 1 composite resin (Panavia F 2.0), 3 self-adhesive resin (Clearfil SA luting, Zirconite, RelyX U200) cements was measured at 20-second intervals after mixing of the cements up to 200 seconds under a load of 50 N. Linear regression was fitted to verify the effect of working time on the film thickness of each cement. Data were compared to the working time recommended by manufacturers using Wilcoxon test ($\alpha$=.05). Results: All of the materials showed a positive linear correlation between the film thickness and working time. There was no statistically significant difference between the working time based on our results and the values recommended by the manufacturers even though there was a discrepancy between those two values. Conclusion: The film thickness of resin cements could increase with the increase of working time. Working time to meet the ISO standard of $50-{\mu}m$ maximum film thickness could be different from the manufacturer's recommended value.

Toxicological Effects of Some Insecticides against Welsh Onion Beet Armyworm (Spodoptera exigua) (Metaflumizone을 포함한 몇 가지 약제의 파밤나방(Spodoptera exigua)에 대한 독성검정)

  • Kang, E.J.;Kang, M.G.;Seo, M.J.;Park, S.N.;Kim, C.U.;Yu, Y.M.;Youn, Y.N.
    • Korean journal of applied entomology
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    • v.47 no.2
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    • pp.155-162
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    • 2008
  • The Welsh onion beet armyworm, Spodoptera exigua (Hubner), has attacked Welsh onion and is now the most important pest of Welsh onion in southwestern Korea. The beet armyworm has a wide host range, occurring as a serious pest of vegetable and fields. The relatively high abundance of beet armyworm has stimulated frequent application of insecticides to foliage. Insecticide resistance is a major problem in management of this insect. Accordingly, pesticide application for the control of beet armyworm was tried in both the open field and in laboratory, using 4 synthetic compounds such as metaflumizone and chlorfenapyr, indoxacarb, flufenoxuron, emamectin benzoate. In the laboratory, each developmental stages from eggs, larva to pupa was tested against 4 insecticides. Against the eggs of welsh onion beet armyworm, there was no significantly different with each other. These tested chemicals no killing effect to eggs. However, the population of 1st larva hatched from eggs were reduced because they eaten the egg shell with residual insecticides. The tested insecticides were taken very high mortalities to 1st to 3rd larva of Welsh onion beet armyworm. Otherwise, there were decreased the death rate from 4th to 6th larva. On the other hand, their value of control effects were relatively good against Welsh onion beet armyworms in the field between 87.2 and 90.5% on 10 days after insecticide application.

Quality characteristics of fermented vinegar prepared with the detoxified Rhus verniciflua extract (무독화 옻 추출물로 제조한 발효식초의 품질 특성)

  • Baek, Seong Yeol;Lee, Choong Hwan;Park, Yoo Kyoung;Choi, Han-Seok;Mun, Ji-Young;Yeo, Soo-Hwan
    • Food Science and Preservation
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    • v.22 no.5
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    • pp.674-682
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    • 2015
  • In this study, vinegar was produced using urushiol-free fermented Rhus verniciflua extract to create a lacquer with added value. The effect of manufacturing conditions on the quality of vinegar using detoxified R. verniciflua extract for fermentation was investigated. The acidity of the vinegar for inoculations with various liquid starter contents was 4.8~4.9%, and it was similar among all treatment groups. The acidity of vinegar was higher when the initial alcohol content was high. The acetic acid yields were 82.8%, 84.4%, 77.7%, and 69.5%, and the maximum yield was observed when the initial alcohol content was 6%. For acetic acid fermentation using different amounts of detoxified R. verniciflua extracts, the acidity of the vinegar with the extract after fermentation was 5.3~5.9%. However, the acidity of vinegar without the extract was 5.5%. The intensity of the brown color was high for vinegar without the extract. Hunter's L values were high for vinegar with an extract content of 2%. Acetic acid (53.3~65.8 mg/mL) was the predominant acid. Arginine ($190.3{\sim}333.3{\mu}g/mL$), proline ($125.6{\sim}290.8{\mu}g/mL$), alanine ($126.1{\sim}270.9{\mu}g/mL$), and glutamic acid ($159.0{\sim}262.4{\mu}g/mL$) were the predominant amino acids in detoxified R. verniciflua vinegar.