• 생약학회지
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• 제36권4호통권143호
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• pp.338-343
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• 2005

Inflammatory mediators such as interleukin-1 (IL-1), tumor necrosis $factor-{\alpha}\;(TNF-{\alpha}),\;interferon-{\gamma}\;(IFN-{\gamma})$ and lipopolysaccharide (LPS) are thought to play major roles in joint diseases such as a rheumatoid arthritis (RA), and there is considerable evidence playing a role for these cytokines in osteoarthritis (OA). Therefore, we have studied the effects on anti-inflammation and analgesic by ethyl acetate fraction from 70% ethanol extract of Artemisia capillaries (EAC). As a positive control, apigenin, which is known as an anti-inflammatory agent as an iNOS inhibitor, was used and showed the dose-dependent inhibitory effect. EAC showed strong inhibitory efficacy against cytokine-induced proteoglycan degradation, $PGE_2$ production, nitric oxide (NO) production, and matrix-matalloproteinases (MMPs) expression in rabbit articular chondrocyte. In the writhing test induced by acetic acid, EAC $(200{\sim}400\;mg/kg)$ exhibited a dose-dependent inhibition of writhing. The results indicate that EAC have anti-inflammatory and analgesic activities, and could be a good herbal medicine candidate for curing of RA and/or OA.

• 대한기계학회논문집
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• 제17권6호
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• pp.1330-1341
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• 1993

본 연구에서는 회전대우(revolute joint)들로 이루어진 1자유도 평면기구들의 특성을 파악하고 그래이프이론(graph theory)을 이용하여 기구의 형태를 행렬로 표시 하여 체이터베이스에 저장하였다. 또한 기구의 특성중의 하나인 작업조건(function specification)에 따른 무오차점(precision point)의 최대 개수를 알아내는 프로그램 을 개발하여 이로써 얻은 정보를 또 다른 데이타베이스에 저장하였다. 이와같이 구축 된 데이터베이스들로부터 설계자의 요구에 적합한 기구를 선택하여 형태합성 문제를 해결하였다.

• Journal of Animal Science and Technology
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• 제62권2호
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• pp.121-140
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• 2020

Anaerobic fungi habitat in the gastrointestinal tract of foregut fermenters or hindgut fermenters and degrade fibrous plant biomass through the hydrolysis reactions with a wide variety of cellulolytic enzymes and physical penetration through fiber matrix with their rhizoids. To date, seventeen genera have been described in family Neocallimasticaceae, class Neocallimastigomycetes, phylum Neocallimastigomycota and one genus has been described in phylum Neocallimastigomycota. In National Center for Biotechnology Information (NCBI) database (DB), 23,830 nucleotide sequences and 59,512 protein sequences have been deposited and most of them were originated from Piromyces, Neocallimastix and Anaeromyces. Most of protein sequences (44,025) were acquired with PacBio next generation sequencing system. The whole genome sequences of Anaeromyces robustus, Neocallimastix californiae, Pecoramyces ruminantium, Piromyces finnis and Piromyces sp. E2 are available in Joint Genome Institute (JGI) database. According to the results of protein prediction, average Isoelectric points (pIs) were ranged from 5.88 (Anaeromyces) to 6.57 (Piromyces) and average molecular weights were ranged from 38.7 kDa (Orpinomyces) to 56.6 kDa (Piromyces). In Carbohydrate-Active enZYmes (CAZY) database, glycoside hydrolases (36), carbohydrate binding module (11), carbohydrate esterases (8), glycosyltransferase (5) and polysaccharide lyases (3) from anaerobic fungi were registered. During four decades, 1,031 research articles about anaerobic fungi were published and 444 and 719 articles were available in PubMed (PM) and PubMed Central (PMC) DB.

• Journal of Ship and Ocean Technology
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• 제8권4호
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• pp.26-33
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• 2004

PFFEM software, PFADS has been developed for the vibration predictions and analysis of coupled system structures in medium-to-high frequency ranges. PFFEM is numerical method which solves energy governing equation using finite element technique for complicated structures where the exact solutions are not available. Through the upgrades, present PFADS R3 could cover the general beam and plate structures including various kinds of beam-plate rigid joints and other joint systems such as spring-damper junction and rigid bar connection. This software is composed of 3 parts; translator, model converter and solver. The translator makes its own FE-model from bulk data of commercial FE software, and the model converter is used to convert FE-model to PFFE-model automatically. The solver calculates vibrational energy density and intensity for PFFE-model by solving global matrix equations of PFFEM. For the applications of real transportation systems, a container ship model has been examined with respect to major parameters, and reliable results have been obtained.

• Restorative Dentistry and Endodontics
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• 제25권3호
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• pp.446-458
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• 2000

In this study, compressive strengths of three condensable composite resins(ALERT, SureFil, Solitaire), conventional hybrid composite resin(Z-100) and amalgam(HI-Aristaloy 21) according to the 6 types of cavity design(cylinder, trapezoidal, butt-joint, round bevel, long bevel and short bevel) were measured and appearance of fracture surfaces were observed with SEM, thus evaluated clinical applications of condensable composite resins according to the cavity designs. The results were as follows; 1. Compressive strengths according to experimental materials were the highest in SureFil, and Z-100, ALERT, Solitaire, HI-Aristaloy 21 in order. 2. SureFil showed the highest compressive strength(p<0.05). compressive strengths of ALERT and Solitaire were lower than that of Z-100, hybrid composite(p<0.05). 3. Compressive strengths according to specimen design were the highest in trapezoidal shape(p<0.05) and no significant difference was detected between other specimen designs. 4. The appearance of condensable composite resin under SEM was of a diverse configuration according to component of resin matrix, shapes of filler and surface treatments between resin and filler.

• The Korean Journal of Ecology
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• 제9권3호
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• pp.135-147
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• 1986

The simplification and the searching trends of complex data which assumed relationship between predictor variables and object variables are one of primary objective of ecological research. This study was aimed to apply cononical analysis consisting of canonical correlation analysis and canonical variate analysis related to lichen vegetation and several environmental variables which are elevation, height on grond, exposure side and cover values. Data collected from the Duckyoo National Park in August 1985. Lichen species was ranked by eqivocation information theory with cover values. Canonical correlation analysis was applied to one data set both set both environmental variables and lichem family. In order to make two sets of data matrix the scale of position vector ordination was calculated from the vector scalar product for lichen species. Canonical variate analysis was applied to rearranged data which was made by interval class code for environmental variables. The sharpness values was calculated in frequency of cotingency tables and the dispersion profiles of each species in classes of environmental variables was designed to extract component values based on the decomposition of expected frequencies in contingency table. The results of canonical correlation analysis revealed canonical first correlation value 0.815(89%), and second correlation value 0.083(11%). Significance test showed that the hypothesis of joint mutuallity of canonical correlation is accepted (P>0.05). The relation between canonical score of vegetation variables and that of environmental variable indicated linear tendency.

• 제어로봇시스템학회논문지
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• 제4권3호
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• pp.360-371
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• 1998

In this paper, output precision characteristics of a planar 6 degree-of-freedom parallel mechanisms are investigated, where the 6 degree-of-freedom mechanism is formed by adding an additional link along with an actuated joint in each serial subchain of the planar 3 degree-of-freedom parallel mechanism. Kinematic analysis for the parallel mechanism is performed, and its first-order kinematic characteristics are examined via kinematic isotropic index, maximum and minimum input-output velocity transmission ratios of the mechanisms. Based on this analysis, two types of planar 6 degrees-of-freedom parallel manipulators are selected. Then, dynamic characteristics of the two selected planar 6 degree-of-freedom parallel mechanisms, via Frobenius norms of inertia matrix and power modeling array, are investigated to compare the magnitudes of required control efforts of both three large actuators and three small actuators when the link lengths of three additional links are changed. It can be concluded from the analysis results that each of these two planar 6 degrees-of-freedom parallel mechanisms has an excellent control-in-the-small characteristics and therefore, it can be very effectively employed as a high-precision macro-micro manipulator when both its link lengths and locations of small and large actuators are properly chosen.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제9권10호
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• pp.3887-3907
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• 2015

This paper introduces a full duplex single secondary user multiple-input multiple-output (FD-SSU-MIMO) cognitive radio network, where secondary user (SU) opportunistically accesses the authorized spectrum unoccupied by primary user (PU) and transmits data based on FD-MIMO mode. Then we study the network achievable average sum-rate maximization problem under sum transmit power budget constraint at SU communication nodes. In order to solve the trade-off problem between SU's sensing time and data transmission time based on opportunistic spectrum access (OSA) and the power allocation problem based on FD-MIMO transmit mode, we propose a simple trisection algorithm to obtain the optimal sensing time and apply an alternating optimization (AO) algorithm to tackle the FD-MIMO based network achievable sum-rate maximization problem. Simulation results show that our proposed sensing time optimization and AO-based optimal power allocation strategies obtain a higher achievable average sum-rate than sequential convex approximations for matrix-variable programming (SCAMP)-based power allocation for the FD transmission mode, as well as equal power allocation for the half duplex (HD) transmission mode.

• Structural Engineering and Mechanics
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• 제56권2호
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• pp.169-188
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• 2015

There are two types of nonlinear analysis methods for building frameworks depending on the method of modeling the plastification of members including lumped plasticity and distributed plasticity. The lumped plasticity method assumes that plasticity is concentrated at a zero-length plastic hinge section at the ends of the elements. The distributed plasticity method discretizes the structural members into many line segments, and further subdivides the cross-section of each segment into a number of finite elements. When a reinforced concrete member experiences inelastic deformations, cracks tend to spread form the joint interface resulting in a curvature distribution. The program IDARC includes a spread plasticity formulation to capture the variation of the section flexibility, and combine them to determine the element stiffness matrix. In this formulation, the flexibility distribution in the structural elements is assumed to be the linear. The main objective of this study is to evaluate the accuracy of linear flexibility distribution assumed in the spread inelasticity model. For this purpose, nonlinear analysis of two reinforced concrete frames is carried out and the linear flexibility models used in the elements are compared with the real ones. It is shown that the linear flexibility distribution is incorrect assumption in cases of significant gravity load effects and can be lead to incorrect nonlinear responses in some situations.

• 로봇학회논문지
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• 제16권2호
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• pp.137-146
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• 2021

When controlling manipulator, degree of freedom is lost in singularity so specific joint velocity does not propagate to the end effector. In addition, control problem occurs because jacobian inverse matrix can not be calculated. To avoid singularity, we apply Deep Deterministic Policy Gradient(DDPG), algorithm of reinforcement learning that rewards behavior according to actions then determines high-reward actions in simulation. DDPG uses off-policy that uses 𝝐-greedy policy for selecting action of current time step and greed policy for the next step. In the simulation, learning is given by negative reward when moving near singulairty, and positive reward when moving away from the singularity and moving to target point. The reward equation consists of distance to target point and singularity, manipulability, and arrival flag. Dual arm manipulators hold long rod at the same time and conduct experiments to avoid singularity by simulated path. In the learning process, if object to be avoided is set as a space rather than point, it is expected that avoidance of obstacles will be possible in future research.