• BMB Reports
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• v.37 no.2
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• pp.139-143
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• 2004

The antioxidant responsive element (ARE) is a cis-acting regulatory element of genes encoding phase II detoxification enzymes and antioxidant proteins, such as NAD(P)H: quinone oxidoreductase 1, glutathione S-transferases, and glutamate-cysteine ligase. Interestingly, it has been reported that Nrf2 (NF-E2-related factor 2) regulates a wide array of ARE-driven genes in various cell types. Nrf2 is a basic leucine zipper transcription factor, which was originally identified as a binding protein of locus control region of ss-globin gene. The DNA binding sequence of Nrf2 and ARE sequence are very similar, and many studies demonstrated that Nrf2 binds to the ARE sites leading to up-regulation of downstream genes. The function of Nrf2 and its downstream target genes suggests that the Nrf2-ARE pathway is important in the cellular antioxidant defense system. In support of this, many studies showed a critical role of Nrf2 in cellular protection and anti-carcinogenicity, implying that the Nrf2-ARE pathway may serve as a therapeutic target for neurodegenerative diseases and cancers, in which oxidative stress is closely implicated.

• Smart Structures and Systems
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• v.15 no.3
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• pp.847-862
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• 2015

Typical base isolated buildings are designed so that the superstructure remains elastic in design-level earthquakes, though the isolation layer is often quite nonlinear using, e.g., hysteretic elements such as lead-rubber bearings and friction pendulum bearings. Similarly, other well-performing structural control systems keep the structure within the linear range except during the most extreme of excitations. Design optimization of these isolators or other structural control systems requires computationally-expensive response simulations of the (mostly or fully) linear structural system with the nonlinear structural control devices. Standard nonlinear structural analysis algorithms ignore the localized nature of these nonlinearities when computing responses. This paper proposes an approach for the computationally-efficient optimal design of passive isolators by extending a methodology previously developed by the authors for accelerating the response calculation of mostly linear systems with local features (linear or nonlinear, deterministic or random). The methodology is explained and applied to a numerical example of a base isolated building with a hysteretic isolation layer. The computational efficiency of the proposed approach is shown to be significant for this simple problem, and is expected to be even more dramatic for more complex systems.

• Structural Engineering and Mechanics
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• v.61 no.1
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• pp.117-124
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• 2017

Load testing is one of the important tests to determine if the structural elements can be used at the intended locations for which they have been designed. It is nothing but gradually applying the loads and measuring the deflections and other parameters. It is usually carried out to determine the behaviour of the system under service/ultimate loads. It helps to identify the maximum load that the structural element can withstand without much deflection/deformation. It will also help find out which part of the element causes failure first. The load-deflection behaviour of the road bridge girder has been studied by carrying out the load test after simulating the field conditions to the extent possible. The actual vertical displacement of the beam at mid span due to the imposed load was compared with the theoretical deflection of the beam. Further, the recovery of deflection at mid span was also observed on removal of the test load. Finally, the beam was checked for any cracks to assert if the beam was capable of carrying the intended live loads and that it could be used with confidence.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.34 no.4
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• pp.82-88
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• 2011

A typical job sequencing problem is studied in this research to improve productivities in manufacturing companies. The problem consists of two-stage parts and assembly processes. Two parts are provided independently each other and then two sequential assembly processes are followed. A new heuristic is developed to solve the new type of sequencing problem. Initial solution is developed in the first stage and then the initial solution is improved in the second stage. In the first stage, a longer part manufacturing time for each job is selected between two, and then a sequence is determined by descending order of the times. This initial sequence is compared with Johnson's sequence obtained from 2-machine assembly times. Any mismatches are tried to switch as one possible alternative and completion time is calculated to determine whether to accept the new sequence or not to replace the current sequence. Searching process stops if no more improvement can be made.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2005.05a
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• pp.275-278
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• 2005

INCONEL 718, nickel based superalloy, has good formability, high strength, excellent corrosion resistance and mechanical properties at high temperature. Owing to theses attractive properties, it finds use in applications such as combustion system, turbine engines and nuclear reactors. In such applications, components are typically required to be tolerant of high stress impact loading. This may cause material degradation and lead to catastrophic failure during service operation. In order to design optimal structural parts made of INCONEL 718, accurate understanding of material's mechanical properties, dynamic behavior and fracture characteristic as a function of strain rates are required. This paper concerned with the dynamic material properties of the INCONEL 718 for the various strain rates. The dynamic response of the INCONEL 718 at intermediate strain rate is obtained from the high speed tensile test machine test and at the high strain rate is from the split Hopkinson pressure bar test. Based on the experimental results, the effects of strain rate on dynamic flow stress, work hardening characteristics, strain rate sensitivity and elongation to the failure are evaluated. Experimental results from both quasi-static and high strain rate up to the 5000/sec are interpolated in order to construct the Johnson-Cook model as the constitutive relation that should be applied to simulate and design the structural parts made of INCONEL 718.

• Transactions of Materials Processing
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• v.14 no.6 s.78
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• pp.559-564
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• 2005

INCONEL 718, nickel based superalloy, has good formability, high strength, excellent corrosion resistance and mechanical properties at high temperature. Owing to theses attractive properties, it is utilized in applications such as combustion system, turbine engines and nuclear reactors. In such applications, components are typically required to be tolerant of high stress impact loading. This may cause material degradation and lead to catastrophic failure during service operation. Accurate understanding of material's mechanical properties with various strain rates is required in order to guarantee the reliability of structural parts made of INCONEL 718. This paper is concerned with the dynamic material properties of the INCONEL 718 at various strain rates. The dynamic response of the INCONEL 718 at the intermediate strain rate is obtained from the high speed tensile test and at the high strain rate is from the split Hopkinson pressure bar test. The effect of the strain rate on dynamic flow stress, work hardening characteristics, strain rate sensitivity and elongation to the failure is evaluated with the experimental results. Experimental results from both the quasi-static and the high strain rate up to 5000/sec are interpolated in order to construct the Johnson-Cook model as the constitutive relation that should be applied to simulate and design the structural parts made of rNCONEL 718.

• Nuclear Engineering and Technology
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• v.54 no.3
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• pp.877-887
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• 2022

A new reactor concept is described that directly couples a supercritical CO₂ (sCO₂) power cycle with a CO₂-cooled, heavy water moderated pressure tube core. This configuration attains the simplification and economic potential of past direct-cycle sCO₂ concepts, while also providing safety and power density benefits by using the moderator as a heat sink for decay heat removal. A 200 MWe design is described that heavily leverages existing commercial nuclear technologies, including reactor and moderator systems from Canadian CANDU reactors and fuels and materials from UK Advanced Gas-cooled Reactors (AGRs). Descriptions are provided of the power cycle, nuclear island systems, reactor core, and safety systems, and the results of safety analyses are shown illustrating the ability of the design to withstand large-break loss of coolant accidents. The resulting design attains high efficiency while employing considerably fewer systems than current light water reactors and advanced reactor technologies, illustrating its economic promise. Prospects for the design are discussed, including the ability to demonstrate its technologies in a small (~20 MWe) initial system, and avenues for further improvement of the design using advanced technologies.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.33 no.4
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• pp.392-399
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• 1988

The experiments were conducted to establish the effective barley haploid production system using interspecific crosses. Three spring barley cultivars. Bruce. Klages and Rodeo were used for this experiment. 1, 687 florets of three barley cultivars were crossed with bulbosum pollens. 1, 079 seeds were harvested and obtained 834 embryos so that seed set rate and embryo production rate were 64% and 77%, respectively. IAA effect was superior to NAA for root development and 1 ppm concentration of IAA gave the best result among five concentrations; 0ppm, 1ppm., 5ppm, 10ppm and 30ppm.

• Clinical and Experimental Pediatrics
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• v.51 no.5
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• pp.533-537
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• 2008

Mycoplasma pneumoniae (M. pneumoniae) infection causes a wide variety of clinical manifestations in children and young adults, the main one being pneumonia. M. pneumoniae is transmitted from person to person by infected respiratory droplets. Symptoms caused by M. pneumoniae infection can be divided into those involving the respiratory tract, and those caused by extrapulmonary disease. M. pneumoniae infections may cause central nervous system (CNS) complications-with encephalitis being the most frequent-and stroke being a rare complication. The pathogenesis of the CNS disease is unclear; possibilities include direct infection and an immune-mediated reaction. We present two cases of CNS complications subsequent to infection with M. pneumoniae; both cases had convincing evidence of preceding M. pneumoniae respiratory disease with no evidence of viable M. pneumoniae in the cerebrospinal fluid. We report cases of encephalitis and stroke following a recent M. pneumoniae infection.

• The Bulletin of The Korean Astronomical Society
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• v.40 no.1
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• pp.51.4-52
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• 2015

From 2010 to 2014, CQUEAN (Camera for QUasars in EArly uNiverse) has been operated for the observation at the 82 inch Otto Struve Telescope of the McDonald Observatory, US. This camera is optimized at wavelength range of 0.7 - 1.1 um with seven (g', r', I', z', Y, Iz and Is) broad-band filters for the survey of high redshift (z > 5) quasars in the early universe. We are upgrading this system to identify more details of SED (Spectral Energy Distribution) of quasar candidates and other astronomical sources. The SQUEAN is comprised of a focal reducer, a CCD camera, a new filter wheel, new auto guiding system and new control software. The new filter wheel consists of interchangeable cartridges for various wavelength and size of filters. 50 nm medium bandwidth filters from 600 - 1050 nm, seven SDSS (Sloan Digital Sky Survey) filters and Johnson-Cousin BVRI filters are installed for now. We also have a plan to use narrow band interference filters to classify high redshift quasars or to obtain SEDs of interesting astronomical sources in details more efficiently. We also developed KAP82 (Kyung Hee University Auto guiding Package for 82 inch telescope) for auto guiding software. CQUEAN and SQUEAN have been developed by CEOU (Center for the Exploration of the Origin of the Universe).