Clinical and Experimental Pediatrics

대한소아청소년과학회 (The Korean Pediatric Society)
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Mycoplasma pnuemonia 감염에 의한 중추신경계 합병증 2례

Two cases of central nervous system complications caused by Mycoplasma pneumoniae infection

  • 김신미 (한림대학교 의과대학 소아과학교실) ;
  • 허지승 (한림대학교 의과대학 소아과학교실) ;
  • 심은정 (한림대학교 의과대학 소아과학교실) ;
  • 이대형 (한림대학교 의과대학 소아과학교실) ;
  • 조도준 (한림대학교 의과대학 소아과학교실) ;
  • 김덕하 (한림대학교 의과대학 소아과학교실) ;
  • 민기식 (한림대학교 의과대학 소아과학교실) ;
  • 유기양 (한림대학교 의과대학 소아과학교실)
  • Kim, Shin Mi (Department of Pediatrics, College of Medicine, Hallym University) ;
  • Heo, Ji Seung (Department of Pediatrics, College of Medicine, Hallym University) ;
  • Shim, Eun Jung (Department of Pediatrics, College of Medicine, Hallym University) ;
  • Lee, Dae Hyoung (Department of Pediatrics, College of Medicine, Hallym University) ;
  • Cho, Do Jun (Department of Pediatrics, College of Medicine, Hallym University) ;
  • Kim, Dug Ha (Department of Pediatrics, College of Medicine, Hallym University) ;
  • Min, Ki Sik (Department of Pediatrics, College of Medicine, Hallym University) ;
  • Yoo, Ki Yang (Department of Pediatrics, College of Medicine, Hallym University)
  • 투고 : 2008.01.05
  • 심사 : 2008.01.22
  • 발행 : 2008.05.15
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초록

M. pnuemonia 감염은 사람에서 사람으로 전파되며 모든 연령의 소아에서 발생할 수 있으나 주로 학동기, 젊은 성인에서 하부 호흡기 계통의 질환을 유발하여 인두염, 기관지염, 모세기관지염, 크루프, 폐렴의 질환을 유발한다. M. pneumoniae 는 호흡기 감염 외에도 다양한 장기에 감염을 일으키며 합병증으로 다형홍반, Steven-Johnson syndrome, 수막뇌염, 무균성 수막염, 간염, 관절염, 심근염, 용혈성 빈혈 등이 발생할 수 있다. M. pneumoniae 의해 발생하는 신경계 합병증의 병태생리는 아직 명확하게 밝혀지지 않았으며 여러가지 가설이 제시되고 있다. 저자들은 M. pneumoniae 에 의한 중추 신경계 합병증으로 뇌염과 뇌경색의 각각 1례를 경험 하였기에 이를 보고하고자 한다.

Mycoplasma pneumoniae (M. pneumoniae) infection causes a wide variety of clinical manifestations in children and young adults, the main one being pneumonia. M. pneumoniae is transmitted from person to person by infected respiratory droplets. Symptoms caused by M. pneumoniae infection can be divided into those involving the respiratory tract, and those caused by extrapulmonary disease. M. pneumoniae infections may cause central nervous system (CNS) complications-with encephalitis being the most frequent-and stroke being a rare complication. The pathogenesis of the CNS disease is unclear; possibilities include direct infection and an immune-mediated reaction. We present two cases of CNS complications subsequent to infection with M. pneumoniae; both cases had convincing evidence of preceding M. pneumoniae respiratory disease with no evidence of viable M. pneumoniae in the cerebrospinal fluid. We report cases of encephalitis and stroke following a recent M. pneumoniae infection.

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참고문헌

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