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http://dx.doi.org/10.3345/kjp.2008.51.5.533

Two cases of central nervous system complications caused by Mycoplasma pneumoniae infection  

Kim, Shin Mi (Department of Pediatrics, College of Medicine, Hallym University)
Heo, Ji Seung (Department of Pediatrics, College of Medicine, Hallym University)
Shim, Eun Jung (Department of Pediatrics, College of Medicine, Hallym University)
Lee, Dae Hyoung (Department of Pediatrics, College of Medicine, Hallym University)
Cho, Do Jun (Department of Pediatrics, College of Medicine, Hallym University)
Kim, Dug Ha (Department of Pediatrics, College of Medicine, Hallym University)
Min, Ki Sik (Department of Pediatrics, College of Medicine, Hallym University)
Yoo, Ki Yang (Department of Pediatrics, College of Medicine, Hallym University)
Publication Information
Clinical and Experimental Pediatrics / v.51, no.5, 2008 , pp. 533-537 More about this Journal
Abstract
Mycoplasma pneumoniae (M. pneumoniae) infection causes a wide variety of clinical manifestations in children and young adults, the main one being pneumonia. M. pneumoniae is transmitted from person to person by infected respiratory droplets. Symptoms caused by M. pneumoniae infection can be divided into those involving the respiratory tract, and those caused by extrapulmonary disease. M. pneumoniae infections may cause central nervous system (CNS) complications-with encephalitis being the most frequent-and stroke being a rare complication. The pathogenesis of the CNS disease is unclear; possibilities include direct infection and an immune-mediated reaction. We present two cases of CNS complications subsequent to infection with M. pneumoniae; both cases had convincing evidence of preceding M. pneumoniae respiratory disease with no evidence of viable M. pneumoniae in the cerebrospinal fluid. We report cases of encephalitis and stroke following a recent M. pneumoniae infection.
Keywords
Mycoplasma pneumoniae; Central nervous system; Encephalitis; Stroke;
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1 Fernald GW, Collier AM, Clyde WA Jr. Respiratory infections due to Mycoplasma pneurnoniae in infants and children. Pediatrics 197555:327-35.
2 Cassell GH, Cole Be. Mycoplasmas as agents of hurnan disease. N Engl J Med 1981:304:80-9.   DOI   ScienceOn
3 Bitnun A, Ford-Jones E, Blaser S, Richardson S. Mycoplasma pneurnoniae ecephalitis. Semin Pediatr Infect Dis 2003:14:96-107.   DOI   ScienceOn
4 Guleria R, Nisar N, Chawla TC, Biswas NR. Mycoplasma pneurnoniae and central nervous system complications: a review. J Lab Clin Med 2005:146:55-63.   DOI   ScienceOn
5 Bitnun A, Ford-Jones EL, Petrie M, MacGregor D, Heurter H, Nelson S, et al. Acute childhood encephalitis and Mycoplasma pneurnoniae. Clin Infect Dis 2001;32:1674-84.   DOI   ScienceOn
6 Lind K. Manifestations and complications of Mycoplasma pneurnoniae disease: a review. Yale J BioI Med 1983;56:461-8.
7 Koskiniemi M. CNS manifestations associated with Mycoplasma pneurnoniae infections: summary of cases at the University of Helsinki and review. Clin Infect Dis 1993;17 Suppl I:S52-7.   DOI
8 Alexander ER, Foy HM, Kenny GE, Kronmal RA, McMahan R, Clarke ER, et al. Pneumonia due to Mycoplasma pneumoniae. Its incidence in the membership of a co-operative medical group. N Engl J Med 1966:275: 131-6.   DOI   ScienceOn
9 Ovetchkine P, Brug ieres P, Seradj A, Reinert P, Cohen R. An 8-y-old boy with acute stroke and radiological signs of cerebral vasculitis after recent Mycoplasma pneurnoniae infection. Scand J Infect Dis 2002;34:307-9.   DOI
10 Takeoka M, Takahashi M. Infectious and inflammatory disorders of the circulatory system and stroke in childhood. Curr Opin Neurol 2002:15:159-64.   DOI   ScienceOn
11 Lin WC, Lee PI, Lu CY, Hsieh YC, Lai HP, Lee CY, et al. Mycoplasma pneurnoniae encephalitis in childhood. J Microbiol Immunol Infect 2002:35:173-8.
12 Foy HM. Infections caused by Mycoplasma pneurnoniae and possible carrier state in different populations of patients. Clin Infect Dis 1993:17 Suppl 1:S37-46.   DOI
13 Mulder LJ, Spiering s EL. Stroke in a young adult with Mycoplasma pneurnoniae infection complicated by intravascular coagulation. Neurology 1987;37:1430-1.   DOI