• Geomechanics and Engineering
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• 제30권6호
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• pp.503-515
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• 2022

The permeability coefficient is an essential parameter for the study of seepage flow in fractured rock mass. This paper discusses the feasibility and application value of using readily available RQD (rock quality index) data to estimate mine water inflow and grouting quantity. Firstly, the influence of different fracture frequencies on permeability in a unit area was explored by combining numerical simulation and experiment, and the relationship between fracture frequencies and pressure and flow velocity at the monitoring point in fractured rock mass was obtained. Then, the stochastic function generation program was used to establish the flow analysis model in fractured rock mass to explore the relationship between flow velocity, pressure and analyze the universal law between fracture frequency and permeability. The concepts of fracture width and connectivity are introduced to modify the permeability calculation formula and grouting formula. Finally, based on the on-site grouting water control example, the rock mass quality index is used to estimate the mine water inflow and the grouting quantity. The results show that it is feasible to estimate the fracture frequency and then calculate the permeability coefficient by RQD. The relationship between fracture frequency and RQD is in accordance with exponential function, and the relationship between structure surface frequency and permeability is also in accordance with exponential function. The calculation results are in good agreement with the field monitoring results, which verifies the rationality of the calculation method. The relationship between the rock mass RQD index and the rock mass permeability established in this paper can be used to invert the mechanical parameters of the rock mass or to judge the permeability and safety of the rock mass by using the mechanical parameters of the rock mass, which is of great significance to the prediction of mine water inflow and the safety evaluation of water inrush disaster management.

• Earthquakes and Structures
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• 제23권2호
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• pp.169-181
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• 2022

To research the dynamic response of the high-rise structure under the rocking ground motion, which we believed that the effect cannot be ignored, especially accompanied by vertical ground motion. Theoretical analysis and shaking table seismic simulation tests were used to study the response of a high-rise structure to excitation of a H-V-R ground motion that included horizontal, vertical, and rocking components. The use of a wavelet analysis filtering technique to extract the rocking component from data for the primary horizontal component in the first part, based on the principle of horizontal pendulum seismogram and the use of a wavelet analysis filtering technique. The dynamic equation of motion for a high-rise structure under H-V-R ground motion was developed in the second part, with extra P-△ effect due to ground rocking displacement was included in the external load excitation terms of the equation of motion, and the influence of the vertical component on the high-rise structure P-△ effect was also included. Shaking table tests were performed for H-V-R ground motion using a scale model of a high-rise TV tower structure in the third part, while the results of the shaking table tests and theoretical calculation were compared in the last part, and the following conclusions were made. The results of the shaking table test were consistent with the theoretical calculation results, which verified the accuracy of the theoretical analysis. The rocking component of ground motion significantly increased the displacement of the structure and caused an asymmetric displacement of the structure. Thus, the seismic design of an engineering structure should consider the additional P-△ effect due to the rocking component. Moreover, introducing the vertical component caused the geometric stiffness of the structure to change with time, and the influence of the rocking component on the structure was amplified due to this effect.

• Structural Engineering and Mechanics
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• 제81권2호
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• pp.219-230
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• 2022

Due to the large number of railway bridges along China's high-speed railway (HSR) lines, which cover a wide area with many lines crossing the seismic zone, the possibility of a HSR train running over a bridge when an earthquake occurs is relatively high. Since the safety performance of the train will be threatened, it is necessary to study the safety of trains running over HSR bridges during earthquakes. However, ground motion (GM) is highly random and selecting the appropriate ground-motion intensity measures (IMs) for train running safety analysis is not trivial. To deal this problem, a model of a coupled train-bridge system under seismic excitation was established and 104 GM samples were selected to evaluate the correlation between 16 different IMs and train running safety over HSR bridges during earthquakes. The results show that spectral velocity (SvT₁) and displacement (SdT₁) at the fundamental period of the structure have good correlation with train running safety for medium-and long-period HSR bridges, and velocity spectrum intensity (VSI) and Housner intensity (HI) have good correlation for a wide range of structural periods. Overall, VSI and HI are the optimal IMs for safety analysis of trains running over HSR bridges during earthquakes. Finally, based on VSI and HI, the IM thresholds of an HSR bridge at different speed were analyzed.

• Geomechanics and Engineering
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• 제34권1호
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• pp.103-113
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• 2023

This study focused on understanding the relationship between the design of a tunnel boring machine disc cutter ring and its rock-breaking efficiency, as well as the applicable conditions of different cutter ring types. The discrete element method was used to establish a numerical model of the rock-breaking process using disc cutters with different ring types to reveal the development of rock damage cracks and variation in cutter penetration load. The calculation results indicate that a sharp-edged (V-shaped) disc cutter penetrates a rock mass to a given depth with the lowest load, resulting in more intermediate cracks and few lateral cracks, which leads to difficulty in crack combination. Furthermore, the poor wear resistance of a conventional V-shaped cutter can lead to an exponential increase in the penetration load after cutter ring wear. In contrast, constant-cross-section (CCS) disc cutters have the highest quantity of crack extensions after penetrating rock, but also require the highest penetration loads. An arch-edged (U-shaped) disc cutter is more moderate than the aforementioned types with sufficient intermediate and lateral crack propagation after cutting into rock under a suitable penetration load. Additionally, we found that the cutter ring wedge angle and edge width heavily influence cutter rock-breaking efficiency and that a disc cutter with a 16 to 22 mm edge width and 20° to 30° wedge angle exhibits high performance. Compared to V-shaped and U-shaped cutters, the CCS cutter is more suitable for soft or medium-strength rocks, where the penetration load is relatively small. Additionally, two typical case studies were selected to verify that replacing a CCS cutter with a U-shaped or optimized V-shaped disc cutter can increase cutting efficiency when encountering hard rocks.

• Geomechanics and Engineering
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• 제32권4호
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• pp.375-385
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• 2023

There are many joint fissures distributed in the engineering rock mass. In the process of geological history, the underground rock mass undergoes strong geological processes, and undergoes complex geological processes such as fracture breeding, expansion, recementation, and re-expansion. In this paper, the damage-stick-slip process (DSSP), an analysis model used for rock mass failure slip, was established to examine the master control and time-dependent mechanical properties of the new and primary fractures of a multi-fractured rock mass under the action of stress loading. The experimental system for the recemented multi-fractured rock mass was developed to validate the above theory. First, a rock mass failure test was conducted. Then, the failure stress state was kept constant, and the fractured rock mass was grouted and cemented. A secondary loading was applied until the grouted mass reached the intended strength to investigate the bearing capacity of the recemented multi-fractured rock mass, and an acoustic emission (AE) system was used to monitor AE events and the update of damage energy. The results show that the initial fracture angle and direction had a significant effect on the re-failure process of the cement rock mass; Compared with the monitoring results of the acoustic emission (AE) measurements, the master control surface, key blocks and other control factors in the multi-fractured rock mass were obtained; The triangular shaped block in rock mass plays an important role in the stress and displacement change of multi-fracture rock mass and the long fissure and the fractures with close fracture tip are easier to activate, and the position where the longer fractures intersect with the smaller fractures is easier to generate new fractures. The results are of great significance to a multi-block structure, which affects the safety of underground coal mining.

• Geomechanics and Engineering
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• 제37권1호
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• pp.73-84
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• 2024

Owing to the high strength and abrasive characteristics of cobble-boulders, cutters are easily worn and damaged during shield tunneling, making construction inefficient. In the present work, the stress on the ripper and scraper on the cutterhead was analyzed by the PFC3D-FLAC3D coupling model of shield tunneling to get insight into the performance of the cutterhead for cutting underground cobble and boulders. The numerical calculation results revealed that the increase in trajectory radius leads to a rising stress on the cutters, and the stress on the front cutting surface is greater than that on the back of the cutters. Moreover, the correlation between cutter wear and stress is revealed based on field measurement data. The distribution of the cutter stress is consistent with the cutter wear and breakage characteristics in actual construction, in which more extensive cutter stress is exhibited, extreme cutter wear appears, and more cutter breakage occurs. Finally, the relationship between the cutterhead opening area's layout and cutter wear distribution was investigated, indicating that the cutter wear extent is the most severe in the region where the radial opening ratio dropped sharply.

• IMMUNE NETWORK
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• 제22권3호
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• pp.25.1-25.11
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• 2022

IL-34 can promote osteoclast differentiation and activation, which may contribute to steroid-induced osteonecrosis of the femoral head (ONFH). Animal model was constructed in both BALB/c and IL-34 deficient mice to detect the relative expression of inflammation cytokines. Micro-CT was utilized to reveal the internal structure. In vitro differentiated osteoclast was induced by culturing bone marrow-derived macrophages with IL-34 conditioned medium or M-CSF. The relative expression of pro-inflammation cytokines, osteoclast marker genes, and relevant pathways molecules was detected with quantitative real-time RT-PCR, ELISA, and Western blot. Up-regulated IL-34 expression could be detected in the serum of ONFH patients and femoral heads of ONFH mice. IL-34 deficient mice showed the resistance to ONFH induction with the up-regulated trabecular number, trabecular thickness, bone value fraction, and down-regulated trabecular separation. On the other hand, inflammatory cytokines, such as TNF-α, IFN-γ, IL-6, IL-12, IL-2, and IL-17A, showed diminished expression in IL-34 deficient ONFH induced mice. IL-34 alone or works in coordination with M-CSF to promote osteoclastogenesis and activate ERK, STAT3, and non-canonical NF-κB pathways. These data demonstrate that IL-34 can promote the differentiation of osteoclast through ERK, STAT3, and non-canonical NF-κB pathways to aggravate steroid-induced ONFH, and IL-34 can be considered as a treatment target.

• Asian Pacific Journal of Cancer Prevention
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• 제16권9호
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• pp.3645-3651
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• 2015

Background: Previous studies evaluating the association between the xeroderma pigmentosum group G (XPG) Asp1104His polymorphism and head and neck cancer susceptibility have proven controversial. This meta-analysis of the literature was performed to obtain a more precise estimation of the relationship. Materials and Methods: We systematically searched PubMed, Embase and Web of Science with a time limit of Dec 18, 2014. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of any association. Results: We performed a meta-analysis of eight published case-control studies, including 3,621 cases and 5,475 controls. Overall, no significant association was found between the XPG Asp1104His polymorphism and head and neck cancer susceptibility under all genetic models. In the subgroup analysis by ethnicity, the XPG Asp1104His polymorphism had statistically significant association with elevated head and neck cancer risk under CC vs GG (OR=1.24, 95% CI=1.00~1.54) and the recessive model (OR=1.22, 95%CI=1.01~1.46) in Asian populations. A similar result was found under CC vs GG (OR =1.22, 95%CI=1.01~1.47) in the population based subgroup by source of control. When performed by tumor site, the XPG Asp1104His polymorphism had statistically significant association with elevated laryngeal cancer under all genetic models (CC vs GG: OR=1.59, 95% CI=1.16~2.19; GC vs GG: OR=1.38, 95%CI=1.10~1.72; dominant model: OR=1.42, 95% CI=1.15~1.74; recessive model: OR=1.36, 95% CI=1.02~1.81). Conclusions: This meta-analysis suggested that the XPG Asp1104His polymorphism is a risk factor for head and neck cancer susceptibility, especially for laryngeal cancer and in Asian populations.

• Journal of Pharmaceutical Investigation
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• 제31권4호
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• pp.241-256
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• 2001

Alginate microspheres, containing fluorescein isothiocyanate-bovine serum albumin (FITC-BSA) or green fluorescent protein (GFP) were prepared and used as a model drug to develop the oral vaccine delivery system. The alginate microspheres were coated with poly-L-lysine or chitosan. Two methods, w/o-emulsion and spray, were used to prepare alginate microspheres. To optimize preparation conditions, effects of several factors on the particle size and particle morphology of microsphere, and loading efficiency of model antigen were investigated. In both preparation methods, the particle size and the loading efficiency were enhanced when the concentration of sodium alginate increased. In the w/o-emulsion preparation method, as the concentration of Span 80 was increased from 0.5% to 2%, the particle size was decreased, but the loading efficiency was increased. The higher the emulsification speed was, the smaller the particle size and loading efficiency were. The concentration of calcium chloride did not show any effect on the particle size and loading efficiency. In the spray preparation method, the particle size was increased as the nozzle pressure $(from\;1\;kgf/m^2\;to\;3\;kgf/m^2)$ and spray rate was raised. Increasing calcium chloride concentration (<7%) decreased the particle size, in contrast to no effect of calcium chloride concentration on the w/o-emulsion preparation method. Alginate microspheres prepared by two methods were different in the particle size and loading efficiency, the particle size of microspheres prepared by the spray method was about $2-6\;{\mu}m$, larger than that prepared by the w/o emulsion method $(about\;2{\mu}m)$, and the loading efficiency was also higher with spray method. Furthermore, drying process for the microspheres prepared by the spray was simpler and easier, compared with the w/o emulsion preparation. Therefore, the spray method was chosen to prepare alginate microspheres for further experiments. Release pattern of FITC-BSA in alginate microspheres was evaluated in simulated intestinal fluid and PBS (phosphate buffered saline). Dissolution rate of FITC-BSA from alginate/chitosan microsphere was lower than that from alginate microsphere and alginate/poly-L-lysine microsphere. By confocal laser scanning microscope, it was revealed that alginate/FITC-poly-L-lysine microspheres were present in close apposition epithelium of the Peyer's patches of rabbits following inoculation into lumen of intestine, which proved that microspheres could be taken up by Peyer's patch. In conclusion, it is suggested that alginate microsphere prepared by spray method, showing a particle size of & $10\;{\mu}m$ and a high loading efficiency, can be used as a model drug for the development of oral vaccine delivery system.

• 한국유통학회지:유통연구
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• 제16권2호
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• pp.1-24
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• 2011

오프라인 구매환경과는 달리 온라인 환경에서는 제품을 직접 눈으로 확인하고 만져 볼 수 없다. 때문에 온라인 쇼핑몰을 구축하고 운영하는 입장에서는 보다 구체적인 제품정보를 제공해야 하며(김광석 2008), Alba (1997)는 제공된 정보의 질은 소비자들이 구매 후 만족을 얼마나 예상할 수 있는 가로 결정된다고 정의한 바 있다. 이에 패션 의류 온라인 쇼핑몰을 중심으로 실제 모델이 제품을 착용한 사진정보(실착사진)를 제공함으로써 실제 제품사용에 따른 결과를 제시하여 제품정보의 유용성을 높이고 있다. 한편 온라인 환경에서 소비자들의 제품에 대한 제한된 지각을 극복하는 또 다른 수단으로써, 가상제품경험은 가장 효과적인 것으로 논의되어 왔다(Jiang & Benbasat 2005). 그러나 가상현실도구의 도입과 지속적 활용에는 일반적인 텍스트/사진 정보와 비교해 높은 비용과 기술적 전문성을 요구한다(Shaffer 2006). 이는 특히 영세 소매상 입장에서 시장에 대한 진입장벽으로 작용하는 한편, 소비자의 정보처리과정에서는 오히려 단순한 형태의 정보에 비하여 더 높은 수준의 인지적 노력을 요구할 수 있다. 따라서 이러한 도구들의 활용하는 것이 소비자들의 정보과부하를 초래해 제품에 대한 핵심정보 취득을 방해하고, 소비자의 지각된 정보유용성에 부정적 영향을 미칠 수 있다. 이에 본 연구에서는 제품유형을 소비자들의 제품 사용상황에 따라 휴대제품과 설치제품으로 구분하고, 이때 정지사진, 실착사진, VR로 대별되는 제품정보의 형태에 따른 소비자들의 지각된 정보의 유용성, 쇼핑몰에 대한 태도와 품질평가, 구매의도, 재방문 의도를 측정하기 위한 실험을 진행했다. 그 결과 소비자 구매의도에 영향을 미치는 종속변수군에 대해 제품유형과 제품정보형태가 상호작용효과를 일으키는 것을 확인할 수 있었다.