• Archives of Pharmacal Research
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• 제24권6호
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• pp.557-563
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• 2001

Oral tolerance is thought to play a role in preventing allergic responses and immune-mediated diseases. An improved mouse model of the oral tolerance to Japanese cedar pollen (JCP) as antigen was developed in order to detect induction of the tolerance, and the immunological characteristics of this model were also elucidated. Oral tolerance was induced by C3H/ HeN mice given an oral administration of 10 mg JCP 7 days before immunization with an i.p. injection of 0.1 mg JCP in complete Freunds adjuvant (CFA). The effects of oral JCP on systemic immunity were assessed by enzyme-linked immunosorbent assay (ELISA) of immunoglobulin (Ig) levels in serum collected on day 7 or 14 after immunization. Oral tolerance to JCP was adequately induced on day 7 after immunization and was more effective in C3H/HeN mice than in BALB/c mice. The tolerance was primarily concerned with the decreased serum levels of antigen-specific IgG. In these mice, oral administration of JCP also suppressed various immune responses to the antigen including delayed-type hypersensitivity (DTH), total Igl level and anti-JCP IgGl level. The suppression of these immune responses by the oral antigen was associated with a significant reduction in interleukin-4 (IL-4) production. These findings therefore indicate that this C3H/HeN mice model has potential use in detecting the induction of oral tolerance by JCP and suggest that this tolerance model may be effective in the treatment and prevention of allergic responses caused by the antigen.

• Journal of Radiation Protection and Research
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• 제46권3호
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• pp.83-97
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• 2021

Background: The lifetime risk of lung cancer incidence due to radiation for nonsmokers is overestimated because of the use of the average cancer baseline risk among a mixed population, including smokers. In recent years, the generalized multiplicative (GM)-excess relative risk (ERR) model has been developed in the life span study of atomic bomb survivors to consider the joint effect of radiation and smoking. Based on this background, this paper discusses the issues of radiation risk assessment considering smoking in two parts. Materials and Methods: In Part 1, we proposed a simple method of estimating the baseline risk for nonsmokers using current smoking data. We performed sensitivity analysis on baseline risk estimation to discuss the birth cohort effects. In Part 2, we applied the GM-ERR model for Japanese smokers to calculate lifetime attributable risk (LAR). We also performed a sensitivity analysis using other ERR models (e.g., simple additive (SA)-ERR model). Results and Discussion: In Part 1, the lifetime baseline risk from mixed population including smokers to nonsmokers decreased by 54% (44%-60%) for males and 24% (18%-29%) for females. In Part 2, comparison of LAR between SA- and GM-ERR models showed that if the radiation dose was ≤200 mGy or less, the difference between these ERR models was within the standard deviation of LAR due to the uncertainty of smoking information. Conclusion: The use of mixed population for baseline risk assessment overestimates the risk for lung cancer due to low-dose radiation exposure in Japanese males.

• 국제지역연구
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• 제13권2호
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• pp.168-188
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• 2009

일본은 과거 10년(1993-2002) 동안 버블붕괴로 극심한 경기침체기를 경험하였다. 최근 미국에서도 유사한 현상이 발생하였고, 그 여파로 세계 각국이 불경기를 겪고 있다. 본 연구의 목적은 과거 일본 경기침체기를 분석하여 현재 미국 등 여러 나라의 경제 불황을 탈출할 수 있는 방법을 모색하는데 있다. 과거 문헌자료에 의하여 나타난 시사점은 정부부채에는 최적 상태가 존재하고, 경기회복을 위한 정책은 실시 시점이 중요하다는 것이다. VAR 모형과 State Space Model에 의한 통계적 분석으로부터는 다음과 같은 결과가 도출되었다. 정부 재정지출의 경기부양에 대한 영향은 단기적이며 미약했다. 조세는 생산에 장기적이며 부정적 영향을 준다. 그러므로 정부부채 감소를 위한 증세(增稅)는 신중히 실시되어야 한다. 재정지출의 효과는 정책이 발표된 후 반년의 시차를 두고 효과가 나타나는 반면, 조세증가는 공시와 동시에 민간소비와 투자를 감소시키고 그 영향도 길며 크다.

• 전기전자학회논문지
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• 제2권1호
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• pp.61-67
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• 1998

본 연구에서는 다층 순방향 신경망(MFNN) 모델을 이용해서 한국어 및 일본어 숫자음 인식 실험을 수행하였다. 각각 5명의 한국인 남성 및 여성 화자가 0부터 9까지의 10개의 숫자를 7회 발음토록 하였고, 그중 2회 발음한 것을 인식 실험에 사용하였다. 이들 음성 데이터로부터 각각 추출된 피치 계수, 선형 예측 계수, 선형 예측 켑스트럼 계수들을 신경망의 입력 패턴으로 입력시켜 인식 성능을 측정하였다. 한국어를 사용한 실험과 일본어를 사용한 실험 모두에서 피치 계수를 사용하는 것이 다른 계수를 사용하는 것보다 약 4% 정도 우수한 성능을 나타내었다.

• 말소리와 음성과학
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• 제3권3호
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• pp.69-75
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• 2011

This paper investigates phrase positional effects on the timing of F0 (pitch) peaks in Tokyo Japanese disyllabic words with varying accent type (HL or LH) and phrase position (final or non final). The F0 peak timing was normalized by the total word duration ('normalized H timing'). The normalized H timing was significantly affected by accent type and phrase position. The H timing was later in the LH accent type than in the HL accent type, and in non final positions than in final positions. In addition, to examine the validity of the quantitative results, different models of phrase position effects were compared by measuring H timing in two approaches: normalization versus relative distance measures. For the normalization measures, the H timing was measured as the time of the F0 peak divided by the total word duration or by the duration of the tone bearing syllable. For the relative distance measures, the H timing was measured as the distance in milliseconds from the end of the word or from the end of the associated syllable. The best model was the normalization by the total word duration, rather than by the duration of the tone bearing syllable. This means that phrase positional effects on the timing of F0 peaks in Japanese disyllabic words are best modeled in terms of proportion of the total word duration.

• The Journal of Asian Finance, Economics and Business
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• 제6권2호
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• pp.257-267
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• 2019

The paper aims to test long-term and short-term causality from four exchange rates, the Korean won/$US, the Korean won/Euro, the Korean won/Japanese yen, and the Korean won/Chinese yuan, to the Korea Composite Stock Price Index in the presence of several macroeconomic variables using monthly data from January 1986 to June 2018. The results of Johansen cointegration tests show that there exists at least one cointegrating equation, which indicates that long-run causality from an exchange rate to the Korean stock market will exist. The results of vector error correction estimates show that: for long-term causality, the coefficient of the error correction term is significant with a negative sign, that is, long-term causality from exchange rates to the Korean stock market is observed. For short-term causality, the coefficient of the Japanese yen exchange rate is significant with a positive sign, that is, short-term causality from the Japanese yen exchange rate to the Korean stock market is observed. The coefficient of the financial crises i.e. 1997-1999 Asian financial crisis and 2007-2008 global financial crisis on the endogenous variables in the model and the Korean economy is significant. The result indicates that the financial crises have considerably affected the Korean economy, especially a negative effect on money supply.

• The Journal of Korean Physical Therapy
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• 제34권5호
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• pp.224-233
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• 2022

Purpose: In Japan, the Long-Term Care Insurance Act has stipulated visiting rehabilitation since 2000. This study aimed to identify the actual conditions of visiting rehabilitation in Japan through a literature review of reports published by the Japanese government. Methods: This literature review was conducted on eight articles among various government reports on the topic of the actual conditions of visiting rehabilitation. These reports were published by the Ministry of Health, Labor and Welfare of Japan based on their own investigations or reports from an external agency entrusted with the task, and were issued between 2000 and 2021. Results: The characteristics of the visiting rehabilitation offices, their number, manpower allocation, the number of users, and their visits to each office were identified. Also, the characteristics of the users, number of users, age and required degree of long-term care, causative disease, and required medical care were identified. To evaluate the actual status of the visiting rehabilitation service, the service use time, frequency, period of use, intervention by doctors and the degree of such intervention, therapist's service content, visitors' address before the use of the service, reason, and timing of the service introduction, evaluation of the service effectiveness, combination of services and transfer destination after termination, and status after service termination were checked. Conclusion: Based on the Japanese experience where visiting rehabilitation was introduced and applied to long-term care insurance, it would be meaningful to review the factors that required benchmarking among the Japanese service models while designing a similar model in Korea.

• Asian-Australasian Journal of Animal Sciences
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• 제17권9호
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• pp.1281-1285
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• 2004

A line of Japanese quail selected for increased body weight for 15 generations (C) and an unselected control line (K) were used to examine the impact of selection for body weight on the growth curve of Japanese quail. In addition, the effect of sex on the growth curve in each line was also studied, namely females of C (CF), males of C (CM), females of K (KF) and males of K (KM). The monophasic and diphasic growth models were studied for adequacy in describing growth curves of quail in both sexes of the C and K lines. The monophasic function provided almost the same growth rate for both sexes in both lines. However, the growth rates calculated by means of the diphasic function differed between sexes for both lines, except for those calculated for C during the second growth phase. While there were 2-3 days difference between sexes in age at maximum gain in both lines with a monophasic model, the difference between sexes in the age at maximum gain in both lines became greater according to the diphasic model. There were 5 and 7 days difference between sexes in the age at maximum gain in line C for the first and second growth phases, respectively. A difference between sexes of 18 and 11 days in the age at maximum gain for the first and second phases, respectively, was estimated for line K when the diphasic function was fitted. The use of diphasic functions provides more detailed information on growth patterns. The results showed that the use of the diphasic function was better because it provided greater insights into understanding the biology of growth.

• 수산해양기술연구
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• 제45권3호
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• pp.157-164
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• 2009

Due to change of various marine environments according to seawater temperature rising, Japanese common squid(Todarodes pacificus), which was distributed in East Sea, was recently caught in Yellow Sea during a summer season from 2006. The fishery resources density research was carried out in Korea-China Provisional Water Zone using trawl fishing gear and acoustics in National Fisheries Research & Development Institute in Korea. This paper showed the analysis on the acoustical backscattering strength by two frequencies(38kHz, 120kHz) for Japanese common squid by acoustical scattering theoretical model based on size distribution for survey period, and estimate the density distribution for squid s integrated layer which was extracted from any scatterers distributed in water column using two frequency difference method which has been used to distinguish fish shoals or specific target scatterers from sound scattering layer which is composed of various zooplankton. Furthermore, the entire range of their density estimation was suggested using by Monte Carlo simulation under considering each uncertainty such as size distributions or swimming angle and so on in survey area.

• 응용통계연구
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• 제30권3호
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• pp.417-426
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• 2017

국내외적으로 벚꽃의 개화시기와 단풍 시작일에 대한 관련 연구가 많이 되어왔는데, 매해 기상청은 이들에 대하여 보도자료를 통하여 당해 연도 예측시기 및 전년도와의 차이를 발표하고 있다. 본 연구에서는 선형회귀모형을 통해서 이들의 개화시기 및 단풍시기에 영향을 줄 수 있는 월별 평균, 최저, 최고온도, 강수량 그리고 일조량 등과 같은 여러가지 기상변수를 확인하였고 관측되지 않은 지역에 대한 예측을 위해서 기존의 모형에 공간구조를 추가하여 분석하였다. 본 연구에서 제안된 모형을 2009년부터 2016년의 기상청 보도자료에 적용하였고 기존의 기상청 예측값과 비교하였다. 그리고 공간분석을 통해 한반도 전역의 벚꽃 개화시기와 단풍 시작일을 예측하였다.