• Archives of Pharmacal Research
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• v.24 no.6
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• pp.557-563
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• 2001

Oral tolerance is thought to play a role in preventing allergic responses and immune-mediated diseases. An improved mouse model of the oral tolerance to Japanese cedar pollen (JCP) as antigen was developed in order to detect induction of the tolerance, and the immunological characteristics of this model were also elucidated. Oral tolerance was induced by C3H/ HeN mice given an oral administration of 10 mg JCP 7 days before immunization with an i.p. injection of 0.1 mg JCP in complete Freunds adjuvant (CFA). The effects of oral JCP on systemic immunity were assessed by enzyme-linked immunosorbent assay (ELISA) of immunoglobulin (Ig) levels in serum collected on day 7 or 14 after immunization. Oral tolerance to JCP was adequately induced on day 7 after immunization and was more effective in C3H/HeN mice than in BALB/c mice. The tolerance was primarily concerned with the decreased serum levels of antigen-specific IgG. In these mice, oral administration of JCP also suppressed various immune responses to the antigen including delayed-type hypersensitivity (DTH), total Igl level and anti-JCP IgGl level. The suppression of these immune responses by the oral antigen was associated with a significant reduction in interleukin-4 (IL-4) production. These findings therefore indicate that this C3H/HeN mice model has potential use in detecting the induction of oral tolerance by JCP and suggest that this tolerance model may be effective in the treatment and prevention of allergic responses caused by the antigen.

• Journal of Radiation Protection and Research
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• v.46 no.3
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• pp.83-97
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• 2021

Background: The lifetime risk of lung cancer incidence due to radiation for nonsmokers is overestimated because of the use of the average cancer baseline risk among a mixed population, including smokers. In recent years, the generalized multiplicative (GM)-excess relative risk (ERR) model has been developed in the life span study of atomic bomb survivors to consider the joint effect of radiation and smoking. Based on this background, this paper discusses the issues of radiation risk assessment considering smoking in two parts. Materials and Methods: In Part 1, we proposed a simple method of estimating the baseline risk for nonsmokers using current smoking data. We performed sensitivity analysis on baseline risk estimation to discuss the birth cohort effects. In Part 2, we applied the GM-ERR model for Japanese smokers to calculate lifetime attributable risk (LAR). We also performed a sensitivity analysis using other ERR models (e.g., simple additive (SA)-ERR model). Results and Discussion: In Part 1, the lifetime baseline risk from mixed population including smokers to nonsmokers decreased by 54% (44%-60%) for males and 24% (18%-29%) for females. In Part 2, comparison of LAR between SA- and GM-ERR models showed that if the radiation dose was ≤200 mGy or less, the difference between these ERR models was within the standard deviation of LAR due to the uncertainty of smoking information. Conclusion: The use of mixed population for baseline risk assessment overestimates the risk for lung cancer due to low-dose radiation exposure in Japanese males.

• International Area Studies Review
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• v.13 no.2
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• pp.168-188
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• 2009

Japanese economy suffered from a great recession for one decade between 1993 and 2002, because of the bubble bursting. Recently, a similar situation broke out in the USA and spread throughout the world. This paper investigated the effects of economic policy on the Japanese depression in order to find out how the recession, caused by financial crisis, can be reasonably removed. The analysis of documentary records indicate that there exists an optimum rate in government debt and the point in time of economic policy is decisive. Statistical studies with a VAR model and a State Space Model suggest that government expenditures affect the growth rate of national product but with a short term and it has a time lag of a half year. Income tax has a grievous negative effect on the growth rate with a long term and it works without a time lag. Therefore the increasing of taxation should be put into force very carefully. However private investment is a determinate factor for the recovery of depression.

• Journal of IKEEE
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• v.2 no.1 s.2
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• pp.61-67
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• 1998

In this thesis, experiment have performed with the speaker recognition using multilayer feedforward neural network(MFNN) model using Korean and Japanese digits . The 5 adult males and 5 adult females pronounciate form 0 to 9 digits of Korean, Japanese 7 times. And then, they are extracted characteristics coefficient through Pitch deletion algorithm, LPC analysis, and LPC Cepstral analysis to generate input pattern of MFNN. 5 times among them are used to train a neural network, and 2 times is used to measure the performance of neural network. Both Korean and Japanese, Pitch coefficients is about 4%t more enhanced than LPC or LPC Cepstral coefficients.

• Phonetics and Speech Sciences
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• v.3 no.3
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• pp.69-75
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• 2011

This paper investigates phrase positional effects on the timing of F0 (pitch) peaks in Tokyo Japanese disyllabic words with varying accent type (HL or LH) and phrase position (final or non final). The F0 peak timing was normalized by the total word duration ('normalized H timing'). The normalized H timing was significantly affected by accent type and phrase position. The H timing was later in the LH accent type than in the HL accent type, and in non final positions than in final positions. In addition, to examine the validity of the quantitative results, different models of phrase position effects were compared by measuring H timing in two approaches: normalization versus relative distance measures. For the normalization measures, the H timing was measured as the time of the F0 peak divided by the total word duration or by the duration of the tone bearing syllable. For the relative distance measures, the H timing was measured as the distance in milliseconds from the end of the word or from the end of the associated syllable. The best model was the normalization by the total word duration, rather than by the duration of the tone bearing syllable. This means that phrase positional effects on the timing of F0 peaks in Japanese disyllabic words are best modeled in terms of proportion of the total word duration.

• The Journal of Asian Finance, Economics and Business
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• v.6 no.2
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• pp.257-267
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• 2019

The paper aims to test long-term and short-term causality from four exchange rates, the Korean won/$US, the Korean won/Euro, the Korean won/Japanese yen, and the Korean won/Chinese yuan, to the Korea Composite Stock Price Index in the presence of several macroeconomic variables using monthly data from January 1986 to June 2018. The results of Johansen cointegration tests show that there exists at least one cointegrating equation, which indicates that long-run causality from an exchange rate to the Korean stock market will exist. The results of vector error correction estimates show that: for long-term causality, the coefficient of the error correction term is significant with a negative sign, that is, long-term causality from exchange rates to the Korean stock market is observed. For short-term causality, the coefficient of the Japanese yen exchange rate is significant with a positive sign, that is, short-term causality from the Japanese yen exchange rate to the Korean stock market is observed. The coefficient of the financial crises i.e. 1997-1999 Asian financial crisis and 2007-2008 global financial crisis on the endogenous variables in the model and the Korean economy is significant. The result indicates that the financial crises have considerably affected the Korean economy, especially a negative effect on money supply.

• The Journal of Korean Physical Therapy
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• v.34 no.5
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• pp.224-233
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• 2022

Purpose: In Japan, the Long-Term Care Insurance Act has stipulated visiting rehabilitation since 2000. This study aimed to identify the actual conditions of visiting rehabilitation in Japan through a literature review of reports published by the Japanese government. Methods: This literature review was conducted on eight articles among various government reports on the topic of the actual conditions of visiting rehabilitation. These reports were published by the Ministry of Health, Labor and Welfare of Japan based on their own investigations or reports from an external agency entrusted with the task, and were issued between 2000 and 2021. Results: The characteristics of the visiting rehabilitation offices, their number, manpower allocation, the number of users, and their visits to each office were identified. Also, the characteristics of the users, number of users, age and required degree of long-term care, causative disease, and required medical care were identified. To evaluate the actual status of the visiting rehabilitation service, the service use time, frequency, period of use, intervention by doctors and the degree of such intervention, therapist's service content, visitors' address before the use of the service, reason, and timing of the service introduction, evaluation of the service effectiveness, combination of services and transfer destination after termination, and status after service termination were checked. Conclusion: Based on the Japanese experience where visiting rehabilitation was introduced and applied to long-term care insurance, it would be meaningful to review the factors that required benchmarking among the Japanese service models while designing a similar model in Korea.

• Asian-Australasian Journal of Animal Sciences
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• v.17 no.9
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• pp.1281-1285
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• 2004

A line of Japanese quail selected for increased body weight for 15 generations (C) and an unselected control line (K) were used to examine the impact of selection for body weight on the growth curve of Japanese quail. In addition, the effect of sex on the growth curve in each line was also studied, namely females of C (CF), males of C (CM), females of K (KF) and males of K (KM). The monophasic and diphasic growth models were studied for adequacy in describing growth curves of quail in both sexes of the C and K lines. The monophasic function provided almost the same growth rate for both sexes in both lines. However, the growth rates calculated by means of the diphasic function differed between sexes for both lines, except for those calculated for C during the second growth phase. While there were 2-3 days difference between sexes in age at maximum gain in both lines with a monophasic model, the difference between sexes in the age at maximum gain in both lines became greater according to the diphasic model. There were 5 and 7 days difference between sexes in the age at maximum gain in line C for the first and second growth phases, respectively. A difference between sexes of 18 and 11 days in the age at maximum gain for the first and second phases, respectively, was estimated for line K when the diphasic function was fitted. The use of diphasic functions provides more detailed information on growth patterns. The results showed that the use of the diphasic function was better because it provided greater insights into understanding the biology of growth.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.45 no.3
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• pp.157-164
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• 2009

Due to change of various marine environments according to seawater temperature rising, Japanese common squid(Todarodes pacificus), which was distributed in East Sea, was recently caught in Yellow Sea during a summer season from 2006. The fishery resources density research was carried out in Korea-China Provisional Water Zone using trawl fishing gear and acoustics in National Fisheries Research & Development Institute in Korea. This paper showed the analysis on the acoustical backscattering strength by two frequencies(38kHz, 120kHz) for Japanese common squid by acoustical scattering theoretical model based on size distribution for survey period, and estimate the density distribution for squid s integrated layer which was extracted from any scatterers distributed in water column using two frequency difference method which has been used to distinguish fish shoals or specific target scatterers from sound scattering layer which is composed of various zooplankton. Furthermore, the entire range of their density estimation was suggested using by Monte Carlo simulation under considering each uncertainty such as size distributions or swimming angle and so on in survey area.

• The Korean Journal of Applied Statistics
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• v.30 no.3
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• pp.417-426
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• 2017

It is important to predict the flowering dates of Japanese cherry and autumnal dates in Korea. Flowering date is decided by heating requirement with daily maximum and minimum temperature used to calculate the pre-determined heating requirements for flowering. Recent, changes in climate have impacted the flowering season of Japanese cherry in Korea. When compared with the current normal, the flowering of Japanese cherry is expected to be about 10 days earlier than in near future normal years. In this paper, we first consider a linear model based on meteorological data that predicts the flowering date and then incorporate a spatial structure into the model. Real data analysis indicates that the proposed approach provides more reasonable predicted dates.