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Design, Synthesis, and Antimicrobial Activity, of New 1,4-disubstituted Octahydroquinoxaline-2,3-dione Derivatives

  • Hussein, Mostafa A.
    • Bulletin of the Korean Chemical Society
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    • v.32 no.5
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    • pp.1511-1518
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    • 2011
  • A series of 1,4-disubstituted octahydroquinoxaline-2,3-dione derivatives was prepared through two steps reaction. The latter involves the formation of N,N-disubstituted cyclohexane-1,2-diamine derivatives (la-j) through reductive alkylation of 1,2-cyclohexanediamine with different aldehydes in presence of sodium cyanoborohydride. Fusion of compounds (1a-j) with diethyl oxalate affording the target compounds (2a-j). Elucidation of structures of compounds (2a-j) was based upon different spectral data as well as the elemental methods of analyses. In addition, mass spectrometry and X-ray diffraction analyses were carried out. Moreover, the lipophilicity of the target compounds as expressed from the Clog P. Most of the test compounds (2a-j) showed weak to moderate antibacterial and antifungal activities against most of the used bacterial and fungal strains in comparison to chloramphenicol and clotrimazole as reference drugs respectively.

RECURRENCE RELATIONS FOR QUOTIENT MOMENTS OF THE EXPONENTIAL DISTRIBUTION BY RECORD VALUES

  • LEE, MIN-YOUNG;CHANG, SE-KYUNG
    • Honam Mathematical Journal
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    • v.26 no.4
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    • pp.463-469
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    • 2004
  • In this paper we establish some recurrence relations satisfied by quotient moments of upper record values from the exponential distribution. Let $\{X_n,\;n{\geq}1\}$ be a sequence of independent and identically distributed random variables with a common continuous distribution function F(x) and probability density function(pdf) f(x). Let $Y_n=max\{X_1,\;X_2,\;{\cdots},\;X_n\}$ for $n{\geq}1$. We say $X_j$ is an upper record value of $\{X_n,\;n{\geq}1\}$, if $Y_j>Y_{j-1}$, j > 1. The indices at which the upper record values occur are given by the record times {u(n)}, $n{\geq}1$, where u(n)=min\{j{\mid}j>u(n-1),\;X_j>X_{u(n-1)},\;n{\geq}2\} and u(1) = 1. Suppose $X{\in}Exp(1)$. Then $\Large{E\;\left.{\frac{X^r_{u(m)}}{X^{s+1}_{u(n)}}}\right)=\frac{1}{s}E\;\left.{\frac{X^r_{u(m)}}{X^s_{u(n-1)}}}\right)-\frac{1}{s}E\;\left.{\frac{X^r_{u(m)}}{X^s_{u(n)}}}\right)}$ and $\Large{E\;\left.{\frac{X^{r+1}_{u(m)}}{X^s_{u(n)}}}\right)=\frac{1}{(r+2)}E\;\left.{\frac{X^{r+2}_{u(m)}}{X^s_{u(n-1)}}}\right)-\frac{1}{(r+2)}E\;\left.{\frac{X^{r+2}_{u(m-1)}}{X^s_{u(n-1)}}}\right)}$.

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A Scanning Electron Microscopic Study on the Effect of Nd:YAG Laser Irradiation on the Cervical Cementum (Nd:YAG 레이저조사가 치경부 백악질에 미치는 영향에 관한 주사전자현미경적 연구)

  • Choi, Bok;Lee, Jeong-Yeon;Shin, Keum-back
    • Journal of Oral Medicine and Pain
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    • v.25 no.4
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    • pp.415-425
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    • 2000
  • In order to obtain the basic data concerning the optimal lasing conditions in using Nd:YAG laser as an adjunctive modality of periodontal therapy of root planing without irreversible structural deterioration of cervical cementum, the author selected 36 human teeth having no cervical abrasion and caries (; 12 anteriors, 12 premolars. 12 molars) extracted due to periodontal diseases, and divided them into 4 groups as Group I, II, III and IV (; each group of 3 anteriors, 3 premolars, 3 molars), and prepared a cementum specimen with thickness of $1.0mm{\pm}0.2mm$ sectioned longitudinally at the middle of mesio-distal thickness (; Group I) or horizontally at 1mm-2mm below the cemento-enamel junction (; Group II, III, IV) from each tooth of each group by low speed diamond wheel saw, and treated them with 0.5 M ethylene diamine tetraacetic acid (; EDTA, pH=7.4) for 2 minutes for elimination of remnants during tooth-sectioning. And the author applied the laser energy from a fiberoptic delivered, free running, pulsed Nd:YAG laser (; wavelength 1064nm. pulse duration $120{\mu}sec$, fiber diameter $320{{\mu}m}$) to cementum surfaces in triplicates of one experiment under the following lasing conditions: 1. stationary mode of fiber in contact to cementum surfaces without air-spray (; Group I )/with air-spray (; Group II), 2. unidirectional moving mode of fiber in contact to cementum surfaces under speed of 3mm-4mm/sec without air-spray (; Group III)/with air-spray (; Group IV), 3. energy per pulse (mJ/pulse) [; energy density ($J/cm^{2}$)] in order of 1.0W/10Hz (100J/pulse); $124J/cm^{2}$, 0.5W/10Hz (50mJ/pulse); $62J/cm^{2}$, 0.4W/10Hz (40mJ/pulse); $50J/cm^{2}$, 0.3W/10Hz (30mJ/pulse); $37J/cm^{2}$, 4. exposure time of 1 second. And the author applied the platinum coating on surfaces of cementum specimens, and evaluated the characteristics of ultrastructural change on surfaces of cementum using the scanning electron microscopy. In general the ultrastructural loss of cervical cementum irradiated under the same lasing condition of laser energy density occurred least in specimens of Group IV. And especially, the ultrastructural loss of cervical cementum irradiated under the laser energy density of $37J/cm^{2}$ almost did not occur in specimens of Group IV. Therefore, it is considered that the pulsed Nd:YAG laser should be applied with the lasing conditions of unidirectional moving mode of fiber in contact to cementum surfaces under speed of 3mm-4mm/sec with air-spray and of laser energy density within $37J/cm^{2}$ as an adjunctive modality of periodontal therapy of root planing without irreversible structural deterioration of cervical cementum.

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Purification of J-Chain (J-Chain의 순수분리에 관한 연구)

  • Kang, Yoon-Se;Kang, Shin-Sung
    • The Korean Journal of Zoology
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    • v.19 no.2
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    • pp.63-70
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    • 1976
  • J-chain was purified from human serum IgA by three different methods which involve preparative disc electrophoresis, ion exchange chromatography and water precipitation. It was found that the simplest and satisfactory method was precipitation in water. All the J-chain preparations obtained from the above different procedures showed similar electrophoretic mobility and band-patterns.

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$J_{c}$ control ofNb/$Al_{2}$$O_{3}$ /Nb Josephson junction (Nb/$Al_{2}$$O_{3}$ /Nb 조셉슨 접합의 임계전류밀도 제어)

  • 김규태;홍현권;이상길;이규원
    • Proceedings of the Korea Institute of Applied Superconductivity and Cryogenics Conference
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    • 2002.02a
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    • pp.10-12
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    • 2002
  • Single Josephson junctions of 50 $\mu$m $\times$ 50 $\mu$m were fabricated for several oxidation conditions to investigate controllabilities of critical current density ($J_{c}$) with the standard KRISS processes. Considering the self-field effect suppressing the observed critical current ($I_{c}$) at high $J_{c}$ region, we could reasonably estimate $J_{c}$ values from I-V observations. The dependence of the estimated $J_{c}$ as a function of exposure, which is equal to pressure(P) times time(t), was well fitted to a curve of $J_{c}$ ~ $(Pt)^{-0.36}$. The maximum $J_{c}$ value at the controllability margin was found to be 4 kA/$cm^{2}$ with the current equipment set up.

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Analysis of Heating Characteristics Using Aluminum Multi-Layer Curtain for Protected Horticulture Greenhouses

  • Park, Bum-Soon;Kang, Tae-Hwan;Han, Chung-Su
    • Journal of Biosystems Engineering
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    • v.40 no.3
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    • pp.193-200
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    • 2015
  • Purpose: The purpose of this study was to investigate the energy saving effects and characteristics of plant growth in a greenhouse with an aluminum multi-layer curtain compared to a greenhouse with non-woven fabric. Method: The dimensions of both greenhouses $43m{\times}3.6m{\times}8m(L{\times}H{\times}W)$, and both used hot air heater systems for maintaining a constant temperature $15^{\circ}C$. Heating characteristics such as solar intensity, inside and ambient temperatures, and fuel consumption were measured and analyzed. Results: The changes of average temperature of both greenhouses during a 15-days (December 06 - 20) showed approximately $26^{\circ}C$ at around 2 pm when the ambient temperature was highest. The greenhouses were set by the heater to keep a temperature of $15^{\circ}C$ from 4 pm to 8 am the following day. The average heat loss (for 15 days) from the greenhouse with an aluminum multi-layer curtain was $161.2-268.4kJ/m^2{\cdot}h$ during the daytime and $152.3-198.1kJ/m^2{\cdot}h$ during the nighttime. The average heat loss (for 15 days) from the greenhouse with non-woven fabric was $155.7-258.9kJ/m^2{\cdot}h$ during the daytime and $144.9-207.0kJ/m^2{\cdot}h$ during the nighttime. The total heat loss (for one day) from the non-woven fabric system was $7,960kJ/m^2$($2,876kJ/m^2$ during the daytime, $5,084kJ/m^2$ during the nighttime). The heat supply over 36 days for the non-woven fabric system was higher than the aluminum multi-layer curtain system by $616.3-65,079.4kJ/m^2$. Conclusions: These results suggest that a greenhouse with an aluminum multi-layer curtain could save energy usage by 35% over a greenhouse with non-woven fabric.