• Journal of Korean Medical Science
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• v.33 no.51
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• pp.325.1-325.10
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• 2018

Background: To evaluate survival outcomes and prognostic factors for overall survival (OS) in patients with metastatic renal cell carcinoma (mRCC) who received sunitinib (SU) and pazopanib (PZ) as first-line therapy in real-world Korean clinical practice. Methods: Data of 554 patients with mRCC who received SU or PZ at eight institutions between 2012 and 2016 were retrospectively reviewed. Based on the targeted therapy, the patients were divided into SU (n = 293) or PZ (n = 261) groups, and the clinicopathological variables and survival rates of the two groups were compared. A multivariable Cox proportional hazard model was used to determine the prognostic factors for OS. Results: The median follow-up was 16.4 months (interquartile range, 8.3-31.3). Patients in the PZ group were older, and no significant difference was observed in the performance status (PS) between the two groups. In the SU group, the dose reduction rate was higher and the incidence of grade 3 toxicity was more frequent. The objective response rates were comparable between the two groups (SU, 32.1% vs. PZ, 36.4%). OS did not differ significantly between the two groups (SU, 36.5 months vs. PZ, 40.2 months; log-rank, P = 0.955). Body mass index, Eastern Cooperative Oncology Group PS > 2, synchronous metastasis, poor Heng risk criteria, and liver and bone metastases were associated with a shorter OS. Conclusion: Our real-world data of Korean patients with mRCC suggested that SU and PZ had similar efficacies as first-line therapy for mRCC. However, PZ was better tolerated than SU in Korean patients.

• Journal of the Korean Magnetics Society
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• v.16 no.5
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• pp.240-244
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• 2006

In this paper, magnetic properties and annealing behavior of spin valve structures using Mo(MoN) layers as underlayers were studied varying the thickness of the underlayers. The spin valve structure was consisted of Si substrate/$SiO_2(2,000{\AA})/Mo(MoN)(t{\AA})/NiFe(21\;{\AA})/CoFe(28\;{\AA})/Cu(22\;{\AA})/CoFe(18\;{\AA})/IrMn(65\;{\AA})/Ta(25\;{\AA})$. Also, MoN films were deposited on Si substrates and their thermal annealing behavior was analyzed. The resistivity of the MoN film increased as the $N_2$ gas flow rate was increased. After annealing at $600^{\circ}C$, XRD results did not show peaks of silicides. XPS results indicated MoN film deposited with 5 sccm of $N_2$ gas flow rate was more stable than the film deposited with 1 sccm of $N_2$ gas flow rate. The variations of MR ratio and magnetic exchange coupling fold were small for the spin valve structures using Mo(MoN) underlayers up to thickness of45 ${\AA}$. MR ratio of spin valves using MoN underlayers deposited with various $N_2$ gas flow rate was about 7.0% at RT and increased to about 7.5% after annealing at $220^{\circ}C$. Upon annealing at $300^{\circ}C$, the MR ratio decreased to about 3.5%. Variation of $N_2$ gas flow rate up to 5 sccm did not change the MR ratio and $H_{ex}$ appreciably.

• Journal of the Korean Magnetics Society
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• v.25 no.5
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• pp.156-161
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• 2015

The electronic structures of the potential candidate semiconductor nanoparticles for dye-sensitized solar cell (DSSC), such as $ZnSnO_3$ and $Zn_2SnO_4$, have been investigated by employing X-ray photoemission spectroscopy (XPS). The measured X-ray diffraction patterns show that $ZnSnO_3$ and $Zn_2SnO_4$ samples have the single-phase ilmenite-type structure and the inverse spinel structure, respectively. The measured Zn 2p and Sn 3d core-level XPS spectra reveal that the valence states of Zn and Sn ions are divalent (Zn 2+) and tetravalent (Sn 4+), respectively, in both $ZnSnO_3$ and $Zn_2SnO_4$. On the other hand, the shallow core-level measurements show that the binding energies of Sn 4d and Zn 3d core levels in $ZnSnO_3$ are lower than those in $Zn_2SnO_4$. This work provides the information on the valence states of Zn and Sn ions and their chemical bonding in $ZnSnO_3$ and $Zn_2SnO_4$.

• Journal of the Korean Magnetics Society
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• v.26 no.1
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• pp.19-23
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• 2016

In this study, we have constructed a measuring system to investigate tensile stress measurement of tendons, which is employed in bridges, by means of the non-destructive and non-contact method. The measuring system consists of tensile stress applying apparatus up to 2 GPa, and power supply for ac and dc current to tendon directly to magnetize tendon in circular direction and to coil wound on yoke to magnetize tendon in axial direction. We have used two kinds of tendon, which were produced by different companies, using the measuring system constructed in this work. Two kinds of experiments are carried out in this work; $1^{st}$ experiment : ac current was applied to the tendon and dc current was applied to coil wound on the yoke, and voltage induced from search coil wound on yoke (SCY) was measured and $2^{nd}$ experiment : dc current was applied to the tendon and ac current was applied to coil wound on the yoke, and voltage induced from search coil on tendon (SCT) was measured. In case of $1^{st}$ experiment, voltage induced from SCY was changed below 200MPa tensile stress but the voltage was not increased above 200 MPa. In case of $2^{nd}$ experiment, voltage induced from SCT was decreased up to 1.5 GPa linearly. We expect that $2^{nd}$ experiment could be applied to the non-destructive testing of tensile stress measurement of tendon.

• Journal of the Korean Magnetics Society
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• v.25 no.5
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• pp.162-168
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• 2015

The ${\mu}$-turn coil having a width of ${\mu}m$ on the GMR-SV (giant magnetoresistance-spin valve) device based on the antiferromagnetic IrMn layer was fabricated by using the optical lithography process. In the case of GMR-SV film and GMR-SV device, the magnetoresistance ratios and the magnetic sensitivities are 4.4%, 2.0%/Oe and 1.6 %, 0.1%/Oe, respectively. In the y-z plane the distribution of magnetic field of GMR-SV device and $10{\mu}$-turns coil which put under the several magnetic bead(MB)s with a diameter of $1{\mu}m$ attached to RBC (red blood cell) was analyzed by the computer simulation using the finite element method. When the AC currents of 20 kHz from 0.1 mA to 10.0 mA flow to the 10 turns ${\mu}$-coil, the magnetic field at the position of $z=0{\mu}m$ at the center of coil was calculated from $30.1{\mu}T$ to $3060{\mu}T$ in proportion to the current. The magnetic field at the position of $z=10{\mu}m$ was decreased to one-sixth of that of $z=0{\mu}m$. It was confirmed that the $10{\mu}$-turn coil having enough magnitude of magnetic field for the capture of RBC is possible to use as a biosensor for the detection of magnetic beads attached to RBC.

• Journal of the Korean Magnetics Society
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• v.26 no.1
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• pp.1-6
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• 2016

Pd has the highest magnetic susceptibility among single element metals and often shows ferromagnetism under some special environments. In this paper, we report magnetism of 5- and 9-monolayers (ML) calculated by using full-potential linearized augmented plane wave method. Exchange-correlation interaction is taken into account in local density approximation (LDA) and generalized gradient approximation (GGA) and calculational results in LDA and GGA are compared with each other. It is found that calculations by LDA are more reliable compared to those by GGA because LDA prediction of paramagnetism of bulk Pd is consistent with experiments, whereas GGA predicts wrongly ferromagnetim of bulk Pd. Calculational results in LDA on a 5-ML Pd(111) thin film shows a ferromagnetic ground state unlike a paramagnetic ground state of bulk Pd. The center Pd layer of the 5-ML Pd(111) thin film has the largest magnetic moment ($0.273{\mu}_B$) among the layers and |m| = 1 orbital states play a dominant role in stabilizing the ferromagnetism of the 5-ML Pd(111) thin film. A 9-ML Pd(111) thin film in a ferromagnetic state has almost the same total energy as in a paramagnetic state. Since the magnetization of the 9-ML Pd(111) thin film is stable, the ferromagnetic state may be meta-stable.

• Journal of the Korean Magnetics Society
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• v.21 no.6
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• pp.198-203
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• 2011

The electronic structure of ferrimagnetic spinel oxide of $FeV_2O_4$ has been investigated by employing soft x-ray absorption spectroscopy (XAS) and soft x-ray magnetic circular dichroism (XMCD). The Fe 2p and V 2p XAS spectra show that the valence states of Fe and V ions are ${\sim}Fe^{2.3+}$ mixed-valent states and ${\sim}V^{3+}$ states, respectively. In Fe 2p XMCD spectra, finite XMCD signals are observed for divalent $Fe^{2+}$ states only, but not for $Fe^{3+}$ states. This finding indicates that the magnetic moments of $Fe^{2+}$ ions are ordered ferromagnetically but that those of $Fe^{3+}$ ions are cancelled, implying that $Fe^{2+}$ ions play an important role in determining magnetic properties of $FeV_2O_4$.

• Journal of the Korean Magnetics Society
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• v.21 no.5
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• pp.157-162
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• 2011

The effect of ferrous/ferric molar ratio and precipitants on the formation of nano size magnetite particle was investigated by coprecipitation method. Ferrous sulfate and ferric sulfate were used as iron sources and sodium hydroxide and ammonium hydroxide was used as a precipitant. Single phase magnetite was synthesized with all of experiment conditions (ferrous/ferric molar ratios and precipitants). Particle size was smaller, and particle size distribution was narrower when NaOH was used than $NH_4OH$ was used. The crystallinity and particle size was increased and narrower particle size distribution with increasing molar ratio ferrous/ferric sulfate with the same precipitant. Super paramagnetism could be obtained at all of experiment conditions. The highest saturation magnetization (72 emu/g) was obtained when the ferrous/ferric molar ratio was 2.5 and precipitant was used $NH_4OH$.

• Journal of the Korean Magnetics Society
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• v.21 no.6
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• pp.219-224
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• 2011

The motion features of sanals inside of the primo vascular system (PVS), that is so-called the Kyungrak system, are investigated under a low static magnetic field by using the anatomy technology and optical microscope. The sanals with a size of about 1 selected and separated from the primo vessel and node of the real PVS inside of the surface of the internal organs are observed from rabbits' abdominal wall and dipped with PBS liquid inside of petri dish. The sanal's moving velocity along the direction of magnetic field (xdirection) and perpendicular to the direction of magnetic field (y-direction) under the low magnetic field of 0 Oe, 20 Oe, 40 Oe, 60 Oe, and 80 Oe, respectively, is observed below a internal temperature of $38^{\circ}C$. Ten sanals' moving velocities versus magnetic field are shown two differently dominant tendencies with an average velocity of 0.9 pixel/s and a random velocity according to the x-direction and y-direction, respectively. This experimental results imply that the rotating motion of sanal with nuclei DNA composed of many inorganic magnetic materials of Mn and Co is monotonically weakened by the increase of applied magnetic field.

• Journal of the Korean Magnetics Society
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• v.19 no.1
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• pp.12-16
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• 2009

Z-type barium ferrite [($Ba_{3}Co_{0.8}Zn_{1.2}Fe_{24}O_{41}$, $Ba_{3+{\delta}}Co_{0.8}Zn_{1.2}Fe_{24}O_{41}$ ${\delta}$ = 3, 5, 7, 13 wt%. $Ba_{3}Co_{0.8}Zn_{1.2}Fe_{24+{\delta}}O_{41}$ ${\delta}$ = 5, 7, 10 wt% )] were synthesized using co-precipitation method. The microstructure and magnetic properties of synthesized particles were investigated. In all prepared particles M-type Ba ferrite is identified with Z-type Ba ferrite together. It is found that particles having 7 wt% for Ba and 5 wt% for Fe excess addition revealed high saturation magnetization, respectively. All synthesized particles showed relatively high coercivity for device application. This result may be attributed to the contribution of M-type Ba ferrite. Ba and Fe excess addition was not affected to the structural change of CoZnZ Ba ferrite. The certain amount of excess additions of Ba and Fe and the 2 step heat-treatment may be beneficial to the improvement of soft magnetic properties of Z-type barium hexa-ferrite