• Journal of Gastric Cancer
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• v.21 no.4
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• pp.368-378
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• 2021

Purpose: When patients with early gastric cancer (EGC) undergo non-curative endoscopic submucosal dissection requiring gastrectomy (NC-ESD-RG), additional medical resources and expenses are required for surgery. To reduce this burden, predictive model for NC-ESD-RG is required. Materials and Methods: Data from 2,997 patients undergoing ESD for 3,127 forceps biopsy-proven differentiated-type EGCs (2,345 and 782 in training and validation sets, respectively) were reviewed. Using the training set, the logistic stepwise regression analysis determined the independent predictors of NC-ESD-RG (NC-ESD other than cases with lateral resection margin involvement or piecemeal resection as the only non-curative factor). Using these predictors, a risk-scoring system for predicting NC-ESD-RG was developed. Performance of the predictive model was examined internally with the validation set. Results: Rate of NC-ESD-RG was 17.3%. Independent pre-ESD predictors for NC-ESD-RG included moderately differentiated or papillary EGC, large tumor size, proximal tumor location, lesion at greater curvature, elevated or depressed morphology, and presence of ulcers. A risk-score was assigned to each predictor of NC-ESD-RG. The area under the receiver operating characteristic curve for predicting NC-ESD-RG was 0.672 in both training and validation sets. A risk-score of 5 points was the optimal cut-off value for predicting NC-ESD-RG, and the overall accuracy was 72.7%. As the total risk score increased, the predicted risk for NC-ESD-RG increased from 3.8% to 72.6%. Conclusions: We developed and validated a risk-scoring system for predicting NC-ESD-RG based on pre-ESD variables. Our risk-scoring system can facilitate informed consent and decision-making for preoperative treatment selection between ESD and surgery in patients with EGC.

• Nuclear Engineering and Technology
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• v.54 no.2
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• pp.479-485
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• 2022

At the Korea Institute of Radiological and Medical Sciences, physical human phantoms were developed to evaluate various radiation protection quantities, based on the mesh-type reference computational phantoms of the International Commission on Radiological Protection. The physical human phantoms were fabricated such that a radiophotoluminescent glass dosimeter (RPLGD) with a Tin filter, namely GD-352M, could be inserted into them. A Tin filter is used to eliminate the overestimated signals in low-energy photons below 100 keV. The measurement uncertainty of the RPLGD reader system based on GD-352M should be analyzed for obtaining reliable protection quantities before using it for practical applications. Generally, the measurement uncertainty of RPLGD systems without Tin filters is analyzed for quality assurance of radiotherapy units using a high-energy photon beam. However, in this study, the measurement uncertainty of GD-352M was analyzed for evaluating the protection quantities. The measurement uncertainty factors in the RPLGD include the reference irradiation, regression curve, reproducibility, uniformity, energy dependence, and angular dependence, as described by the International Organization for Standardization (ISO). These factors were calculated using the Guide to the Expression of Uncertainty in Measurement method, applying ISO/ASTM standards 51261(2013), 51707(2015), and SS-ISO 22127(2019). The measurement uncertainties of the RPLGD reader system with a coverage factor of k = 2 were calculated to be 9.26% from 0.005 to 1 Gy and 8.16% from 1 to 10 Gy. A blind test was conducted to validate the RPLGD reader system, which demonstrated that the readout doses included blind doses of 0.1, 1, 2, and 5 Gy. Overall, the E_n values were considered satisfactory.

• Journal of The Korean Astronomical Society
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• v.55 no.4
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• pp.123-130
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• 2022

We present the analysis of a planetary microlensing event OGLE-2019-BLG-0362 with a shortduration anomaly (~0.4 days) near the peak of the light curve, which is caused by the resonant caustic. The event has a severe degeneracy with ∆𝜒² = 0.9 between the close and the wide binary lens models both with planet-host mass ratio q ≃ 0.007. We measure the angular Einstein radius but not the microlens parallax, and thus we perform a Bayesian analysis to estimate the physical parameters of the lens. We find that the OGLE-2019-BLG-0362L system is a super-Jovian-mass planet $M_p=3.26^{+0.83}_{-0.58}M_J $ orbiting an M dwarf $M_h=0.42^{+0.34}_{-0.23}M_{\odot}$ at a distance $D_L=5.83^{+1.04}_{-1.55}kpc$. The projected star-planet separation is ${\alpha}_{\bot}= 2.18^{+0.58}_{-0.72}AU$, which indicates that the planet lies beyond the snow line of the host star.

• Nuclear Engineering and Technology
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• v.26 no.3
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• pp.401-410
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• 1994

Validation study of two radionuclide migration models for single fracture developed in geologic medium the hydrodynamic dispersion diffusion model(HDDM) and the channeling dispersion diffusion model(CDDM), was studied by migration experiment of tracers through an artificial granite fracture on the labolatory scale. The tracers used were Uranine and Sodium lignosulfonate know as nonsorbing material. The flow rate ranged 0.4 to 1.5 cc/min. Related parameters for the models were estimated by optimization technique. Theoretical breakthrough curves with experimental data were compared. In the experiment, it was deduced that the surface sorption for both tracers did not play an important role while the diffusion of Uranine into the rock matrix turned out to be an important mass transfer mechanism. The parameter characterizing the rock matrix diffusion of each model agreed well The simulated result showed that the amount of flow rate could not tell the CDDM from the HDDM quantitatively. On the other hand, the variation of fracture length gave influence on the two models in a different degree. The dispersivity of breakthrough curve of the CDDM was more amplified than that of the CDDM when the fracture length was increased. A good agreement between the models and experimental data gave a confirmation that both models were very useful in predicting the migration system through a single fracture.

• Korean Journal of Radiology
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• v.22 no.7
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• pp.1213-1224
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• 2021

Objective: To develop a machine learning (ML) pipeline based on radiomics to predict Coronavirus Disease 2019 (COVID-19) severity and the future deterioration to critical illness using CT and clinical variables. Materials and Methods: Clinical data were collected from 981 patients from a multi-institutional international cohort with real-time polymerase chain reaction-confirmed COVID-19. Radiomics features were extracted from chest CT of the patients. The data of the cohort were randomly divided into training, validation, and test sets using a 7:1:2 ratio. A ML pipeline consisting of a model to predict severity and time-to-event model to predict progression to critical illness were trained on radiomics features and clinical variables. The receiver operating characteristic area under the curve (ROC-AUC), concordance index (C-index), and time-dependent ROC-AUC were calculated to determine model performance, which was compared with consensus CT severity scores obtained by visual interpretation by radiologists. Results: Among 981 patients with confirmed COVID-19, 274 patients developed critical illness. Radiomics features and clinical variables resulted in the best performance for the prediction of disease severity with a highest test ROC-AUC of 0.76 compared with 0.70 (0.76 vs. 0.70, p = 0.023) for visual CT severity score and clinical variables. The progression prediction model achieved a test C-index of 0.868 when it was based on the combination of CT radiomics and clinical variables compared with 0.767 when based on CT radiomics features alone (p < 0.001), 0.847 when based on clinical variables alone (p = 0.110), and 0.860 when based on the combination of visual CT severity scores and clinical variables (p = 0.549). Furthermore, the model based on the combination of CT radiomics and clinical variables achieved time-dependent ROC-AUCs of 0.897, 0.933, and 0.927 for the prediction of progression risks at 3, 5 and 7 days, respectively. Conclusion: CT radiomics features combined with clinical variables were predictive of COVID-19 severity and progression to critical illness with fairly high accuracy.

• Korean Journal of Radiology
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• v.22 no.5
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• pp.697-705
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• 2021

Objective: To investigate the feasibility and the accuracy of the coronary CT angiography (CCTA)-derived Registry of Crossboss and Hybrid procedures in France, the Netherlands, Belgium and United Kingdom (RECHARGE) score (RECHARGECCTA) for the prediction of procedural success and 30-minutes guidewire crossing in percutaneous coronary intervention (PCI) for chronic total occlusion (CTO). Materials and Methods: One hundred and twenty-four consecutive patients (mean age, 54 years; 79% male) with 131 CTO lesions who underwent CCTA before catheter angiography (CA) with CTO-PCI were retrospectively enrolled in this study. The RECHARGECCTA scores were calculated and compared with RECHARGECA and other CTA-based prediction scores, including Multicenter CTO Registry of Japan (J-CTO), CT Registry of CTO Revascularisation (CT-RECTOR), and Korean Multicenter CTO CT Registry (KCCT) scores. Results: The procedural success rate of the CTO-PCI procedures was 72%, and 61% of cases achieved the 30-minutes wire crossing. No significant difference was observed between the RECHARGECCTA score and the RECHARGECA score for procedural success (median 2 vs. median 2, p = 0.084). However, the RECHARGECCTA score was higher than the RECHARGECA score for the 30-minutes wire crossing (median 2 vs. median 1.5, p = 0.001). The areas under the curve (AUCs) of the RECHARGECCTA and RECHARGECA scores for predicting procedural success showed no statistical significance (0.718 vs. 0.757, p = 0.655). The sensitivity, specificity, positive predictive value, and the negative predictive value of the RECHARGECCTA scores of ≤ 2 for predictive procedural success were 78%, 60%, 43%, and 87%, respectively. The RECHARGECCTA score showed a discriminative performance that was comparable to those of the other CTA-based prediction scores (AUC = 0.718 vs. 0.665-0.717, all p > 0.05). Conclusion: The non-invasive RECHARGECCTA score performs better than the invasive determination for the prediction of the 30-minutes wire crossing of CTO-PCI. However, the RECHARGECCTA score may not replace other CTA-based prediction scores for predicting CTO-PCI success.

• Korean Journal of Environment and Ecology
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• v.32 no.5
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• pp.513-531
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• 2018

This study compared forest vegetation in Chungcheongnam-do Provincial Park (Deogsan, Chilgabsan, and Daedunsan) from 2006 to 2016. The results of the analysis on the vegetation of the research sites by the phytosociological method showed that the Deogsan Provincial Park had Quercus mongolica community, Pinus densiflora community, Q. variabilis community, and Zelkova serrata community. Chilgabsan Provincial Park had Q. variabilis community, Q. mongolica community, P. densiflora community, and Carpinus laxiflora community. Daedunsan Provincial Park had Q. mongolica community, Q. variabilis community, Q. serrata community, C. tschonoskii community, C. laxiflora community, P. densiflora community, and Q. acutissima community. The importance value in each Provincial Parks was analyzed as follows. The importance value of Q. mongolica(72.35) was the highest in Deogsan Provincial Park, and followed by P. densiflora(70.25), Q. variabilis(53.11), Styrax japonicus(11.44), Prunus sargentii(11.17), and Fraxinus rhynchophylla(10.41). Q. variabilis(73.34) was the highest in Chilgabsan Provincial Park and followed by, P. densiflora(58.71), Q. mongolica(57.02), C. laxiflora(18.84), Q. serrata(13.48), and Prunus sargentii(13.31). The importance value of Q. mongolica(57.03) was the highest in Daedunsan Provincial Park and followed by Q. variabilis(31.98), Q. serrata(31.53), P. densiflora(16.80), C. tschonoskii(16.50), C. laxiflora(16.07), S. obassia(15.76), and Acer pseudosieboldianum(10.09). The results of DBH analysis of the major species having the high importance value showed the normal density distirbution of Q. mongolica, and Q. variabilis in Deogsan Provincial Park, so the dominance status of these species is likely to continue. Q. variabilis, Q. mongolica, and P. densiflora in Chilgabsan Provincial Park showed the normal density distribution showed the density of normal distribution, so the dominance status of these species is likely to continue. However, the dominance status of C. laxiflora, and Q. serrata is likely to be expanded in the future due to the high density of young individuals. Q. mongolica, and Q. variabilis in Daedunsan Provincial Park showed the density of reverse J-shaped curve, so the dominance status of these species is likely to continue, and C. tschonoskii, and P. densiflora had a formality distribution, suggesting continuous domination of these species over the other species for the time being. Additionally the dominance status of C. laxiflora, and Q. serrata is considered to be expanded in the future due to the high density level of young individuals.

• The Journal of the Petrological Society of Korea
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• v.21 no.3
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• pp.335-365
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• 2012

Fission-track (FT) thermochronological records from SE Korean Cretaceous-Paleogene granitic plutons in different fault-bounded blocks reveal contrasting cooling and later thermal histories. Overall cooling patterns are represented by a monotonous (J-shaped) curve in most plutons except some Cretaceous granites retaining a complicated (N-shaped) path due to post-reset re-cooling. Discriminative cooling rates over different temperature ranges can be explained for individual plutons with respect to relative pluton sizes, differences in initial heat loss depending on country rocks, and the presence and proximity of later igneous activity. Even within a single batholith, cooling times for different isotherms were roughly contemporaneous with respect to positions. Insignificant deviations in cooling ages from two different plutons in succession across the Yangsan fault may suggest their contemporaneity before major horizontal fault movement. The extent of later thermal rise recorded locally along the Yangsan and Dongnae fault zones were reached the Apatite Partial Stability Zone ($70-125^{\circ}C$), but did not exceed $200^{\circ}C$. Thermal alteration from fractured zones in the Yangsan-Ulsan fault junction may suggest a thermal reset above $290^{\circ}C$ resulting a complete reset in FT sphene age (31 Ma), caused by a tectonic subsidence in Early Oligocene. A consistency in FT zircon/apatite ages (24 Ma) may imply a sudden rapid cooling over $200-105^{\circ}C$, plausibly related to the abrupt tectonic uplift of the Pohang-Gampo Block including the fault junction in Late Oligocene. A remarkable trend of lower cooling ages for $300-200-100^{\circ}C$ isotherms (i.e., 19% for FT sphene and K-Ar biotite; 20% for FT zircon; 27% for FT apatite) from the east of the Ulsan fault (Pohang-Gampo Block) comparing to the west of the fault may be attributed to retarded cooling times from the Paleogene granites and also reflected by their partially-reduced apatite ages due to later thermal effects.

• Journal of Ecology and Environment
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• v.29 no.3
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• pp.237-245
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• 2006

Changes of the biomass, net primary productivity and P/B ratio during abandoned field succession after shifting cultivation were investigated in Pyoungchang, Gangwon-Do, Korea. Aboveground standing biomass of herb species showed the maximum value (3.8 ton/ha) in the 5 year old-field, and decreased thereafter. Litter dry weight was depicted as a parabola form showing the gradual increment during the first 50 years and slight decrease thereafter. Basal area tended to increase logarithmically during abandoned field succession. Tree density showed the gradual increment during the first 15 years and decreased thereafter by the self-thinning process. In the later successional stage (80 years old-field), the shoot density distribution of the tree species by DBH class showed the reverse J shaped curve and Quercus mongolica dominated. Total standing biomass increased slowly in the earlier successional stages and later successional stages, and increased rapidly during the mid-successional stages ($10{\sim}50$ years old-field). Total standing biomass in the 5, 10, 20, 50 and 80 years old-fields were estimated 5, 14, 75, 251 and 373 ton/ha, respectively. Annual net primary productivity were depicted as a parabola form showing the gradual increment during the first 35 years and declined thereafter. The increment rates of the annual net primary productivity in the earlier successional stages showed the higher value than mid-successional stages. The annual net primary productivities in the 5, 10, 20, 35, 50 and 80 years old-field were estimated 8.6, 9.3, 12.9, 15.1, 13.7 and 3.6 ton/ha/yr, respectively. The estimated P/B ratio tended to decrease exponentially during abandoned field succession. The estimated P/B ratio in the 5, 10, 20, 50 and 80 years old-field were 0.60, 0.39, 0.19, 0.06 and 0.01, respectively. These results were fairly in accordance with the bioenergetics model during the forest succession projected by Odum(1969).

• Journal of environmental and Sanitary engineering
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• v.15 no.4
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• pp.59-77
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• 2000

This study was carried out to investigate on several factors, which contaminative the water quality through the water pipe during feeding water, in 42 largescaled apart-ments(total 84 cases) and assayed the Volatile Organic Compounds(VOCs) and concen-tration of heavy metals that inflow and outflow in reservior water in Jeonnam area(Mokpo, Suncheon, Yeosu) from January 1999 to December 1999. The results obtained were summarized as follows ; 1. The quality of the water pipe composition in the order of frequency in the quality of water pipes were Copper(45.2%)> Zinc(38.9%)> Stainless steel(9.5%)> PVC(4.8%)> PM(2.4%) in observing 42 sites. All of the drain pipes were used the cast iron quality. 2. The result of certification curve from 12 items(17kind) of VOCs was $1.0-4.0{\mu{g}}/{\ell}$ range, a coefficient of correlation was shown 0.99 over. A MDL of each substance range was within $0.1-1.0{\mu{g}}/{\ell}$. 3. The result of the assay, 5 kinds(Viny chloride, Dichloromethane, Ethylbenzene, M,P-xylene, Styrene) of the VOCs of 14 kinds was not detected and the other items were detected slightly. The detection rate of one item and over in total VOCs samples, were 25.9% in inflow and 27.9% in outflow. And frequency of detect in inflow/outflow of THM(Chloroform, Bromodichloro-methane, Dibromochloromethane, Bromoform) were shown higher than 94.1%, 97.0% each stages. It comes to the conclusion that all of the samples were reason able for drinking water standards. 4. The coefficient of correlation were reasonable, it shown 0.999 over in $0.1-1.0{\mu{g}}/{\ell}$ of a measuring range conditions of 4kinds in organic substance(Zn, Cu, Fe, Mn). 5. The results were showed suitability in 78 cases(92.9%) and unsuitability in 6 cases (7.1%), in 84 cases of in organic substances. Compare to inflow stage, mean concentrations of heavy metal, were increased slightly in Zn, Cu, Fe except Mn than outflow stage. The result of the mean concentration in organic substance inflow and outflow in the apartment water tank using Pair-compared T-test, in 95% reliance index, were $0.179mg/{\ell}(0.151-0.307mg/{\ell})$ in Zinc, $0.136mg/{\ell}(0.113-0.230mg/{\ell})$ in Copper, $0.052mg/{\ell}(0.048-0.098mg/{\ell})$ in Fe, and there was a bit growing tendency but there was no differece in Mn. 6. The mean concentration of Copper which used Cu pipe as a water supply pipe in apartment were $0.216mg/{\ell}(0.161-0.338mg/{\ell})$ in case of the Zine pipe were $0.286mg/{\ell}(0.204-0.435mg/{\ell})$. It shows that the detection rate was more higher than the other material used in Cu or Zn as the water supply pipe. We supposed to Cu and Zn substance were gushing out water supply pipe.