• Title/Summary/Keyword: J domain

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Crystal structures of human DJ-1 and Escherichia coli Hsp31 that share an evolutionarily conserved domain

  • Cha, Sun-Shin
    • Proceedings of the Korean Biophysical Society Conference
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    • 2003.06a
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    • pp.33-33
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    • 2003
  • Human DJ-1 and Escherichia coli Hsp31 belong to ThiJ/PfpI family whose members contain a conserved domain. DJ-1 is associated with autosomal recessive early-onset parkinsonism and Hsp31 is a molecular chaperone. Structural comparisons between DJ-1, Hsp31, and an archeal protease, a member of ThiJ/PfpI family, lead to the identification of the chaperons activity of DJ-1 and the proteolytic activity of Hsp31. Moreover, the comparisons provide insights into how the functional diversity is realized in proteins that share an evolutionarily conserved domain. On the basis of the chaperons activity, the possible role of DJ-1 in the pathogenesis of Parkinson's disease is discussed.

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Numerical calculation of the wind action on buildings using Eurocode 1 atmospheric boundary layer velocity profiles

  • Lopes, M.F.P.;Paixao Conde, J.M.;Gomes, M. Gloria;Ferreira, J.G.
    • Wind and Structures
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    • v.13 no.6
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    • pp.487-498
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    • 2010
  • When designing structures to the wind action, the variation of the mean wind velocity and turbulence parameters with the height above the ground must be taken into account. This paper presents the numerical simulation results of atmospheric boundary layer (ABL) airflows, in a numerical domain with no obstacles and with a cubic building. The results of the flow characterization, obtained with the FLUENT CFD code were performed using the ${\kappa}-{\varepsilon}$ turbulence model with the MMK modification. The mean velocity and turbulence intensity profiles in the inflow boundary were defined in accordance with the Eurocode 1.4, for different conditions of aerodynamic roughness. The maintenance of the velocity and turbulence characteristics along the domain were evaluated in an empty domain for uniform incident flow and the ABL Eurocode velocity profiles. The pressure coefficients on a cubic building were calculated using these inflow conditions.

Three-dimensional Detonation Cell Structures in a Circular Tube

  • Cho, D.R.;Won, S.H.;Shin, Edward J.R.;Choi, J.Y.
    • Proceedings of the Korean Society of Propulsion Engineers Conference
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    • 2008.03a
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    • pp.597-601
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    • 2008
  • Three-dimensional structures of detonation wave propagating in circular tube were investigated. Inviscid fluid dynamics equations coupled with a conservation equation of reaction progress variable were analyzed by a MUSCL-type TVD scheme and four stage Runge-Kutta time integration. Variable-$\gamma$ formulation was used to account for the variable properties between unburned and burned states and the chemical reaction was modeled by using a simplified one-step irreversible kinetics model. The computational code was parallelized based on domain decomposition technique using MPI-II message passing library. The computations were carried out using a home made Windows based PC cluster having 160 AMD AthloxXP and Athlon64 processor. The computational domain consisted of through a roundshaped tube with wall conditions. As an initial condition, analytical ZND solution was distributed over the computational domain with disturbances. The disturbances has circumferential large gradient. The unsteady computational results in three-dimension show the detailed mechanisms of multi-cell mode of detonation wave instabilities resulting diamond shape in smoked-foil record.

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Aerodynamic Analysis of Helicopter Rotor by Using a Time-Domain Panel Method

  • Kim, J.K.;Lee, S.W.;Cho, J.S.
    • Proceedings of the Korean Society of Propulsion Engineers Conference
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    • 2008.03a
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    • pp.638-642
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    • 2008
  • Computational methods based on the solution of the flow model are widely used for the analysis of lowspeed, inviscid, attached-flow problems. Most of such methods are based on the implementation of the internal Dirichlet boundary condition. In this paper, the time-domain panel method uses the piecewise constant source and doublet singularities. The present method utilizes the time-stepping loop to simulate the unsteady motion of the rotary wing blade. The wake geometry is calculated as part of the solution with no special treatment. To validate the results of aerodynamic characteristics, the typical blade was chosen such as, Caradonna-Tung blade and present results were compared with the experimental data and the other numerical results in the single blade condition and two blade condition. This isolated rotor blade model consisted of a two bladed rotor with untwisted, rectangular planform blade. Computed flow-field solutions were presented for various section of the blade in the hovering mode.

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CONTROLLABILITY OF NONLINEAR DELAY PARABOLIC EQUATIONS UNDER BOUNDARY CONTROL

  • Park, Jong-Yeoul;Kwun, Young-Chel;Jeong, Jin-Mun
    • Journal of the Korean Mathematical Society
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    • v.33 no.2
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    • pp.333-346
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    • 1996
  • Let $A(\zeta, \partial)$ be a second order uniformly elliptic operator $$ A(\zeta, \partial )u = -\sum_{j, k = 1}^{n} \frac{\partial\zeta_i}{\partial}(a_{jk}(\zeta)\frac{\partial\zeta_k}{\partial u}) + \sum_{j = 1}^{n}b_j(\zeta)\frac{\partial\zeta_j}{\partial u} + c(\zeta)u $$ with real, smooth coefficients $a_{j, k}, b_j$, c defined on $\zeta \in \Omega, \Omega$ a bounded domain in $R^n$ with a sufficiently smooth boundary $\Gamma$.

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Adaptive Fuzzy Drop Manager for Service of Reliable Distribution Application Domain Objects (신뢰성 있는 분산 도메인 객체 서비스를 위한 적응형 퍼지 드럽 관리기)

  • Jeong, Taeg-Won;Lee, Chong-Deuk
    • Journal of the Korean Institute of Intelligent Systems
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    • v.19 no.4
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    • pp.511-518
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    • 2009
  • A lot of methods are proposed to provide services for object informations in distributed domain to satisfy the recent increase of user-centered services. This paper proposed a method called fuzzy drop manager for the service of reliable distribution application domain objects. The proposed system accesses the domain using replica parameter ci,j and access matrix Z, and evaluates the reference relatedness inside the domain using the relatedness, given by the mapping of intra-domain fuzzy relevance, between fuzzy sets. Objects in the domain generated an $\alpha$-level set according to the reference relatedness obtained by applying $\alpha$-level to extend queries. Simulation results showed that the proposed method has better performance than the other methods.

FINDING THE OPTIMUM DOMAIN OF A NONLINEAR WAVE OPTIMAL CONTROL SYSTEM BY MEASURES

  • J., A.Fakharzadeh
    • Journal of applied mathematics & informatics
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    • v.13 no.1_2
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    • pp.183-194
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    • 2003
  • We will explain a new method for obtaining the nearly optimal domain for optimal shape design problems associated with the solution of a nonlinear wave equation. Taking into account the boundary and terminal conditions of the system, a new approach is applied to determine the optimal domain and its related optimal control function with respect to the integral performance criteria, by use of positive Radon measures. The approach, say shape-measure, consists of two steps; first for a fixed domain, the optimal control will be identified by the use of measures. This function and the optimal value of the objective function depend on the geometrical variables of the domain. In the second step, based on the results of the previous one and by applying some convenient optimization techniques, the optimal domain and its related optimal control function will be identified at the same time. The existence of the optimal solution is considered and a numerical example is also given.

Reduced Complexity Signal Detection for OFDM Systems with Transmit Diversity

  • Kim, Jae-Kwon;Heath Jr. Robert W.;Powers Edward J.
    • Journal of Communications and Networks
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    • v.9 no.1
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    • pp.75-83
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    • 2007
  • Orthogonal frequency division multiplexing (OFDM) systems with multiple transmit antennas can exploit space-time block coding on each subchannel for reliable data transmission. Spacetime coded OFDM systems, however, are very sensitive to time variant channels because the channels need to be static over multiple OFDM symbol periods. In this paper, we propose to mitigate the channel variations in the frequency domain using a linear filter in the frequency domain that exploits the sparse structure of the system matrix in the frequency domain. Our approach has reduced complexity compared with alternative approaches based on time domain block-linear filters. Simulation results demonstrate that our proposed frequency domain block-linear filter reduces computational complexity by more than a factor of ten at the cost of small performance degradation, compared with a time domain block-linear filter.