• Toxicological Research
• /
• 제29권1호
• /
• pp.27-34
• /
• 2013

This study was conducted to investigate the potential embryo-fetal toxicity and toxicokinetics of the antimalarial agent artesunate (ARTS) in Sprague-Dawley rats. Pregnant rats were administered ARTS daily from gestational day 6~15 via oral gavage, at test doses of 0, 2, 4, or 8 mg/kg (22 females per group). The fetuses were examined for external, visceral, and skeletal abnormalities on gestational day 20. With regard to the dams, there were no deaths, treatment-related clinical signs, changes in body weight, or food intake in any of the treatment groups. There were no treatment-related gross findings at necropsy in any treatment group. In the 8 mg/kg group, there was a decrease in gravid uterine weight and in the weight of female fetuses. There was also an increase in fetal deaths (primarily late resorptions) and an increase in post-implantation losses (37%) at 8 mg/kg. An increase in the incidence of visceral and skeletal variations at 4 and 8 mg/kg was observed. These defects included minor changes in the appearance of the kidney and thymus, as well as absent ribs or thoracic vertebrae. Toxicokinetics were assessed in a parallel study, using 4 mated females per group. Using liquid chromatography-mass spectrometry (LC-MS) analysis, the concentration of ARTS and its metabolite dihydroartemisinin (DHA) were quantified in plasma from rats on gestational days 5, 6, 10, and 15. Amniotic fluid was assayed for ARTS and DHA on gestational day 15. There was evidence of rapid conversion of ARTS to the metabolite DHA in maternal plasma, since ARTS could not be consistently detected in plasma at the three doses tested. ARTS and DHA were not detected in amniotic fluid at gestational day 15, indicating limited placental transfer of the two agents. The embryo-fetal no-observable-adverse-effect level (NOAEL) of the test item was considered to be 8 mg/kg/day for dams, and 2 mg/kg/day for embryo-fetal development.

• 한국동물위생학회지
• /
• 제36권4호
• /
• pp.291-296
• /
• 2013

The purpose of this study was to determine food safety practices and procedures based on Hazard Analysis Critical Control Point (HACCP) system and to suggest more effective method of HACCP implementation in meat packaging industry in Korea. We used the non-compliance rate of each evaluation item to compare the weak points of prerequisite requirements and HACCP. The prerequisite items related to facility, equipment, and tools showed inadequate level of requirements or unsanitary conditions for proper HACCP operation. A lack of understanding of sanitation standard operation procedures was identified as a fundamental barrier to HACCP implementation. High rate of non-compliance in HACCP items compared to prerequisite requirements signify that small businesses have potential difficulties of applying HACCP due to lack of technical expertise, financial resources for prerequisite requirements, and available personnel to prepare and operate HACCP plan. Also we suggest to revise and minimize current critical control points (CCPs). Time-temperature control of cold-storage rooms for carcasses and final products could be performed by control points of prerequisite requirements. As the occurrence frequency getting lower, metal detector should be replaced by intensified training of sanitary handling and safety procedure. This will be more effective and preventive measures against physical contaminants including metal particles. In conclusion, control point of prerequisite requirement may replace CCP in the plant with simple processing line and no heating process such as meat packaging industry.

• 한국물환경학회지
• /
• 제30권5호
• /
• pp.524-531
• /
• 2014

Korea has been trying to manage water quality of rivers and lakes in many ways. Ministry of Environment is making continuous efforts of operation control improvement such as strengthening effluent standards in sewage treatment plants and expanding Tele-Monitoring System (TMS). However, evaluation method for operations of sewage treatment plants and establishment system of effluent standards are inadequate. The objective of this study is to evaluate for operations of sewage treatment plants using statistics technique such as frequency analysis, percentile, normal distribution analysis. We used the effluent data (BOD, COD, SS) collected at 299 plants in 2012. The values were very low by comparison with standards. The Data followed a normal distribution. We think that distribution characteristics are closely related with effluent standards, especially T-P and BOD. Statistics technique attempted in this study can be used to evaluate for operations of sewage treatment plants and assess the appropriateness of effluent standards based on TBEL(Technology-based effluent limitation). And, this technique can be used to figure out the overall level of plants, the status of each plant and the favorable treatment process for each item (BOD, COD etc.). Data acquired through this method can be used to improve facilities and operation techniques and decide on a sewerage policy.

• 한국의류학회지
• /
• 제14권2호
• /
• pp.117-128
• /
• 1990

The purpose of this study is to find fitness of brassiere by means of body measuring value, its variation volume, the evaluation of perceptive image, and the evaluation of the sense of wearing. The results were as follows; 1) According to comparison for body measuring value before and after wearing brassiere, bust point (B.P.) height, lower bust height, upper chest circumference, chest circumference, and bust depth are increased, and lower chest circumference, bust point breadth, shoulder middle point - B.P., B.P. -under bust, and cup horizontal girth are decreased. 2) The difference of variation volume by material is not accepted. The part above $20\%$ at variation rate is under the region of the armpit, that is, the region connected arm from the back. 3) The subjects replied that they wore the brassiere in order to compensate the breast and needed to wear it regardless of thiness and obesity. They wore the brassiere in order to dress themselves in good shape, and felt that it put pressure upon the body, while it had nothing to do with adjusting bodily temperature and gave the sense of security. 4) The estimate of the sense of wearing by material is recognized as the difference of the attention at attentive level $1\%$. The multiple factor analysis of each item in the sense of wearing showed that the items which are explained over $90\%$ by common factors are '1. Unpreasant in touch', '2. The part of edge is haggard', '15. Not to be fit'.

• 한국치위생학회지
• /
• 제12권4호
• /
• pp.741-749
• /
• 2012

Objectives : High school students to measure fear of dental treatment, dental health care workers according to the level of reliability of this study is to determine the extent of terror was carried out. Methods : Located in Gwangju, 165 high school students were surveyed. SPSS windows ver. 11.0 by demographic characteristics and oral health characteristics of the frequency and percentage, and dental health care workers about the reliability of the Chi-square test, the general characteristics and oral health characteristics by dental fear of the t-test and one way ANOVA and were factors associated with dental fear of the stepwise multiple regression analysis was performed. General characteristics, except Cronbach-${\alpha}$ coefficient was 0.911. Results : According the general fear of Dental Treatment Fear Factor item 4, you'll feel the highest fear when you feel the muscle tension and the needle pricks your skin. The reliability of dental health care workers if the dentist lower the higher the grade, subjective oral health status is considered more reliable health was higher, the stronger the reliability of pain was significantly lower (p<0.05). Other care coordination include the reliability of sources of interest in subjective oral health history, no past experience in treating pain and increase the number of reliability was low (p<0.05), past experience and increase the number of pain during treatment the stronger the fear of more pain showed an increase (p<0.05). Conclusion : According the related factors about the fear of dental treatment, stimulus-response and fear of dental office have increased, the fear of dental treatment increase.

• 보건행정학회지
• /
• 제26권4호
• /
• pp.333-342
• /
• 2016

Background: The use of therapeutic materials based on new health technology has increased in recent years in the field of medicine, raising concerns for medical practitioners regarding increased spending on the new therapeutic materials amid the rapid population ageing and increase of chronic diseases in Korea. While therapeutic materials have significant importance in the health care system, they have not been given appropriate attention in the academic world of Korea. The purpose of this study is to identify factors that affect the growth of expenditure on therapeutic materials and to derive implications for an effective management considering the diversity of therapeutic materials. Methods: Using the claims data of the National Health Insurance Services, specific utilization patterns of groups of therapeutic materials in the middle classification level of Health Insurance Review and Assessment Service from 2007 to 2014 were analyzed. Four categories (J5083: drug eluting coronary stent, D0302: nonmetallic anchor, K6014: gauze, K6023: gauze) that exhibit unique patterns with respect to price and volume were selected. Then, decomposition analysis was performed to identify the largest contributor to the spending growth by dividing the products into existing, new, and abandoned products for the period between 2010 and 2013. Results: The effect of new products had larger impact on spending growth than the effect of core items in drug eluting coronary stent (J5083) and nonmetallic anchor (D0302). In addition, existing products in general included items priced relatively lower when compared with another item manufactured by the same company. In the gauze category, however, existing products had the largest impact on expenditure and the effect of volume was greater than that in other categories. Conclusion: This study provides evidence that appropriate management measures classified by the characteristics of therapeutic materials are required for therapeutic materials pricing and reassessment in Korea.

• 대한수학교육학회지:학교수학
• /
• 제18권1호
• /
• pp.15-42
• /
• 2016

남녀의 학업 특성에서 나타나는 차이를 밝히는 것은 그 차이를 해소하기 위한 첫 걸음이다. 이것은 한 번의 검사로는 파악하기 어려우며, 소수의 피험자로는 일반성을 잃을 수 있다. 그래서 많은 피험자를 대상으로 여러 해에 걸쳐서 피험자가 배운 내용을 포괄적으로 평가하여야 객관적이고 타당한 결과를 얻을 수 있다. 이에 본 연구는 초 중 고등학생을 대상으로 2010~2014년에 전수평가로 치러진 국가수준 학업성취도 평가를 다루었다. 그로부터 성취도 점수와 평균 정답률 등을 검사 전체, 문항 유형, 내용 영역 측면에서 정리하면서 성취수준별로 남녀학생의 학업 특성에서 나타나는 차이를 도출하였다. 이를 바탕으로 남녀 차이를 해소할 수 있는 방안을 탐색하고 더 나은 방안을 찾기 위한 제언을 하였다.

• 디지털융복합연구
• /
• 제14권2호
• /
• pp.41-48
• /
• 2016

본 연구는 글로벌 창조적 인재양성을 위해 확대되고 있는 스마트 교육에 대해 국방 분야 성공적인 적용을 위해 사용자 만족도에 미치는 영향요인을 식별하고, 실증적인 연구를 통해 이에 대한 정책적 시사점을 제시하는데 목적이 있다. 연구모형은 스마트교육의 사용자 만족도에 미치는 영향요인을 설정하여 설계하였다. 측정항목의 신뢰성을 검증하기 위해 Cronbach's ${\alpha}$계수를 산출하였고, 요인분석을 실시하여 타당성을 검증하였다. 연구의 실증분석 결과로 스마트 교육의 사용자 만족도에 미치는 영향요인을 시스템, 콘텐츠, 관리, 내부조직, 사용 등 5개 영역으로 특성을 분류하여 세부적인 요인을 독립변수로 설정하여 회귀 분석을 실시한 결과 대부분의 영향요인이 효과적 교육과 사용자 만족도에 미치는 영향요인으로 연관성이 있음을 검증하였다.

• 대한가정학회지
• /
• 제19권4호
• /
• pp.73-84
• /
• 1981

The purpose of this study was to examine the conjugal role structure in the purchasing decision process : problem precognition, information seeking and evaluating, final decision, and actually making the purchase, through a survey of the degree of conjugal involvement. The specific objectives were 1) to examine the conjugal role structure and differences at each phase of the decision process in purchasing of residence and twelve durable household consumer goods, 2) to determine the differences between conjugal role structure in each phase of the purchasing decision process and conjugal demographic factors(number of years married, conjugal education level, conjugal occupation, and income). Questionnaires were given to randomly selected husbands and wives in /seoul I October, 1980. data from the 275 responses were analyzed by percentage, mean, and F-test(analysis of variance). The results are as follows : 1) The conjugal role structure for the purchasing decision process of residence and twelve durable household consumer goods was analyzed by percent. It was found that role structure was specialized by the type of item. for instance, furniture and home appliances were purchased by wives; amusement goods and cars were purchased by husbands' and residence was purchased by joint. However, conjugal role structure in the purchasing decision process differed by phased of process : (1) Wives involvement in the phase of problem recognition was greater than their involvement in information seeking and evaluating, but husbands' involvement a in the phase of information seeking and evaluating was slightly greater than their involvement in problem recognition. (2) Husbands' involvement in the phase of making the final decision was far greater than their involvement I information seeking and evaluating. (3) Wives' involvement in the actually making of the purchase was far greater than their involvement in making the final decision. 2) Only one among conjugal demographic factors was significantly related to conjugal role structure. That, is, conjugal role structure in the purchasing decision process showed that the wives' involvement I making the final decision and in actually making the purchase increased with number of years married.

• 대한정형도수물리치료학회지
• /
• 제9권2호
• /
• pp.47-58
• /
• 2003

To closely examine the effects of the massage treatment as one method of curing hypertension by exploring the effects that one-time circulation-centered massage has on a hypertensive's blood pressure, this study selected as the subject ten among fifty-year-old essential hypertensives visiting N clinic, and measured and compared their blood pressures before and after I gave them massage. After stabilizing them, I measured their blood pressures. In their prone and supine postures, I gave them rubbing massage for twenty minutes from positions proximal to their hearts to ones distal from their hearts to help their artery circulation and circulation-centered stroking massage for ten minutes from positions distal from their hearts to ones proximal to their hearts to help their vein circulation. After the massage, I had them rest for five minutes and measured their blood pressures. Regarding each item analyzed, I calculated the mean and standard deviation before and after the massage. The difference before and after the massage was tested by corresponding t-test and the level of significance was made p<0.05. The findings are as follows. First, systolic pressure was $157.70{\pm}7.48$ before the massage and $143.00{\pm}9.39$, which is less than before the massage, after the massage, showing statistically significant difference (p<.05). Secondly, diastolic pressure was $97.80{\pm}6.56$before the massage and $95.20{\pm}5.18$, which is less than before the massage, after the massage, not showing statistically significant difference (p<.05).