• International Journal of Naval Architecture and Ocean Engineering
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• v.11 no.1
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• pp.256-273
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• 2019

Nowadays interceptors have been widely used in a vast range of high-speed crafts. In this study, the results of interceptor adeptness experiments made in Istanbul Technical University's Towing Tank are unveiled. The model was tested through three transverse locations of interceptors with six different deployment depths. For three locations, the interceptor was positioned transverse on the aft; close to chine, in the middle and close to the keel. The fourth interceptor was a full length of 13.00% LWL. The results show a significant drag reduction in benefits of 1.50%-11.30% for Fn 0.58-1.19 and the trim reduction was observed in between 1.60 and $4.70^{\circ}$. Besides, one of the most significant conclusions indicates that the effect of the interceptor decreases from keel to chine for the same blade deployment heights so the blades should be controlled separately at least in three parts from keel to chine area, if operable.

• Wind and Structures
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• v.32 no.5
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• pp.501-508
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• 2021

The turbine industry demands a reliable design with affordable cost. As technological advances begin to support turbines of huge sizes, and the increasing importance of wind turbines from day to day make design safety conditions more important. Wind turbines are exposed to environmental conditions that can affect their installation, durability, and operation. International Electrotechnical Commission (IEC) 61400-1 design load cases consist of analyses involving wind turbine operating conditions. This design load cases (DLC) is important for determining fatigue loads (i.e., forces and moments) that occur as a result of expected conditions throughout the life of the machine. With the help of FAST (Fatigue, Aerodynamics, Structures, and Turbulence), an open source software, the NREL 5MW land base wind turbine model was used. IEC 61400-1 wind turbine design standard procedures assessed turbine behavior and fatigue damage to the tower base of dynamic loads in different design conditions. Real characteristic wind speed distribution and multi-directional effect specific to the site were taken into consideration. The effect of these conditions on the economic service life of the turbine has been studied.

• Geomechanics and Engineering
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• v.37 no.3
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• pp.263-277
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• 2024

Artificial Neural Networks (ANNs) are artificial learning algorithms that provide successful results in solving many machine learning problems such as classification, prediction, object detection, object segmentation, image and video classification. There is an increasing number of studies that use ANNs as a prediction tool in soil classification. The aim of this research was to understand the role of hyperparameter optimization in enhancing the accuracy of ANNs for soil type classification. The research results has shown that the hyperparameter optimization and hyperparamter optimized ANNs can be utilized as an efficient mechanism for increasing the estimation accuracy for this problem. It is observed that the developed hyperparameter tool (HyperNetExplorer) that is utilizing the Covariance Matrix Adaptation Evolution Strategy (CMAES), Genetic Algorithm (GA) and Jaya Algorithm (JA) optimization techniques can be successfully used for the discovery of hyperparameter optimized ANNs, which can accomplish soil classification with 100% accuracy.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.12
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• pp.5043-5047
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• 2014

Nowadays increasing effectiveness in cancer therapy and investigation of formation of new strategies that enhance antiproliferative activity against target organs has become a subject of interest. Although the molecular mechanisms of apoptosis can not be fully explained, it is known that cell suicide program existing in their memory genetically is activated by pathophysiological conditions and events such as oxidative stress. Low pressure (hypobaric) conditions that create hypoxia promote apoptosis by inhibiting cell cycling. In this study, determination of the effects of fractional hypobaric applications at different times on HeLa cells at cellular and molecular levels were targeted. Experiments were carried out under hypobaric conditions (35.2 kPa) in a specially designed hypobaric cabin including 2% $O_2$ and 98% N. Application of fractional hypobaric conditions was repeated two times for 3 hours with an interval of 24 hours. At the end of the implementation period cells were allowed to incubate for 24 hours for activation of repair mechanisms. Cell kinetic parameters such as growth rate (MTT) and apoptotic index were used in determination of the effect of hypobaric conditions on HeLa cells. Also in our study expression levels of the Bcl-2 gene family that have regulatory roles in apoptosis were determined by the RT-PCR technique to evaluate molecular mechanisms. The results showed that antiproliferative effect of hypobaric conditions on HeLa cells started three hours from the time of application and increased depending on the period of exposure. While there was a significant decrease in growth rate values, there was a significant increase in apoptotic index values (p<0.01). Also molecular studies showed that hypobaric conditions caused a significant increase in expression level of proapoptotic gene Bax and significant decrease in antiapoptotic Bfl-1. Consequently fractional application of hypobaric conditions on HeLa cell cultures increased both antiproliferative and apoptotic effects and these effects were triggered by the Bax gene.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.24
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• pp.10697-10703
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• 2015

The laryngeal squamous cell carcinoma (LSCC) is one of the most common malignant tumors occurring in the head and neck. Tumor necrosis factor related apoptosis induce ligand (TRAIL) and TRAIL-receptors (DR4, DR5, DcR1, DcR2) are known as important members of TRAIL-mediated biochemical signaling pathway. Associations between polymorphisms in these genes and clinicopathological characteristics of human laryngeal carcinoma are not well defined. This study therefore aimed to investigate a possible relationship among the TRAIL and TRAIL-DR4 polymorphisms and sTRAIL levels in the risk or progression of LSCC. A total of 99 patients with laryngeal cancer and 120 healthy subjects were enrolled in the study. DR4 C626G and TRAIL 1595 C/T genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) analysis and sTRAIL levels were measured by ELISA. There were significant differences in the distribution of DR4 C626G genotypes and frequencies of the alleles between laryngeal cancer patients and controls (p<0.001) but not in TRAIL 1595 C/T. We found the increased frequency of the DR4 C626G homozygote CC genotype in patients than in controls (p<0.001). Haplotype analysis revealed that there was also a statistically significant relationship between TRAIL and TRAIL-DR4 polymorphisms and laryngeal cancer. Serum sTRAIL levels in the laryngeal patients with CC genotype who had advanced tumour stage were lower than those of patients with early tumor stage (p=0.014). Our findings suggest that DR4 C626G genotypes and sTRAIL levels might be associated with progression of laryngeal cancer in the Turkish population.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.6
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• pp.2427-2431
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• 2014

Triple-negative breast cancers (TNBC), characterized by absence of the estrogen receptor (ER) and progesterone receptor (PR) and lack of overexpression of human epidermal growth factor receptor 2 (HER2), have a poor prognosis. To overcome therapy limitations of TNBC, various new approaches are needed. This mini-review focuses on discovery of new targets and drugs which might offer new hope for TNBC patients.

• Bulletin of the Korean Mathematical Society
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• v.45 no.4
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• pp.615-620
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• 2008

For analytic functions f(z) in the open unit disc $\mathbb{D}$, an operator $N_{\alpha}(f(z))$ relating with starlike functions is introduced. The object of the present paper is to discuss some properties of the operator $N_{\alpha}(f(z))$.

• Advances in aircraft and spacecraft science
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• v.2 no.2
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• pp.199-215
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• 2015

This study focuses on the limit cycle oscillations (LCOs) of cantilever swept-back wings containing a cubic nonlinearity in an incompressible flow. The governing aeroelastic equations of two degrees-of-freedom swept wings are derived through applying the strip theory and unsteady aerodynamics. In order to apply strip theory, mode shapes of the cantilever beam are used. The harmonic balance method is used to calculate the frequencies of LCOs. Linear flutter analysis is conducted for several values of sweep angles to obtain the flutter boundaries.

• Honam Mathematical Journal
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• v.41 no.4
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• pp.707-724
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• 2019

We investigate the new Clairaut conditions for anti-invariant submersions whose total manifolds are cosymplectic. In particular, we prove the fibers of a proper Clairaut Lagrangian submersion admitting horizontal Reeb vector field are one dimensional and classify such submersions. We also check the existence of the proper Clairaut anti-invariant submersions in the case of the Reeb vector field is vertical. Moreover, illustrative examples for both trivial and proper Clairaut anti-invariant submersions are given.

• Structural Engineering and Mechanics
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• v.15 no.6
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• pp.735-752
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• 2003

The quasi-static and dynamic responses of a linear viscoelastic circular beam on Winkler foundation are studied numerically by using the mixed finite element method in transformed Laplace-Carson space. This element VCR12 has 12 independent variables. The solution is obtained in transformed space and Schapery, Dubner, Durbin and Maximum Degree of Precision (MDOP) transform techniques are employed for numerical inversion. The performance of the method is presented by several quasi-static and dynamic example problems.