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Participation of COX-1 and COX-2 in the contractile effect of phenylephrine in prepubescent and old rats

  • Guevara-Balcazar, Gustavo;Ramirez-Sanchez, Israel;Mera-Jimenez, Elvia;Rubio-Gayosso, Ivan;Aguilar-Najera, Maria Eugenia;Castillo-Hernandez, Maria C.
    • The Korean Journal of Physiology and Pharmacology
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    • v.21 no.4
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    • pp.407-413
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    • 2017
  • Vascular reactivity can be influenced by the vascular region, animal age, and pathologies present. Prostaglandins (produced by COX-1 and COX-2) play an important role in the contractile response to phenylephrine in the abdominal aorta of young rats. Although these COXs are found in many tissues, their distribution and role in vascular reactivity are not clear. At a vascular level, they take part in the homeostasis functions involved in many physiological and pathologic processes (e.g., arterial pressure and inflammatory processes). The aim of this study was to analyze changes in the contractile response to phenylephrine of thoracic/abdominal aorta and the coronary artery during aging in rats. Three groups of rats were formed and sacrificed at three distinct ages: prepubescent, young and old adult. The results suggest that there is a higher participation of prostanoids in the contractile effect of phenylephrine in pre-pubescent rats, and a lower participation of the same in old rats. Contrarily, there seems to be a higher participation of prostanoids in the contractile response of the coronary artery of older than pre-pubescent rats. Considering that the changes in the expression of COX-2 were similar for the three age groups and the two tissues tested, and that expression of COX-1 is apparently greater in older rats, COX-1 and COX-2 may lose functionality in relation to their corresponding receptors during aging in rats.

Study on the Interanal Physical Changes of Kiwi Fruit Using Magnetic Resonance Imaging Technique (자기공명영상 기술을 이용한 저장 중 키위의 내부 변화 연구)

  • Baek, Seung Hoon;Kim, Myoung Ho;Choi, Kyu Hong;Kim, Seong Min
    • Proceedings of the Korean Society for Agricultural Machinery Conference
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    • 2017.04a
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    • pp.96-96
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    • 2017
  • 농산물 수확 이후 저장 유통 과정에서 일어나는 생리적 현상 변화에 따른 내부품질의 측정 분석연구가 활발히 진행되고 있다. 이 연구에서는 비파괴 측정 방법들 중 하나인 자기공명영상(Magnetic Resonance Imaging, MRI) 기술을 활용하여 후숙 과일인 키위의 저장 일수에 따른 형태 및 내부 구조의 변화를 조사하였다. 공시재료는 국내에서 판매되고 있는 키위들 중 3품종(뉴질랜드산 Sun Gold, 뉴질랜드산 Green, 칠레산 Jin Green)별로 균일한 크기의 과일 5개씩을 이용하였으며, 시료를 실험실내($16.6^{\circ}C$, 38% RH)에서 18~19 일간 보관하면서 3~5일 간격으로 5회 시험하였다. 전북대 농업과학기술연구소가 보유하고 있는 MRI(M10, Aspect Imaging, Israel)를 활용하여 영상 이미지를 얻었으며, 저장 기간에 따른 무게 감소는 전자저울(한성, HK-series)을 이용하였다. 자기공명영상 이미지는 Gradient-Eco 펄스열을 사용하였고, 횡단면(Axial)의 영상면(Image-direction)을 중심으로 영상영역(Field of View, FOV)은 $80mm{\times}80mm$로 1회 촬영 할 때 마다 30개의 영상들을 얻었다. 저장 기간이 길어질수록 내부 공동현상이 커지는 것으로 나타났고, 뉴질랜드산 Sun Gold 품종은 다른 두 품종보다 내부 공동이 빠르게 나타났다. 실험이 끝나는 날에는 껍질이 연화되어 타원형의 형체를 계속 유지하지 못하고 붕괴되는 이미지를 MRI를 통해서 관찰 할 수 있었다. 시간이 지남에 따라 영상들의 위치가 일정하지 않고 일부 회전을 한 것처럼 나타났다. 이는 키위 전용 홀더를 만들어 고정하지 않고 측정하다보니 생긴 오차로 생각 되었다. 키위를 건조한 공간에 오래 보관하였기 때문에 시간이 지남에 따라 수분증발과 연화된 껍질 사이로 과육이 흘러 일부를 제외한 대부분의 키위 무게가 일정하게 감소하는 것을 알 수 있었다.

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Molecular Evidence of Recombination on Korean Isolates of Tomato yellow leaf curl virus by Nucleotide Transversions and Transitions

  • Lee, Hye-Jung;Park, Jung-An;Auh, Chung-Kyoon;Lee, Kyeong-Yeoll;Kim, Chang-Seok;Lee, Gwan-Seok;Soh, Hyun-Cheol;Choi, Hong-Soo;Lee, Suk-Chan
    • The Plant Pathology Journal
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    • v.27 no.4
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    • pp.378-384
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    • 2011
  • Tomato yellow leaf curl virus (TYLCV), a member of genus Begomovirus, was isolated in Korea in 2008. We sequenced and analyzed the DNA-A of 51 TYLCV isolates from Korea, and 13 of the TYLCV isolates were selected as type representatives of TYLCV from six Korean provinces. The 13 TYLCV isolates were classified into Korea Group 1 (KG1, nine isolates) and Korea Group 2 (KG2, four isolates) based on the results of phylogenetic analysis and genome size (2774 and 2781 nucleotides, respectively). A recombination detection program 3 (RDP3) revealed two recombinations between the TYLCV Korea isolates and other TYLCV isolates [Thailand (AF206674), Iran (AJ132711), and Israel (X76319)]. TYLCV Jeju isolate was characterized by two recombination events (E1 and E2) caused by the presence of E1 in ORF V1 and C3, which may seem to be the mutations of the high nucleotide transversion and transition rate. Collectively, our results suggest that the occurrence of nucleotide transversions and transitions in TYLCV DNA-A might have induced novel recombination events within the TYLCV Korea isolates.

Time-varying modeling of the composite LN-GPD (시간에 따라 변화하는 로그-정규분포와 파레토 합성 분포의 모형 추정)

  • Park, Sojin;Baek, Changryong
    • The Korean Journal of Applied Statistics
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    • v.31 no.1
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    • pp.109-122
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    • 2018
  • The composite lognormal-generalized Pareto distribution (LN-GPD) is a mixture of right-truncated lognormal and GPD for a given threshold value. Scollnik (Scandinavian Actuarial Journal, 2007, 20-33, 2007) shows that the composite LN-GPD is adequate to describe body distribution and heavy-tailedness. This paper considers time-varying modeling of the LN-GPD based on local polynomial maximum likelihood estimation. Time-varying model provides significant detailed information of time dependent data, hence it can be applied to disciplines such as service engineering for staffing and resources management. Our work also extends to Beirlant and Goegebeur (Journal of Multivariate Analysis, 89, 97-118, 2004) in the sense of losing no data by including truncated lognormal distribution. Our proposed method is shown to perform adequately in simulation. Real data application to the service time of the Israel bank call center shows interesting findings on the staffing policy.

A study of Korean traditional Food in Kang Won Do (I) (강원 지역 농촌 주부들의 전통 식생활 관리 현황에 관한 실태 조사(I) -식생활에 대한 태도와 일반적 현황을 중심으로-)

  • 김은실
    • Korean journal of food and cookery science
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    • v.11 no.4
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    • pp.342-350
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    • 1995
  • The purpose of this study was to improve and hand down traditional dining habits. Questionnaires were distributed to rural house wives in Kangwon-do. The results were as follows; 1. 30.8% of the respondents was 40 to 49 years old. 35.2% of their education was primary school. 49.5% of them had husbands and children. 44.2% of them had 3 to 4 family members. 26.9% of them earned 8 to 11 millon won yearly. 2. Their housing environment showed that 52.5% of housing was a Korean traditional house or Hanok. 72.1% of kitchen was a stand-up one. 66% of fuel was oil. 3. 99.3% of the respondents had refrigerators. 66.3% electronic range, 95.9% electronic rice cooker, 97.2% gas range, 59.6% mixer, 62% electronic fry pan respectively. 4. 73.5% of the respondents got information about Korean traditional food from seniors or friends. 36.6% of them learned new recipe from TV, newspapers and magazines. 43.3% of them thought their concern about meals was average. 48.4% of them paid much attention to prepare meals for themselves. 52.7% of them spent a half to one hour for preparing dinner. 48.3% of them ate processed foodstaffs often. 31.5% of them dined out once every two or three months. 5. 79.5% of them had rice for breakfast, 74.5% for lunch, and 98.4% for dinner respectively. 96.2% of the respondents made Kimchi and 55% among them had two kinds of Kimchi. 91.1% of them had two to three kinds of dishes except Kimchi for breakfast. 68% of them used a synthetic flavoring. 6. 16.2% of the respondents ate beef once a week, 40% pork, 23% chicken, 3% dog meat respectively. 37% of them ate mackerel pike, 25.5% mackerel once a week, 11.6% hairtail, 25.5% mackerel pike, 25.6% yeemunshu, 13.7% tuna respectively. Freshwater fishes such as mudfish, trout and Israel carp were their favorite onces.

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Influence of supplemental canola or soybean oil on milk yield, fatty acid profile and postpartum weight changes in grazing dairy goats

  • Lerma-Reyes, Israel;Mendoza-Martinez, German D.;Rojo-Rubio, Rolado;Mejia, Mario;Garcia-Lopez, J.C.;Lee-Rangel, Hector A.
    • Asian-Australasian Journal of Animal Sciences
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    • v.31 no.2
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    • pp.225-229
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    • 2018
  • Objective: This experiment was designed to evaluate the effect of supplementation with soybean or canola oil on milk production and the composition of long chain fatty acids as well as weight changes in the goats and their kids. Methods: Thirty nine mulitparous crossed Alpine${\times}$Nubian goats (initial body weight [BW] $43.5{\pm}1.7kg$) from the day of parturition were assigned to the treatments: grazing control (n = 15); grazing plus 20 mL/goat/d of supplemental soybean oil (n = 12); and grazing plus 20 mL/goat/d of supplemental canola oil (n = 12) from November 26, 2014 to March 7, 2015. The planned contrasts were: CI (control vs supplemented with oils); CII (soybean vs canola oil) to compare the treatment effects. Results: The vegetable oil supplementation reduced weight losses in lactating goats (CI: -0.060 vs 0.090 kg/d; p = 0.03) but did not improve milk production or affect kids' growth. The content of C4, C6, C8, C10, C11, C14, and C18:1n9t in the milk was increased (p<0.05) with respect to control. However, C12, C14, C16, C18, C18:1n9c, C18:2n6c, and C18:3n3 were reduced (p<0.05) in supplemented goats. Conjugated linoleic acid (CLA) was increased (p<0.05) in goats supplemented with oils compared to the control group. Conclusion: Supplementation with 20 mL/d of soybean or canola oil did not affect milk production or kids' performance; however, it increased CLA concentration and reduced the reduced weight losses in lactating goats.

Environmental Education Program in Small Planning Community -In Cases of yamagiscism Village, Findhorn & Dongsasup Program- (공동체 학습 프로그램의 환경교육적 실현 -야마기시, 핀드혼 공동체와 동사섭 프로그램을 중심으로-)

  • 김태경
    • Hwankyungkyoyuk
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    • v.9 no.1
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    • pp.72-89
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    • 1996
  • Environmental problem and eco-crisis don't mean pollution itself any more, although general people have believed that environmental problems can be resolves by removing pollution. The mos important is environmental problems are linked with social structure which individualism, rationalism is extremely prevailed in the market oriented capitalism society, so public value is ignored especially. In the point of environmental education, this is very important because environmental education is not completed through schooling process, such s class learning, discussion. observation etc, but in the our practical life itself. This means that environmental education can be done by changing of lifestyle anywhere we live, and anytime. But any places governed our social life are polluted by efficiency pursuiting individualism in market oriented capitalism society. So environmental education can't hold the water in this system, in the aspect that we can't stimulate feelings of the student and general people, getting to public resource value and harmony with nature by throwing individual mind away. It is big problem. In this field, I have thought the unique space and social structure which can be used as environmental education place is small-planning community, such as Kibbutz in Israel, educational community Finhorn in Scotland, harmony community Yamagicism Village in Japan and DURE in Korea etc. For the research of this educational possibility in these small community, I visited and investigated immediately, and confirmed. In this thesis, I insist that the training process and practical life experience in this community themselves are good environmental education. So, in case of YAMAGICISM in Japan and FINDHORN in Scotland, DONGSASUP program in Korea, I introduce these small community environmental- education program.

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A Comparative Study on Louis L Kahn's Architectural Philosophy and Kabbalah based on Psychoanalysis (정신분석학에 의한 루이스 칸의 건축철학과 카발라와의 비교 연구)

  • Choi, Hyo-Sik
    • Journal of architectural history
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    • v.18 no.2
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    • pp.85-105
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    • 2009
  • This study set out to compare and analyze the influences Kabbalah, which was Louis I. Kahn's faith as a Jew, on his architecture based on Freud's psychoanalysis that had many exchanges with modernism and contemporary architecture and theories. The specific goals of the study were to shed light to Kahn's presence in contemporary architecture anew and establish the methodology of using psychoanalysis in building new theories of architectural planning. When the theories of psychoanalysis were introduced for comparison and analysis purposes, Kahn tried to differentiate his buildings by placing a function or symbolic central space at the heart of a building even though he did adopt a characteristic of modernism architecture, which was placing a core at the centre of plan, for a while. Such a tendency of his was based on Jung's opinions rather than Freud's and affected by Ecole des Beaux-Art. The analysis results also indicate that he conceived "Served Space & Servant Space," "architecture of connection" and "silence and light" that made up the essence of his architectural theory from the relationships between Ayin-Sof, Kabbalah's absolute god, and Sefiroth. It's also very likely that his often use of triangles and circles in his architecture was affected by the Tree of Sefiroth diagram of Kabbalah. His tendency is well reflected in Salk Institute and Philips Exeter Academy Library, where he placed a laboratory or courtyard at the center where a core was supposed to be, created a corridor or courtyard space between those central spaces and the core, and connected them one another with to perceive the being of Ayin-Sof into an architectural space, which is well proven with Mikveh Israel Synagogue where he directly applied the Tree of Sefiroth diagram. The synagogue also contained a hollow column that served as an important concept in his late architecture. The hollow column was also the result of him applying the concept of Sefiroth of the place where Ayin-Sof Was reduced in Kabbalah.

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Computing Curriculum Design in Secondary School Focused On Computer Science Curriculum (컴퓨터과학 교육을 중심으로 한 중등 컴퓨팅 교육과정 설계)

  • Shin, SangKook;Kwon, DaeYong;Kim, HyungShin;Yeum, YongCheu|;Yoo, SeungWook;Lee, WonGyu
    • The Journal of Korean Association of Computer Education
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    • v.8 no.3
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    • pp.61-76
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    • 2005
  • The seventh secondary computer education curriculum is focused on computer literacy education. This computer curriculum is an elective course not a required course and is a part of other specific course. This computer education has problems that it is not consecutive, overlapped with other classes and not systematic. This research analyzes the computer education in Israel, India, and Japan. And it suggests the new secondary school computing education curriculum based on computer educating of Computer Curricula 2001 Computer Science, lEEE Computer Society and ACM has suggested 2001 for computer science education in university, and with a standard of 'A Model Curriculum for K-12 Computer Science', the suggestion for computer-science education for all grade of school.

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Performance Prediction Model of Solid Oxide Fuel Cell Stack Using Deep Neural Network Technique (심층 신경망 기법을 이용한 고체 산화물 연료전지 스택의 성능 예측 모델)

  • LEE, JAEYOON;PINEDA, ISRAEL TORRES;GIAP, VAN-TIEN;LEE, DONGKEUN;KIM, YOUNG SANG;AHN, KOOK YOUNG;LEE, YOUNG DUK
    • Transactions of the Korean hydrogen and new energy society
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    • v.31 no.5
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    • pp.436-443
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    • 2020
  • The performance prediction model of a solid oxide fuel cell stack has been developed using deep neural network technique, one of the machine learning methods. The machine learning has been received much interest in various fields, including energy system mo- deling. Using machine learning technique can save time and cost requried in developing an energy system model being compared to the conventional method, that is a combination of a mathematical modeling and an experimental validation. Results reveal that the mean average percent error, root mean square error, and coefficient of determination (R2) range 1.7515, 0.1342, 0.8597, repectively, in maximum. To improve the predictability of the model, the pre-processing is effective and interpolative machine learning and application is more accurate than the extrapolative cases.