• The Korean Journal of Physiology
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• v.22 no.2
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• pp.207-218
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• 1988

Effects of 1, 4-dihydropyridine compounds, such as nifedipine, nisoldipine, nitrendipine, and nimodipine which were calcium antagonists on the normal and Ca-dependent, slow channel mediated action potentials in the guinea pig's papillary muscle were investigated. The glass microelectrode was impaled into a papillary muscle cell for measurements of potential changes with the simultaneous tracing of isometric contraction. The concentration of Ca antagonists were 1 mg/l (nifedipine and nisoldipine), 2 mg/l (nitrendipine and nimodipine), which showed the maximal inhibition of isometric contraction (above 90%) and simultaneous effects on the normal action potentials and only the halves of those concentrations were sufficient to observe the effects on the calcium action potentials. The data for analysis were only chosen when the microelectrode was maintained in a cell throughout the experiments. 1, 4-Dihydropyridine compounds decreased the action potential duration but did not affect the resting membrane potential, overshoot, and upstroke velocity of the normal action potentials with the decrease in the isometric contraction. And with the decrease in the area and amplitude of isometric contraction, the area, amplitude, upstroke velocity and duration of Ca action potential was decreased. But the differences in the effects of the Ca antagonists were not observed. Therefore it is inferred that the changes in normal and Ca action potential induced by the 1, 4-dihydropyridine compounds with a common chemical structure would be caused by the slow inward Ca-current, not by a fast Na-current.

• The Journal of Korean Academy of Prosthodontics
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• v.27 no.2
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• pp.37-52
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• 1989

The purpose of this study was to investigate the relationship between sternocleidomastoid (SCM) and masseter muscles during occlusal functions by means of EMG recordings of examined muscles. For the study, eighteen normal subjects were selected and the Bio-electric Processor EM2 (Myo-tronics Research, Inc., U.S.A.) with the surface electrodes was used to record the EMG activity from the right and left middle of masseter and insertion of SCM of each subject during right and left gum-chewing and isometric contraction by changing the biting force at right eccentric position of jaw. The amount of biting force ranged from 5 to 70kg during isometric contraction were measured by use of Jaw Force Meter. (Nihon Koden Kogyo, Japan.) The results were as follows: 1. The activity onset of SCM and masseter on the same side was almost at the same time, and integrated EMG values of two muscles on the chewing side were higher than the same named muscles on the non-chewing side during gum-chewing. (p<0.01) 2. The regression correlation was not present between both masseters (p>0.05), but between both SCM muscles or muscles of two kinds on the chewing or non-chewing side. ($p{\leqq}0.05$) 3. The integrated EMG value of SCM on chewing or non-chewing side were about 10 percent of that of ipsilateral masseter. 4. Mean voltage of each examined muscles were almost proportional to biting force during isometric contraction and the slope of voltage/biting force line was steepest at the ipsilateral masseter, followed by contalateral masseter, ipsi- and contra-lateral SCM muscles. 5. Mean voltage of ipsilateral masseter was highest during isometric contraction, followed by ipsilateral masseter, contra- and ipsi-lateral SCM muscles.

• Korean Journal of Applied Biomechanics
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• v.21 no.1
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• pp.115-121
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• 2011

This study was to investigate the change of muscle fatigue through maximum contraction during flexion and extension of knee joint before and after the isometric trunk exercise was implemented on elderly Hansen's disease. 18 subjects exercised for 60 minutes twice a week for 12 weeks. The subjects were divided into normal sensory group, group with sensory loss in left sole, group with sensory loss in right sole, and group with sensory loss in both soles, according to the sensory condition on their soles. We obtained following results. Muscle fatigue in normal sensory group, there were significant differences in left right hamstring, left rectus femoris(p<.05), in group with sensory loss in left sole, there were significant differences in left right hamstring(p<.05), in group with sensory loss in right sole, there were significant differences in left right hamstring, right rectus femoris and group with sensory loss in both sole, there were significant differences in right hamstring(p<.05). The differences of muscle fatigue according to the sensory condition on their soles, there were significant differences in left hamstring between normal sensory group and group with sensory loss in both sole(p<.05).

• Journal of the Korean Academy of Clinical Electrophysiology
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• v.2 no.3
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• pp.25-35
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• 2004

The purpose of this study was compared to MTICs(maximal tolerated isometric contraction), decrement and recovery. For this, using isokinetic exercise analysis device(Biodex Medical Systems Inc., Biodex System 3PRO, USA), low rate(20 Hz) and high rate(100 Hz) NMES(neuromuscular electrical stimulation) were applied to the quadriceps muscles of fifteen patients with spastic hemiplegia caused by lesions in the central nervous system. The results were as follows: 1. It was shown to fast decrement in the middle of phase at low rate NMES and to slow decrement of MTIC response at high rate NMES(p<.01). 2. It was shown to fast recovery at high rate NMES and to slow recovery at low rate NMES in recovery tendency of MTIC(p<.01). These conclusions suggest that NMES of high rate caused to slow fatigue and fast recovery different from low rate NMES.

• The Journal of Korean Physical Therapy
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• v.19 no.3
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• pp.11-17
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• 2007

Purpose: The purpose of this study were to analyze fatigue patterns of the rectus femoris muscle by isometric contraction. Methods: Twenty healthy subjects(10 male, 10 female) participated in this study. Maximal voluntary isometric contraction(MVIC) was measured by the dynamometer. Muscle activity was recorded from the rectus femoris muscle. During the experiment, the subject was seated in the chair. The measured items, median frequency(MDF) and root mean square (RMS), were collected from the surface EMG. All data were analyzed using repeated measures ANOVA. Results: There was significant difference of MVIC between male and female. Endurance time was significant difference by the level of MVIC but no significant in the main effect(sex) and interaction effect. The MDF and fatigue index were significant differences in the interaction effect. The RMS was not significant difference in both of main and interaction effect. The muscle fatigue patterns of female was greater than male after 60% MVIC. Conclusion: This study showed that sex differences of muscle fatigue were started from 60% MVIC.

• The Journal of Korean Physical Therapy
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• v.20 no.3
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• pp.53-59
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• 2008

Purpose: The non-receptor-type protein tyrosine kinase Syk (636 amino acids, 72 kDa) is ubiquitously expressed in hematopoietic stem cells and has been widely studied as a regulator and effector of B cell receptor signaling that occurs in processes such as differentiation, proliferation and apoptosis. However, the mechanism relating Syk and p38 mitogen-activated protein kinases (p38MAPK) by endothelin-1 (ET-1, 21 amino acids) stimulation in muscle cells, especially in the volume-dependent hypertensive state, remains unclear. Methods: In this study, we investigated the relationship between Syk and p38MAPK for isometric contraction and enzymatic activity by ET-1 from rat aortic smooth muscle cells and aldosterone-analogue deoxycorticosterone acetate (DOCA) hypertensive state rats (ADHR). Results: The systolic blood pressure was significantly increased in ADHR than in a control group of animals. ET-1 induced isometric contraction and phosphorylation of p38MAPK, which was increased in muscle strips from ADHR. Increased vasoconstriction and phosphorylation of p38MAPK induced by treatment with 30 nM ET-1 were inhibited by the use of 10${\mu}M$ SB203580, an inhibitor of p38MAPK from ADHR. Furthermore, ET-1 induced isometric contraction and phosphorylation of Syk and p38MAPK, which were increased in the aortic smooth muscle cells. Increased tension and phosphorylation of Syk and p38MAPK induced by ET-1 were inhibited by SB203580 from rat aortic smooth muscle cells. Conclusion: These results, suggest that the Syk activity affects ET-1-induced contraction through p38MAPK in smooth muscle cells and that the same pathway directly or indirectly is associated with volume dependent hypertension. The findings suggest the need to develop cardiovascular disease-specialized physical therapy.

• Proceedings of the KIEE Conference
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• 2002.07d
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• pp.2696-2698
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• 2002

In this study, the comparison of the contractile states change at prime mover muscle with that at synergist muscle was executed, while the muscle contracted continuously with isometric contraction. The contractile states of muscle becomes to change when the voluntary contraction of skeletal muscle is progressed continuously. Such the contractile states change is divided into three states in consideration for not only physiological change but also the psychological change by CNS(central nervous system) as "stable state", "fatigue state" and "pain state". As a result of this study, the prime mover muscle is reached "pain state" but the synergist muscle is not reached. Namely the synergist muscle is delayed state than the prime mover muscle. This result judged that although the prime mover muscle have reached a limit when contraction is continued, owing to effect of delayed state of the synergist muscle, the prime mover muscle is endured some more contraction.

• Physical Therapy Korea
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• v.23 no.1
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• pp.20-30
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• 2016

Background: Total knee arthroplasty (TKA) recovers the alignment of the knee joint, but fails to automatically restore the alignment and function of the hip and ankle joints. It may affect the alignment and stability of the knee joint, therefore therapeutic intervention in hip and ankle joint is necessary for the rehabilitation process after TKA. Objects: The aim of this study was to comparison of the effects of the two exercise methods on the coronal plane alignment after TKA. This study conducted an experiment by dividing subjects into a lower extremity isometric co-contraction group (LEIC) and a quadriceps isolated isometric contraction (QIIC) group. Methods: A total of 37 subjects were randomly assigned to the LEIC ($n_1$=19) or the QIIC ($n_2$=18). Exercise was applied to five times per week for three weeks, starting on the eighth day after surgery. Range of motion exercises were performed as a common intervention and then each group performed quadriceps isometric contraction exercises with 10 sets of 5 repetitions. Radiological imaging was performed prior to surgery, one month and six months after surgery. In addition, the hip-knee-ankle angle (HKA) and tibiotalar angle (TTA) were measured. Results: The HKA was close to neutral in the LEIC rather than the QIIC (p<.05). The LEIC showed varus and the QIIC exhibited valgus TTA (p<.05). In a comparison of HKA and TTA over time, there was no significant change in either group (p>.05). According to the comparison of the TTA before surgery, the LEIC showed significant changes in the varus direction (p<.05), while there was no significant change in the QIIC (p>.05). Conclusion: The LEIC method triggered changes in the TTA and brought the HKA close to the neutral. Thus, LEIC is more effective than QIIC in creating stability in the coronal plane alignment of the knee and ankle joints after TKA.

• Journal of Oral Medicine and Pain
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• v.17 no.1
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• pp.41-50
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• 1992

The authors performed a experimental study to evaluate the effects of masticatory muscle fatigue on tooth contact and masticatory muscle activity in 26 normal healthy women. The experimental masticatory muscle fatigue was induced by unilateral biting of 5kg force on mandibular first molar. The results were as follows : 1. The initial symptom related to muscle fatigue pain appeared in 85.19 seconds of isometric contraction and the endurance time of isometric contraction was 203.15 seconds. 2. The pain occurred more frequently in masseter region than in temporal region. In masseter pain the incidence was almost equal between both sides, whereas the temporal pain was more in contralateral side. 3. The spontaneity and the symmetry of tooth contact during maximum clenching were reduced after isometric unilateral biting. 4. After induction of experimental muscle fatigue, the EMG activities of masseter muscles of both sides and ipsilateral temporal muscle showed the tendency of decreasing activities. 5. The asymmetry indicies of masseter and temporal muscles were reduced after isometric bilateral biting.

• The Journal of Korean Physical Therapy
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• v.26 no.1
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• pp.9-14
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• 2014

Purpose: The purpose of this study was to investigate how different knee alignments (genu varum and genu valgum) affected activations of quadriceps muscles with measurements of onset-time differences between vastus medialis and vastus lateralis during isometric contractions at both 30 and 60 degree knee flexion. Methods: Fifty-two adults (20 genu varum, 12 genu valgum, and 20 control) were enrolled in this study. Subjects with over 4cm distance between knee medial epicondyles were assigned to Genu varum, while subjects with over 4cm distance between ankles medial malleolus were considered as genu valgum group. Surface EMG was used to measure onset time of both vastus medialis and vastus lateralis during isometric contraction at 30 and 60 degree knee flexion. Results: The onset time of vastus lateralis was delayed in genu varum group, and that of vastus medialis was delayed in genu valgum group at both 30 and 60 degree knee flexions. Moreover, onset time difference at $30^{\circ}$ knee flexion between muscles was larger in genu valgum group than genu varum group. Conclusion: Subjects with genu varum or valgum activated quadriceps muscles with different orders pending on flexion degrees. Therefore, when quadriceps training program were planned to prevent pain or deformities, the findings that quadriceps were activated with different orders affected by knee alignments and joint degree at which trainings were performed, must be considered. If the selective training programs of quadriceps femoris are planned to prevent pain or deformities due to poor knee alignments, these should consider the subject's knee alignment condition.