• Title/Summary/Keyword: Irradiation Effect

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Development of Detailed Korean Adult Eye Model for Lens Dose Calculation

  • Han, Haegin;Zhang, Xujia;Yeom, Yeon Soo;Choi, Chansoo;Nguyen, Thang Tat;Shin, Bangho;Ha, Sangseok;Moon, Sungho;Kim, Chan Hyeong
    • Journal of Radiation Protection and Research
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    • v.45 no.1
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    • pp.45-52
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    • 2020
  • Background: Recently, the International Commission on Radiological Protection (ICRP) lowered the dose limit for the eye lens from 150 mSv to 20 mSv, highlighting the importance of accurate lens dose estimation. The ICRP reference computational phantoms used for lens dose calculation are mostly based on the data of Caucasian population, and thus might be inappropriate for Korean population. Materials and Methods: In the present study, a detailed Korean eye model was constructed by determining nine ocular dimensions using the data of Korean subjects. The developed eye model was then incorporated into the adult male and female mesh-type reference Korean phantoms (MRKPs), which were then used to calculate lens doses for photons and electrons in idealized irradiation geometries. The calculated lens doses were finally compared with those calculated with the ICRP mesh-type reference computational phantoms (MRCPs) to observe the effect of ethnic difference on lens dose. Results and Discussion: The lens doses calculated with the MRKPs and the MRCPs were not much different for photons for the entire energy range considered in the present study. For electrons, the differences were generally small, but exceptionally large differences were found at a specific energy range (0.5-1 MeV), the maximum differences being about 10 times at 0.6 MeV in the anteroposterior geometry; the differences are mainly due to the difference in the depth of the lens between the MRCPs and the MRKPs. Conclusion: The MRCPs are generally considered acceptable for lens dose calculations for Korean population, except for the electrons at the energy range of 0.5-1 MeV for which it is suggested to use the MRKPs incorporating the Korean eye model developed in the present study.

Protective Effects of a Herb, Artemisia capillaris, Against Radiation-induced DNA Damage (방사선 유도 DNA 손상에 대한 인진쑥의 방어효과)

  • Jo, Sung-Kee;Oh, Heon;Cheon, Eui-Hyun;Jeong, U-Hee;Cho, Nam-Jeong
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.33 no.1
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    • pp.22-27
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    • 2004
  • In the present study, the protective effects of Artemisia capillaris (AC) on the DNA damage induced by $^{60}$ Co ${\gamma}$-rays were evaluated using alkaline single-cell gel electrophoresis (SCGE, comet assay) in the mouse peripheral lymphocytes and micronuclei (MN) formation test in the Chinese hamster ovary (CHO) cells. We also investigated the effect of AC on 8-hydroxy-2'-deoxyguanosine (8-OHdG) formation in the mouse liver and thymus exposed to ${\gamma}$-ray, The tail moment and the frequency of MN, which were markers of DNA damage in the SCGE and MN formation test, were decreased in the groups treated with AC extract before exposure to 200 cGy of ${\gamma}$-ray. We also observed its activities, lowering 8-OHdG level, an index of oxidative DNA damage, in the groups treated with AC extract before whole body ${\gamma}$-irradiation (800 cGy). It is plausible that scavenging of free radicals by AC may have played an important role in providing the protection against the radiation-induced damage to the DNA. These results indicated that AC protects the DNA damage induced by ${\gamma}$-rays and might be a useful radioprotector, especially since it is a relatively nontoxic product.

Effects of hydrogen plasma on the formation of self-organized InAs-quantum dot structure (자기조직화에 의한 InAs 양자점 구조 형성에 미치는 수소플라즈마의 효과)

  • ;;;K. Ozasa;Y. Aoyagi
    • Journal of the Korean Crystal Growth and Crystal Technology
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    • v.6 no.3
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    • pp.351-359
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    • 1996
  • We have investigated the effect of hydrogen plasma on the formation of InAs QDs (quantum dots) structure by using a CBE (chemical beam epitaxy)system equipped with ECR (electron cyclotron resonance) plasma source. It is confirmed that the formation of self-organized InAs-QDs on GaAs is started after the growth of InAs layer up to 2.6 ML (monolayer) with the irradiation of hydrogen plasma while it is started after 1.9 ML without hydrogen gas and hydrogen plasma through the observation of RHEED patterns. Density and size of the QDs formed at $T_{sub}=370^{\circ}C$ are $1.9{\times}10^{11}cm^{-2}$ and 17.7 nm without hydrogen plasma, and $1.3{\times}10^{11}cm^{-2}$ and 19.4 nm with hydrogen plasma, respectively. It is also observed from the PL(photoluminescence) measurement on InAs-QDs that red shift in PL peak energy and broadening in FWHM (full width at half maximum)of PL peak caused by the effects of hydrogen plasma on the increment of size and its distribution. These effects of hydrogen plasma are considered as a act of atomic hydrogen which enhances the layer-growth of InAs on GaAs resulted from the relief of misfit strain between GaAs substrate and InAs.

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Quality Characteristics of Chocolate with Added Hot Water Extracts of Undaria pinnatifida Sporophylls under Gamma Irradiation (감마선 조사 미역귀(Undaria pinnatifida Sporophyll) 열수추출물을 첨가한 초콜릿의 품질 및 항산화 활성)

  • Kim, Da-Mi;Kim, Kyoung-Hee;Yook, Hong-Sun
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.41 no.1
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    • pp.103-109
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    • 2012
  • The objectives of this study were to find the optimal mixing conditions and evaluate the antioxidant activity of chocolate with both non-irradiated and gamma-irradiated (50 kGy) hot water extracts from Undaria pinnatifida sporophylls (WEUS) at weight percentages of 0, 1, 3, and 5%. The moisture content of the WEUS chocolate was significantly higher than that of the control. On the other hand, the pH of chocolate had a tendency to decrease with the addition of WEUS, but there were no significant differences between non-irradiated and gamma-irradiated samples of the same concentrations. The lightness (L) value and yellowness (b) value decreased significantly with the addition of WEUS powder. However, the redness (a) value increased as the concentration increased. The hardness increased on the addition of WEUS powder, and gamma-irradiated chocolates were higher than non-irradiated chocolates. As the amount of WEUS powder increased, DPPH radical scavenging activity and total polyphenol content increased. The DPPH radical scavenging activity of gamma-irradiated groups was also higher than that of non-irradiated groups. The aroma, taste, sweetness, and overall acceptability of chocolate were significantly higher in the chocolate containing 1% WEUS powder. These results indicate that gamma-irradiated 1% WEUS chocolate was optimal.

Measurement of the Skin Dose of Patient Using the Optically Stimulated Luminescent Dosimeter at Diagnostic Radiography (진단방사선촬영에서 광자극발광선량계를 이용한 환자 피부선량의 측정)

  • Kim, Jong-Eon;Im, In-Chul;Min, Byung-In
    • The Journal of the Korea Contents Association
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    • v.11 no.9
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    • pp.437-442
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    • 2011
  • The purpose of this study is an measurement of the skin dose of a patient by using the OSLD(optically stimulated luminescent dosimeter) under several irradiation conditions of the X-ray beam for diagnostic radiography. The measurements of skin dose were performed for head, chest, and pelvis. And test of reproducibility was carried out at the chest. As a result, we obtained the skin dose at forehead of head to be 1.30 mSv. The skin doses at xiphoid process, breast and apex of the lung of the chest were acquired 0.92, 0.52 and 0.70 mSv, respectively. And we obtained the skin doses at the left pelvis and the right pelvis to be 2.78 and 3.08 mSv, respectively. As for reproducibility, a coefficient of variation was 0.033. The skin doses were exhibited the values corresponding from 1/100 to 1/17 of the dose limit of the public(50 mSv) at the deterministic effect. In order to make accurate measurements of the skin doses for each tube voltage, the measured values have to multiply by the displayed values of reader by a correction factor. The energy response of the OSLD with the tube voltage will be studied in the near future.

Effects of High Performance Greenhouse Films on Growth and Fruit Quality of Tomato (기능성 피복재가 토마토 생육 및 품질에 미치는 영향)

  • Kwon, Joon-Kook;Cho, Myeomg-Whan;Kang, Nam-Jun;Kang, Yun-Im;Park, Kyoung-Sub;Lee, Jae-Han
    • Journal of Bio-Environment Control
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    • v.18 no.3
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    • pp.232-237
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    • 2009
  • This study was performed to investigate the effect of high performance greenhouse films on growth and fruit quality of tomato. For this purpose, polyolefin (PO), fluoric, antidrop, antifog and thermal films were compared to normal film, ethylene vinyl acetate (EVA). In spectral irradiance of the films, UV ($300{\sim}400nm$) transmittance was highest in fluoric film and lowest in PO film. PAR (photosynthetically active radiation, $400{\sim}700nm$) transmittance was higher in fluoric, thermal and PO film, and near infrared ray (NIR, $700{\sim}1,100nm$) transmittance was higher in high performance films, compared to the EVA film. Total light transmittance was higher in order of fluoric, antifog, anti drop, PO, thermal, and EVA film. Day air temperature in greenhouse was highest under fluoric film and lowest under EVA film due to the light transmittance, while night air temperature was highest under PO and anti drop film due to the thickness of film. Tomato fruits grown under the high performance films had 0.2 to $0.5^{\circ}Bx$ higher soluble solids and 15 to 30% higher lycopene content, compared to those grown under the EVA film. The results showed that tomato fruit quality such as soluble solids and lycopene content can be heightened in terms of much irradiation and better light quality of high performance films, compared to the nomal film, EVA film.

Anti-Inflammatory Effect of Ixeris dentata on Ultraviolet B-Induced HaCaT Keratinocytes

  • Kim, Sung-Bae;Kang, Ok-Hwa;Keum, Joon-Ho;Mun, Su-Hyun;An, Hyun-Jin;Jung, Hyun-Ju;Hong, Seung-Heon;Jeong, Dong-Myong;Kweon, Kee-Tae;Kwon, Dong-Yeul
    • Natural Product Sciences
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    • v.18 no.1
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    • pp.60-66
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    • 2012
  • Human skin is the first line of defense for the protection of the internal organs of the body from different stimuli. Ultraviolet B (UVB) irradiation induces skin damage and inflammation through the secretion of various cytokines, which are immune regulators produced by cells. To prevent the initiation of skin inflammation, keratinocytes that have been irreversibly damaged by radiation must be removed through the apoptotic mechanism. Ixeris dentata (family: Asteraceae) is a perennial medicinal herb indigenous to Korea. It has been used in Korea, China, and Japan to treat in digestion, pneumonia, diabetes, hepatitis, and tumors. To gain insight into the anti-inflammatory effects of I. dentata, we examined its influence on UVB-induced pro-inflammatory cytokine production in human keratinocytes (HaCaT cells), by observing cells that were stimulated with UVB in the presence or absence of I. dentata. In the present study, pro-inflammatory cytokine production was determined by performing enzyme-linked immunosorbent assay, reverse transcription polymerase chain reaction, and western blot analysis to measure the activation of mitogen-activated protein kinase (MAPKs). I. dentata inhibited UVBinduced production of the pro-inflammatory cytokine interleukin (IL)-6 in a dose-dependent manner. Further, I. dentata inhibited the UVB-induced expression of cyclooxygenase (COX)-2. Furthermore, I. dentata inhibited the phosphorylation of c-Jun NH2-terminal kinase and p38 MAPKs, suggesting that it inhibits the secretion of the pro-inflammatory cytokines IL-6 and IL-8, and COX-2 expression, by blocking MAPK phosphorylation. These results suggest that I. dentate can potentially protect against UVB-induced skin inflammation.

The Effect of Lithospermum erythrorhizon Extracts in UVB-Irradiated Mouse Skin (자초(Lithospermum erythrorhizon) 추출물이 UVB로 조사된 생쥐 피부에 미치는 영향)

  • Song, Seon-Young
    • Applied Microscopy
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    • v.38 no.3
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    • pp.195-204
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    • 2008
  • This study was intended to identify the effectiveness of Lithospermum erythrorhizon in the UVB-irradiated mouse skin. The C57BL mice were divided into three groups; the control group, the UVB irradiated group(UVB group), and the group treated with Lithospermum erythrorhizon extracts after UVB irradiation(UVB+Le group). 10 mouses were collected and sacrificed at 24 hrs, 48 hrs, 72 hrs, 120 hrs, and 168 hrs, respectively. In the result, the transepidermal water loss (TEWL) was decreased the UVB+Le group than UVB groups by time. At the 168 hrs group was significantly lower(p<0.05). In the result, the melanin value was decreased in the UVB+Le group than UVB group, but meaningless(p>0.05). In the result of erythema index, the UVB+Le group was meaningfully lower at 24 hrs, 48 hrs, and 72 hrs group than UVB group(p<0.05). In the result of scanning electron micrograph observation, the UVB+Le group was allevited swelling than UVB group at the 24 hrs, formation of the scab at the 48 hrs, regular plate shap at the 72 hrs, new keratin observated at the 120 hrs partially, and fine fiber covered epidermis surface at the 168 hrs. In the result of transmission electron micrograph observation, the UVB+Le group was facilitation of increased lamellar bodies and reformation lamellar bodies than UVB group at the all groups. Almost all the structures were recovered at the 160 hrs group. In conclusion, Lithospermum erythrorhizon extracts may recovery on the UVB-irradiated mouse skin.

The Effect of Dose Distribution under Treatment Techniques on Cerebrospinal Irradiation (뇌 및 척수조사시 치료기법의 변화가 선량분포에 미치는 영향)

  • Lee, Seungchul;Kim, Youngjae
    • Journal of the Korean Society of Radiology
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    • v.10 no.1
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    • pp.21-28
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    • 2016
  • This study tries to evaluate the usefulness CSI treatment. Compare the standard technique and simple technique, using the volume region of a high dose of Field joints (hot spot) or low dose regions (cold Spot). In patients who agreed to this study, obtain CT image using CT simulator skull to pelvis region. Standard Technique were performed on the movement of the joint radiation field range and simple technique has set a treatment plan to secure the radiation field range and analyzed treatment planning. Under analysis standard technique occurred the area of the high dose(Hot Spot) for the area overlapping the field and simple technique showing a uniform doses. CI indices of standard technique and simple technique was 1.6~3, 1.6~1.87, CN indices was 0.32~0.53, 0.46~0.51 and HI indices was 0.11~0.33, 0.2~0.26. Therefore, adjacent to part of the dose distribution junction more equally than simple technique compared to the Standard Technique. Compare the dose distribution patterns using CI, CN, HI indices, showed a uniform dose distribution in the simple technique. so, simple technique was determined appropriate treatment the CSI.

An Experimental Study on the Effect of Laser to Bond Strength between Composite Resin and Bovine Teeth (우치치질에 레이저조사시 레진과의 결합강도에 관한 연구)

  • Cho, Ju-On;Song, Kwang-Yeob;Park, Charn-Woon
    • The Journal of Korean Academy of Prosthodontics
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    • v.27 no.2
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    • pp.155-172
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    • 1989
  • The purpose of this study is to measure the bonding strength at the enamel and dentin of extracted bovine incisors when they are irradiated by W Nd: YAG, EoQ Nd: YAG, and CW $CO_2$ laser, etched and then attached by composite resin. The laser-irradiated surface, the etched surface after the laser-irradiation and the interface of the treated surface and resin are observed by using scanning electron microscope. The NP Nd:YAG laser is used at the peam power of 207 KW. The EOQ Nd: YAG laser is used at the peak power of 1.15Mk. The CW $CO_2$ laser is used at the energy output of 5W and 10W in enamel; in dentin, at the energy output of 2W. The obtained results were as follows: 1. The shear bond strength of enamel decreased in the following order: EOQ Nd:YAG laser group, NP Nd:YAG laser group, CW $CO_2$ laser groups, unlased group. The unlased group showed a significant difference from EOQ Nd:YAG laser group (P<0.01), NP Nd:YAG laser group (P<0.05), but no significant difference from CW $CO_2$ laser group (P>0.05). 2. The shear bond strength of dentin decreased in the following order: CW $CO_2$ laser group, NP Nd:YAG laser group, unlased group, EOQ Nd:YAG laser group. The unlased group showed a significant difference from CW $CO_2$ laser group (P<0.01), but no significant difference from Nd:YAG laser groups (P>0.05). 3. The scanning electron microscope of enamel revealed irregular microcrack and pore at the surface in the NP Nd:YAG laser group and CW $CO_2$ laser group, but the crackless flat surface in the EOQ Nd:YAG laser group. 4. The scanning electron microscope of dentin revealed obstruction of in most of dentinal tubule and decrease of diameter. 5. The scanning electron microscope of the interface of resin and enamel revealed prominent penetration of resin tag in the EOQ Nd:YAG laser group.

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