• Title/Summary/Keyword: Inverse factors

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Mutational Analysis of the MTHFR Gene in Breast Cancer Patients of Pakistani Population

  • Akram, Muhammad;Malik, Fa;Kayani, Mahmood Akhtar
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.4
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    • pp.1599-1603
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    • 2012
  • Objectives: Since methylenetetrahydrofolate reductase (MTHFR) maintains the balance of circulating folate and methionine and blocks the formation of homocysteine, its regulation in relation to different cancers has extensively been studied in different populations. However, information on Pakistani breast cancer patients is lacking. The MTHFR gene has two most common mutations that are single nucleotide additions which result in change of amino acids C677T to Ala222val and A1298C to Glu429Ala. Methodology: 110 sporadic breast patients with no prior family history of cancer or any other type of genetic disorders along with 110 normal individuals were screened for mutations in exons 1 to exon 9 using single strand conformational polymorphism, RFLP and sequencing analyzer. Results: The p values for the 677CC, 677CT, and 677TT genotypes were 0.223, 0.006, and 0.077, respectively. Those for the 1298AA, 1298AC, and 1298CC genotypes were 0.555, 0.009, and 0.003, respectively. Conclusions: We found an overall a significant, weak inverse association between breast cancer risk and the 677TT genotype and an inverse association with the 1298C variant. These results for MTHFR polymorphism might be population specific in sporadic breast cancer affected patients but many other factors need to be excluded before making final conclusions including folate intake, population and disease heterogeneity.

Development of Hydroplaning Estimation on an Uninterrupted Road (연속류 도로구간의 수막정보 발생구간 추정 및 적용연구 - 서울시 내부순환도로를 중심으로 -)

  • Lee, Jong Hak;Roh, Jeonghoon;Park, Seok Ju
    • International Journal of Highway Engineering
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    • v.19 no.6
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    • pp.147-153
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    • 2017
  • PURPOSES : This research aims to estimate the occurrence of hydroplaning on roads based on the road alignment types and rainfall intensity in Seoul. METHODS : Three types of data were used for estimation of hydroplaning in this study. The Inner Circulation Road (12.5 km) to the Bukbu Expressway (7.4 km) in Seoul was selected as the test road and data was collected for road information using a probe-vehicle. Precipitation was observed from Automatic Weather System in Seoul. These data were interpolated by applying Inverse Distance Weighted Methodology for hydroplaning estimation. Finally, the water depth information of the roads was observed using an RCM411 device. RESULTS : This study demonstrated that the cross slope with small-angle-tilt or vertical section with large-angle-tilt are the primary factors causing hydroplaning on the roads. The flow velocity on steep slope is high; however, large drainage lengths result in hydroplaning on the roads. CONCLUSIONS : This result can contribute towards the reduction of car accidents on rainy days. Furthermore, information regarding hydroplaning can be delivered to drivers more rapidly and precisely in the future.

A Study on a Geometrical Analysis for the Manual Mode of an Advanced Teleoperator System (지적 원격조작시스템의 수동모드 개선을 위한 기하학적 해석에 관한 연구)

  • Lee, Sun-Yo;Kim, Chang-Dae;Park, Se-Gwon
    • Journal of the Ergonomics Society of Korea
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    • v.7 no.2
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    • pp.31-44
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    • 1988
  • If an error occurs in the automatic mode when the advanced teleoperator system performs a task in hostile environment then the automatic mode changes into the manual mode. The operation by the control program and the operation by a human recover the error in the manual mode. The system resumes the automatic mode and continues the given task. It is necessary to improve the manual mode in order to make the best use of a man-robot system, as a part of the human interface technique. Therefore, the error recovery task is performed by combining the operation by the control program representing autonomy of a robot and the operation by a human representing versatility of a human operator effectively in the view point of human factors engineering. The geometric inverse kinematics is used for the calculation of the robot joint values in the operation by the control program. The singularity operation error and the parameter operation error often occur in this procedure. These two operation errors increase the movement time of the robot and the coordinate reading time, during the error recovery task. A singularity algorithm, parameter algorithm and fuzzy control are studied so as to remove the disadvantages of geometric inverse kinematics. And the geometric straight line motion is studied so as to improve the disadvantages of the operation by a human.

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Some Factors Affecting Lipid Metabolism (지질대사(脂質代謝)에 관여하는 인자(因子))

  • Nam, Hyun-Keun
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.15 no.2
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    • pp.191-200
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    • 1986
  • It is now generally accepted that individuals at increased risk for cardiovascular disease may be identified by certain traits or habbits. The factors such as high blood pressure, elevated blood cholestrol, age, sex and obesity are associated with increseaed frequency of disease. The blood cholesterol level lowering will decrease cardiovascular disease risk. The regression of atherosclerosis can be achieved by lowering the level of circulating cholesterol. Those things are connected with the quantity and quality of protein, fats, carbohydrates, especially soluble and non-soluble fiber, magnesium and calcium. The lipoprotein and lipid metabolism are connected with the lipid transport. The factors on lipid absorption and blood serum lipid pattern of human are exist. The factors have a variety of materials with different chemical and physical properties. The soluble fiber diet make a low blood and liver lipids. Many kind of soluble fiber results in a lowering of blood cholesterol and triglyceride levels. The cholesterol lowering effects of dietery fiber may be a results of alterations of in intestinal handling of fats, hepatic metabolism of fatty acid or triglyceride acid metabolism of lipoprotein. It is investigated that the high density lipoprotein (HDL) is inversely related to coronary artery disease. It has been postulated that HDL may be an important factor in cholesterol efflux from the tissues, therby reducing the amount of cholesterol deposited there. Alternatively, the HDL may pick up cholestyl ester and phospholipid during normal VLDL lipolysis in the plasma. The HDL levels are relatively insensitive to diet. At present time, the cause-and -diet effect of HDL's inverse relation to CHD remains unclear.

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Predictors of Behavioral and Psychological Symptoms of Dementia: Based on the Model of Multi-Dimensional Behavior (다차원적 행동 모델에 근거한 치매 노인의 정신행동 증상 예측요인)

  • Yang, Jeong Eun;Hong, Gwi-Ryung Son
    • Journal of Korean Academy of Nursing
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    • v.48 no.2
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    • pp.143-153
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    • 2018
  • Purpose: The purpose of this study was to identify factors predicting behavioral and psychological symptoms of dementia (BPSD) in persons with dementia. Factors including the patient, caregiver, and environment based on the multi-dimensional behavioral model were tested. Methods: The subjects of the study were 139 pairs of persons with dementia and their caregivers selected from four geriatric long-term care facilities located in S city, G province, Korea. Data analysis included descriptive statistics, inverse normal transformations, Pearson correlation coefficients, Spearman's correlation coefficients and hierarchical multiple regression with the SPSS Statistics 22.0 for Windows program. Results: Mean score for BPSD was 40.16. Depression (${\beta}=.42$, p<.001), exposure to noise in the evening noise (${\beta}=-.20$, p=.014), and gender (${\beta}=.17$, p=.042) were factors predicting BPSD in long-term care facilities, which explained 25.2% of the variance in the model. Conclusion: To decrease BPSD in persons with dementia, integrated nursing interventions should consider factors of the patient, caregiver, and environment.

Factors Affecting Consumer's Choice of Retail Store Chain: Empirical Evidence from Vietnam

  • BUI, Thu Thi;NGUYEN, Huong Thi;KHUC, Long Dai
    • The Journal of Asian Finance, Economics and Business
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    • v.8 no.4
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    • pp.571-580
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    • 2021
  • The study explores the factors affecting the brand selection behavior of retail chains in Vietnam and to what extent they have an impact on the customer's choice intention. This research employs a combination of both qualitative and quantitative mixed methods with the help of SPSS version 22.0 in data analysis. Expert interviews are used to design the questionnaire for the survey conducted on 700 consumers. Research results show that the eight factors of store image (1-to-3 split factor of store image including the display of goods and services), price perception, risk perception, brand attitude, brand awareness, and brand familiarity were determined. They all influence the intention to choose the retail chain brand. With a positive β coefficient, the more store image, price perception, brand attitude, and brand awareness are enhanced, the more likely the intention to choose the retail chain brand. The factor of risk perception has negative ��, resulting in an inverse impact on choosing a retail chain brand name. Price perception and risk perception have the strongest impact on retail chain decision behavior while commodity display factors the least. Based on these important results, the study proposes implications for retailers and manufacturers.

The Analysis of Relationships between Road Alignment and Terrain Conditions for National Forest Road (국유림도(國有林道)의 노선선형(路線線形)과 지형(地形)과의 관계분석(關係分析))

  • Cha, Du Song;Cho, Koo Hyun
    • Journal of Korean Society of Forest Science
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    • v.84 no.4
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    • pp.517-524
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    • 1995
  • This study was conducted to investigate the characteristics of the road alignment, correlations among evaluation factors of the alingment, and the relationships between the evaluation factors and terrain factors for the forest road of five National Forest Offices. The results were as follows : 1. The elongation coefficients(${\eta}$) of forest road in Kangnung and Wonju National Forest Office were ranged 0.3~0.5, and those of Andong, Namwon, and Kongju National Forest Offices were ranged 0.2~0.3 in straight line of 100m, 200m, and 300m. 2. Three different types of plane alignment were identified for Kangnung and Wonju National Forest Offices, Namwon and Kongju National Forest Offices, Andong National Forest Office. However, longitudinal alignment for five National Forest Offices tended to be similar conditions. 3. Low correlation coefficients were calculated in the relation between elongation coefficients(${\eta}$) and evaluation factors of plane alignment(curve length ratio(%), sum of inverse number of each curve radius(m/km), and sum of each intersection angle($^{\circ}/km$)) for three straight lines. On the contrary, high correlation coefficients were obtained among the relations of curve length ratio(%), sum of inverse number of each curve radius(m/km), and sum of each intersection angle($^{\circ}/km$). 4. Slope(%) were closely correlated with plane alignment, and so were the relationships between frequency of valleys and streams(No./km) and elongation coefficients(${\eta}$) of forest road.

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Effect of the Meteorological Conditions on the Cocoon Production in silkwom, in Kyungsang-Nam-Do, Korea (제기상조건이 잠견생산량에 미치는 영향(경상남도를 중심으로))

  • 장창식
    • Journal of Sericultural and Entomological Science
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    • v.15 no.2
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    • pp.55-60
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    • 1973
  • The statistical interpretations are on the correlations and the linear regressions between the various meteorological conditions the branch Pusan-Observatory of the National-Central-Meteorological-Observatory had measured from 1930 to 1962, and the production of silk worm cocon that the Section of Sericulture in the Ministry of Agriculture & Fishery had recorded from 1930 to 1962 in Gyung Sang Nam Do Korea. These were most in proportion to the sun shine time, an inverse proportion to the atmosphere humidity and the lowest temperature, in proportion to the mean temperature, the highest temperature and the amount of the rain fall. The correlations and linear regressions between the various meteorological factors to control the production of the silkworm cocoon of both per a box of the silk worm egg and per 10a of mulberry field was as follows. (1) The production of the spring silk worm cocoon was dicided by the various meteorological factors. 1. This was in proportion to the total sun shine time between 5 and 6 month. r=0.40*-(0.42$^{**}$) Y=0.0269$\chi$+6.46-(0.2795$\chi$+10.25) 2. This was an inverse proportion to the total amount between 5 and 6 month atmosphere humidity. r=-0.49$^{***}$-(-0.40*) Y=-0.2989$\chi$+62.77-(0.1474$\chi$+31.86) 3. This wasin proportion to the total rain fall amount between 6 and 7 month. r=0.47$^{***}$-(0.44$^{***}$) Y=0.0037$\chi$+16.42-(0.0035$\chi$+8.35) (2) The production of the autumn silk worm cocoon was decided by the various meteorological factors. 1. This was in proportion to the total sun shine time between 5 and 6 month. r=0.37*-(0.45$^{***}$) Y=0.0205$\chi$+5.51-(0.0173$\chi$+2.41) 2. This was an inverse proportion to the total amount between 5 and 6 month atmosphere humidity. r=-0.41$^{**}$-(-0.42$^{**}$) Y=-0.2085$\chi$+45.33-(-0.0599$\chi$+12.17) 3. This was in proportion to the total of rain fall amount of 6 and 7 month. r=0.48$^{***}$-(0.35*) Y=0.0050$\chi$+11.97-( ) 4. This was in proportion to the total sun shine time among 3, 4, 5, and 6 month. r=0.51$^{****}$-(0.49$^{***}$) Y=0.0178$\chi$-1.27-(0.0096$\chi$-3.60) 5. This was an inverse proportion to the total amount among 3, 4, 5, and 6 month atmosphere humidity r=-0.41/$^{**}$-(-0.44$^{***}$) Y=-0.0938$\chi$+40.14-(-0.05693$\chi$+20.49) 6. This was in proportion to the total of a year sun shine time. r=0.58$^{****}$-(0.43) Y=0.0037$\chi$+5.35-(0.0015$\chi$+1.02) (3) The production of the next year spring silk worm cocoon was decided by the this year various meteorological factors. 1. This was in proportion to the total of a year sun shine time. r=0.55$^{****}$-(0.52$^{****}$) Y=0.0034$\chi$+12.02-(0.0025$\chi$+3.84).>+3.84).3.84).>+3.84).

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Partial Safety Factors by SOSM/RC Combined Method (제2계 2차모멘트/신뢰성조건 조합방법에 의한 부분안전계수)

  • 이종헌;신현묵;손승요
    • Computational Structural Engineering
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    • v.1 no.1
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    • pp.79-85
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    • 1988
  • The inverse algorithm of Point-Fitted Paraboloid Approximation is derived and used in reliability-based calculations. The algorithm of Reliability- Conditioned method is modified in the calculation of failure points such that nonlinear performance functions can be treated in like manner as linear cases without new formulations. SOSM/RC combined method results in probability of failure closed to specified one, and partial safety factors become nearly constant for a wide range of load ratio.

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A Study on Escalation of Commitment Behavior in Software Projects : The Perspective of Cultural Differences (소프트웨어 개발 프로젝트에서 수행의 지속행위에 관한 연구 : 문화적 차이의 관점에서)

  • 김인재;심형섭;김종은
    • Journal of Information Technology Applications and Management
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    • v.11 no.2
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    • pp.1-14
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    • 2004
  • The level of sunk cost and risk-taking theory have been offered as one explanation for the escalation of commitment behavior. This Study attempted to replicate Keil's study in Korea. Keil examined the level of sunk cost associated with the risk propensity and risk perception of decision-makers, and these factors are assessed for cross-cultural robustness using matching laboratory experiments carried out in three countries. The level of sunk cost and the risk perception of decision-makers contributed significantly to their continuous willingness to their project. Moreover, the risk propensity of decision-makers was inversely related to risk perception, and this inverse relationship was significantly more weak in Korea than in Singapore. These results show that the sunk-cost effect exists across cultures, and that the risk-taking behaviors are partially mediated by cultural factors.

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