• BMB Reports
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• 제44권4호
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• pp.217-231
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• 2011

T cell exhaustion develops under conditions of antigen-persistence caused by infection with various chronic pathogens, such as human immunodeficiency virus (HIV) and myco-bacterium tuberculosis (TB), or by the development of cancer. T cell exhaustion is characterized by stepwise and progressive loss of T cell function, which is probably the main reason for the failed immunological control of chronic pathogens and cancers. Recent observations have detailed some of the intrinsic and extrinsic factors that influence the severity of T cell exhaustion. Duration and magnitude of antigenic activation of T cells might be associated with up-regulation of inhibitory receptors, which is a major intrinsic factor of T cell exhaustion. Extrinsic factors might include the production of suppressive cytokines, T cell priming by either non-professional antigenpresenting cells (APCs) or tolerogenic dendritic cells (DCs), and alteration of regulatory T (Treg) cells. Further investigation of the cellular and molecular processes behind the development of T cell exhaustion can reveal therapeutic targets and strategies for the treatment of chronic infections and cancers. Here, we report the properties and the mechanisms of T cell exhaustion in a chronic environment.

• Asia pacific journal of information systems
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• 제16권3호
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• pp.95-116
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• 2006

Although the study of post-adoption has increased in recent years, few studies have focused on the moderating effect of uncertainty avoidance on the relationship between post-expectation and behavior. The purpose of this study is to examine the moderating effect of uncertainty avoidance in the mobile Internet domains. This study proposed a post-adoption model based on prior continuance model. This theoretical model was verified empirically by conducting web surveys and multi-group analysis. Based on the survey data, we classified users into those with high uncertainty avoidance and those with low uncertainty avoidance. The results indicate that post expectations have significant impacts on satisfaction and continuance intention. The results also show that the impacts of intrinsic motivational factors of mobile Internet services on satisfaction and continuance intention are stronger for users with high uncertainty avoidance. On the other hand, the impacts of extrinsic motivational factors on satisfaction and continuance intention are stronger for users with low uncertainty avoidance, with a few exceptions. This paper ends with theoretical and managerial implications of the study results, as well as limitations and future research directions.

• Journal of Preventive Medicine and Public Health
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• 제51권3호
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• pp.154-162
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• 2018

Objectives: Early retirement occurs when one's job satisfaction suffers due to employment mismatch resulting from factors such as inadequate compensation. Medical doctors report high levels of job stress and burnout relative to other professionals. These levels are highest among emergency physicians (EPs), and despite general improvements in their working conditions, early retirement continues to become more common in this population. The purpose of this study was to identify the factors influencing EPs intention to retire early and to develop a probability equation for its prediction. Methods: A secondary analysis of data from the 2015 Korean Society of Emergency Physicians Survey was performed. The variables potentially influencing early retirement were organized into personal characteristics, extrinsic factors, and intrinsic factors. Logistic regression analysis was performed to identify risk factors and to develop a probability equation; these findings were then arranged in a nomogram. Results: Of the 377 survey respondents included in the analysis, 48.0% intended to retire early. Risk factors for early retirement included level of satisfaction with the specialty and its outlook, slanderous reviews, emergency room safety, health status, workload intensity, age, and hospital type. Intrinsic factors (i.e., slanderous reviews and satisfaction with the specialty and its outlook) had a stronger influence on early retirement than did extrinsic factors. Conclusions: To promote career longevity among EPs, it is vital to improve emergency room safety and workload intensity, to enhance medical professionalism through a stronger vision of emergency medicine, and to strengthen the patient-doctor relationship.

• 한국유통학회지:유통연구
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• 제15권1호
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• pp.1-24
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• 2010

국내 대형마트 점포 수는 2008년 기준 403개로 포화시점에 근접하고 있다. 이러한 경쟁상황에서 '점포충성도(store loyalty)'가 지속적 경쟁우위를 위한 전략적 도구로써 그 활용성이 점점 더 중요시 되고 있다. 다양한 관점에서 점포충성도를 대형마트 연구의 핵심적 과제 다루어왔으나, 통합적인 연구 접근 방법이 미흡한 실정이다. 따라서 본 연구에서는 통합적 관점에서 점포충성도가 형성되는 두 가지 경로를 제안하였다. 이중경로모형은 첫째, 내재적 경로 '서비스품질$\rightarrow$고객만족$\rightarrow$점포충성도', 둘째, 외재적 경로 '점포개성$\rightarrow$점포동일시$\rightarrow$점포 충성도'로 구성된다. 조사대상은 대형마트를 이용하는 소비자들을 대상으로 진행하였으며, 구조방정식모형 분석을 통하여 제안된 이중경로모형의 적합성 및 가설검증을 실시하였다. 연구결과, 모형의 적합지수들은 상당히 좋은 값들을 보여주고 있다. 또한 본 연구에서 새롭게 제시된 내재적 경로인 서비스품질은 고객만족에 정의 영향을 미치고, 고객만족은 결과변수인 대형마트의 점포충성도에 매우 유의하게 영향을 준 것으로 나타났다. 그리고 외재적 경로에서 대형마트의 점포개성은 점포동일시에 긍정적인 영향을 주고 매개변수인 점포개성은 점포충성도에 영향을 미치는 것으로 나타났다. 이를 통해 본 연구는 대형마트의 점포충성도 형성에 관한 두 가지 경로를 제시함으로써, 이론적, 관리적 시사점을 도출하였고 연구의 한계점과 미래연구방향을 제시하였다.

• 대한치과보철학회지
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• 제41권2호
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• pp.160-168
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• 2003

Statement of problem : Direct denture reline resins tend to discolor during service in the oral environment by intrinsic and extrinsic factor. Purpose : This study was designed to evaluate the color stability of direct denture reline resins. Material and methods : Mild Rebaron(GC Corp., Japan), Meta Base M(Sun medical Co., Japan), Mild Rebaron LC(GC Corp., Japan) and as a control group, Vertex SC(Dentimex Zeist, Holland) were chosen for this study. Ten specimens of each direct denture reline resins were fabricated. Treatment methods designed for this study were the coffee staining test(7days) and the accelerated aging test(100hours). The color changes before and after treatment were measured by Tristimulous colorimeter(Yasuda seiki seisakusho, Ltd. Japan) and analyzed. Results All the direct denture reline resins subjected to the coffee staining test and the accelerated aging test showed noticible difference in color change. After coffee staining test, Meta Base M showed the highest color change followed by Vertex SC. Mild Rebaron LC and Mild Rebaron. There were no statistical differences between Meta Base M and Vertex SC and between Mild Rebaron LC and Mild Rebaron(p>0.05). After accelerated aging test. Mild Rebaron LC showed the highest color change followed by Vertex SC, Meta Base M and Mild Rebaron. There were no statistical differences only between Mild Rebaron and Mata Base M(p>0.05) but among the others, there were statistical differences(p<0.05). Conclusion : Within the limitation of this study, all the direct denture reline resins subjected to the extrinsic and intrinsic factors showed noticible difference in color change, and there were differences among manufacturers.

• 디지털융복합연구
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• 제20권5호
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• pp.253-260
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• 2022

21세기의 핵심역량 중 하나인 창의성은 사회구성원의 필수 항목으로 요구되다. 원하는 방향으로 사용할 수 있도록 하는 개성적인 측면에서 그 능력을 강조한다. 그러나 창의성은 새로운 아이디어나 제품을 만들어내는 것뿐만 아니라 변화하는 환경에 적응하고 문제를 해결하는 등 조직의 긍정적인 변화에 기여하는 것으로 간주되다. 이에 따라 선행연구를 검토하여 보상이 창의성을 촉진하거나 방해할 수 있다는 결론을 내렸으며, 이는 보상의 성격과 연구자가 보유한 창의성 개념, 개인차 및 외부 환경에 따라 달라질 수 있다. 우리는 또한 보상이 동기, 인지 및 합성 기능을 통하여 창의성에 영향을 미칠 수 있다고 제안하였다. 분석을 바탕으로 보상이 창의성에 미치는 영향을 구체적으로 모델을 제안하였다. 본 연구는 기존의 연구를 기반으로 하며, 어떠한 외적 동기와 내적 동기가 어떠한 관계를 가지고 있는지 비교를 바탕으로 창의성에 영향을 미치는 과정에서 작용하는 다양한 요소와 메커니즘을 분석하였다. 다음으로, 보상은 사람마다 환경적 상황에서 주어지는 방식에 따라 다른 것으로 나타났다. 마지막으로 다양한 유형의 창작과제를 보상함으로써 적극적인 보상의 역할을 확보할 수 있다.

• 한국의류학회지
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• 제33권3호
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• pp.343-354
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• 2009

This study examined the factors(intrinsic cues, extrinsic cues, private brands familarity, store loyalty) influencing clothing PB preference of large-scale discount stores, and investigated the differences according to the consumer's decision types. Questionaries were collected from 316 female customers in front of the discount stores and the data were analyzed by SPSS 12.0 using T-test, correlation, regression analysis and cluster analysis. The results were as follows. First of all, According to the correlation and regression analysis, the private brand preference were influenced by store loyalty and PB familiarity. Secondly, Differences are found according to the consumer's decision types. That is the price-conscions consumers regard store loyalty, PB familiarity, extrinsic cues, and PB preference more importantly than the value-conscious consumers.

• 가족자원경영과 정책
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• 제23권1호
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• pp.115-128
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• 2019

The purpose of this study was to explore factors influencing on work values of female college students focusing on parental effect to enhance their participation in labor market. The respondents were asked to answer a questionnaire, and the collected 400 data were analyzed using SPSS 23.0. The results showed that the students and their parents had more leisure-oriented and extrinsic work values than labor-oriented and intrinsic work values. The labor-oriented and intrinsic work values appeared to be high in the group with experience of part time jobs, with high educated father or with middle household income. The influencing factors on college students' work values were parental work values, gender consciousness, self-efficacy and major. The results from this study suggest that parents of college students should be educated to change their work values.

• The Korean Journal of Physiology and Pharmacology
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• 제26권6호
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• pp.447-456
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• 2022

The present study was carried out to investigate the effect of Arctigenin on cell growth and the mechanism of cell death elicited by Arctigenin were examined in FaDu human pharyngeal carcinoma cells. To determine the apoptotic activity of Arctigenin in FaDu human pharyngeal carcinoma cells, cell viability assay, DAPI staining, caspase activation analysis, and immunoblotting were performed. Arctigenin inhibited the growth of cells in a dose-dependent manner and induced nuclear condensation and fragmentation. Arctigenin-treated cells showed caspase-3/7 activation and increased apoptosis versus control cells. FasL, a death ligand associated with extrinsic apoptotic signaling pathways, was up-regulated by Arctigenin treatment. Moreover, caspase-8, a part of the extrinsic apoptotic pathway, was activated by Arctigenin treatments. Expressions of anti-apoptotic factors such as Bcl-2 and Bcl-xL, components of the mitochondria-dependent intrinsic apoptosis pathway, significantly decreased following Arctigenin treatment. The expressions of pro-apoptotic factors such as BAX, BAD and caspase-9, and tumor suppressor -53 increased by Arctigenin treatments. In addition, Arctigenin activated caspase-3 and poly (ADP-ribose) polymerase (PARP) induced cell death. Arctigenin also inhibited the proliferation of FaDu cells by the suppression of p38, NF-κB, and Akt signaling pathways. These results suggest that Arctigenin may inhibit cell proliferation and induce apoptotic cell death in FaDu human pharyngeal carcinoma cells through both the mitochondria-mediated intrinsic pathway and the death receptor-mediated extrinsic pathway.

• 한국방사성폐기물학회:학술대회논문집
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• 한국방사성폐기물학회 2009년도 학술논문요약집
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• pp.73-73
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• 2009

There are many factors to evaluate nuclear fuel cycle such as safety, public acceptance, economics, etc.. Transparency, proliferation, environment issues, public acceptance and safety are essential to expansion of nuclear industry and proliferation resistance is one of key constraints in the deployment of advanced nuclear energy systems. Proliferation resistance is being considered as one of the most important factors in assessing advanced and innovative nuclear systems. IAEA defmes proliferation resistance as characteristics of nuclear energy system that impedes the diversion or undeclared production of nuclear material [1]. Barriers to proliferation is consist of intrinsic and extrinsic barriers(institutional measures). Intrinsic barriers are characterized in material barriers and technical barriers in general. Material barriers is intrinsic, or inherent, qualities of materials that reduce the inherent desirability or attractiveness of the material as an explosive. Isotopic, chemical, radiological, mass and bulk, detectability barriers are considered as material barriers attributes [2]. Proliferation resistance is examined for several nuclear fuel cycles based on previous study which is focused on the intrinsic barriers [3-4]. Pyroprocessing and DUPIC are considered as reprocessing technologies in Korea and the PWR direct disposal is considered. Comparative assessments of the proliferation attributes and merits of different fuel cycle systems will be performed and the optimal back-end fuel cycle and strategy will be proposed.