• 제목/요약/키워드: Intestinal injury

검색결과 73건 처리시간 0.028초

항암화학요법환자의 오심.구토 및 자가간호 실태 (Nausea/Vomiting and Self-care in Patients with Cancer on Chemotherapy)

  • 김혜진;김희승
    • 기본간호학회지
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    • 제12권2호
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    • pp.180-185
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    • 2005
  • Purpose: The purpose of this study was to investigate the incidence and self care practice for nausea/vomiting in patients with cancer during chemotherapy. Method: The participants were 100 patients with cancer over 20 years of age who visited the outpatient department or were hospitalized for chemotherapy Self care in the case of nausea and vomiting was measured by the Dodd's scale. Data were analyzed using the SAS program and the following statistics were used frequency, percentage, unpaired t test, and Pearson correlation coefficient. Results: The ratio of the occurrence of nausea/ vomiting in the participants was 70.0%. The incidence of nausea/ vomiting was significantly higher for women than for men. The incidence of nausea/ vomiting was also higher for patients with cancer not in the gastro-intestinal system (GIS) compared to that for patients with GIS cancer. The incidence of nausea/ vomiting positively correlated with anorexia, skin injury, and fatigue. Conclusion: The ratio of occurrence of nausea/ vomiting for the participants was 70.0%. The incidence of nausea/ vomiting was higher fur women and patients with cancer not in the GIS. The incidence of nausea/ vomiting positively correlated with anorexia, skin injury, and fatigue. The results indicate that nausea/vomiting is a frequent symptom, particularly in women and there is a need to provide interventions to decrease the effects of this symptom.

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Theoretical Protein Structure Prediction of Glucagon-like Peptide 2 Receptor Using Homology Modelling

  • Nagarajan, Santhosh Kumar;Madhavan, Thirumurthy
    • 통합자연과학논문집
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    • 제10권3호
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    • pp.119-124
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    • 2017
  • Glucagon-like peptide 2 receptor, a GPCR, binds with the glucagon-like peptide, GLP-2 and regulates various metabolic functions in the gastrointestinal tract. It plays an important role in the nutrient homeostasis related to nutrient assimilation by regulating mucosal epithelium. GLP-2 receptor affects the cellular response to external injury, by controlling the intestinal crypt cell proliferation. As they are therapeutically attractive towards diseases related with the gastrointestinal tract, it becomes essential to analyse their structural features to study the pathophysiology of the diseases. As the three dimensional structure of the protein is not available, in this study, we have performed the homology modelling of the receptor based on single- and multiple template modeling. The models were subjected to model validation and a reliable model based on the validation statistics was identified. The predicted model could be useful in studying the structural features of GLP-2 receptor and their role in various diseases related to them.

쥐에서 허혈-재관류 소장 손상에 대한 담관결찰 및 Insulin-like Growth Factor-I의 영향 (Bile Duct Ligation and Insulin-like Growth Factor-I on the Ischemia-Reperfusion Injury of the Small Bowel)

  • 차제선;이명덕
    • Advances in pediatric surgery
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    • 제3권2호
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    • pp.98-107
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    • 1997
  • To determine whether bile juice exclusion can prevent the mucosal damage, and Insulin-like growth factor-I can promote mucosal regeneration in ischemia-reperfusion injury of the bowel, 39 weanling rats with 10 cm of Thiry-Vella loop were studied. Animal groups were; Control, BL(common bile duct ligation), IGF{insulin-like growth factor-I(IGF-I) infusion} and IGF-BL(combined treatment). IGF-I(1.5 mg/kg/day) was continuously delivered through a subcutaneously implanted miniosmotic pump. After 15 minutes of superior mesenteric artery clamping, a tissue specimen(P) was taken after 30 minutes of reperfusion. Intestinal continuity was restored to allow oral feeding. A specimen of main tract(M) and another of the Thiry-Vella loop(T) were collected for histomorphometry after 48 hours of reperfusion and free feeding. Villus size ratio(VSR), crypt depth(CD), crypt-depth/villus-height ratio(CVR) and injury score(IS) were measured in 15 consecutive villi. The postoperative mortalities of bile duct ligation groups(BL and IGF-BL) were higher than those of other groups. In control group, VSR of M was lower(P<0.05) than P or T, but not in the other groups. VSR of M in control was lower than those in other groups. CD of T in control, IGF and IGF-BL group were higher than those of M. CD of M and T showed gradual increments from control, IGF and IGF-BL group, respectively. CVR of M and T in IGF group were higher than those in control. CVR in IGF-BL group, T was higher than M, and M was higher than P. About IS, M of BL($20.1{\pm}2.5$) and IGF-BL($20.9{\pm}3.3$) groups were significantly lower than that of control($32.4{\pm}2.5$). These results suggest that the exclusion of bile juice reduces the severity of the reperfusion injury of the mucosa, by inability to activate pancreatic enzymes and IGF-I stimulates mucosal regeneration in injured bowel, and the effect is potentiated by bile juice exclusion.

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Initial assessment of hemorrhagic shock by trauma computed tomography measurement of the inferior vena cava in blunt trauma patients

  • Lee, Gun Ho;Choi, Jeong Woo
    • Journal of Trauma and Injury
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    • 제35권3호
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    • pp.181-188
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    • 2022
  • Purpose: Inferior vena cava (IVC) collapse is related to hypovolemia. Sonography has been used to measure the IVC diameter, but there is variation depending on the skill of the operator and it is difficult to obtain accurate measurements in patients who have a large amount of intestinal gas or are obese. As a modality to obtain accurate measurements, we measured the diameters of the IVC and aorta on trauma computed tomography scans and investigated the correlation between the IVC to aorta ratio and the shock index in blunt trauma patients. Methods: We retrospectively analyzed the medical records of 588 trauma patients who were transferred to the regional trauma center (level 1) of Wonkang University Hospital from March 2020 to February 2021. We included trauma patients 18 years or older who met the trauma activation criteria and underwent trauma computed tomography scans with intravenous contrast within 40 minutes of admission. The shock index was calculated from vital signs before trauma computed tomography scan, and measurements of the anteroposterior diameter of the IVC (AP), the transverse diameter of the IVC (T), and aorta were made 10 mm above the right renal vein in the venous phase. Results: Overall, 271 patients were included in this study, of whom 150 had a shock index ≤0.7 and 121 had a shock index >0.7. The T to AP ratio and AP to aorta ratio were significantly different between groups. Cutoffs were identified for the T to AP ratio and AP to aorta ratio (2.37 and 0.62, respectively) that produced clinically useful sensitivity and specificity for predicting a shock index >0.7, demonstrating moderate accuracy (T to AP ratio: area under the curve, 0.71; sensitivity, 59%; specificity, 87% and AP to aorta ratio: area under the curve, 0.70; sensitivity, 55%; specificity, 91%). Conclusions: The T to AP ratio and AP to aorta ratio are useful for predicting hemorrhagic shock in trauma patients.

방사선 조사와 Adriamycin 병용 투여가 마우스 소장에 미치는 영향에 관한 연구 (The Combined Effect of Adriamycin and Irradiation on the Small Intestinal Villi of Mice)

  • 홍성언;안치열
    • Radiation Oncology Journal
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    • 제4권1호
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    • pp.1-13
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    • 1986
  • 방사선 조사와 adriamycin 병용투여가 마우스 소장 소낭선세포의 방사선 감수성에 미치는 영향을 관찰하고 adriamycin의 방사선 증강효과를 측정하기 위하여 $C_3H$계 마우스 120마리를 cobalt-60원 격치료기로 전복부에 조사하였다. 방사선 단독조사군은 1,000rad에서 1,600rad까지, adriamycin병용투여군은 900rad에서 1,400rad까지 각각 100rad씩 증강시켜 조사하였고 adriamycin 10mg/kg을 조사 2시간전과 4시간후에 각각 복강내에 주사하였다. 실험군은 84시간 후에 공장을 절제하고 소낭선 측정법을 이용하여 세포생존곡선을 작성하므로써 adriamycin 병용투여시의 조사효과를 측정하였으며, 주사전자현미경(SEM)으로 소장융모의 형태변화를 관찰하여 다음과 같은 효과를 얻었다. 1) 조사군의 환상면당 소낭선수는 평균 $130{\pm}16$개이었다. 2) 방사선 단독조사 군에서 소낭선세포의 평균 치사선량은 160rad이었으며, 방사선조사 2시간과 4시간후 adriamycin 병용투여군은 모두 170rad이었다. 3) 방사선조사 2시간전과 4시간 후에 adriamycin 투여군의 dose effect factor(DEF)는 1.19와 1.26이었다. 4) 주사전자현미경소견에서 조사선량 증가에 따라 소장융모의 손상이 각각 다른 형태로 뚜렷이 변하였으며, conical collapse형태로 면한 것은 단독조사군의 1,200rad와 adriamycin병용투여군의 1,000rad에서 각각 관찰되었다. 이상의 실험결과로 보아 마우스 소장에서 방사선과 adriamycin 병용투여시 $19{\sim}26%$의 유의한 조사효과 상승이 관찰되었으므로 향후 복부나 골반부에 방사선조사와 항암제를 병용하는 경우에는 방사선 감수성이 높은 장기인 소장에 대한 손상을 고려하여 임상에서 암의 방사선치료에 깊은 배려가 필요하다고 사료된다.

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What is body underweight?

  • Beeram, Eswari;Eshita, Ishrat Rafique
    • 식품보건융합연구
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    • 제5권5호
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    • pp.33-36
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    • 2019
  • Arginine is one of the basic aminoacid found to be associated with histones and also one of the essential aminoacids now. Arginine is provided by diet, and also found to be synthesised in the body through intestinal-renal axis. Justification---BMI---Associated Risks-How to gain body weight---Healthy. Foods to Gain Weight Fast---High-Protein Vegetables and Fruits(with Image)-Recipes---Physical exercises-List of fruits and vegetables grown in Bangladesh with local names, English names and Botanical names-taxonomic family names. Arginine as drug was first approved by FDA and has recognised as a excellent dietary supplement for curing diseases like preeclampsia during gestation, diabetes and insulin resistance in obese patients. Preeclampsia is characterised by high blood pressure and proteinuria in gestational period of after 20 weeks. Severe preeclampsia is characterised by headaches, blurred vision, and inability to have high photovision, nausea and vomiting. L-Arginine along with Vit C and E are given as medical food to the patients and decrease in condition symptoms is the project now under phase II clinical trial. However the role of arginine in ameolirating preeclampsia symptoms is uncertain except with that of hypertension. Arginine is used to treat pain in sickle cell anaemia, lung damage, reperfusion injury, Trauma and shock but should be excluded during sepsis.

위가실(胃家實)에 관(關)한 연구(硏究) ('Study on Oui-Ga-Sil( 胃家實 )')

  • 한규언;류봉하;박동원;류기원;장인규
    • 대한한방내과학회지
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    • 제10권1호
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    • pp.65-80
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    • 1989
  • About Oui-Ga-Sil(胃家實) in order to considerate the contents recorded in Nai-Gyung Sang-Han-Lon and latter literature, definition, etiopathology, syndrome, differential diagnosis, therapy, Prognosis and prevention were classified. And the results were as follows: 1. Oui-Ga(胃家)was a term which indicated the whole digestive system such as stomach, small intestine, large intestine, rectum and anus. Sil(實)could be defined as the peculiar concept pertaining to the acute and last stage which was invaded to inside bowels because of abundance with evil influence. 2. Eliology of Oui-Ga-Sil was abunt gastric fever originally, injured mucus because of mistreatment, the invasion to inside of outside evil influence through meridian. Pathology was the opening and shutting appearance of gastric abundance with intestinal emptiness, and intestinal abundance with gastric emptiness, Oui-Ga-Sil could be occurred because of gastric abundant dryness and splenic humidifying capacity decrease. 3. Symptom of Oui-Ga-Sil was classified as for the sunlight outside syndrome and the inside abundant syndrome. The sunlight outside syndrome was body fever, sweating, no chilling, on the contrary hatred of fever. The chief complaint of inside abundant syndrome was daily fever, talking in delirium, hand and foot sweating, abdominal distention, difficult defection and those could be pertained to sunlight bowel syndrome. 4. Diagnostic views of Oui-Ga-Sil were that pulse was descending abundant large strong and smooth quick, a coated tongue was yellow, deep yellow, old yellow, thick, scorching dry rough or gray black. On abdominal diagnosis, pressing by hand, patient was conscious of pain, excessive pain, rejection against press, impossible press or intermittent abdominal pain and bowel cutting pain without press. 5. Differential diagnosis was that the sunlight of Nai-Gyung-Fever-Theory was outside desease making meridian the prime object, Baik-Ho-Tang syndrome was making figureless abundant fever the pivotal point. And important differential standard of splenic shrink syndrome was that a daily fever, an irritation with fever were not occurred. 6. Theory of Oui-Ga-Sil was that Seng-Gi-Tang classes had been used in attacking downward or making balance, and moxibustion on Jung-Wan, honey boiling induction theory had been also used. Attacking downward therapy was invigorating method to preserve mucus, and if mucus had been exausted with complicating emptiness prognosis had been appeared badly. 7. Preventing from Oui-Ga-Sil diet by rule, fitness to cold and warmth may be needed to prevent outside evil influence attack and inside evil influence occurrence. Prudence with being very busy, fatigue, wine and woman may be also needed not to be an injury to splanic and gastric spirit.

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치료방사선 조사가 잡종 백색마우스의 대장에 미치는 병리조직학적 영향 (The Effect of Total Dose of Radiation on Normal Colon of Hybrid Mice)

  • 조길호;김명세
    • Radiation Oncology Journal
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    • 제4권2호
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    • pp.99-105
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    • 1986
  • 암의 방사선 치료는 단독, 혹은 수술이나 화학요법과의 병합치료를 통하여 좋은 생존율을 보여주고 있으나 정상 조직의 손상으로 인한 후유증은 아직도 해결되지 못하고 있는 문제중의 하나이다. 그러므로 정상조직의 손상에 대한 연구는 암 조직의 방사선에 대한 연구와 함께 필수적이며, 근래에 계속되고는 있으나 실제 임상에서 사용되고 있는 방법과 같은 분할조사에 대한 계통적인 연구는 매우 드물다. 이에 저자는 60마리의 백색 마우스를 사용하여 $2\times3cm$의 조사야로 고식적인 방법으로 분할 조사한 후 전 조사량에 따른 병리조직학적인 변화를 분석하고 잠혈반응 검사와의 상관관계를 규명하여, 직장에 심한 후유증이 오지 많을 수 있는 가능한 최대 내 선량을 추정하여 임상치료에 이용할 수 있는 기본 자료로 삼고자 하였으며 그 결과는 다음과 같다. 점막 및 점막하 부종은 1,000 rad군에서부터 관찰되었다. 소혈관 울혈은 2,000 rad군에서 현저하였고 염증세포의 침윤은 3,000 rad군에서 현저하였다. 점막의 탈락은 3,000 rad군에서부터 관찰되기 시작하였다. 잠혈반응은 점막탈락, 혹은 괴양의 정확한 척도로 삼기에는 부적당하였으나 총 조사량의 증가와 함께 잠혈반응의 양성도도 증가하는 추세를 보여 간접적인 지표로 삼을 수는 있으리라고 생각되었다. 소낭선세포의 분열상이 5,000 rad군에서도 관찰되는 것으로 미루어 5,000 rad의 조사에서도 재생능력이 남이 있음을 시사하였다.

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Simotang Alleviates the Gastrointestinal Side Effects of Chemotherapy by Altering Gut Microbiota

  • Deng, Lijing;Zhou, Xingyi;Lan, Zhifang;Tang, Kairui;Zhu, Xiaoxu;Mo, Xiaowei;Zhao, Zongyao;Zhao, Zhiqiang;Wu, Mansi
    • Journal of Microbiology and Biotechnology
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    • 제32권4호
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    • pp.405-418
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    • 2022
  • Simotang oral liquid (SMT) is a traditional Chinese medicine (TCM) consisting of four natural plants and is used to alleviate gastrointestinal side effects after chemotherapy and functional dyspepsia (FD). However, the mechanism by which SMT helps cure these gastrointestinal diseases is still unknown. Here, we discovered that SMT could alleviate gastrointestinal side effects after chemotherapy by altering gut microbiota. C57BL/6J mice were treated with cisplatin (DDP) and SMT, and biological samples were collected. Pathological changes in the small intestine were observed, and the intestinal injury score was assessed. The expression levels of the inflammatory factors IL-1β and IL-6 and the adhesive factors Occludin and ZO-1 in mouse blood or small intestine tissue were also detected. Moreover, the gut microbiota was analyzed by high-throughput sequencing of 16S rRNA amplicons. SMT was found to effectively reduce gastrointestinal mucositis after DDP injection, which lowered inflammation and tightened the intestinal epithelial cells. Gut microbiota analysis showed that the abundance of the anti-inflammatory microbiota was downregulated and that the inflammatory microbiota was upregulated in DDP-treated mice. SMT upregulated anti-inflammatory and anticancer microbiota abundance, while the inflammatory microbiota was downregulated. An antibiotic cocktail (ABX) was also used to delete mice gut microbiota to test the importance of gut microbiota, and we found that SMT could not alleviate gastrointestinal mucositis after DDP injection, showing that gut microbiota might be an important mediator of SMT treatment. Our study provides evidence that SMT might moderate gastrointestinal mucositis after chemotherapy by altering gut microbiota.

Changes of Clinical Practice in Gastrointestinal Perforation with the Increasing Use of Computed Tomography

  • Park, Ji-Min;Yoon, Young-Hoon;Horeczko, Timothy;Kaji, Amy Hideko;Lewis, Roger J
    • Journal of Trauma and Injury
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    • 제30권2호
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    • pp.25-32
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    • 2017
  • Purpose: The use of computed tomography (CT) to evaluate acute abdominal complaints has increased over the past two decades. We investigated how the clinical practice of patients with intestinal perforation has changed with the increasing use of abdominal CT in the emergency department (ED). Methods: We compared ED arrival to CT time, ED arrival to surgical consultation time, and ED arrival to operation time according to the method of diagnosis from 2003-2004 and 2013-2014. Results: In patients with gastrointestinal perforation, time from ED arrival to CT was shorter ($111.4{\pm}66.2min$ vs. $199.0{\pm}97.5min$, p=0.001) but time to surgical consultation was longer ($135.1{\pm}78.8$ vs. $77.9{\pm}123.7$, p=0.006) in 2013-2014 than in 2003-2004. There was no statistically significant difference in time to operation for perforation confirmed either by plain film or CT between the two time periods. There was no statistically significant difference in length of hospital or ICU stay or mortality between the two groups. Conclusion: With the increasing use of abdominal CT in ED, ED arrival to CT time has decreased and ED arrival to surgical consultation time has increased in gastrointestinal perforation. These changes of clinical performance do not delay ED arrival to operation time or adversely influence patient outcome.