• 한방안이비인후피부과학회지
• /
• 제22권1호
• /
• pp.76-88
• /
• 2009

Back ground and Objective : There is a need for objectification and scientific verification of Pattern identification in Oriental medicine. The purpose of this study was to investigate the skin characteristics of Qi deficiency and Blood deficiency animal models. Material and Methods : Sprague-Dawley rats were divided into three groups: normal group, Qi deficiency group and Blood deficiency group. The Qi deficiency animal model was induced through restriction of food (75g/kg/day) for 20 days. Blood deficiency animal model was induced by bleeding from tail vein(0.3 ml/time) 8 times. The normal animal model was kept without any intervention. The general condition was observed by measuring body weight, body temperature, blood pressure, pulse rate, and hematological and biochemical parameters. The skin characteristics were observed by measuring the erythema index(EI), melanin index(Ml), transepidermal water loss(TEWL) and dermal microcirculation. Results : 1. In the Qi deficiency group, body weight was lower than the other groups. In the Qi deficiency group, blood pressure was lower than in the Normal group. There was no difference in body temperature and pulse rate between the three groups. 2. In the Qi deficiency group, blood sugar was lower than in the Blood deficiency group. There was no difference in triacylglycerol between the three groups. In the Qi deficiency group, the WBC count was lower than in the Blood deficiency group. RBC count was highest in the Qi deficiency group, Normal group and Blood deficiency group respectively. In the Qi deficiency group, Hb and Hct were higher than the other groups. 3. EI and MI were decreased in the Qi deficiency group, and EI showed a significant decrease. 4. EI and MI were increased in the Blood deficiency group, and MI showed a significant increase. 5. TEWL was significantly increased in the Qi deficiency group, while it was decreased in the Blood deficiency group, TEWL was highest in the Qi deficiency group, Normal group and Blood deficiency group respectively and all three groups showed significant difference. 6. In the Qi deficiency group, dermal microcirculation was lower than the other groups. Conclusion : The above results show that the erythema index decreases in the Qi deficiency model, and the melanin index increases in the Blood deficiency model. The Qi deficiency animal model shows an increase in transepidermal water loss, while the Blood deficiency animal model shows a decrease. Further studies should develop new models of Pattern Identification that are more specific.

• Korean Journal of Acupuncture
• /
• 제27권3호
• /
• pp.1-23
• /
• 2010

Objectives and methods : The Standards for Reporting Interventions in Clinical Trials of Acupuncture (STRICTA) were published in five journals in 2001 and 2002. These guidelines, in the form of a checklist and explanations for use by authors and journal editors, were designed to improve reporting of acupuncture trials, particularly the interventions, thereby facilitating their interpretation and replication. Subsequent reviews of the application and impact of STRICTA have highlighted the value of STRICTA as well as scope for improvements and revision. To manage the revision process a collaboration between the STRICTA Group, the CONSORT Group, and the Chinese Cochrane Centre was developed in 2008. An expert panel with 47 participants was convened that provided electronic feedback on a revised draft of the checklist. At a subsequent face-to-face meeting in Freiburg, a group of 21 participants further revised the STRICTA checklist and planned dissemination. Results : The new STRICTA checklist, which is an official extension of CONSORT, includes six items and 17 sub-items. These set out reporting guidelines for the acupuncture rationale, the details of needling, the treatment regimen, other components of treatment, the practitioner background, and the control or comparator interventions. In addition, and as part of this revision process, the explanations for each item have been elaborated, and examples of good reporting for each item are provided. In addition, the word "controlled" in STRICTA is replaced by "clinical", to indicate that STRICTA is applicable to a broad range of clinical evaluation designs, including uncontrolled outcome studies and case reports. Conclusions : It is intended that the revised STRICTA, in conjunction with both the main CONSORT Statement and extension for nonpharmacologic treatment, will raise the quality of reporting of clinical trials of acupuncture.

• 한국임상약학회지
• /
• 제19권1호
• /
• pp.18-22
• /
• 2009

Oxaliplatin is a tolerable and effective drug of choice in the treatment of advanced or metastatic gastric cancer. However, it has many dose-limiting neurotoxicities. This study was performed to assess the incidence and types of oxaliplatin-related neurotoxicities. Sixty-four patients receiving oxaliplatin-involved regimen as salvage therapy on metastatic gastric cancer or as the first-line therapy on advanced gastric cancer were evaluated during the period between September 1, 2006 and February 29, 2008. The patients were treated with oxaliplatin 100 $mg/m^2$ and leucovorin 100 $mg/m^2$ simultaneously as 2-hour-lasting infusion on Day-1 followed by 5-FU 1200 $mg/m^2$ as a 22-hour-lasting continuous infusion both on Day-1 and Day-2 by every other week. We developed questionnaires to evaluate patient-recognized neurotoxic symptoms rather than the observer-described events. Surveys were completed at bedside or via telephone interview. Acute and chronic neurotoxicities were graded according to the National Cancer Institute Common Toxicity Criteria (NCI-CTC, version 3) as well as the Oxaliplatin-specific Neurotoxicity Scale. The Grade-3 neuropathy was reported in 19% of the patients (n=12) and grade-1/2 neuropathy occurred in 70% (n=45). The most common symptom was cold-related dysesthesia (83%) regarded as nociperception by the patients. Some patients (19%) experienced functional impairment affecting activities of daily living such as writing, buttoning, and walking. Even though 74% of the patients (42/57) were prescribed with gabapentin to reduce these peripheral symptoms, it did not appear to derive any benefit from this medication. It is suggested that notify the patients about their oxaliplatin-associated, debilitating symptoms, and educate them any self-care strategy at the initiating phase of the chemotherapy. Moreover, it needs to design the intervention studies regarding the prevention and management of the peripheral neuropathy.

• 지역사회간호학회지
• /
• 제6권2호
• /
• pp.234-249
• /
• 1995

Essential hypertension, one of the leading primary cause of death in Korea, is a typical chronic disease requiring adequate and continuous management. Though these hypertensives need to maintain desirable health practice by themselves for their life time, many previous studies indicated that most of the essential hypertensives have no specific symptoms and thus, reluctant to follow appropriate medical regimens causing the condition further aggravated and complicated. Thus the comprehensive self-regulation program was conducted as a nursing intervention on the promotion self-care 'performance and improvement in physical parameters of hypertensives. For this purpose, a one group quasi -experimental research with pre and post test design was used. And the whole program was carried out from October, 1993 to February, 1994. Self-regulation program was consisted with group education on hypertension and self-care, self-regulation including the blood pressure self-monitoring and recording, recording of daily self-care activities, and encouraging and reinforcing self-efficacy through verbal persuation and enactive attainment. The subjects were asked to measure their own blood pressure by themselves twice per day and to record blood pressure and the daily self-care performance according to the instructions provided during the whole period of 9 weeks. The data was analyzed by experimental stages: the first week, the fifth week, and the ninth week since the experimental imput began. Data were analyzed by the SPSS PC+ program with paired t -test and F-test, and multiple correlation to determine the variables affecting the effect of program. The results were as follows : 1) Subjects in J company were significantly lower diastolic blood pressure than K company after the program (t=2.39, p=.024). Level of cholesterol was significant difference according to position(t=2.23, p=.034), family history (t=-2.66, p=.013), diagnosis duration, and career(t=2.88, p=.055). Perceived self-efficacy was more significantly increased among the group with family history(t=-3.00, p=.013). 2) Before the program, there were significant positive correlation among the variables: internal-LOC and self-efficacy(r=.3952, p=.015), external-LOC and barriers (r=.6515, p=.000), chance-LOC and Barriers(r=.4133, p=.012). However there were significant negative correlation between internal-LOC and barriers (r=-.3236, p=.041, external-LOC and self -efficacy(r=-.3517, p=.028), self-efficacy and barriers(r=-.6654, p=.000). 3) There were significant relationships between changes in self - care performance and self-efficacy at 5th week (r=.5313, p=.001) and changes in self-efficacy at 9th week(r=.4586, p=.005). 4) After the program, internal health locus of control and perceived benefits showed significant correlation(r=.5673, p=.001, but perceived barriers was negative correlation with perceived self-efficacy (t=-4242, p=.01). From the above results, it can be concluded that the self-regulation program is an effective nursing strategy through the change of variables to promote self-care performance of hypertensives and to increase the self-efficacy. Thus this program can be recommended in the management of the hypertensives in workplaces and community settings.

• 한국융합학회논문지
• /
• 제11권5호
• /
• pp.87-96
• /
• 2020

만성 뇌졸중 환자를 대상으로 메타분석 기법을 활용하여 트레드밀 훈련의 융복합적 효과성을 평가하고자 한다. PICOS 기준에 의거하여 문헌을 검색한 후 총 22편의 국내 '뇌졸중', '트레드밀' 관련 연구물을 선정하였다. 메타분석을 위해 CMA 프로그램을 이용하여 효과크기를 산출하였으며, 국내 트레드밀 훈련의 전체 효과크기는 0.661(95%CI: 0.456~0.865)로 중간크기로 유의한 차이가 있었다(p<.05). 트레드밀 훈련의 효과를 족저압(1.147), 하지 근 기능(0.875), 균형(0.664)으로 나누어 효과크기를 비교한 결과, 족저압의 효과크기가 가장 크게 나타났다. 추가로 균형은 하위항목들을 나누어 분석하였고, 균형은 TUG(0.553), BBS(0.760), 정적균형지수(0.654)의 효과크기가 나타났다. 따라서 트레드밀 훈련이 만성 뇌졸중 환자의 삶의 질 향상에 긍정적인 영향을 제공한다. 트레드밀 훈련에 대한 메타분석 연구는 정보, 통신 및 의료기술의 헬스케어 융합을 향한 업계 패러다임의 전환으로 이어질 수 있을 것이다.

• 동의생리병리학회지
• /
• 제26권4호
• /
• pp.511-518
• /
• 2012

The mechanisms of Toll-like receptor (TLR) signaling have been the focus of extensive studies because TLRs are the target of therapeutic intervention on multiple diseases. In this study, we investigated the inhibitory potential of Vigna angularis (azuki bean) on the TLR signaling. The effect of Vigna angularis extract (JSD) on TLR activation was investigated by assessing NF-${\kappa}B$ and AP-1 inducible secreted embryonic alkaline phosphatase (SEAP) activity. JSD significantly inhibited SEAP activity induced by poly I:C (TLR3 ligand) and poly I (TLR7 ligand) in a dose-dependent manner at concentration below 100 ${\mu}g/ml$ with no sign of cytotoxicity. Pretreatment of JSD markedly suppressed mRNA expressions of pro-inflammatory cytokines and adhesive molecules such as TNF-${\alpha}$, IL-6, RANTES, MCP-1 and ICAM-1 induced by TLR ligands. It also diminished the phosphorylation of $I{\kappa}B$ kinase and $I{\kappa}B$, and followed by $I{\kappa}B$-mediated nuclear translocation of p50, p65, and phosphorylation of p38, JNK, and IRF signaling pathway. In conclusion, our results suggest that Vigna angularis has inhibitory activity on TLR-3 and -7 signaling and it can be further developed as a remedy in curing TLR-related multiple diseases.

• 한방재활의학과학회지
• /
• 제20권2호
• /
• pp.63-77
• /
• 2010

Objectives : It is known that abdominal obesity increases the possibility of cardiovascular diseases, early death, and metabolic syndrome including dyslipidemia and insulin resistance. Clinical trials have been under way to verify the effectiveness of treatment for abdominal obesity. The objective of this study is to set criteria about how effective oriental medicine and acupuncture are in abdominal obesity. Methods : I manually search "www.clinicaltrial.gov", 4 Korean medical databases and 4 Korean medical journals of abdominal obesity. Search terms used were "abdominal obesity" or "visceral obesity". In order to see detail review, searching was performed from 01, 01, 2005 to 11, 31, 2009. And I classified all the searched studies into design, intervention, purpose, end point, diseases, condition and etc. Results : 1. I could search total 67 trials in "www.clinicaltrial.gov". I found 9, 10, 13, 8, 6 clinical trial from 2005 to 2009 every year. 2. Test on both gender and adult or adult and senior have been most frequent. 3. Randomization clinical trial is 51 cases that occupied 96.2%. 38 cases use control group. 4. Body mass index(BMI) and waist circunference(WC) are major criteria of abdominal obesity clincal trial. WC, BMI, abdominal fat mass, body weight are measured at end point of abdominal obesity clincal trial. 5. I could search total 86 cases in domestic study. I found 15, 23, 23, 20, 5 cases from 2005 to 2009 every year. 6. Test on female and adult have been most frequent in domestic study. 7. Randomization clincal trial is only 2 cases that occupied 2.3%. 62 cases use control group in domestic study. 8. BMI, body fat percent, WC, visceral-subcutaneous fat ratio(VSR), waist-hip ratio(WHR) are criteria of abdominal obesity clincal trial in domestic study. WC, BMI, abdominal fat mass, body weight are measured at end point of abdominal obesity clincal trial in domestic study. Conclusions : To improve abdominal obesity study in traditional korean medicine, it is need to activate clinical trial, meta analysis, develope of clinical practice guidelines, co-works with conventional medicine and etc.

• 한국산학기술학회논문지
• /
• 제21권1호
• /
• pp.468-476
• /
• 2020

본 연구의 목적은 자녀 출생부터 5년까지의 아버지 양육참여의 변화 궤적에 따른 잠재집단을 확인하고, 확인된 잠재집단에 따라 자녀의 문제행동 및 어머니의 양육스트레스, 부부갈등, 결혼만족도, 우울에 차이가 있는지 확인하는 것이다. 한국아동패널 1차년도(2008년)에서 5차년도(2012년)까지 자료의 1,316명 데이터를 분석하였으며, 잠재계층성장분석과 다변량분산분석을 활용하였다. 분석 결과, 첫째, 2차 함수 모형에 기초한 잠재계층성장분석을 통해 어머니가 지각한 아버지의 양육참여 변화 유형은 '최저수준 무변화형 집단', '중수준 감소형 집단', '중상수준 변동형 집단', '최상수준 변동형 집단'의 네 유형이 확인되었다. 본 연구에서 확인한 잠재집단의 특징은 아버지 양육참여 수준이 가장 낮은 집단의 경우 양육참여 수준의 변화가 잘 나타나지 않으며, 아버지의 양육참여 수준이 높은 집단의 경우에도 자녀가 네 살이 되는 시점부터는 양육참여 수준이 감소한다는 것이다. 둘째, 아버지의 양육참여 수준이 지속적으로 감소하는 '중수준 감소형 집단'이 아버지 참여수준이 제일 높은 '최상수준 변동형 집단'보다 자녀의 외현화 문제행동이 더 많은 것으로 나타났다. 셋째, '최저수준 무변화형 집단'과 '중수준 감소형 집단'이 '중상수준 변동형 집단'과 '최상수준 변동형 집단'보다 어머니의 양육스트레스, 부부갈등, 우울 수준은 높은 반면, 결혼만족도는 '최상수준 변동형 집단', '중상수준 변동형 집단', '중수준 감소형 집단', '최저수준 무변화형 집단' 순으로 높은 것으로 확인되었다. 본 연구는 아버지 양육참여의 변화 특성이 자녀뿐 아니라 어머니의 삶에 많은 영향을 미칠 수 있음을 시사하며, 아버지 양육참여를 촉진하기 위한 사회적 노력과 정책적 개입이 필요함을 시사한다.

• 한국산학기술학회논문지
• /
• 제16권5호
• /
• pp.3111-3120
• /
• 2015

본 연구에서는 대학졸업예정자의 Holland 유형에 따라 진로결정상태를 분석하고 진로결정상태에 진로걱정이 미치는 영향을 연구하여 매개효과를 밝힘으로서 상담자들이 상담 장면에서 대학생들의 진로걱정의 다양함을 고려한 상담진행으로 내담자의 자기실현을 이루는데 도움을 줄 수 있다. 또한 현재까지 우리나라에서 실시되고 있는 집단 상담 프로그램 및 진로상담의 효과에 관한 연구들이 내담자의 진로걱정의 차이를 고려하지 않고 동일한 프로그램과 상담방식으로 진행해왔음을 고려해 볼 때, 본 연구는 보다 효과적인 진로상담을 위해, 차별적인 상담개입과 전략을 세우기 위한 기초의 연구로서 중요한 의의가 있다. 본 연구대상은 서울, 경기, 충정지역의 4년제 대학교 중 4학년 2학기의 졸업예정자 총 606명이며, 자료 수집은 2013년 11월 4일부터 약 2주간에 걸처 표준화된 자기기입식 설문지를 사용하여 수집하였다. 연구 결과 첫째, Holland 유형별 대학생의 진로걱정과 진로결정상태에 대한 차이를 검증한 결과 진로걱정정도와 진로걱정유형이 Holland 유형별로 다르게 나타나 유의한 차이를 보였다. 둘째, Holland 유형별로 차이를 보인 진로결정상태에서 진로걱정이 미치는 영향을 검증한 결과 진로에 대한 무걱정과 걱정, 그리고 진로결정유형 중 의존성이 매개역할을 하는 것으로 나타났다. 결론적으로 진로걱정이 대학생의 진로결정상태에 미치는 영향을 분석함으로써 매개효과를 밝혔다는데 의의가 있다.

• 한국산학기술학회논문지
• /
• 제14권1호
• /
• pp.214-222
• /
• 2013

본 연구는 노인의 감각처리유형과 통증 파국화 수준과의 상관관계에 대하여 알아보고, 이를 통해 재활중재를 위한 기초자료로 제시하고자 하였다. 연구대상은 65세 이상 노인 216명으로 하였다. 감각처리의 유형은 청소년/성인 감각프로파일을 사용하여 측정하였고, 통증의 심리적인 변인들은 통증파국화척도를 사용하여 측정하였다. 성별과 연령에 따른 차이는 t-검정을, 감각처리유형과 통증파국화와의 상관관계를 피어슨 상관분석을 실시하였다. 감각처리유형은 여성이 남성에 비해 '감각민감', '감각회피'의 경향이 높았으며(p<.05), 연령이 75세 이상인 군이 65~74세 군에 비해 '감각회피', '등록저하', '감각찾기'의 경향이 높은 것으로 나타났다(p<.05). 감각처리유형이 '등록저하'일 때 통증파국화의 '반추적사고'와 그리고 '감각찾기'일 때 통증 파국화의 '무력감'과 음의 상관관계를 나타내었다. '감각민감', '감각회피' 일 때 통증파국화의 모든 항목에서 양의 상관관계를 나타내었다. 65세 이상 노인의 감각처리 유형은 통증에 대한 심리적인 변인과 관련되어 있으며, 성별과 연령에 따라 차이가 있음을 알 수 있었다. 앞으로는 노인의 감각처리 유형 및 통증관련 요인들에 관한 더 진전된 연구가 이루어지기를 기대한다.