• The Korean Journal of Pain
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• 제29권4호
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• pp.239-248
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• 2016

Background: The present study was undertaken to evaluate the incidence of chronic persistent post-surgical pain (CPPP) and the role of signal transduction genes in patients undergoing staging laparotomy for carcinoma ovary. Methods: The present observational study was undertaken following institutional ethical committee approval and informed consent from all the participants. A total 21 patients of ASA grade I to III with age 20-70 years, scheduled for elective staging laparotomy for carcinoma ovary were included. Patients were excluded if had other causes of pain, cognitive dysfunction or chronic neurological disorders. Statistical analysis of pool data was done using SPSS version-17. For various scales like GPE, PDQ, NPSI, the visual analogue scale (VAS), global perceived effect (GPE), the pain DETECT questionnaire (PDQ), and neuropathic pain symptoms inventory (NPSI), one factor repaeted measure ANOVA applied with simple contrast with baseline as on post-operative day 1 (considered as reference and compared with subsequent time-interval), and the P values were adjusted according to "Bonferroni adjustments". In patients with CPPP, the ${\Delta}ct$ values of mRNA expressions of genes at the end of postoperative day 90 were compared with the baseline control values by one factor repeated ANOVA. P value < 0.005 significant. Results: The present study demonstrates 38.1% (8 out of 21 patients) incidence of CPPP. The functional status and quality of life as were observed to be significantly diminished in all patients with chronic pain. An up-regulation in the mRNA expression of signal transduction and a positive correlation was noted between the mRNA expression of signal transduction genes and VAS score in all patients with CPPP at the end of postoperative day 90. Conclusions: The reported incidence of CPPP in patients with carcinoma ovary was 38.1%. An up-regulation and positive correlation between mRNA expression of signal transduction genes and VAS score depicts its potential role in the pathogenesis of CPPP.

• The Korean Journal of Physiology
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• 제4권1호
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• pp.19-28
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• 1970

In order to investigate the changes in the temperature regulation mechanism following ingestion of red pepper, twenty healthy man were given 2 gms of powdered red pepper each in 100 ml of water at room temperature, $20^{\circ}C$, Simultaneous recordings of temperature and electrical resistance of the skin of forehead were taken by means of Physiograph, using appropriate transducers. Temperature of various spots such as the cheek, upper tack and the forearm was also measured by the telethermometer at interval of two minutes. The results obtained were as follows: 1. Seventeen out of 20 subjects showed immediate rise in the skin temperature of the forehead, and 11 of them manifested the oscillating pattern of the skin temperature. The average of the largest peak amplitude was $0.58{\pm}0.355^{\circ}C$. 2. Even those who failed to show the immediate rise in the temperature did not keep the quiescence over 9 minutes, and delayed responses were revealed. 3. The rise in tile skin temperature is the favourable sign for the heat discipating mechanism only because the sweat glands are activated with the concomittant rise in the temperature of the skin. 4. There was a preceding or coincide fall in the electrical resistance of the skin, and it was also attributed to the glandular activity. 5. At rather cool room temperature, $20^{\circ}C$, no visible sweat was seen during the period of observation. Nevertheless it was obvious that latent activation of the sweat glands was triggered and the. threshold was lowered. This situation imitates the acclimatized condition in the hot environment, and it is likely to increase the tolerance in tropical climate from the view point of temperature regulation.

• 한국응용과학기술학회지
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• 제36권1호
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• pp.142-152
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• 2019

본 연구는 담배흡연자에서 비만과 심장자율신경조절의 관련성 규명을 목적으로 수행되었다. 의료기록 및 외관상 건강한 총 85명의 남자 대학생 흡연자들을 대상으로 자료를 수집하였으며, 모든 참가자들의 안정 시 심장자율신경조절 평가를 위해 단기간 표준프로토콜에 따른 심박변이도(heart rate variability, HRV) 지표들을 산출하였다. 한편 체질량지수, 체지방률, 허리둘레 및 허리/엉덩이 둘레비는 표준 비만지표로서 활용되었다. 연구결과 허리/엉덩이 둘레비를 기준으로 분류된 상위집단은 하위집단에 비해 부교감신경활동을 반영하는 HRV의 rMSSD, pNN50, HF 및 SD1에서 유의하게 낮은 값을 나타내었다. 그러나 HRV의 교감신경활동지수 LF/HF에서는 집단 간 통계적 차이가 없었다. 또한 상관분석 결과 시간, 주파수 및 비선형영역의 HRV 부교감신경 지수들이 체질량지수와 관련하지 않는 반면 허리둘레, 허리/엉덩이 둘레비 및 체지방률과 같은 비만지표들과는 유의한 상관관계를 나타내었다. 특히 허리둘레와 체지방률에 비해 허리/엉덩이 둘레비가 부교감신경활동과 더 밀접하게 관련하는 경향을 나타냈다. 이상의 결과들은 남자 대학생 흡연자들에서 전반적인 비만도를 반영하는 체질량지수와는 독립적으로 중심부 비만이 심장부교감신경 저하와 관련하는 주된 상관 요인임을 뒷받침한다.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제30권1호
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• pp.69-73
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• 2004

뮤코르 진균증은 드물게 발생하지만 종종 치명적일 수 있으며, Phycomycetes종의 기회 감염에 의해 발생한다. 이 미생물은 부생의 호기성 진균(saprophytic aerobial fungus)이며 구강 점막, 부비동과 목에 통상적으로 존재하며 부패해 가는 식물, 거름, 고당 함유 음식 등에 나타난다. 뮤코르 진균증은 다양한 유형의 임상 형태로 면역결핍환자들에서 빠른 진행과 높은 치사율로 나타난다. 그러나 건강한 사람에서 두경부 영역에 감염된 예는 거의 없다. 본 교실에서는 58세 당뇨병이 있는 남자 환자에서 상악에 발생한 뮤코르 진균증의 증례에서 외과적 절제술과 ampotericin B의 정맥내 투여로 치료 되었으며, 현재까지 특별한 재발 소견 없이 양호한 결과를 얻었기에 이를 문헌 고찰과 함께 보고하는 바이다.

• The Korean Journal of Physiology and Pharmacology
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• 제3권6호
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• pp.605-613
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• 1999

The purpose of the present study was to evaluate cardiovascular regulation during passive standing (PS) after ethanol ingestion by spectral analysis of heart rate variability (HRV) in flushed and nonflushed subjects. Of 24 young male subjects, 8 belonged to flushed group (F) and 16 to nonflushed group (NF). Two sessions of 10-min PS were performed before and after ethanol (0.5 g/kg) ingestion. Powers of R-R interval variability in very low frequency $(VLF,\;0{\sim}0.05\;Hz),$ low frequency $(LF,\;0.05{\sim}0.15\;Hz)$ and high frequency $(HF,\;0.15{\sim}0.50\;Hz)$ bands, normalized powers (LFn and HFn) and LF/HF ratio were obtained. After ethanol ingestion, F showed higher heart rate than NF. PS increased LFn $(+22.9{\pm}3.6\;in\;NF,\;+12.8{\pm}4.7$ in F, in normalized units) and LF/HF $(+3.10{\pm}0.57\;in\;NF,\;+3.00{\pm}1.08\;in\;F)$ and decreased HFn powers. Ethanol ingestion increased LFn and LF/HF and decreased HFn. PS after ethanol resulted in higher LFn and LF/HF and lower HFn than the prior PS. F showed a greater and more sustained HRV change than NF after ethanol. In conclusion, PS or ethanol ingestion increased LFn and LF/HF and decreased HFn. Flushed subjects showed an accentuated HRV response to ethanol.

• 정보처리학회논문지D
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• 제14D권6호
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• pp.689-700
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• 2007

정보시스템 운영리스크를 최소화하고, 장애시간 동안의 영업기회 손실비용 규모를 줄이기 위해서는 장애의 예방과 사전준비가 필요하다. 그런데 장애가 발생할 경우, 대부분의 기업에서는 장애발생 직후에 대응과 복구 조치를 취하고 있다. 프로그램 개발자나 시스템운영자들은 과거의 경험과 직관에 의존하여 장애를 관리하고 있을 뿐, 장애를 체계적으로 관리하고 사전에 예방하는 사례를 찾아보기가 힘든 실정이다. 본 논문은 정보시스템 운영리스크의 관점에서, 디스크 장애예방을 위한 피해저감모델의 개발에 초점을 맞추었다. 연구모델은 디스크장치에서 정보시스템 운영리스크가 발생하는 위험원인, 그리고 이러한 원인들을 사전에 점검하는 점검주기, 점검에 필요한 운영규정으로 구성된다. 또한 정보시스템 부문의 하드웨어 장애요인 중에서 가장 크게 나타나고 있는 디스크 장애에 대하여 피해저감모델을 적용함으로써 활용 가능성을 보여 준다.

• 대한인간공학회지
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• 제17권3호
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• pp.13-22
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• 1998

Aircraft and the three-dimensional environment in which they operate are not user-friendly for human beings. As a result, maintaining the proficiencies necessary to safely and efficiently fly an airplane are difficult, and costly. The physiological and emotional status of the human element remains crucial in maintaining safe performance by all crew members. In the study of Hagiwara et al.(1993). they called the physiological and emotional status of the human element into the human alertness or physiological activity and stress, fatigue, circadian rhythm, alcohol. smoking, and self-medication are known the major factors that deteriorate the human alertness. Accordingly. this paper deals with the quantitative and objective performance test based on tracking error and reaction time by means of the new computer test program into which the perception-motion system of human beings is applied. Throughout this experiment using performance test, the results suggest that performance capability in state of sleep deprivation 2 hours and alcoholic 0.05~0.06% in blood were more impaired than one in a normal state, and they further showed statistically significant differences between them, which were influenced by impairment factors of body regulation and pilot's grade. We also obtained the prediction value and the 95% confidence interval of tracking error and reaction time at the normal state for the purpose of distinguishing performance capability between the normal state and the abnormal state. And it is expected that the evaluation of human alertness using performance test will be applied to the quantitative assessment of an each pilot's realistic consciousness/attention, and will lead a flight commander to the accurate decision of mission approval prior to a flight.

• 한국정보통신학회논문지
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• 제10권4호
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• pp.652-658
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• 2006

본 논문은 승압형 컨버터, 강압형 컨버터 및 저주파 인버터를 이용한 고휘도 Short-Arc 램프용 전자식 안정기의 설계 및 제작에 관하여 기술하였다. 제안한 안정기는 130 [Hz]의 구형 저주파를 램프에 인가함으로써 고압 방전 램프에서 발생할 수 있는 음향공명현상을 제거하였으며, 25 [kHz]의 고주파 전압을 중첩시켜 아크튜브의 전극에서 발생할 수 있는 열적 불균형을 해소하였다. 또한 전압 전류의 합을 이용한 정전력 제어를 수행하여, 주위 환경 및 램프의 노화에 따른 램프 전압의 변화에 대하여 안정한 점등상태를 유지하였다. 실험 결과로부터, 제작한 전자식 안정기의 램프 전압, 전류 및 전력은 각각 123.8 [V], 8.1 [A] 1,002 [W]로 측정되었다.

• Safety and Health at Work
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• 제5권3호
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• pp.131-135
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• 2014

Background: Cassava and corn milling is a growing small-scale enterprise in Africa. We aimed to determine the incidence of hand-arm musculoskeletal complaints among vibration-exposed Congolese cassava and corn millers in the previous 12 months. Methods: A cross-sectional study was conducted, prior to a follow-up study, from March to May 2013 among cassava/corn millers in Lubumbashi, Democratic Republic of Congo, in which 365 millers age-matched to 365 civil workers anonymously answered a questionnaire. Results: Overall incidence of hand-arm musculoskeletal complaints was 25.8% in millers (vs. 5.2% in civil workers; p < 0.001). The risk of experiencing musculoskeletal symptoms was seven times higher in millers [vs. civil workers; odds ratio (OR) = 7.10; 95% confidence interval (CI): 4.03-12.50; p < 0.0001]; 2.4 times higher in smoking millers (vs. smoking civil office workers; OR = 2.36; 95% CI: 1.42-3.88; p < 0.001); 3.6 times higher in millers with longer daily exposure (> 8 hours; vs. those working ${\leq}8$ hours; OR = 3.56; 95% CI: 1.93-3.61; p = 0.026); and 7.4 times higher in young millers (vs. older millers, OR = 7.39; 95% CI: 1.29-75.52; p < 0.001). Smoking, number of cigarettes, and daily exposure duration were positively correlated with musculoskeletal complaints. Conclusion: This study revealed a relatively high incidence of musculoskeletal complaints among African cassava and corn millers. The use of anti-vibration protective equipment and the regulation of this hazardous occupation may reduce the burden of musculoskeletal disorders in millers.

• 한국식품과학회지
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• 제29권3호
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• pp.460-463
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• 1997

콩나물 재배시 수주방식은 콩나물 재배기 자동화에 중요한 관건이다. 본 재배기는 기존 콩나물 재배기의 단점을 획기적으로 개선한 재배기로 싸이폰이 내설된 저수조와 분수통 및 재배통으로 구성되어 구조가 간단하면서 완전 자동으로 수주가 가능하고 고장이 없는 내구성 콩나물 재배기이다. 수주방법은 적수(滴水)를 모아 일정시간 간격으로 자동 수주가 이루어 지는데 수주간격은 분당 떨어지는 적수량을 조절하여 쉽게 조절할 수 있다. 이 재배기는 사용할 때 경제적이며 사용중 고장이 없고 소음이 발생하지 않고, 특히 염소 가스로 살균된 수돗물을 이용하여 건전하게 콩나물을 재배할 수 있다. 더욱이 중요한 것은 본재배기는 콩나물 속성재배 적온인 $25{\sim}30^{\circ}C$에서 건전한 재배가 가능하였으나 다른 재배기는 $20^{\circ}C$ 이하에서만 재배가 가능하였다.