• The Journal of Advanced Prosthodontics
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• v.16 no.3
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• pp.151-162
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• 2024

PURPOSE. This study aimed to analyze factors influencing the success and failure of implant prostheses and to estimate the lifespan of prostheses using standardized evaluation criteria. An online survey platform was utilized to efficiently gather large samples from multiple institutions. MATERIALS AND METHODS. During the one-year period, patients visiting 16 institutions were assessed using standardized evaluation criteria (KAP criteria). Data from these institutions were collected through an online platform, and various statistical analyses were conducted. Risk factors were assessed using both the Cox proportional hazard model and Cox regression analysis. Survival analysis was conducted using Kaplan-Meier analysis and nomogram, and lifespan prediction was performed using principal component analysis. RESULTS. The number of patients involved in this study was 485, with a total of 841 prostheses evaluated. The median survival was estimated to be 16 years with a 95% confidence interval. Factors found to be significantly associated with implant prosthesis failure, characterized by higher hazard ratios, included the 'type of clinic', 'type of antagonist', and 'plaque index'. The lifespan of implant prostheses that did not fail was estimated to exceed the projected lifespan by approximately 1.34 years. CONCLUSION. To ensure the success of implant prostheses, maintaining good oral hygiene is crucial. The estimated lifespan of implant prostheses is often underestimated by approximately 1.34 years. Furthermore, standardized form, online platform, and visualization tool, such as nomogram, can be effectively utilized in future follow-up studies.

• Korean Journal of Radiology
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• v.22 no.3
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• pp.366-375
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• 2021

Objective: To evaluate the radiological tumor response patterns and compare the response assessments based on immune-based therapeutics Response Evaluation Criteria in Solid Tumors (iRECIST) and RECIST 1.1 in metastatic clear-cell renal cell carcinoma (mccRCC) patients treated with programmed cell death-1 (PD-1) inhibitors. Materials and Methods: All mccRCC patients treated with PD-1 inhibitors at Henan Cancer Hospital, China, between January 2018 and April 2019, were retrospectively studied. A total of 30 mccRCC patients (20 males and 10 females; mean age, 55.6 years; age range, 37-79 years) were analyzed. The target lesions were quantified on consecutive CT scans during therapy using iRECIST and RECIST 1.1. The tumor growth rate was calculated before and after therapy initiation. The response patterns were analyzed, and the differences in tumor response assessments of the two criteria were compared. The intra- and inter-observer variabilities of iRECIST and RECIST 1.1 were also analyzed. Results: The objective response rate throughout therapy was 50% (95% confidence interval [CI]: 32.1-67.9) based on iRECIST and 30% (95% CI: 13.6-46.4) based on RECIST 1.1. The time-to-progression (TTP) based on iRECIST was longer than that based on RECIST 1.1 (median TTP: not reached vs. 170 days, p = 0.04). iRECIST and RECIST 1.1 were discordant in 8 cases, which were evaluated as immune-unconfirmed PD based on iRECIST and PD based on RECIST 1.1. Six patients (20%, 6/30) had pseudoprogression based on iRECIST, of which four demonstrated early pseudoprogression and two had delayed pseudoprogression. Significant differences in the tumor response assessments based on the two criteria were observed (p < 0.001). No patients demonstrated hyperprogression during the study period. Conclusion: Our study confirmed that the iRECIST criteria are more capable of capturing immune-related atypical responses during immunotherapy, whereas conventional RECIST 1.1 may underestimate the benefit of PD-1 inhibitors. Pseudoprogression is not rare in mccRCC patients during PD-1 inhibitor therapy, and it may last for more than the recommended maximum of 8 weeks, indicating a limitation of the current strategy for immune response monitoring.

• 제어로봇시스템학회:학술대회논문집
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• 1997.10a
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• pp.1856-1859
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• 1997

This paper describes the arousal measurement and the control system using fuzzy logic to prevent drowsy driving. Sugeno's method was used for fuzzy inference in this study. Membership function and rule base were determined form the modfied arousal level criteria. The output of fuzzy inference tracked well the change of subject's arousal level. When IRI(Inter-SIR interval) was under the 60sec, maximum output of three step warning method was medium sound, but that of fuzzy logic system was changed from medium to big. Furthermore, the output of the fuzzy inference was highly correlated with $N_{z}$(r=0.99). Therefore, the fuzzy inference method for evaluation and the control of arousal will be more effective at real driving sityation than three step warning method.ning method.

• Journal of the Korean Society for Precision Engineering
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• v.17 no.12
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• pp.121-128
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• 2000

The scope of this paper is focused to the systems which have the time period and they should be necessarily studied in the sense of stability and design method of controller to stabilize the orignal unstable systems. In general, the time periodic systems or the systems having same motions during certain time interval are easily found in rotating motion device, i.e., satellite or helicopter and widely used in factory automation systems. The characteristics of the selected dynamic systems are analyzed with the new stability concept and stabilization control method based on Lyapunov direct method. The new method from Lyapunov stability criteria which satisfies the energy convergence is studied with linear algebraic method. And the numerical procedures are developed with computational programming method to apply to the practical linear periodic systems. The results from this paper demonstrate the usefulness in analysis of the asymptotic stability and stabilization of the unstable linear periodic system by using the developed simulation procedures.

• Communications for Statistical Applications and Methods
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• v.6 no.1
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• pp.99-106
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• 1999

This paper considers an imperfect repair model for which the repairable system is maintained preventively at periodic times and is replaced by a new system when a predetermined number of preventive maintenance has been applied. our main objective of this is to determine the optimal number of preventive maintenances before the system is replaced and the optimal length of interval between two consecutive preventive maintenances under a new repair model which is referred to as an ineffective preventive maintenance. Such a model assumes a periodic preventive maintenance in which the system is effectively maintained with a certain probability. Otherwise the system is not improved at all after each maintenance and thus the failure rate remains the same as before. The criteria to determine the optimal number of preventive maintenances and length of period is the expected cost rate per unit time for an infinite time span. We give the explicit expressions for the expected cost rate per unit time. Some numerical examples are presented for illustrative purposes.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.23 no.57
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• pp.1-10
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• 2000

The purpose of this paper is to propose a method of rest to reduce work load of night shift workers for night shift work. The experiment was carried out 10minutes preparing time, 45minutes first work, 10minutes first rest, 45minutes second work, 10minutes second rest between 2 and 4 o'clock that the lowest physiological function of workers. The methods of rest set up as four patterns (1) non-action rest (2) non-action rest + listening music (3) action rest + non-action rest, (4) action rest + non-action rest + listening music. For the measurements of experiment, heart rates(R-R interval), critical flicker fusion frequency(CFF), blood pressure, oral temperature, reaction time and error rates were considered as criteria for work performance. As a result, action rest + non-action rest and action rest + non-action rest + listening music were more effective to reduce work load additional work than non-action rest and non-action rest + listening music.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.14 no.5
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• pp.8-14
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• 2015

Heat treatment for car body molds is mainly a manual process performed by a worker. The performance of this process is affected by workers' skill level, and has limitation in maintaining uniform product quality. In this study, we developed a diode laser heat treatment robot system that implements an OLP type simulator to overcome the limitation of manual process, and to improve and stabilize the quality level. In addition, we verified the efficiency of the robot system and mechanism stability from the early stage through design verification and simulated analysis in the development stage. In addition, we carried out a field test to study the way to establish optimized D/B for diode laser heat treatment criteria for car body molds, such as heat treatment speed, interval, etc. via site experiment.

• Biomolecules & Therapeutics
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• v.6 no.4
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• pp.417-422
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• 1998

Loxoprofen sodium (sodium 2-[4-(2-oxocyclopentylmethyl)phenyl] propionate dehydrate) is a nonsteroidal antiinflammatory drug of $\alpha$-phenyl propionic acid derivative. To test the bioequivalence of loxoprofen, the pharmacokinetic parameters of new preparation of loxoprofen, LENOX was compared with LOXONIN as a reference drug. Fourteen healthy volunteers were entered to the stydy (Yonsei University College of Medicine, Severance Hospital IRB approval No. 9608). They were administered 60 mg of loxoprofen in 2$\times$2 cross-over design. There was one week of drug-free interval between doses. The blood sample was taken on schedule up to 8 hours, and the plasma concentration loxoprofen was measured by reverse phase high-performance liquid chromatography (HPLC) with UV-detector. There were no significant difference between two preparations when AUC, Cmax, and Tmax were compared by ANOVA. The mean differences of AUC, Cmax, and Tmax were within 20% of the reference drug: the values were 2.22,5.61, and 12.50%, respectively. The confidence limits of AUC and Cmax but not Tmax satisfied the bioequivalence criteria. These results suggest that the tested LENOX is bioequivalent to the reference drug.

• Communications for Statistical Applications and Methods
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• v.24 no.1
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• pp.29-41
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• 2017

The estimation problem of expected time to failure of units is studied in a discrete set up. A simple step-stress accelerated life testing is considered with a Type-I censored sample from geometric distribution that is a commonly used distribution to model the lifetime of a device in discrete case. Maximum likelihood estimators as well as the associated distributions are derived. Exact, approximate and bootstrap approaches construct confidence intervals that are compared via a simulation study. Optimal confidence intervals are suggested in view of the expected width and coverage probability criteria. An illustrative example is also presented to explain the results of the paper. Finally, some conclusions are stated.

• Communications for Statistical Applications and Methods
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• v.23 no.2
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• pp.119-129
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• 2016

A new sampling method is introduced based on the idea of a ranked set sampling scheme in which taken samples in each set are dependent on previous ones. Some theoretical results are presented and distribution-free confidence intervals are derived for the quantiles of any continuous population. It is shown numerically that the proposed sampling scheme may lead to 95% confidence intervals (especially for extreme quantiles) that cannot be found based on the ordinary ranked set sampling scheme presented by Chen (2000) and Balakrishnan and Li (2006). Optimality aspects of this scheme are investigated for both coverage probability and minimum expected length criteria. A real data set is also used to illustrate the proposed procedure. Conclusions are eventually stated.