• The Korean Journal of Applied Statistics
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• v.25 no.3
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• pp.435-446
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• 2012

Epidemiologic studies frequently try to estimate the impact of a specific risk factor. The risk difference and the risk ratio are generally useful measurements for this purpose. When using such measurements for rare events, the standard approaches based on the normal approximation may fail, in particular when no events are observed. In this paper, we discuss and evaluate several existing methods to construct confidence intervals around risk differences and risk ratios using Monte-Carlo simulations when the disease of interest is rare. The results in this paper provide guidance how to construct interval estimates of the risk differences and the risk ratios when no events are detected.

• Management & Information Systems Review
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• v.26
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• pp.293-309
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• 2008

This study examined the market efficiency of korea stock market by comparing variance ratios(VR) of stock groups which is sorted by market capitalization. We compute variance ratios of KOSPI large capitalization, midium capitalization, and small capitalization for 546 trading days from 2006/01/02 to 2008/04/15. For our study, we also use high frequency data that is; intra-day 1 minute data. The characteristics of variance ratios of stock groups by market capitalization as follows: From 1 to 5 minute interval, variance ratios of three stock group increase far from zero(0). The longer time interval, the more variance ratios decrease, but only large capitalization converge on around zero. This means that the market of large capitalization is more efficient compare to other stock groups. The entire sample period can be divided two sub-period because the impact of sub prime crisis arised from U.S.A. influences Korea stock market. Before sub prime crisis, the VRs of mid cap and small cap do not converge on around zero except large cap although the time interval is longer. After sub prime crisis, the VRs of three stock groups decrease when time interval is longer, but only large cap converge on around zero. We conclude that large cap is more efficient than other stock groups in Korea Stock Market.

• Journal of Preventive Medicine and Public Health
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• v.39 no.6
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• pp.455-461
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• 2006

Objectives : Prolongation of the heart rate-corrected QT (QTc) interval has been reported to be associated with cardiovascular morbidity and mortality. However, few studies have examined the relationship between the QTc interval and cardiovascular risk factors in young healthy people, The aim of this study was to examine the associations between the QTc interval and cardiovascular risk factors in young healthy adults. Methods : This study was performed as part of the Kangwha study, which started in 1986, and is an on-going follow-up study on blood pressure and related cardiovascular risk factors. In follow-up examinations during 2005, cardiovascular risk factors, including anthropometrics, blood pressure, blood chemistry and carotid ultrasonography, were measured, and questionnaires on health behaviors completed by 127 men and 149 women aged 25 years. The QTc interval was measured on the resting 12-lead electrocardiogram using an automatic analysis program. Results : The mean QTc interval was significantly longer in women $(419{\pm}17ms)$ than in men $(405{\pm}17ms)$ (p<0.001). A significant positive correlation was found between the QTc interval and waist-hip ratio (p=0.030) in men. Women showed a positive correlation between the QTc interval and systolic blood pressure (p=0.017). On a multiple regression analysis, the QTc interval was positively associated with the waist-hip ratio in men (p=0.012) and with the systolic blood pressure (p=0.020) in women. Conclusions : In young healthy Korean adults, the QTc interval was independently associated with the waist-hip ratio in men and with the systolic blood pressure in women.

• Communications for Statistical Applications and Methods
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• v.16 no.4
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• pp.713-722
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• 2009

The estimation of odds ratio and corresponding confidence intervals for case-control data have been done by traditional generalized linear models which assumed that the logarithm of odds ratio is linearly related to risk factors. We adapt a lower-dimensional approximation of Gu and Kim (2002) to provide a faster computation in nonparametric method for the estimation of odds ratio by allowing flexibility of the estimating function and its Bayesian confidence interval under the Bayes model for the lower-dimensional approximations. Simulation studies showed that taking larger samples with the lower-dimensional approximations help to improve the smoothing spline estimates of odds ratio in this settings. The proposed method can be used to analyze case-control data in medical studies.

• Asian-Australasian Journal of Animal Sciences
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• v.19 no.2
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• pp.176-180
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• 2006

This study was carried out to establish clipping interval of Pennisetum orientale (PO) and Panicum antidotale (PA) to get maximum biomass production with optimal nutritional value for Nili buffaloes. Two clipping intervals i.e. $CI_1$, and $CI_2$ (clipped after every one and two months, respectively) were studied for both grasses. The data on various parameters were compared with PO and PA each clipped at 4 months of age (control). Leaf to stem ratio in both PO and PA declined with increasing clipping interval. Concentration of dry matter (DM) and organic matter (OM) increased (p<0.05) whereas crude protein contents decreased with increasing clipping interval in both grasses. Crude protein and dry herbage yields in PO and PA increased (p<0.05) with increasing clipping interval. The DM and neutral detergent fiber (NDF) digestibilities of PO and PA in ruminally cannulated buffalo bulls decreased (p<0.05) due to more lignification with increasing clipping interval. Ruminal extent of digestion, rate of disappearance of DM and neutral detergent fiber of PO and PA decreased in buffaloes while ruminal lag time of these nutrients increased significantly (p<0.05) with increasing clipping interval. The results from the study imply that two month clipping interval for both PO and PA grasses favored higher biomass with greater nutritional value for Nili buffaloes and sustained grass vigor.

• Journal of Biosystems Engineering
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• v.24 no.3
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• pp.259-266
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• 1999

This research was carried out to investigate the possibility of real time rice milling ratio measurement using the spectral reflection characteristics. In this study, various methods were compared such as \circled1 using the whiteness meter, \circled2 using the colorimeter, \circled3 using the Visible and the NIR reflection spectrum. The samples were milled in the domain of 84~96% by 0.5% interval classified by milling ratio. The NMG treatment method required about 20 minutes to determine the milled ratio and r2 was 0.0028 to 0.7959 that was very low. In case of whiteness meter, r2 was high but speed of measurement was 5 minutes that was very low. Measurement with the colorimeter required about 5 minutes and r2 was 0.60 to 0.85 that was low. The reflection spectrum were measured in the range of 400~2,500nm with 2nm interval and the MLR model with six-wavelength obtained from first derivative of spectra gave the best results(r2 = 0.967, SEP = 0.729%)

• Journal of the Korean Statistical Society
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• v.32 no.1
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• pp.1-10
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• 2003

We consider obtaining graphical summaries of uncertainty in estimates of parameters in nonlinear models. A nonlinear constrained optimization algorithm is developed for likelihood based confidence intervals for the functions of parameters in the model The results are applied to the problem of finding significance levels in nonlinear models.

• Tuberculosis and Respiratory Diseases
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• v.48 no.6
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• pp.944-955
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• 2000

Background : In patients with chronic obstructive pulmonary disease(COPD), several factors have been associated with a poor prognosis. These include old age, low $FEV_1$ low diffusing capacity, high alveolar-arterial oxygen pressure difference, and finally cor pulmonale. This study was done to investigate if the ECG signs suggesting cor pulmonale were independent prognostic factors in patients with COPD. Method : We analyzed ECG, pulmonary function data and arterial blood gas values in 61 patients who were admitted through the emergency department with an acute exacerbation of COPD. The ECG signs reflecting cor pulmonale were right strial overloading(RAO), right bundle branch block, right ventricular hypertrophy and low-voltage QRS. The 61 patients were divided into 2 groups ; group I with no ECG signs(n=36) and group II with one or more ECG signs(n=25) suggesting cor, pulmonale. Results : Poor, prognostic factors by univariate analysis were low $FEV_1$, $FEV_1$ % pred., VC % pred., DLco, DLco % pred., $PaO_2$ and $SaO_2$ high $PaCO_2$ presence of ECG signs reflecting cor pulmonale, presence of mental status change, use of mechanical ventilator, and long term use of glucocorticoid. A multivariate analysis indicated that age(risk ratio=1.13, 95% confidence interval 1.05-1.23), DLco % pred. (risk ratio=0,97. 95% confidence interval 0.94-0.99), $PaO_2$ (risk ratio=0.95, 95% confidence interval 0.90-0.99) and RAO(risk ratio=5.27, 95% confidence interval 1.40-19.85) were independent prognostic factors of survival. There was a significant difference in survival between the patients with and without RAO(p=0.038). The survival rates at 1, 2, and 5 years were 94.5%. 81.4%, and 50.0% in patients without RAO and 82.4%, 70.6%, and 27.5% in patients with RAO, respectively. Conclusion : These results suggest that the presence of ECG signs reflecting cor pulmonale is a predictor of survival and that RAO of these ECG signs is a significant independent predictor of survival in patients with COPD.

• Korean Journal of Animal Reproduction
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• v.16 no.3
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• pp.261-267
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• 1992

The reproductive performance of SPF ICR mice under single paired mating were examined to get reproductive background data and to establish single paired rotational mating system. The results obtained were as follows : average litter size was 15.4$\pm$2.0 heads ; average weaning rate was 95.7$\pm$4.9% ; sex ratio(male/female) was 1.09$\pm$0.26 ; aveage delivery interval was 23.0$\pm$2.4 days. It was given the largest litter size at the age of 121~150 days and in 2nd~4th parities, but at the age of under 90 days and in 1st parity weaning rate and delivery interval were higher and shorter than those of the other ages and parities, respectively. In sex ratio, the number of male litters was slightly increased from that of female litters. The weaning rate of litters from dams which nuresed 12 litters was the highest among those of different litter sizes, and it was decreased dependent upon increment of litter size. There were no difference among 4 groups for reproductive performance, therefore the present study could have important sources for animal breeders who produce mice using the single paired rotational mating system.

• Journal of Society of Preventive Korean Medicine
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• v.14 no.2
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• pp.105-120
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• 2010

Objectives : This study aims to evaluate the effects of expiration-to-inspiration time ratio (E/I-ratio) on heart rate, which represents cardiac autonomic function, and cold-heat in the healthy people. Methods : 49 healthy young volunteers(male : female = 32 : 17) were recruited in the study. The participants completed the questionnaire for yin-yang pattern identification and then we measured the chest plethysmogram for respiration signal and the electrocardiogram for NN intervals during different E/I-ratio from 1 to 2. We compared heart rate variability including RMS-SD, VLF, LF and HF, and the trend-cycle factors decomposed from NN interval data by time series analysis among the respective E/I-ratio. We also confirmed the difference on the trend-cycle factors according to the score of the questionnaire for cold and heat pattern identification. Results : There were differences on the trend-cycle factors from NN interval data, but no significant difference on heart rate variability, among the respective E/I-ratio. We also found significant relationship between the trend-cycle factors and the heat pattern identification scores. Conclusions : The results indicate that cardiac autonomic function can be modulated by the E/I-ratio and the modulation will be slower and more tendencious than respiratory sinus arrhythmia.