• International Journal of Automotive Technology
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• v.8 no.6
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• pp.697-704
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• 2007

Recently, a variable valve timing system has been widely adopted in internal combustion engine in order to improve the fuel economy and torque at low engine speed. In addition, it is known that varying valve timing according to the various engine operations could reduce exhaust gas, especially NOx, because of residual gas by valve overlap. In this study, to improve the low exhaust gas and fuel economy at part load condition, the residual gas and back flow of exhaust gas due to valve overlap were calculated computationally. Moreover, the characteristics of engine performances and NOx formations were investigated with the experiment of combination of intake and exhaust valve timing condition. Under these various valve operating conditions, the effects of both the positive valve overlap and negative valve overlap(valve underlap) were examined simultaneously. Finally, the characteristics of cyclic THC emission were analyzed by using Fast Response FID(FR-FID) in the cylinder, intake port and exhaust port positions. Besides, the effect of the different gradients of the valve timing change on engine performance was investigated and an optimum control strategy was suggested.

• Biomolecules & Therapeutics
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• v.31 no.5
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• pp.515-525
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• 2023

The most common heart valve disorder is calcific aortic valve stenosis (CAVS), which is characterized by a narrowing of the aortic valve. Treatment with the drug molecule, in addition to surgical and transcatheter valve replacement, is the primary focus of researchers in this field. The purpose of this study is to determine whether niclosamide can reduce calcification in aortic valve interstitial cells (VICs). To induce calcification, cells were treated with a pro-calcifying medium (PCM). Different concentrations of niclosamide were added to the PCM-treated cells, and the level of calcification, mRNA, and protein expression of calcification markers was measured. Niclosamide inhibited aortic valve calcification as observed from reduced alizarin red s staining in niclosamide treated VICs and also decreased the mRNA and protein expressions of calcification-specific markers: runt-related transcription factor 2 and osteopontin. Niclosamide also reduced the formation of reactive oxygen species, NADPH oxidase activity and the expression of Nox2 and p22^phox. Furthermore, in calcified VICs, niclosamide inhibited the expression of β-catenin and phosphorylated glycogen synthase kinase (GSK-3β), as well as the phosphorylation of AKT and ERK. Taken together, our findings suggest that niclosamide may alleviate PCM-induced calcification, at least in part, by targeting oxidative stress mediated GSK-3β/β-catenin signaling pathway via inhibiting activation of AKT and ERK, and may be a potential treatment for CAVS.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2008.04a
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• pp.425-430
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• 2008

To verify the system performance of portable AE leak diagnosis system which can measure with moving conditions, AE activities such as RMS voltage level, AE signal trend, leak rate degree according to AE database, FFT spectrum were measured during operation on total 11 valves of the secondary system in nuclear power plant. AE activities were recorded and analyzed from various operating conditions including different temperature, type of valve, pressure difference, valve size and fluid. The results of this field study are utilized to select the type of sensors, the frequency band for filtering and thereby to improve the signal-to-noise ratio for diagnosis for diagnosis or monitoring of valves in operation. As the final result of application study above, portable type leak diagnosis system by AE was developed. The outcome of the study can be definitely applied as a means of the diagnosis or monitoring system for energy saving and prevention of accident for power plant valve. The purpose of this study is to verify availability of the acoustic emission in-situ monitoring method to the internal leak and operating conditions of the major valves at nuclear power plants. In this study, acoustic emission tests are performed when the pressurized temperature water and steam flowed through glove valve(main steam dump valve) and check valve(main steam outlet pump check valve) on the normal size of 12 and 18 ". The valve internal leak monitoring system for practical field was designed. The acoustic emission method was applied to the valves at the site, and the background noise was measured for the abnormal plant condition. To improve the reliability, a judgment of leak on the system was used various factors which are AE parameters, trend analysis, frequency analysis, voltage analysis and amplitude analysis of acoustic signal emitted from the valve operating condition internal leak.

• Transactions of the Korean Society for Noise and Vibration Engineering
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• v.14 no.4
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• pp.310-318
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• 2004

For many industrial problems originating from aerodynamic noise, noise prediction techniques, reliable and easy to apply, would be of great value to engineers and manufacturers. General algorithm is presented for the prediction of internal flow-induced noise from quick opening throttle valve in an automotive engine. This algorithm is based on the integral formula derived by using the General Green Function, Lighthill's acoustic analogy and Curle's extension of Lighthill's. Novel approach of this algorithm is that the integral formula is so arranged as to predict frequency-domain acoustic signal at any location in a duct by using unsteady flow data in space and time, which can be provided by the Computational Fluid Dynamics Techniques. This semi-analytic model is applied to the prediction of internal aerodynamic noise from a throttle valve in an automotive engine. The predicted noise levels from the throttle valve show good agreement with actual measurements. The results show that the dipole noise is dominant in this phenomena and the origin of noise sources is attributed to the anti-vortex lines formed in the down-stream from a throttle valve. This illustrative computation shows that the current method permits generalized predictions of flow noise generated by bluff bodies and turbulence in flow ducts.

• Journal of Hydrogen and New Energy
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• v.26 no.5
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• pp.463-468
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• 2015

This study describes the effect of upstream curved pipe on internal flow characteristics ball valve. Continuity and three-dimensional Reynolds-averaged Navier-Stokes equation have been used as governing equations for the numerical analysis. The upstream curved pipe - ball valve model was assumed that it is used for Alaska pipeline project which was planned to provide reliable transportation of natural gas from ANS to Alaska-Yukon border. Therefore the characteristics of pipe and operating condition of pipeline were from report of Alaska pipeline project. The three curvature and three location of upstream curved pipe were analyzed. The results shows that there are typical flow patterns at ball valve and the upstream curved pipe makes some differences to the internal flow of ball valve.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.17 no.1
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• pp.69-75
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• 2018

This study aims to provide ways to achieve structural improvements of the internal flow path of the discharge plenum of a swash plate piston pump valve block vulnerable to cracks. This paper corresponds to Part I, which consists of a structural analysis of the valve block, identification of the stress distribution and stress raisers, and creation of a Simple Model of the valve block to review the optimal design. Structural analysis was performed by assigning the same conditions as those found in the valve block model, and the design was reviewed by examining three different design improvement plans for the internal flow path of the discharge plenum.

• International Journal of Automotive Technology
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• v.8 no.6
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• pp.687-696
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• 2007

To increase the reliability of auto-ignition in CAI engines, the thermodynamic properties of intake flow is often controlled using recycled exhaust gases, called internal EGR. Because of the internal EGR influence on the overall thermodynamic properties and mixing quality of the gases that affect the subsequent combustion behavior, optimizing the intake and exhaust valve timing for the EGR is important to achieve the reliable auto-ignition and high thermal efficiency. In the present study, fully 3D numerical simulations were carried out to predict the mixing characteristics and flow field inside the cylinder as a function of valve timing. The 3D unsteady Eulerian-Lagrangian two-phase model was used to account for the interaction between the intake air and remaining internal EGR during the under-lap operation while varying three major parameters: the intake valve(IV) and exhaust valve(EV) timings and intake valve lift(IVL). Computational results showed that the largest EVC retardation, as in A6, yielded the optimal mixing of both EGR and fuel. The IV timing had little effect on the mixing quality. However, the IV timing variation caused backflow from the cylinder to the intake port. With respect to reduction of heat loss due to backflow, the case in B6 was considered to present the optimal operating condition. With the variation of the intake valve lift, the A1 case yielded the minimum amount of backflow. The best mixing was delivered when the lift height was at a minimum of 2 mm.

• Journal of Mechanical Science and Technology
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• v.17 no.3
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• pp.357-369
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• 2003

Electromagnetic valve (EMV) actuation system is a new technology for improving fuel efficiency and at the same time reducing omissions in internal combustion engines. It can provide more flexibility in valve event control compared with conventional variable valve actuation devices. The electromagnetic valve actuator must be designed by taking the operating conditions and engine geometry limits of the internal combustion engine into account. To help develop a simple design method, this paper presents a procedure for determine the basic design parameters and dimensions of the actuator from the relations of the valve dynamics, electromagnetic circuit and thermal loading condition based on the lumped method. To verify the accuracy of the lumped method analysis, experimental study is also carried out on a prototype actuator. It is found that there is a relatively good agreement between the experimental data and the results of the proposed design procedure. Through the whole speed range, the actuator maintains proper performances in valve timing and event control.

• Journal of Chest Surgery
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• v.46 no.6
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• pp.457-460
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• 2013

Dynamic left ventricular (LV) outflow tract obstruction is a characteristic feature of hypertrophic cardiomyopathy; however, it can also occur in association with hyperdynamic LV contraction and/or changes in the cardiac loading condition, even in a structurally normal or near-normal heart. Here, we report a case of anemia-induced systolic anterior motion of the mitral valve and the resultant intraventricular obstruction in a patient who underwent coronary artery bypass grafting and suffered from anemia associated with recurrent gastrointestinal bleeding.

• Transactions of the Korean Society of Automotive Engineers
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• v.11 no.6
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• pp.30-36
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• 2003

Variable valve timing(VVT) mechanisms are used widely for improving fuel consumption and reducing emissions. Most of application, however, are limited in the DOHC engine. Dual equal retard/advance strategy is relatively simple one and can be applied to both SOHC and DOHC engines. In this study, effects of dual equal valve timing retard/advance are investigated to observe the feasibility of VVT system on an SOHC SI engine. The result shows that fuel economy and emissions are improved in the dual retard condition due to increased internal EGR. Some amount of increase in volumetric efficiency can be achieved by advancing valve timing at low speed and by retarding at high speed. In this case, however, full load power is not so much improved as the volumetric efficiency increases because of severe knock. In the dual advance condition, there is no merit in the fuel economy and emission.