• 대한토목학회논문집
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• 제29권6A호
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• pp.577-585
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• 2009

이 논문은 원전 격납건물의 극한내압능력 평가와 비선형해석을 수행하기 위하여 개발된 해석프로그램인 9절점 퇴화 쉘 유한요소에 대하여 기술하였다. 개발된 쉘 유한요소는 퇴화 고체기법과 구조물에서 발생하는 횡전단변형도를 고려하기 위하여 Reissner-Mindlin(RM)가정을 도입하였다. 콘크리트의 재료모델은 등가응력-등가변형률의 관계를 이용하여 콘크리트의 응력과 변형률의 수준을 결정하고, 콘크리트에 균열이 발생하면 부착응력을 고려하는 인장강성모델과 균열면에서의 전단전달 메카니즘 그리고 균열면에서 압축강도 감소모델 등으로 재료적 거동을 나타내었다. 또한 균열발생기준으로 압축-인장영역에는 Niwa가 제안한 응력포락선을 도입하였고, 인장-인장영역에는 Aoyagi-Yamada가 제안한 응력포락선을 사용하였다. 개발된 프로그램의 성능은 다양한 수치예제를 통하여 검증하였다. 검증예제 결과로부터 개발된 쉘 유한요소를 이용한 해석결과는 실험결과 또는 다른 해석결과와 유사한 결과를 도출하였다.

• 대한기계학회논문집A
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• 제36권12호
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• pp.1489-1495
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• 2012

본 논문에서는 부유식 플랫폼의 동적 거동을 고려하여 해상 풍력 발전기 타워의 구조 해석을 수행하였다. 풍력 발전기는 플랫폼, 타워, 낫셀, 허브 그리고 3 개의 블레이드로 구성된다. 타워는 3 차원 빔 요소를 사용하여 탄성체로 모델링하여 탄성 다물체계 동역학을 기반으로 한 운동 방정식을 구성하였다. 회전하는 블레이드에는 블레이드 요소 운동량 이론에 따라 계산된 공기역학적 힘이 적용되었고, 부유식 플랫폼에는 유체정역학적 힘, 유체동역학적 힘 그리고 계류력이 적용되었다. 타워의 구조 동역학적 거동을 수치적으로 시뮬레이션하였다. 시뮬레이션 결과를 이용하여 굽힘 모멘트와 응력을 산출하고 허용치와 비교하였다.

• Structural Engineering and Mechanics
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• 제66권2호
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• pp.273-283
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• 2018

Currently, the dynamic amplification effect of suction is described using the wind vibration coefficient (WVC) of external loads. In other words, it is proposed that the fluctuating characteristics of suction are equivalent to external loads. This is, however, not generally valid. Meanwhile, the effects of the ventilation rate of louver on suction and its WV are considered. To systematically analyze the effects of the ventilation rate of louver on the multi-dimensional WVC of ultra-large cooling towers under suctions, the 210 m ultra-large cooling tower under construction was studied. First, simultaneous rigid pressure measurement wind tunnel tests were executed to obtain the time history of fluctuating wind loads on the external surface and the internal surface of the cooling tower at different ventilation rates (0%, 15%, 30%, and 100%). Based on that, the average values and distributions of fluctuating wind pressures on external and internal surfaces were obtained and compared with each other; a tower/pillar/circular foundation integrated simulation model was developed using the finite element method and complete transient time domain dynamics of external loads and four different suctions of this cooling tower were calculated. Moreover, 1D, 2D, and 3D distributions of WVCs under external loads and suctions at different ventilation rates were obtained and compared with each other. The WVCs of the cooling tower corresponding to four typical response targets (i.e., radial displacement, meridional force, Von Mises stress, and circumferential bending moment) were discussed. Value determination and 2D evaluation of the WVCs of external loads and suctions of this large cooling tower at different ventilation rates were proposed. This study provides references to precise prediction and value determination of WVC of ultra-large cooling towers.

• 한국전산구조공학회논문집
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• 제26권1호
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• pp.79-87
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• 2013

레벨셋방법과 헤비사이드 강화를 이용한 아이소-지오메트릭 위상최적설계 방법을 개발하였다. 레벨셋 방법에서는 초기해석영역은 고정되어 있으며 경계는 레벨셋 함수값을 이용한 암시적인 동적 경계로 표현되며, 이는 복잡한 위상적 변화를 용이하게 표현할 수 있게 한다. 헤비사이드 강화는 기존의 기저함수에 내부 경계를 표현하는 강화 함수를 더함으로써 아이소-지오메트릭 해석법의 정밀도를 향상시킨다. 제안된 위상 최적설계 방법은 다음과 같은 이점을 갖는다. 아이소-지오메트릭 해석법을 이용하여 정밀한 기하 형상을 얻을 수 있으며 텐서 곱을 이용하여 정의된 패치의 한계를 헤비사이드 강화를 이용함으로써 해결할 수 있다. 단일 패치를 사용함으로써 연속적인 응력 분포를 얻어낼 수 있을 뿐 아니라 불연속적인 변위장 또한 표현해 낼 수 있다. 레벨셋 방법론이 암시적 동적 경계를 잘 표현하기 때문에 이를 이용하여 헤비사이드 강화를 이용한 아이소-지오메트릭 해석법에서 위상의 변화를 잘 표현해 낼 수 있다.

• Molecules and Cells
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• 제45권6호
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• pp.403-412
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• 2022

Hypoxia leads to significant cellular stress that has diverse pathological consequences such as cardiovascular diseases and cancers. MicroRNAs (miRNAs) are one of regulators of the adaptive pathway in hypoxia. We identified a hypoxia-induced miRNA, miR-34c, that was significantly upregulated in hypoxic human umbilical cord vein endothelial cells (HUVECs) and in murine blood vessels on day 3 of hindlimb ischemia (HLI). miR-34c directly inhibited BCL2 expression, acting as a toggle switch between apoptosis and autophagy in vitro and in vivo. BCL2 repression by miR-34c activated autophagy, which was evaluated by the expression of LC3-II. Overexpression of miR-34c inhibited apoptosis in HUVEC as well as in a murine model of HLI, and increased cell viability in HUVEC. Importantly, the number of viable cells in the blood vessels following HLI was increased by miR-34c overexpression. Collectively, our findings show that miR-34c plays a protective role in hypoxia, suggesting a novel therapeutic target for hypoxic and ischemic diseases in the blood vessels.

• 한국산림과학회지
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• 제94권4호통권161호
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• pp.281-286
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• 2005

수목은 뿌리에 의한 토양수분의 제거와 기계적인 보강효과를 통해 토괴가 사면 하부로 이동하는 것을 막아 안정하게 하는 역할을 한다. 본 연구는 자연사면상에서 이런 보강효과를 정량화하기 위해, 표준사에 다른 형태로 수목의 뿌리를 내재시켜 직접전단시험을 실시하였으며, 공시뿌리로서는 잣나무가 이용되었다. 실험은 뿌리가 내재된 것과 그렇지 않은 토양에서 실시하였으며, 여러 수준의 수직구속 압력에서 최대 전단저항력을 측정하였다. 뿌리에 의해 증가된 토양전단저항력은 측정된 토양의 내부마찰각과 점착력 등의 토양변수를 이용하여 계산하였으며, 전단상자내의 뿌리배열에 의한 효과도 함께 분석하였다. 실험결과 전단저항력은 뿌리의 개수와 직경이 증가할수록 증가하였으며, 뿌리의 배열 형태가 십자 배열일 때 가장 큰 효과를 나타내었다. 또한 실험을 통해 확인한 전통적인 토양보강 모델과의 비교에서는 기존 모델의 선형성으로 실제 실험 결과와 일치하지 않는 경향을 나타내었다.

• 대한약침학회지
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• 제11권4호
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• pp.65-77
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• 2008

Objective The purpose of this study was to analyze the directions of Korean Medicine treatment of diabetes mellitus. Methods We reviewed the 52 studies about diabetes mellitus which had been published from 2000 to 2007. We selected those studies from the search engine of the web site of five journals. Those were the Journal of Korean Oriental Medical Society, Korean Journal of Oriental Physiology & Pathology, the Journal of Korean Acupuncture & Moxibustion Society, Korean Journal of Oriental Internal Medicine and the Journal of Korean Pharmacopuncture Institute. Results 1. The types of diabetes mellitus model in studies were the model used Alloxan(2cases), the model used Streptozotocin(41cases), NOD mice(1case), ob/ob mice(1case), db/db mice(5cases) and rats fed highfat diet(2cases). 2. The types of method in studies were pharmacopuncture(8cases), herbal medcine(47case) and both pharmacopuncture and herbal medcine(3cases). the types of materials in studies were single herb(24cases), multiple herbs(32cases) and both single and multiple herbs(4cases). 3. The types of evaluation criteria in studies were glucose, pancreas, liver, kidney, serum lipid, oxidative stress, nervous system, vascular system and immunity. Conclusions There have been reported many studies of diabetes mellitus in Korean Medicine. It requires to study further types of diabetes mellitus, kinds of herbs and complications of diabetes mellitus for Korean Medicine treatment of diabetes mellitus was covered the ground.

• Journal of Community Nutrition
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• 제3권1호
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• pp.21-29
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• 2001

This study was conducted to examine factors with attendance in hyperlipidemia nutrition eduction program among 101 hyperlipidemic outpatients (38 males 63 females) at Samsung Medical Center We employed the Health Belief Model (HBM) as the theoretical framework The individual nutrition education and counseling program was scheduled with 4- half hour session sin 2 to 4 weeks intervals. Upon initiation of the program a trained dietitian surveyed HBM constructs and psychosocial factors. The following were included perceived susceptibility to cardiovascular disease(CVD) perceived severity to CVD percieved benefits to diet modification perceived barriers to persistence in maintaining therapy and self efficicacy and social support from family Sociodemographic data health factors stress level nutrition knowledge, and 24-hour dietary recall behavior were also surveyed All these data was analyzed according to the number of nutrition sessions attended The subjects were 55.9$\pm$9.4 year old and 24.6$\pm$kg/㎡ Sociodemographic factors were not associated with the number of nutrition sessions attended HBM constructs and psychosocial factors were significantly associated with the number of nutrition sessions attended. According to Spearman correlation coefficients. From stepwis regression analyses using HBM constructs as independent variables perceive barriers to persistence in maintaining diet therapy (negative) proved to be the strongest predictors for the number of nutrition sessions attended (partial R$^2$= 72.3%) followed by perceived severity to CVD and self efficacy (model R$^2$=76.6% The findings indicate that HBM constructs and psychosocial factors were closely associated with patient attendance It suggests that information and guidance to minimize patients perceived barriers to diet therapy might help to improve patients to scheduled appointments in nutrition education programs.

• Geomechanics and Engineering
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• 제13권5호
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• pp.715-742
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• 2017

Earth berms are often left in place to support retaining walls or piles in order to eliminate horizontal struts in excavations of soft soil areas. However, if the excavation depth is relatively large, an earth berm-supported retaining system may not be applicable and could be replaced by a multi-bench retaining system. However, studies on multi-bench retaining systems are limited. The goal of this investigation is to study the deformation characteristics, internal forces and interaction mechanisms of the retaining structures in a multi-bench retaining system and the failure modes of this retaining system. Therefore, a series of model tests of a two-bench retaining system was designed and conducted, and corresponding finite difference simulations were developed to back-analyze the model tests and for further analysis. The tests and numerical results show that the distance between the two rows of retaining piles (bench width) and their embedded lengths can significantly influence the relative movement between the piles; this relative movement determines the horizontal stress distribution in the soil between the two rows of piles (i.e., the bench zone) and thus determines the bending moments in the retaining piles. As the bench width increases, the deformations and bending moments in the retaining piles decrease, while the excavation stability increases. If the second retaining piles are longer than a certain length, they will experience a larger bending moment than the first retaining piles and become the primary retaining structure. In addition, for varying bench widths, the slip surface formation differs, and the failure modes of two-bench retained excavations can be divided into three types: integrated failure, interactive failure and disconnected failure.

• 항공우주시스템공학회지
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• 제13권1호
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• pp.1-10
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• 2019

교반기에서의 유동 특성은 광범위한 산업 분야에서 매우 유용하다. 일반적으로 교반되는 용기에서의 유동 패턴, 전력 소비 및 혼합 시간은 임펠러의 설계뿐만 아니라 용기 형상 및 내부 구조에 달려 있다. 본 연구에서는 베플 형상과 임펠러의 상호 작용에 의해 생성되는 불안정하고 비정상상태의 복잡한 유동 특성 분석을 ANSYS FLUENT LES 난류 모델을 사용하여 수행하였다. Axial Flow 와 Radial Flow 두 가지 타입의 회전 임펠러와 3가지 베플의 형상 사이의 상호 작용과 영향을 전산유체역학(CFD)으로 예측 비교함으로써 교반 시 임펠러와 베플 주변에서의 유동 특성과 혼합 유동장에서 상대적으로 효율적인 경향을 보이는 설계 모델을 검증할 수 있었다.