• Title/Summary/Keyword: Internal fit

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Molecular Docking, 3D QSAR and Designing of New Quinazolinone Analogues as DHFR Inhibitors

  • Yamini, L.;Kumari, K. Meena;Vijjulatha, M.
    • Bulletin of the Korean Chemical Society
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    • v.32 no.7
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    • pp.2433-2442
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    • 2011
  • The three dimensional quantitative structure activity relationship (3D QSAR) models were developed using Comparative molecular field analysis (CoMFA), comparative molecular similarity indices analysis (CoMSIA) and docking studies. The fit of Quinazolinone antifolates inside the active site of modeled bovine dihydrofolate reductase (DHFR) was assessed. Both ligand based (LB) and receptor based (RB) QSAR models were generated, these models showed good internal and external statistical reliability that is evident from the $q^2_{loo}$, $r^2_{ncv}$ and $r^2_{pred}$. The identified key features enabled us to design new Quinazolinone analogues as DHFR inhibitors. This study is a building bridge between docking studies of homology modeled bovine DHFR protein as well as ligand and target based 3D QSAR techniques of CoMFA and CoMSIA approaches.

The Development of a Friendship Quality Scale for Elementary School Children (학령기 아동을 위한 친구관계의 질 척도 개발에 관한 연구)

  • Rhee, Un Hai;Koh, Yun Joo
    • Korean Journal of Child Studies
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    • v.20 no.2
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    • pp.225-242
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    • 1999
  • The psychometric properties of a preliminary version of the Friendship Quality Scale(FQS) were examined with data collected from 300 3rd and 5th grade children. Scores on the Self-Perception Scale were obtained to examine convergent validity. The FQS assesses friendship quality in 9 sub-scales, inclusive of 6 friendship functions. Factor analysis confirmed the 9 sudscale structure of the FQS for 5th graders, but 4 friendship functions instead of 6 were a better fit for 3rd graders. Except for one, the sub-scales showed relatively high internal consistency ; Cronbach ${\alpha}$ ranged from .70 to .93. Convergent validity was indicated by correlations between self-perception and sex differences in friendship functions. Friendship functions and satisfaction were related to self-perceptions in social acceptance, behavior, and global self-worth. Girls reported higher friendship functions and satisfaction in friendship than boys.

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A Study on Enterprise CRM Strategy from Valued Customers (소비자 관점에서의 기업 CRM활동 평가와 향후 개선방향에 관한 연구)

  • Suh Chang Juck;Pang Hye-Kyung
    • Proceedings of the Korean Society for Quality Management Conference
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    • 2004.04a
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    • pp.576-582
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    • 2004
  • This research addresses the customers' reaction on enterprise CRM(customer relationship management) activities. Most of companies adopt CRM solution expecting revenue generation through customers' repurchasing, while customers accept to provide their personal information expecting some benefit from companies. Previous studies pointed out that many commercial organizations had difficulties yet to meet their goal of CRM due to lack of internal strategies. Moreover, the researches were focused only on companys' point of view. However, this paper finds the reason why companies' expectation does not fit and suggests the way to reduce mutual gap of expectation for successful CRM.

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Reliability and Validity of Korean-Translated Mathematics Teaching Efficacy Beliefs Inventory (수학 교수 효능감 도구 MTEBI 한글판의 신뢰도와 타당도)

  • Ryaug, Do-Hyoung
    • The Mathematical Education
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    • v.46 no.3
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    • pp.263-272
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    • 2007
  • Mathematics Teaching Efficacy Beliefs Inventory (MTEBI) was translated into Korean and conducted among Korean pre-service mathematics teachers. The Korean-translated MTEBI consists of two subscales with 16 items. Personal Mathematics Teaching Efficacy (PMTE) subscale has 10 items and Mathematics Teaching Outcome Expectancy (MTOE) subscale has 6 items. The purpose of this study is to investigate the internal reliability and the construct validity of the Korean-translated MTEBI. The Cronbach alpha coefficient of Korean-translated MTEBI and its two subscales are respectively .87, .83, and .74 which imply that the instrument is reliable. The construct validity was achieved by performing factor analysis. Principal component solution with varimax rotation for the Korean-translated MTEBI was used in factor analysis and thus the best fit simple structure was obtained by two factors which correspond to the self-efficacy dimension and the outcome expectancy dimension of Bandura's self-efficacy theory.

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The Relationships among E-commerce, BSC, Inter-organizational Information Flow and Supply-Chain Performance (전자상거래, 균형성과표, 조직간 정보교류와 공급망 성과 간의 관계 연구)

  • Choe, Jong-Min
    • Korean Management Science Review
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    • v.30 no.1
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    • pp.149-165
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    • 2013
  • This study empirically investigated the changes of performance evaluation systems under the environment of supply-chain e-commerce. The objectives of e-commerce include obtaining financial profit, internal innovation through processes integration, learning with information flow, and customer satisfaction through quick response. These objectives are generally consistent with the four evaluation measures of balanced scorecard(BSC). This study, first, demonstrated that perceived environmental uncertainty(PEU) has a significant effect on the adoptions of e-commerce and BSC, and severe competition positively influences the use of e-commerce. With cluster analysis and subgroup analysis, we also showed that under the high adoption levels of e-commerce, the high utilization of BSC can improve the supply-chain performance of a firm. In addition, it was found that the use of e-commerce indirectly and significantly affects supply-chain performance through inter-organizational information flow, and the supply-chain performance of a firm leads to the improvement of organizational performance.

Transient Response Improvement of Multiple Model/Controller IMC Using Recurrent Neural Networks (재귀신경망을 이용한 다중모델/제어기 IMC의 과도 응답 개선)

  • O, Won-Geun;Jo, Seong-Eon;So, Ji-Yeong
    • Journal of Institute of Control, Robotics and Systems
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    • v.7 no.7
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    • pp.582-588
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    • 2001
  • The Multiple Model/Controller IMC(MMC-IMC) is a model-based control method which uses a set of model/controller pairs rather than a single model/controller to handle all possible operating conditions in the IMC control structure. During operation, one model/controller pair that best fit, for current plant situation is chosen by the switching algorithm. The major drawback of the switching controller is the bad transient performance due to the model error and the use fo linear controller for nonlinear plants. In this paper, we propose a method that transient response of the MMC-IMC using two recurrent neural networks. Simulation result shows that the proposed method represents better performance than the usual MMC-IMC`s.

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Parenting Stress Scale for Parents of School-Aged Children (학동기 자녀를 둔 부모의 양육스트레스 척도 개발)

  • 강희경
    • Journal of Families and Better Life
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    • v.21 no.2
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    • pp.31-38
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    • 2003
  • This study was conducted to develop a Parenting Stress Scale that measures the day-to-day difficulties entailed in parenting for school-aged children. First, sixty seven items were collected as a baseline. Some of these items were pooled from existing parenting stress scales(Abidin, 1990; Kim & Kang, 1997), and the rest were generated based on interviews with parents of school-aged children. Secondly, Chi-Square tests were conducted and framer's V coefficients were calculated to determine the goodness-of-fit of the items. Twenty four items were selected from this step. The results of a factor analysis on these 24 items revealed two dimensions of this new Parenting Stress Scale, namely, 'school-related parenting stress' and 'general everyday life stress'. A test of construct validity also showed that this scale has adequate internal consistency.

A Study on Controlling the Effects of the Internal Explosion of the Explosive Disposal Structure (폭발물 처리 구조물의 내부폭발 영향 제어에 관한 연구)

  • 강영철;최정욱
    • Journal of the Korea Institute of Military Science and Technology
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    • v.3 no.2
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    • pp.204-212
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    • 2000
  • The waste ammunitions have been accumulated in excessive amounts these days. This study focused on the problems related to the method of ammunition disposal which leads the explosion inside the enclosure structure and controls the effects of detonation. This study enables us to design a new type of explosive disposal facilities that would fit to our environments. And this study gives us the prototype design of the explosive disposal structure that are explored in this research and will give us a chance to develop a new type structure that have not been devised by Army, and also will be applicable to construct a civilian explosive disposal structure located in airports, harbors, and public facilities.

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Change of the Old City by the Modernization

  • Nakagawa, Osamu
    • Journal of East-Asian Urban History
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    • v.1
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    • pp.25-54
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    • 2019
  • Kyoto, which was Japan's political and cultural capital for more than a millennium before the dawn of the modern era, shows distinctive characteristics formed in the process of urban modernization. A citizen plaza perfectly fit to a modern city is lying on the east side, but a delayed urban reconstruction in the city center due to a strong conservative self-government awareness, as well as a delayed modernization of tax system, caused disorderly urban sprawl to appear in the suburbs. Thanks to the enactment of urban planning law enacted in 1919 by the government (Ministry of Internal Affairs) and an increasing awareness about the necessity and rationality of urban planning projects, urban renovation took place at a rapid pace. In the meantime, new ways of urban design were sought for and experimented to conserve it as a historical city against the city' quickly changing landscape.

A Study on the Factors Affecting the Coping Behavior of the Unemployed (실직자의 대처행동에 영향을 미치는 요인에 관한 연구)

  • Kim, Young-Jae;Kim, Jong-Wan;Kim, Se-Hwan
    • Journal of Industrial Convergence
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    • v.6 no.1
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    • pp.17-33
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    • 2008
  • The purpose of this study is to examine what sort of causes have the effect on the coping behavior of the unemployed against their job loss. For the purpose of the study, following independent variables have been selected, locus of control, self-efficacy and autotelic personality. As dependent variables, two types of coping behaviors of individual have been used, problem-focused coping strategies and symptom-focused coping strategies. To test the hypotheses, structural equation modeling was employed. The model showed adequate fit to the data. The results of structural equation modeling exhibit that internal locus of control, self-efficacy and autotelic personality were positively related problem-focused coping strategies. And self-efficacy was negatively related to symptom-focused coping strategies. Implications are discussed and future research directions are outlined.

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