• BMB Reports
• /
• 제52권3호
• /
• pp.202-207
• /
• 2019

Keloids are the most common pathological form of trauma healing, with features that seriously affect appearance and body function, are difficult to treat and have a high recurrence rate. Emerging evidence suggests that miRNAs are involved in a variety of pathological processes and play an important role in the process of fibrosis. In this study, we investigated the function and regulatory network of miR-152-5p in keloids. The miRNA miR-152-5p is frequently downregulated in keloid tissue and primary cells compared to normal skin tissue and fibroblasts. In addition, the downregulation of miR-152-5p is significantly associated with the proliferation, migration and apoptosis of keloid cells. Overexpression of miR-152-5p significantly inhibits the progression of fibrosis in keloids. Smad3 is a direct target of miR-152-5p, and knockdown of Smad3 also inhibits fibrosis progression, consistent with the overexpression of miR-152-5p. The interaction between miR-152-5p and Smad3 occurs through the Erk1/2 and Akt pathways and regulates collagen3 production. In summary, our study demonstrates that miR-152-5p/Smad3 regulatory pathways involved in fibrotic progression may be a potential therapeutic target of keloids.

• International Journal of Computer Science & Network Security
• /
• 제21권9호
• /
• pp.267-274
• /
• 2021

The article deals with problems of innovation development on a network basis, which require effective mechanisms of innovation communications. In research the organizational aspects of ICT infrastructure development for innovation networks sustainable development based on cooperative marketing principles is considered. The proposed research idea is based on the idea that ICT implementation is based not only on the operational approach for innovation management as a factor of efficiency of internal communications, but also on knowledge economy and post-industrial economy trends. Therefore, the purpose of study is to develop an ICT model of innovation infrastructure to improve its effectiveness (strategic character) and efficiency (operative character) through increasing the efficiency of network communication interactions. Creation of information space and communication tools to support innovation network sustainable development and cooperation activities in research is proposed to be solved with the help of specialized ICT platform. It is shown, that ICT platform of innovation cooperation innovation network is important tool for common work of participants. ICT platform is considered as an integrated information system designed to automate business processes related to the sustainable development of innovation network, segment management and integration with HEI information systems and industrial cooperation. The main factors that determine the need to use a special ICT platform for innovation network cooperation were considered. The main issues of concurrent engineering (C-technology) application in high-technology industries and innovation cooperation for integrated product development were studied.

• BMB Reports
• /
• 제54권9호
• /
• pp.464-469
• /
• 2021

Cardiomyocyte differentiation occurs through complex and finely regulated processes including cardiac lineage commitment and maturation from pluripotent stem cells (PSCs). To gain some insight into the genome-wide characteristics of cardiac lineage commitment, we performed transcriptome analysis on both mouse embryonic stem cells (mESCs) and human induced PSCs (hiPSCs) at specific stages of cardiomyocyte differentiation. Specifically, the gene expression profiles and the protein-protein interaction networks of the mESC-derived platelet-derived growth factor receptor-alpha (PDGFRα)⁺ cardiac lineage-committed cells (CLCs) and hiPSC-derived kinase insert domain receptor (KDR)⁺ and PDGFRα⁺ cardiac progenitor cells (CPCs) at cardiac lineage commitment were compared with those of mesodermal cells and differentiated cardiomyocytes. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway analyses revealed that the genes significantly upregulated at cardiac lineage commitment were associated with responses to organic substances and external stimuli, extracellular and myocardial contractile components, receptor binding, gated channel activity, PI3K-AKT signaling, and cardiac hypertrophy and dilation pathways. Protein-protein interaction network analysis revealed that the expression levels of genes that regulate cardiac maturation, heart contraction, and calcium handling showed a consistent increase during cardiac differentiation; however, the expression levels of genes that regulate cell differentiation and multicellular organism development decreased at the cardiac maturation stage following lineage commitment. Additionally, we identified for the first time the protein-protein interaction network connecting cardiac development, the immune system, and metabolism during cardiac lineage commitment in both mESC-derived PDGFRα⁺ CLCs and hiPSC-derived KDR⁺PDGFRα⁺ CPCs. These findings shed light on the regulation of cardiac lineage commitment and the pathogenesis of cardiometabolic diseases.

• 대기
• /
• 제32권4호
• /
• pp.381-394
• /
• 2022

The Korea Meteorological Administration (KMA) National Typhoon Center has been officially releasing reanalyzed best tracks for the previous year's northwest Pacific typhoons since 2015. However, while most typhoon researchers are aware of the data released by other institutions, such as the Joint Typhoon Warning Center (JTWC) and the Regional Specialized Meteorological Center (RSMC) Tokyo, they are often unfamiliar with the KMA products. In this technical note, we describe the best track data released by KMA, and the algorithms that are used to generate it. We hope that this will increase the usefulness of the data to typhoon researchers, and help raise awareness of the product. The best track reanalysis process is initiated when the necessary database of observations-which includes satellite, synoptic, ocean, and radar observations-has become complete for the required year. Three categories of best track information-position (track), intensity (maximum sustained winds and central pressure), and size (radii of high-wind areas)-are estimated based on scientific processes. These estimates are then examined by typhoon forecasters and other internal and external experts, and issued as an official product when final approval has been given.

• Korean Journal of Chemical Engineering
• /
• 제35권11호
• /
• pp.2256-2268
• /
• 2018

Hydrophilic and hydrophobic polyethersulfone (PES)-zinc oxide (ZnO) sublayers were prepared by loading of ZnO nanoparticles into PES matrix. Both porosity and hydrophilicity of the hydrophilic sublayer were increased upon addition of hydrophilic ZnO, while these were decreased for the hydrophobic sublayer. In addition, the results demonstrated that the hydrophilic membrane exhibited smaller structural parameter (S value or S parameter or S), which is beneficial for improving pure water permeability and decreasing mass transfer resistance. In contrast, a higher S parameter was obtained for the hydrophobic membrane. With a 2 M NaCl as DS and DI water as FS, the pure water flux of hydrophilic TFN0.5 membrane was increased from $21.02L/m^2h$ to $30.06L/m^2h$ and decreased for hydrophobic TFN0.5 membrane to $14.98L/m^2h$, while the salt flux of hydrophilic membrane increased from $10.12g/m^2h$ to $17.31g/m^2h$ and decreased for hydrophobic TFN0.5 membrane to $3.12g/m^2h$. The increment in pure water permeability can be ascribed to reduction in S parameter, which resulted in reduced internal concentration polarization (ICP). The current study provides a feasible and low cost procedure to decrease the ICP in FO processes.

• 한국문헌정보학회지
• /
• 제55권1호
• /
• pp.343-364
• /
• 2021

본 연구에서는 현재 클라우드 기반 도서관 시스템을 사용하고 있는 국내 도서관들을 사례로 각 시스템의 도입, 전환, 그리고 운영의 과정으로 구분된 사용경험에 나타난 주요 특성과 현안을 조사하였으며, 그 결과는 다음과 같다. 첫째, 새로운 시스템들은 기존 시스템의 운영에 따른 문제의 대안으로 도입하게 되었으며, 비용 효율적인 이유로 현재의 제품을 선정하였다고 한다. 둘째, 전환과정의 주요 현안은 데이터의 전환작업, 기존 서비스 기능의 구현, 도서관 내외부 시스템의 연동문제 등이었다. 셋째, 운영과정에서 파악된 주요 장점은 비용절감, 간편한 설치와 자동적인 관리 및 유지보수, 그리고 모바일 기기들에서의 편리한 사용이었다. 주요 단점은 도서관 특성을 반영한 맞춤화의 어려움, 네트워크의 안정성 요구였다. 정보기술 담당사서의 없어진 역할은 시스템 정기점검 및 유지보수 지원 업무이며, 새롭게 생긴 역할은 다양하게 제시되었다. 도입 시스템에 대한 사서와 이용자의 반응은 대체로 불만보다는 만족한다는 의견이었다.

• Journal of Astronomy and Space Sciences
• /
• 제39권2호
• /
• pp.67-77
• /
• 2022

The elements that impact the dynamics and collaborations of waves and particles in the magnetosphere of planets have been considered here. Saturn's internal magnetosphere is determined by substantiated instabilities and discovered to be an exceptional zone of wave activity. Interchanged instability is found to be one of the responsible events in view of temperature anisotropy and energization processes of magnetospheric species. The generated active ions alongside electrons that constitute the populations of highly magnetized planets like Saturn's ring electron current are taken into consideration in the current framework. The previous and similar method of characteristics and the perturbed distribution function have been used to derive dispersion relation. In incorporating this investigation, the characteristics of electromagnetic ion cyclotron wave (EMIC) waves are determined by the composition of ions in plasmas through which the waves propagate. The effect of ring distribution illustrates non-monotonous description on growth rate (GR) depending upon plasma parameters picked out. Observations made by Cassini found appropriate for modern study, have been applied to the Kronian magnetosphere. Using Maxwellian ring distribution function of ions and detailed mathematical formulation, an expression for dispersion relation as well as GR and real frequency (RF) are evaluated. Analysis of plasma parameters shows that, proliferating EMIC waves are not developed much when propagation is parallelly aligned with magnetosphere as compared to waves propagating in oblique direction. GR for the oblique case, is influenced by temperature anisotropy as well as by alternating current (AC) frequency, whereas it is much affected only by AC frequency for parallel propagating waves.

• Nuclear Engineering and Technology
• /
• 제54권2호
• /
• pp.514-522
• /
• 2022

Non-destructive testing (NDT) technology is a widely used inspection method for agricultural products. Compared with the conventional inspection method, there is no extensive sample preparation for NDT technology, and the sample is not damaged. In particular, NDT technology is used to inspect the internal structure of agricultural products infested by pests. The introduction and spread of pests during the import and export process can cause significant damage to the agricultural environment. Until now, pest detection in agricultural products and quarantine processes have been challenging because they used external inspection methods. However, NDT technology is advantageous in these inspection situations. In this pilot study, we investigated the feasibility of X-ray computed tomography (X-ray CT) and magnetic resonance imaging (MRI) to identify pest infestation in agricultural products. Three kinds of artificially pest-infested fruits (mango, tangerine, and chestnut) were non-destructively inspected using X-ray CT and MRI. X-ray CT was able to identify all pest infestations in fruits, while MRI could not detect the pest-infested chestnut. In addition, X-ray CT was superior to the quarantine process than MRI based on the contrast-to-noise ratio (CNR), image acquisition time, and cost. Therefore, X-ray CT is more appropriate for the pest quarantine process of fruits than MRI.

• 한국산업융합학회 논문집
• /
• 제24권6_2호
• /
• pp.773-779
• /
• 2021

CNG, which has recently been attracting attention as an alternative fuel in the transportation field to reduce emissions caused by global warming, is natural gas with abundant reserves and mainly composed of methane. Being in a gaseous state, natural gas requires the compression and liquefaction processes for transportation. Until now, general shut-off valves for liquid and gas piping have been developed in Korea, but there are few studies on shut-off valves for high pressures of about 200 bar. Currently, research on the flow analysis of valves is being actively conducted around the world. However, there are relatively many studies on large valves such as low-pressure valves or shipbuilding and marine, and the safety factor through structural analysis to check the structural integrity of the valve is checked at the design stage. Since it is necessary to have a fast response speed while minimizing pressure and speed loss due to flow change, basic research was conducted on the flow analysis of the valve to secure design data, and the numerical analysis was performed on high-pressure automatic shut-off valves applied to CNG refueling stations. After securing the basic valve shape through reverse engineering for advanced products, we compared the valve flow coefficient Cv coefficient with advanced products. As a result, it was found that the reverse engineering model was at the level of about 60%. However, we compared the Cv coefficient by modifying the reverse engineering model, and the result showed that it was improved to about 96%.

• International Journal of Computer Science & Network Security
• /
• 제22권6호
• /
• pp.25-32
• /
• 2022

The hypothesis of the study of the article is that the use of elements of artificial intelligence will increase the effectiveness of the educational process of the university if: a set of pedagogical conditions for the construction and use of an expert system with elements of artificial intelligence in the educational process of the university is revealed; a model for preparing a future teacher of vocational training for the use of elements of artificial intelligence has been developed; a special course has been developed that contributes to the implementation of the professional orientation of education. In accordance with this, the following tasks were studied in the article: An analysis of scientific and methodological research in the field of the current state, prospects for the development and use of elements of artificial intelligence in the preparation of a future teacher of vocational training and to determine the dynamics of the introduction of intelligent expert systems in education; A set of pedagogical conditions for the construction and use of an expert system with elements of artificial intelligence in the educational process of a university is revealed; It is substantiated to develop a model for preparing a teacher of vocational training to use elements of artificial intelligence.