• Asian-Australasian Journal of Animal Sciences
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• 제5권2호
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• pp.369-374
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• 1992

In order to determine the effect of dietary cellulose levels on chick performance, 1-week-old White Leghorn male chicks were fed semi-purified diets containing either 5%, 10%, 15% or 20% cellulose for 3 weeks. All diets were iso-nitrogenous and iso-caloric. Feed intake and body weight were increased as the cellulose level was increased. Feed conversion was lower in the 5% cellulose diet than in the other diets. Compared to the case of 10% to 20% cellulose diets, relative length (per 100 g body weight) of esophagus, duodenum, small intestine and cecum was longer, and relative weight of esophagus, duodenum and crop was also heavier in the chicks fed the 5% cellulose diet. The other internal organs were not affected by the cellulose level. The retention rates of dry matter and nitrogen were lower in the 5% cellulose group than in the other groups. Concentration of carcass phospholipids was higher in the 5% cellulose group, and that of carcass cholesterol was increased as the cellulose level increased. In conclusion, the dietary cellulose level should be more than 5% to give an adequate chick performance, and no ill effect was found even at 20% level.

• 한국전자파학회논문지
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• 제25권1호
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• pp.62-69
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• 2014

본 논문에서는 WBAN(Wireless Body Area Network) On-body 시스템에서 표면 지향 안테나를 사용하여 인체 내부 기관에 의한 영향을 분석하였다. 인체 내부 기관의 영향을 확인하기 위하여 인체 상반신 모델과 실제 인체에 안테나를 부착하여 수신 신호의 세기를 측정하였다. 실험은 인체에 대한 고유 영향을 보기 위하여 무반향실에서 움직임 없이 수행하였고, VNA(Vector Network Analyzer)를 이용하여 수신 신호 세기를 측정하였다. 측정된 데이터를 이용하여 인체 모델과 상반신 모델의 수신 신호 세기를 비교하였고, 인체 내부 기관이 안테나 수신 신호 세기에 미치는 효과를 분석하였다.

• 한국패류학회지
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• 제23권2호
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• pp.173-180
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• 2007

Health state of the Japanese scallop, Mizuhopecten yessoensis, cultured in the Experimental Marine Farm in Minonosok Bay (Peter the Great Bay, Sea of Japan) was investigated. The wide spectrum of histopathological changes has been identified in the internal organs and tissues of scallops: prokaryotic infection with prevalence 100%, destruction of digestive epithelium and other changes in digestive system, infiltration of organs by hemocytes and granulocytome formation. The most affected by prokaryotic infection organs are labial palps, lips, esophagus, intestine and gills. Several of the observed alterations seem to be related to prokaryotic infection.

• 혜화의학회지
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• 제17권2호
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• pp.155-160
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• 2008

Pelvic inflammatory disease (PID) is a general term that refers to infection of the internal reproductive organs such as the female uterus, fallopian tubes, and ovaries. PID is caused by germs that invade the genital organs, causing the acute inflammatory reaction, and chronic PID is to have a recurrence of PID because of the lack of effective treatment of acute PID. Symptoms of PID include pelvic pain, fever, leukorrhea, infertility, and fatigue. Treatments for PID can be improved by combining herb medicine therapy, intestinal irrigation, or the therapy that put herb medicine on the abdominal region with antibiotics, or analgesic drugs.

• 대한한방내과학회지
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• 제31권3호
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• pp.539-553
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• 2010

Objectives : The object of this study was to obtain accurate information (single oral dose toxicity) of Lonicerae Flos (LF; Dried flower bud parts of Lonicera japonica Thunb (Caprifoliaceae)), which has traditionally been used in Korean medicine for treating various inflammatory diseases. Methods : In order to observe the 50% lethal dose (LD 50), approximate lethal dosage (ALD) and target organs, test articles were once orally administered to female and male ICR mice at dose levels of 2,000, 1,000, 500 and 0 (control) mg/kg (body weight.). The mortality and changes on body weight, clinical signs and gross observation were monitored for 14 days after single oral treatment of LF aqueous extracts with organ weights and histopathological observations of 12 types of principle organs. Results : 1. After single oral treatment of LF aqueous extracts, we could not find any mortality and toxicological evidences up to 2,000 mg/kg treated group, the limited dosages in rodents at body and organ weights, clinical signs, gross and histopathological observations. 2. Slight diarrhea was detected in most mice treated with 2,000 mg/kg of LF aqueous extracts and male mice of LF aqueous extracts 1,000 mg/kg within 2 days after end of treatment, respectively. Conclusion : The results obtained in this study suggest that the LD 50 and ALD of LF aqueous extracts in both female and male mice after single oral treatment were considered as over 2,000 mg/kg because no mortalities were detected up to 2000 mg/kg, the highest dose recommended by KFDA and OECD. However, we also observed the possibility of digestive disorders like diarrhea when over 1,000 mg/kg of LF aqueous extracts were administered in the present study.

• 대한한방내과학회지
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• 제34권1호
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• pp.46-58
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• 2013

Objectives : The object of this study was to obtain acute information (single oral dose toxicity) of Scutellariae Radix Aqueous Extracts (SR; yield = 27.20%) which traditionally have been used in Korean medicine for treating various diseases including inflammatory diseases. Methods : In order to observe the 50% lethal dose ($LD_{50}$), approximate lethal dosage (ALD) and target organs, SR Aqueous Extracts were once orally administered to female and male ICR mice at dose levels of 2,000, 1,000, 500 and 0 (control) mg/kg (body weight.) according to the recommendation of KFDA Guidelines. The mortality and changes on body weight, clinical signs and gross observation were monitored during 14 days after single oral treatment of SR according to KFDA Guidelines with organ weights and histopathological observations of 14 types of principle organs. Results : After single oral treatment of SR, we could not find any mortality and toxicological evidences up to 2,000 mg/kg treated group, the limited dosages in rodents, on the body and organ weights, clinical signs, gross and histopathological observations, except for some accidental findings. Conclusions : The results obtained in this study suggest that the $LD_{50}$ and ALD of SR in both female and male mice after single oral treatment be considered as over 2,000 mg/kg because no mortalities were detected up to 2,000 mg/kg that was the highest dose recommended by KFDA and OECD, and can be safely used in clinics.

• 대한한의학회지
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• 제20권1호
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• pp.172-184
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• 1999

This study was aimed to evaluate the anti-stress effect of Kungchihwadamjeun on the body weight. organs weight, S- GOT. S-GPT. lipid peroxidase in organs and contents of cathecholamine in brain of rats stressed by immobilization. The main results obtained were summarized as follow 1. The body weights increased in the group treated with Kungchihwadamjeun of rats stressed by immobilization compared with in the group treated with non Kungchihwadamjeun. 2. The weight of the spleen. kidney. pancreas, thymus and heart increased in the group treated with Kungchihwadamjeun of rats stressed by immobilization compared with in the group treated with non Kungchihwadamjeun. 3. The contents of serum GOT GPT decreased in the group treated with Kungchihwadamjeun of rats stressed by immobilization compared with in the group treated with non Kungchihwadamjeun 4. The lipid peroxidase in liver decreased in the group treated with Kungchihwadamjeun of rats stressed by immobilization compared with in the group treated with non Kungchihwadamjeun. 5. The contents of norepinephrine and serotonine in brain decreased in the group treated with Kungchihwadamjeun of rats stressed by immobilization compared with in the group treated with non Kungchihwadamjeun, but epinephrine and dopamine in brain increased. According to the above results, this experiments concluded that Kungchihwadamjeun had significant effects in reducing stress.

• 대한본초학회지
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• 제21권4호
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• pp.213-218
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• 2006

Objectives : Radix Bupleuri is from the dried root of the herb of the Perennial herbaceous plant, Bulpleurum falcatum L. or Bulpleurum chinense DC. or Bulpleurum. scorzonerifolium Willd., family Umbelliferae. Medicinal Properties are bitter and pungent in flavor, slightly cold in nature and attributed to the liver and gallbladder meridians. Actions in modern Materia Medica are regulate the functional relation of internal organs to relieve fever, disperse the stagnated liver-qi and uplift yang-qi to raise sinking. The ‘uplift yang-qi to raise sinking’ efficacy, out of three efficacies (regulate the functional relation of internal organs to relieve fever, disperse the stagnated liver-qi and uplift yang-qi to raise sinking), has been disputed in the medical profession for a long period. Hereupon, this study ascertained the reason why it has been disputed. Methods : With respect to this medicinal herb, the efficacies of regulate the functional relation of internal organs to relieve fever, disperse the stagnated liver-qi and uplift yang-qi to raise sinking were described as to what was written in ‘Shen Nong's Herbal’ from Chin and Han dynasties until Jin and Yuan dynasties. Results : The beginning of Jin and Yuan dynasties, it began to deal with the ‘uplift yang-qi to raise sinking’ efficacy and so it has been carried on modern textbooks and medical books. The reason why it was added is that it was influenced by the theory of ‘Raise Sinking’ advocated by Zhang jieku who lived in the period of Jin and Yuan dynasties. Since then, the properties of ‘Radix Bupleuri’ have been wrongly known to the public. Additionally, ‘Radix Stellariae Seu Gypsophilae’, which was begun to be introduced from the Four Cities since the Five Dynasties, has been combined with the best stuffs of ‘Radix Bupleuri’ produced from Yin Zhou. Consequently, its original properties were remarkably disordered. Likewise, respective medical schools’ theories were changed by the influence of ‘Bulpleurum. scorzonerifolium Willd’ begun to be used since Tang dynasty. Conclusion : it is considered that the current ‘Raise Sinking’ efficacy of Radix Bupleuri is unreasonable to be applied to the efficacy of the whole Radix Bupleuri because it is limited to certain species.

• 한국수산과학회지
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• 제19권6호
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• pp.521-528
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• 1986

고등어와 정어리의 각 장기조직에 분포하는 단백질분해효소의 최적활성조건을 분석${\cdot}$비교하고, 열안정성과 저온저장중의 활성의 변화 등을 검토한 결과를 요약하면 다음과 같다. 1. 고등어와 정어리의 각 장기에서 단백질분해효소를 추출하여 pH에 따른 단백질분해능을 분석한 결과, 소화관, 췌장, 유문수 및 비장은 알칼리성에서, 위는 산성에서, 그리고 간은 산성, 중성 및 알칼리성의 세 영역에서 각각 단백질분해능이 있음을 알았다. 그리고, 소화기관인 위, 췌장, 및 유문수에서 추출한 조효소는 활성이 높았으나, 간 및 비장에서 추출한 조효소는 활성이 아주 낮았다. 2. 각 장기에서 추출한 단백질분해효소의 열안정성을 분석한 결과, 두 어종의 위와 유문수 및 정어리의 췌장에서 추출한 효소의 내열성이 가장 약했으며, 비장과 간에서 추출한 중성단백질분해효소는 내열성이 강한 것으로 판단되었다. 3. 각 장기에서 추출한 조효소의 저장성을 검토한 결과. $5^{\circ}C$ 저장시 두 어종의 유문수와 고등어의 췌장${\cdot}$위 및 비장에서 추출한 효소는 안정성이 높았으며, 그 이외의 조직에서 추出한 효소는 저장 28일까지 많은 실활이 일어났다. 또한 방부제 sodium azide에 의한 영향은 어종과 조직에 따라 미미한 차이를 보였으며, $-15^{\circ}C$에서 저장한 경우가 $5^{\circ}C$에 저장한 경우보다 효소의 실활이 더욱 컸다.

• 한국식품과학회지
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• 제33권1호
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• pp.89-93
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• 2001

본 연구는 울릉도를 비롯한 오징어 산지에서 소규모로 제조 식용되고 있는 오징어된장의 품질 특성을 조사하였다. 재래된장과 오징어된장(I, II, III)의 수분함량, 염도, 아미노태 질소 함량은 유사한 수준이었으나, pH 및 과산화물가는 오징어된장에서 높았고, 색상에서도 차이를 보였다. 오징어된장은 taurine 함량이 $53.26{\sim}170.90\;mg%$로 특이적으로 높았으며, ${\alpha}-aminobutyric$ acid 함량도 $35.17{\sim}151.00\;mg%$로 높아 재래된장과는 구별되었다. 이밖에 구수한 맛을 나타내는 aspartic acid, glutamic acid 및 단맛성분인 threonine, serine, proline의 함량도 오징어된장에서 다소 높았으며, 쓴맛에 관여하는 isoleucine, leucine의 함량은 재래된장과 오징어된장 간에 큰 차이가 없었다. 한편 오징어된장의 휘발성 성분은 ethylbutylether와 같은 에스테르류 및 2-propenal, 3-methylbutanal 등 알데히드류의 비율이 전반적으로 높고 알콜류의 비율은 상대적으로 낮은 경향이었으며, 특히 ethylbutylether, 2-propeanl, 3-methyl1-butanal, 2,6,10,14-tetramethyl-pentadecane, ethyllinoleate 등이 특이적으로 확인되었다. 저장 4주후 맛에 대한 기호도는 오징어내장을 10% 첨가한 오징어된장(II)에서 가장 높았으며 오징어된장(I)과 유의적인 차이가 있었다. 저장 8주후 오징어된장(I, II)의 경우 맛에 대한 기호도는 비교적 높은 점수를 나타내었으나, 향과 색에 대한 기호도는 재래된장에 비해 크게 감소하는 것으로 나타났다.