• Genomics & Informatics
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• 제5권2호
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• pp.68-76
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• 2007

Due to the increasing interest in SNPs and mutational hot spots for disease traits, it is becoming more important to define and understand the relationship between SNPs and their flanking sequences. To study the effects of flanking sequences on SNPs, statistical approaches are necessary to assess bias in SNP data. In this study we mainly applied Markov chains for SNP sequences, particularly those located in intronic regions, and for analysis of in-del data. All of the pertaining sequences showed a significant tendency to generate particular SNP types. Most sequences flanking SNPs had lower complexities than average sequences, and some of them were associated with microsatellites. Moreover, many Alu repeats were found in the flanking sequences. We observed an elevated frequency of single-base-pair repeat-like sequences, mirror repeats, and palindromes in the SNP flanking sequence data. Alu repeats are hypothesized to be associated with C-to-T transition mutations or A-to-I RNA editing. In particular, the in-del data revealed an association between particular changes such as palindromes or mirror repeats. Results indicate that the mechanism of induction of in-del transitions is probably very different from that which is responsible for other SNPs. From a statistical perspective, frequent DNA lesions in some regions probably have effects on the occurrence of SNPs.

• World Technopolis Review
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• 제6권1호
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• pp.2.1-2.9
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• 2017

Humanity is experiencing a very fast-paced technological evolution. As technological systems evolve exponentially, societies are becoming more global and are starting to have impacts beyond their geographic demarcations. This implies that, the actions of a person who is across the ocean from where we live could have significant impacts on our everyday lives. This article explores the complexity of globalization, identifies a number of global issues, and looks at the University and the Science and Technology Parks as potential sources of human capital to tackle current and forthcoming global challenges, ranging from new energy sources to potable water distributions. The article focuses on current efforts that are taking place across universities and science and technology parks around the world. We propose a new methodology whereby interdisciplinary work can inform the development of multidisciplinary approaches to solve some of the most complex global issues such as cyber security and educating the next generations of global leaders, providing them them with the necessary skills to be successful in a globally distributed workforce.

• Journal of Interdisciplinary Genomics
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• 제3권2호
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• pp.41-46
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• 2021

Inherited platelet function disorders (IPFDs) are a disease group of heterogeneous bleeding disorders associated with congenital defects of platelet functions. Normal platelets essential role for primary hemostasis by adhesion, activation, secretion of granules, aggregation, and procoagulant activity of platelets. The accurate diagnosis of IPFDs is challenging due to unavailability of important testing methods, including light transmission aggregometry and flow cytometry, in several medical centers in Korea. Among several IPFDs, Glanzmann thrombasthenia (GT) is a most representative IPFD and is relatively frequently found compare to the other types of rarer IPFDs. GT is an autosomal recessive disorder caused by mutations of ITGA2B or ITGB3. There are quantitative or qualitative defects of the GPIIb/IIIa complex in platelet, which is the binding receptor for fibrinogen, von Willbrand factor, and fibronectin in GT patients. Therefore, patients with GT have normal platelet count and normal platelet morphology, but they have severely decreased platelet aggregation. Thus, GT patients have a very severe hemorrhagic phenotypes that begins at a very early age and persists throughout life. In this article, the general contents about platelet functions and respective IPFDs, the overall contents of GT, and the current status of genetic diagnosis of GT in Korea will be reviewed.

• 대한한의학회지
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• 제33권1호
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• pp.90-106
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• 2012

Objectives: Eight constitution medicine (ECM), which was first introduced in 1965, has been further developed and refined over the decades, and has consolidated its foundation through many studies on theories, diagnosis and clinical application. However, there have been few reviews on dissertations of ECM. In this study, we reviewed previously published studies related to ECM. Methods: We reviewed a total of 55 ECM-related studies published from 1965 to 2010 found on PubMed and various domestic Oriental medicine journals. Each thesis was classified as a theoretical, diagnostic, or remedy-related study. Results: 1. In the review of theoretical studies, shortly after ECM's introduction in 1965 by Kwon, the authors found studies on constitutional diseases, diets and food table which helped establish the background of ECM. ECM has further developed by comparing its theories with Sasang constitutional medicine, Huang-di-nei-jing, Saam, and Taegeuk acupuncture theories. 2. Research on diagnosis has been focused on its objectivity and accuracy. Constitution could be diagnosed by pulse-taking. To compensate for the lack of accuracy innate in pulse-taking, the Eight Constitution Questionnaire has been invented. 3. Remedies can be largely divided into acupuncture and diet. There were case studies comparing treatment effect of ECM acupuncture to other treatments. Diet related studies were carried out in the fields of immunology and nutrition. Conclusions: The authors reviewed studies that contributed to improved understanding of theories and clinical implications of ECM. Although there were various approaches to its theoretical and clinical grounds, more clinical research is needed. There is also a need to evaluate the accuracy of the experts' diagnoses of the constitution. The relationship between the diet and constitution also needs further research.

• 대한의용생체공학회:의공학회지
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• 제35권6호
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• pp.203-210
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• 2014

Wearable medical device has been a resurgence of interest thanks to the development of technology and propagation of smart phone in recent years. Various types of wearable devices have been introduced and available in market. Capacitive coupled electrode which measures electrocardiogram over cloth is able to be applied wearable device. In previous approaches of capacitive electrode, they need proper pressure for stable contact of the electrode to body surface. However, wearable device that gives pressure on body surface is not suitable for long-term monitoring. In this study, we proposed adhesive polyurethane-based capacitive electrode for patch-type wearable electrocardiogram (ECG) monitoring device. Self-adhesive polyurethane make the electrode and whole system be adhered to the surface of skin without any pressure. The patch-type system is consisted of analog filter, analog-to-digital converter and wireless transmission module and designed to be attached on the body as a patch. To validate the feasibility of the developed system, we measured ECG signal in stable and active state and extracted heart rate. Therefore, we observed skin response after long-term attachment for biocompatibility of the adhesive polyurethane and adhesive strength of it. The result shows the possibility of applying the developed system for ECG monitoring in real-life.

• Genomics & Informatics
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• 제10권4호
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• pp.256-262
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• 2012

Most common complex traits, such as obesity, hypertension, diabetes, and cancers, are known to be associated with multiple genes, environmental factors, and their epistasis. Recently, the development of advanced genotyping technologies has allowed us to perform genome-wide association studies (GWASs). For detecting the effects of multiple genes on complex traits, many approaches have been proposed for GWASs. Multifactor dimensionality reduction (MDR) is one of the powerful and efficient methods for detecting high-order gene-gene ($G{\times}G$) interactions. However, the biological interpretation of $G{\times}G$ interactions identified by MDR analysis is not easy. In order to aid the interpretation of MDR results, we propose a network graph analysis to elucidate the meaning of identified $G{\times}G$ interactions. The proposed network graph analysis consists of three steps. The first step is for performing $G{\times}G$ interaction analysis using MDR analysis. The second step is to draw the network graph using the MDR result. The third step is to provide biological evidence of the identified $G{\times}G$ interaction using external biological databases. The proposed method was applied to Korean Association Resource (KARE) data, containing 8838 individuals with 327,632 single-nucleotide polymorphisms, in order to perform $G{\times}G$ interaction analysis of body mass index (BMI). Our network graph analysis successfully showed that many identified $G{\times}G$ interactions have known biological evidence related to BMI. We expect that our network graph analysis will be helpful to interpret the biological meaning of $G{\times}G$ interactions.

• 문화기술의 융합
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• 제10권1호
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• pp.325-335
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• 2024

본 연구에서는 패션디자인학과에서 다양한 디자인 전공 학생들의 융합 교육에 따른 SDGs 지속가능한 디자인 교과목 운영 사례를 연구하였다. 문헌 연구를 통해 교과목 운영의 필요성을 살펴보고, 수업설계, 실행, 운영 결과로 교과목을 분석하였다. 지속가능한 디자인 교과목은 2~4학년 학생의 통합 구성으로 패션디자인 및 다양한 디자인 전공 학생이 수강하여 SDGs 과제에 따른 전공 심화와 주제 중심 통합교육에 따른 융합 역량을 강화하였다. 수업에서의 교육내용은 문제 발견과 해결을 통한 디자이너의 지속가능한 가치 추구를 위해 지역업체에서 개발된 폐페트병 섬유의 업싸이클 디자인을 통한 지속가능 발전 목표를 실현하고 다양한 업싸이클 상품 디자인을 개발하고 평가 지표 및 만족도를 평가하였다. 이를 통해 SDGs의 실현 가치를 이해하고 지역문제 해결을 위한 디자인적 접근을 통한 지속가능한 발전 기여와 다양한 디자인 전공과의 융합교육의 중요성을 인식하였다.

• 비교문화연구
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• 제33권
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• pp.143-169
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• 2013

Recently, because of the danger and damages that following the steady development of scientific technologies, natural science is faced with many humane and ethical problems. So it is asserted the interdisciplinary with social and human science. However, it comes commonly that the ethical issues such as world view and one's view of life caused the development of sociology, especially development of the market economy. But in many cases, the interdisciplinary can be useful for widen the view of scholars. The interdisciplinary is actually connected with the problems of philosophy, and located in that domain. In this case, this is noticed as a model to the philosophers in 18th century, especially Denis Diderot. Diderot published De $l^{\prime}interpr{\acute{e}}tation$ de la nature during editing the Encyclopedia, from there he picked out the contents from piles of documents of Encyclopedia. Even though the contents or opinions of De $l^{\prime}interpr{\acute{e}}tation$ de la nature are inaccuracy or erroneous, it shows that how human-social science and natural science encountered. Diderot studied mathematics and then Diderot accepted to the natural science proposal, he approaches philosophy with translate English books to the French. Next he understood natural science by reading Buffon and Maupertuis, and during working for Encyclopedia, he possessed his knowledge that he can claim his opinion to other scholars. However in this De $l^{\prime}interpr{\acute{e}}tation$ de la nature, Diderot who sometimes rebutted other scholars' theory and demonstration, tried to build a philosophy on metaphysics in order to it was important for himself that he imposed the methods of science and importance of experience. Anyhow, this De $l^{\prime}interpr{\acute{e}}tation$ de la nature cause consider the recognition of Diderot in the field of natural science, and is suggested as a model about his Nature. This mean that it is an expression of his philosophy, and the content is found from natural philosophy and empirical philosophy. Like giving these attache the importance of method study for science and technique, these are targeted the promotion of popularization of natural-science and scientific-technology. Also it advocates fulfilling from reasonable philosophy to empirical philosophy. Therefore, the philosophy which was speculative and abstracted became his philosophy which was writing the meaning, as waiting the discovery of science. And at that time, the humanities made interdisciplinary with natural science.

• 의료ㆍ복지 건축 : 한국의료복지건축학회 논문집
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• 제19권1호
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• pp.35-46
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• 2013

Purpose: Health is one of the most important interests in current and future human society. Various efforts, which to maintain and promote their good health conditions, continue to be tried in future urban and architectural environment. The purpose of this study is to establish an integrated framework of research approaches for healthy urban and architectural environment that continuously promotes health according to people's entire life course. Methods: This was done by literature reviews, which is related to interdisciplinary researches for the determinants of health and healthy environment. Results: As a result of this study, an integrated research model, as a methodology, was proposed. This explains the concept of integrated research approaches for urban and architectural environment in the respect of people's health. Integrated health concept includes not only the area of health care environment to have recovery and treatment but also the daily living environment for people who have potential of being ill, and finally the city environment for entire people as health supporting elements including safety and primary prevention. Implications: Under the basis of this model, according to the life course, various researches on sustainable healthy urban and architectural environment should be followed from now on. The model should also be continuously complemented and developed into a standard of healthy environment.

• The Korean Journal of Ecology
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• 제20권1호
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• pp.69-78
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• 1997

The development of stream ecology, especially the progress of that field in North America, has been briefly reviewed, and stream studies in Korea were analyzed through literature survey. During the last two decades, theoretical advances in stream ecology and understanding of the structure and function of stream ecosystem were made from the studies mainly in North America. Early studies (1960-1970) focused on determination of the environmental factors controlling the distribution and abundance of organisms dwelling in streams. Introduction of conceptual development, such as the functional feeding concept, river continuum concept, and nutrient spiraling was notable in the late 70's and the 80's. For last 20 years, experimentation approaches to apply ecological principles were very fruitful in the understanding of community structure. Even though studies on the stream ecosystem is Korea have a long history, most of works were concentrated on limited subjects: water quality, abundance and distribution of aquatic insects and fishes. Basic ecological attributes of stream organi는 and test of ecological principles have rarely been a subject of research topics. We must concentrate our effort to enhance our understanding of stream and river ecosystem through qualitative, experimental and interdisciplinary approaches.