• Biomolecules & Therapeutics
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• v.26 no.5
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• pp.458-463
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• 2018

The phosphorylation of JNK is known to induce insulin resistance in insulin target tissues. The inhibition of JNK-JIP1 interaction, which interferes JNK phosphorylation, becomes a potential target for drug development of type 2 diabetes. To discover the inhibitors of JNK-JIP1 interaction, we screened out 30 candidates from 4320 compound library with In Cell Interaction Trap method. The candidates were further confirmed and narrowed down to five compounds using the FRET method in a model cell. Among those five compounds, Acebutolol showed notable inhibition of JNK phosphorylation and elevation of glucose uptake in diabetic models of adipocyte and liver cell. Structural computation showed that the binding affinity of Acebutolol on the JNK-JIP1 interaction site was comparable to the known inhibitor, BI-78D3. Our results suggest that Acebutolol, an FDA-approved beta blocker for hypertension therapy, could have a new repurposed effect on type 2 diabetes elevating glucose uptake process by inhibiting JNK-JIP1 interaction.

• Journal of Ship and Ocean Technology
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• v.9 no.1
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• pp.11-26
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• 2005

In this study, the program to investigate the multiple body interaction effects between a floating platform and a shuttle tanker considering the coupled effect of hull (FPSO) with mooring lines and risers was developed. The coupled analysis program, which is called WINPOST-MULT using the hydrodynamic analysis results by WAMIT, was made. For the verification of WINPOST-MULT by means of numerical experiments, two multiple-body models of an FPSO-FPSO and an FPSO-shuttle tanker system are adopted. With the FPSO-FPSO model and a two-mass-spring system to idealize two identical bodies for the 100-year storm wave condition in GOM, the numerical simulations were performed to investigate the interaction effects between two identical bodies. For the more reality, the coupled analysis for the FPSO-shuttle tanker model in the tandem arrangement was carried out in the consideration of the environmental condition of the West Africa Sea as a rather mild condition. Through the case studies with interaction effect and without interaction effect by the iteration method and the combined method, it is verified that the program is a very useful tool for the analysis of the interaction problem of multiple-body system and the coupled problem of the hull/mooring/riser.

• International Journal of Naval Architecture and Ocean Engineering
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• v.12 no.1
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• pp.918-927
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• 2020

Flows induced by hybrid CRP pod propulsion systems (CRP-POD) are fundamentally characterized by unsteadiness. This work presents a numerical study on the unsteady flow of a CRP-POD at behind-hull condition based on CFD (Computational Fluid Dynamics). Unsteady RANS method is adopted, coupled with SST k-u turbulence model and sliding mesh method. The propeller thrusts and torques obtained by CFD is validated by model tests and acceptable agreements are obtained. The time histories of shingle-blade loads and pressures near the hull surface are recorded for the analysis of unsteady flow features. The cases of forward propeller alone and aft propeller alone are also computed to distinguish the hull-propeller interaction and propeller-propeller interaction. The results show the blade loads of both forward and aft propellers strongly fluctuate with phase angles. For the forward propeller, the blade load fluctuation is mainly governed by the hull-propeller interaction, while the aft blade load is remarkably affected by the propeller-propeller interaction in terms of the load average and fluctuation pattern. The fields of pressure, vorticity and velocity are also analyzed to reveal the unsteady flow features.

• Journal of Ocean Engineering and Technology
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• v.27 no.4
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• pp.33-44
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• 2013

IIn this study, a wave-surge-tide coupling numerical model was developed to consider nonlinear interaction. Then, this model was applied and calculations were made for a storm surge on the southeast coast. The southeast coast was damaged by typhoon "Maemi" in 2003. In this study, we used a nearshore wind wave model called SWAN (Simulating WAves Nearshore). In addition, the Meyer model was used for the typhoon model, along with an ocean circulation model called POM (Princeton Ocean Model). The wave-surge-tide coupling numerical model could calculate exact parameters when each model was changed to consider the nonlinear interaction.

• KIPS Transactions on Software and Data Engineering
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• v.2 no.11
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• pp.815-822
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• 2013

Nowadays, the various kind of software packages that support content creation consumed in touch-type terminals as an application have come into the market. These softwares have a different style of user task compare to existing user task. The reason why difference style has been appeared for now is because interaction timing has a important role of both content creation and consumption. For this reason, in this paper, we propose a software UI design framework for content creation using MB-UID and UCD model based on task modeling. The proposed framework is made up of five steps: business rule model, creation role model, creation flow model, creation action model, presentation model. Through this framework, we handle the interaction between a content creator and software user interface at the content creation phase. At the same time, we consider a possible interaction type which can occur by consumers at the consumption phase in advance.

• Structural Engineering and Mechanics
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• v.56 no.1
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• pp.27-47
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• 2015

In this study, the accuracy and reliability of fully nonlinear method against equivalent linear method for dynamic analysis of soil-structure interaction is investigated comparing the predicted results of both numerical procedures with the results of experimental shaking table tests. An enhanced numerical soil-structure model has been developed which treats the behaviour of the soil and the structure with equal rigour. The soil-structural model comprises a 15 storey structural model resting on a soft soil inside a laminar soil container. The structural model was analysed under three different conditions: (i) fixed base model performing conventional time history dynamic analysis, (ii) flexible base model (considering full soil-structure interaction) conducting equivalent linear dynamic analysis, and (iii) flexible base model performing fully nonlinear dynamic analysis. The results of the above mentioned three cases in terms of lateral storey deflections and inter-storey drifts are determined and compared with the experimental results of shaking table tests. Comparing the experimental results with the numerical analysis predictions, it is noted that equivalent linear method of dynamic analysis underestimates the inelastic seismic response of mid-rise moment resisting building frames resting on soft soils in comparison to the fully nonlinear dynamic analysis method. Thus, inelastic design procedure, using equivalent linear method, cannot adequately guarantee the structural safety for mid-rise building frames resting on soft soils. However, results obtained from the fully nonlinear method of analysis fit the experimental results reasonably well. Therefore, this method is recommended to be used by practicing engineers.

• Earthquakes and Structures
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• v.12 no.2
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• pp.251-262
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• 2017

The present research intends to study the effects of the seismic soil-foundation-structure interaction (SFSI) on the dynamic response of various buildings. Two methods including direct and Cone model were studied through 3D finite element method using ABAQUS software. Cone model as an approximate method to consider the SFSI phenomenon was developed and evaluated for both high and low rise buildings. Effect of soil nonlinearity, foundation rigidity and embedment as well as friction coefficient between soil-foundation interfaces during seismic excitation are investigated. Validity and performance of both approaches are evaluated as reference graphs for Cone model and infinite boundary condition, soil nonlinearity and amplification factor for direct method. A series of calculations by DeepSoil for inverse earthquake record modification was conducted. A comparison of the two methods was carried out by root-mean-square-deviation (RMSD) tool for maximum lateral displacement and story shear forces which verifies that Cone model results have good agreement with direct method. It was concluded that Cone method is a convenient, fast and rather accurate method as an approximate way to count for soil media.

• Journal of the Korea Society of Computer and Information
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• v.19 no.5
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• pp.79-87
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• 2014

In this paper, we propose contents sharing model for consolidating distributed collaboration environments. We provide the combined model by integrating different features-scalable resolution display walls resource, sharing contents on local and remote, multi-user interaction, and access control. There is a benefit that every user can interact within an environment, but overlaps would occur because of multi-user interaction. To manage overlap issue, the model includes access control. Access control would interfere flow of work process. Therefore, we conduct user study to evaluate these two factors of the model. The result shows that the proposed contents sharing model makes it possible to concentrate in a work.

• Journal of the Society of Naval Architects of Korea
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• v.56 no.3
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• pp.217-230
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• 2019

In this study, a fatigue damage estimation for an ice-going vessel navigating through broken ice fields was carried out. A numerical model to simulate the interaction between ice and structure developed using the finite element method was introduced. Time series of stresses calculated by the proposed model and the corresponding fatigue analysis results are presented. The numerical model enables the long time analysis through an efficient interaction model, the application of the periodic media analysis and the convolution integral, and it allows the stress time history to be extracted directly using the finite element method. To describe the probability distribution of stress amplitudes, the 2-parameter Weibull model was applied to the calculated stress time history, and the fatigue damage was calculated using the Palmgren-Miner rule. Finally, the fatigue damage considering the ice conditions of the Baltic Sea was calculated using the proposed method and LR method, and the results were compared to each other.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.16 no.3
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• pp.771-791
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• 2022

Protein-protein interaction (PPI) extraction from original text is important for revealing the molecular mechanism of biological processes. With the rapid growth of biomedical literature, manually extracting PPI has become more time-consuming and laborious. Therefore, the automatic PPI extraction from the raw literature through natural language processing technology has attracted the attention of the majority of researchers. We propose a PPI extraction model based on the large pre-trained language model and adversarial training. It enhances the learning of semantic and syntactic features using BioBERT pre-trained weights, which are built on large-scale domain corpora, and adversarial perturbations are applied to the embedding layer to improve the robustness of the model. Experimental results showed that the proposed model achieved the highest F1 scores (83.93% and 90.31%) on two corpora with large sample sizes, namely, AIMed and BioInfer, respectively, compared with the previous method. It also achieved comparable performance on three corpora with small sample sizes, namely, HPRD50, IEPA, and LLL.