• Biomolecules & Therapeutics
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• 제27권2호
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• pp.134-144
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• 2019

The prevalence of nonalcoholic fatty liver disease (NAFLD) has increased with the incidence of obesity; however, the underlying mechanisms are unknown. In this study, high-resolution metabolomics (HRM) along with transcriptomics were applied on animal models to draw a mechanistic insight of NAFLD. Wild type (WT) and catalase knockout (CKO) mice were fed with normal fat diet (NFD) or high fat diet (HFD) to identify the changes in metabolic and transcriptomic profiles caused by catalase gene deletion in correspondence with HFD. Integrated omics analysis revealed that cholic acid and $3{\beta}$, $7{\alpha}$-dihydroxy-5-cholestenoate along with cyp7b1 gene involved in primary bile acid biosynthesis were strongly affected by HFD. The analysis also showed that CKO significantly changed all-trans-5,6-epoxy-retinoic acid or all-trans-4-hydroxy-retinoic acid and all-trans-4-oxo-retinoic acid along with cyp3a41b gene in retinol metabolism, and ${\alpha}/{\gamma}$-linolenic acid, eicosapentaenoic acid and thromboxane A2 along with ptgs1 and tbxas1 genes in linolenic acid metabolism. Our results suggest that dysregulated primary bile acid biosynthesis may contribute to liver steatohepatitis, while up-regulated retinol metabolism and linolenic acid metabolism may have contributed to oxidative stress and inflammatory phenomena in our NAFLD model created using CKO mice fed with HFD.

• 한국치위생학회지
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• 제19권1호
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• pp.105-116
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• 2019

Objectives: This study aimed to confirm the relationship between toothbrushing practice after lunch and typical oral health behaviors in children and adolescents according to the subject and type of social support. Methods: The study used data from the 2010 Korean Survey on the Health of Youth and Children and selected 8,704 elementary, middle, and high school students as final targets. Multiple logistic regression was conducted to confirm the link between social support and toothbrushing after lunch. Results: The results showed that in elementary and vocational high school students, statistical significance of all social support variables disappeared after controlling for both demographic and social factors and oral symptom experience. However, in the middle school students, the emotional support of the neighbors and the emotional support of the teachers showed statistically significant effect on brushing daily after lunch (p<0.05). In general high school students, there was a significant association between family emotional support and toothbrushing after lunch (p<0.01). Conclusions: The oral health promotion program for children and adolescents needs to be integrated and coordinated with the overall health promotion program. In particular, it is believed that the school-based program can strengthen the practice of health behaviors by inducing behavioral changes based on the formation of healthy relationships and trust of colleagues and teachers. Therefore, it is necessary to develop social network-based programs including social support such as emotional health and healthy relationships that can be applied among children for oral health promotion.

• Journal of Platform Technology
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• 제9권1호
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• pp.32-39
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• 2021

기존 환경측정기기는 전자파 및 친환경 제품 인증, 내구성 시험 위주이며, 센서 신뢰성 검증 및 측정 데이터에 대한 검증은 형식 승인 및 등록, 인수시험, 초기교정, 주기시험 등을 통해 센서 성능평가 위주로 수행된다. 본 플랫폼은 각 타겟 센서별 성능평가 뿐만 아니라 센서의 데이터 신뢰성에 대한 검증체계 지원 ICT 기반 환경 모니터링 센서 신뢰성 검증 체계를 구축하였다. 환경 정보에 대한 센서 데이터를 수집할 센서보드를 제작하였고 센서 및 데이터 신뢰성 평가 및 검증 서비스 체계를 규격화 하였다. 또한, ICT 기반 센서 데이터 신뢰성 평가 및 검증을 위해 LoRa 통신을 이용한 센서 데이터 플랫폼 모니터링 프로토타입을 제작하였고 이를 스마트 시티 등에 실증 테스트하였다. 해당 시스템을 통해 받은 데이터 분석을 위해 머신러닝을 이용하여 최적화 알고리즘 개발하였다. 이를 통해 신뢰성 검증을 위한 센서 빅데이터 분석시스템을 구축하였고 통합 평가 및 검증 시스템의 기반을 마련하였다.

• Structural Engineering and Mechanics
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• 제78권2호
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• pp.163-174
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• 2021

Track-bridge interaction has become an essential part in the design of bridges and rails in terms of modern railways. As a unique ballastless slab track, the longitudinal continuous slab track (LCST) or referred to as the China railway track system Type-II (CRTS II) slab track, demonstrates a complex force mechanism. Therefore, a comprehensive track-bridge interaction study between multi-span simply supported beam bridges and the LCST is presented in this work. In specific, we have developed an integrated finite element model to investigate the overall interaction effects of the LCST-bridge system subjected to the actions of temperature changes, traffic loads, and braking forces. In that place, the deformation patterns of the track and bridge, and the distributions of longitudinal forces and the interfacial shear stress are studied. Our results show that the additional rail stress has been reduced under various loads and the rail's deformation has become much smoother after the transition of the two continuous structural layers of the LCST. However, the influence of the temperature difference of bridges is significant and cannot be ignored as this action can bend the bridge like the traffic load. The uniform temperature change causes the tensile stress of the concrete track structure and further induce cracks in them. Additionally, the influences of the friction coefficient of the sliding layer and the interfacial bond characteristics on the LCST's performance are discussed. The systematic study presented in this work may have some potential impacts on the understanding of the overall mechanical behavior of the LCST-bridge system.

• 한국안전학회지
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• 제36권5호
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• pp.71-78
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• 2021

There are regularly planned overhaul periods in thermal power plants, which involve the maintenance of the boiler of the power plants. However, thermal power plants workers are always exposed to risk during overhaul periods owing to the narrow space and significant dust inside the boiler. Therefore, it is essential to develop a safety monitoring system that is suitable for operating in this type of environment. In this study, we developed not only a worker three-dimensional (3D)-location monitoring system that can monitor and record the entry/exit of workers, their 3D-location, and fall accidents but also a method to secure the working environment and operation efficiency. This system comprises of a worker tag, which was equipped with an inertial measurement unit, a barometric pressure sensor, and a Bluetooth low energy (BLE), and the tags were given to each worker. In addition, the location of workers inside the boiler was measured using a pedestrian dead reckoning (PDR) method and BLE beacons. The location data of the workers tag were transmitted to the integrated database (DB) server through a gateway, and to the administrator monitoring system. The performance of the system was demonstrated inside an actual thermal power plant boiler, and the accuracy and reliability of the system were verified through a number of repeated tests. These results provide insights on designing a new system for monitoring enclosed spaces.

• 상하수도학회지
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• 제34권6호
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• pp.495-502
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• 2020

The 37 indicators for performance evaluation of public sewage management agencies are divided into four major categories (agency manpower management ability, wastewater treatment plant operation and management, sludge and water reuse, service quality) in the first stage, and the necessity and score acquisition for the detailed indicators by each major category in the second stages. Priority was investigated through the Analytic Hierarchy Process (AHP) analysis technique for ease and relevance of company efforts. Also, based on the results of this analysis, integrated type weighting and relative importance were analyzed. As a result of the analysis, the weight and relative importance of the first stage classification were in the order of wastewater treatment plant operation and maintenance, operation agency manpower management ability, sludge and water reuse, and service quality. As a result of analyzing the weights and priorities of the detailed performance indicators in the second stage, it was found that operator's career years, the percentage of certification holding rate in operators, compliance with the effluent water quality standards, training times for operators, and efforts to manage hazardous chemicals were important. Some of the indicators of operation agency performance evaluation may include indicators in which the performance of the company's efforts is underestimated or overestimated. In order to improve this, it is necessary to give weights in consideration of the necessity of the indicator, the relevance of the company's efforts, and the ease of obtaining scores.

• 디지털융복합연구
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• 제19권6호
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• pp.259-264
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• 2021

최근 중고 거래를 지원하는 중고 거래 사이트가 증가함에 따라 사용자는 실시간으로 다양한 정보를 검색하고자 한다. 이러한 새로운 변화는 전자상거래 기반에서 새로운 유형의 C2C(Commerce to Commerce) 거래가 활성화 되었다. 그러나 각각의 중고 거래 사이트는 고유한 특성들이 있어 전체 표준화가 어렵다. 따라서 본 논문에서는 사용자가 사용한 거래 데이터를 실시간으로 제공하고 원하는 정보를 신속하게 제공하는 시스템을 연구하였다. 본 논문에서는 인터넷 전자 상거래를 통한 중고품 통합 거래 시스템 개발에 필요한 크롤러 시스템을 연구하고, 정의된 형태소 분석기를 통해 사용자가 원하는 웹 환경에서 정보 제공이 가능하도록 하였다. 따라서 본 연구에서는 다양한 중고 물품 사이트에 접속하지 않고도 사용자가 원하는 정보를 제공하는 시스템을 설계하였다.

• Clinical and Experimental Reproductive Medicine
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• 제48권2호
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• pp.163-173
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• 2021

Objective: This study aimed to characterize a validated model for predicting oocyte retrieval in controlled ovarian stimulation (COS) and to construct model-based nomograms for assistance in clinical decision-making regarding the gonadotropin protocol and dose. Methods: This observational, retrospective, cohort study included 636 women with primary unexplained infertility and a normal menstrual cycle who were attempting assisted reproductive therapy for the first time. The enrolled women were split into an index group (n=497) for model building and a validation group (n=139). The primary outcome was absolute oocyte count. The dose-response relationship was tested using modified Poisson, negative binomial, hybrid Poisson-E_max, and linear models. The validation group was similarly analyzed, and its results were compared to that of the index group. Results: The Poisson model with the log-link function demonstrated superior predictive performance and precision (Akaike information criterion, 2,704; λ=8.27; relative standard error (λ)=2.02%). The covariate analysis included women's age (p<0.001), antral follicle count (p<0.001), basal follicle-stimulating hormone level (p<0.001), gonadotropin dose (p=0.042), and protocol type (p=0.002 and p<0.001 for short and antagonist protocols, respectively). The estimates from 500 bootstrap samples were close to those of the original model. The validation group showed model assessment metrics comparable to the index model. Based on the fitted model, a static nomogram was built to improve visualization. In addition, a dynamic electronic tool was created for convenience of use. Conclusion: Based on our validated model, nomograms were constructed to help clinicians individualize the stimulation protocol and gonadotropin doses in COS cycles.

• 한국컴퓨터정보학회논문지
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• 제25권12호
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• pp.261-270
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• 2020

본 연구는 피기백 화차운송 시스템의 특허문서를 활용하여 관련 분야의 유망기술을 파악하는 것을 목표로 한다. 이를 위해 피기백 운송 시스템의 선행연구 및 관련 보고서로 기술 키워드를 추출하여 특허문서를 추출한다. 추출된 특허문서에 텍스트마이닝 기법을 적용하여 빈도수가 높은 키워드를 확인하고 피기백 운송 시스템의 핵심기술의 토픽을 식별하기 위해 LDA(Latent Dirichlet Allocation) 알고리즘을 적용하였다. 마지막으로, 시계열 분석 기법인 ARIMA 모델을 핵심기술의 토픽에 적용하여 기술 추세를 예측하고 피기백 운송 시스템에 대한 유망한 기술을 식별하였다. 특허 분석 결과, 데이터 기반 통합관리 시스템과 운영 계획 시스템 그리고 복합수송 중 특수 화물(기체, 액체류) 운송 및 보관 기술이 미래에 유망한 핵심기술로 도출되었고, 데이터 송수신 및 분석 기술이 중요한 세부 기술임을 확인하였다. 제안된 분석 방법은 피기백 운송 시스템의 R&D 연구개발 전략 및 기술 로드맵을 개발하는 데 있어 충분한 자료가 될 수 있다.

• 정보교육학회논문지
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• 제25권3호
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• pp.571-578
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• 2021

본 연구는 SW기반 메이커교육을 비대면 온라인 환경에서 블렌디드 러닝 전략에 따라 다르게 적용한 후 자기효능감, 학습동기, 흥미도의 관점에서 비교한 것이다. 먼저 온라인 교육을 위한 SW 메이커 프로그램을 개발하고 이를 실시간 쌍방향을 포함하는 라이브세미나형 수업과 온라인콘텐츠와 질의응답으로 이루어진 지원제공형 수업으로 각각 적용하였다. 사전, 사후로 나누어 두 전략에 따른 학생들의 차이를 비교한 결과 자기효능감 부분에서는 라이브세미나 형태가 긍정적 효능감과 전체 평균 변화 부분에서 유의미한 차이가 있었고, 학습동기 부분에서는 라이브세미나 형태가 자신감 부분에서 유의미하게 높았으며 흥미 부분에서는 지원제공형 형태가 도구적 흥미와 긴장 부분에서 유의하게 높은 평균을 보여주었다. 비대면 온라인 학습에서 기존 대면상황과 같은 메이커 활동의 효과를 유지하기 위해서는 학생 간 공유 시간 증대와 통합적인 학습 환경, 탐색시간과 학습 자료의 충분한 제공이 필요하다.