• Journal of Microbiology and Biotechnology
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• 제34권2호
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• pp.367-378
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• 2024

In this study we sought to elucidate the therapeutic effects of fenchone on constipation-predominant irritable bowel syndrome (IBS-C) and the underlying mechanisms. An IBS-C model was established in rats by administration of ice water by gavage for 14 days. Fenchone increased the reduced body weight, number of fecal pellets, fecal moisture, and intestinal transit rate, and decreased the enhanced visceral hypersensitivity in the rat model of IBS-C. In addition, fenchone increased the serum content of excitatory neurotransmitters and decreased the serum content of inhibitory neurotransmitters in the IBS-C rat model. Meanwhile, western blot and immunofluorescence experiments indicated that fenchone increased the expressions of SCF and c-Kit. Furthermore, compared with the IBS-C model group, fenchone increased the relative abundance of Lactobacillus, Blautia, Allobaculum, Subdoligranulum, and Ruminococcaceae_UCG-008, and reduced the relative abundance of Bacteroides, Enterococcus, Alistipes, and Escherichia-Shigella on the genus level. Overall, fenchone ameliorates IBS-C via modulation of the SCF/c-Kit pathway and gut microbiota, and could therefore serve as a novel drug candidate against IBS-C.

• 한국신재생에너지학회:학술대회논문집
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• 한국신재생에너지학회 2011년도 춘계학술대회 초록집
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• pp.156.1-156.1
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• 2011

It is of great importance to predict operating parameter characteristics of an integrated fuel processor by the increased life-time and system performance. In this study, computational analysis is performed to gain fundamental insights on transport phenomena and chemical reactions in reformer which consists of preheating, steam reforming, and water gas shift reaction beds. Also, a top-fired burner locates inside of the reforming system. The combustor is providing thermal energy necessary for the steam reforming bed which is a endothermic catalytic reactor. Two-dimensional numerical model of the integrated fuel processing system is introduced for the analysis of heat and mass transport phenomena as well as surface kinetics and catalytic process. A kinetic model was developed and then computational results were compared with the experimental data available in the literature. Subsequently, parameter study using the validated steam methane reforming model was conducted by considering operating parameters, i.e. steam to carbon ratio and temperature.

• Journal of Positioning, Navigation, and Timing
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• 제7권3호
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• pp.165-173
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• 2018

Underwater vehicles use Inertial Navigation System (INS) with high-performance Inertial Measurement Unit (IMU) for high precision navigation. However, when underwater navigation is performed for a long time, the INS error gradually diverges, therefore, an integrated navigation method using auxiliary sensors is used to solve this problem. In terms of underwater vehicles, the vertical axis error is primarily compensated through Vertical Channel Damping (VCD) using a depth gauge, and an integrated navigation filter can be designed to perform horizontal axis error and sensor error correction using a speedometer such as Electromagnetic-Log (EM-Log). However, since EM-Log outputs the forward direction relative speed of the vehicle with respect to the sea and sea current, INS correction filter using this may cause a rather large error. Although it is possible to design proper filters if the exact model of the sea current is known, it is impossible to know the accurate model in reality. Therefore, this study proposes an INS/EM-Log integrated navigation filter with the function to estimate sea current using an Interacting Multiple Model (IMM) filters, and the performance of this filter is analyzed through a simulation performed in various environments.

• 전자공학회논문지A
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• 제29A권4호
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• pp.38-48
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• 1992

OEIC(Optoelectronic Integrated Circuit)'s can be integrated horizontally or vertically. Horizontal integration approach is, however, more immune to parasitic and more universally applicable. In this paper, a structural modeling, fabrication and characterization of PIN photodiodes which can be used in the horizontal integration are performed. For device modeling, we build a transmission line model from 2-D device simulation, from which lumped model parameters are extracted. The speed limits of the PIN photodiodes can also be calculated under various structural conditions from the model. Thus optimum design of horizontally integrated PIN photodiodes for high speed operation are possible. Such InGaAs/InP PIN photodiodes for long-wavelength communications are fabricated using pit etch, epi growth, planarization, diffusion and metallization processes. Planarization process using both RIE and wet etching and diffusion process using evaporated Zn$_{3}P_{2}$ film are developed. Characterization of the fabricated devices is performed through C-V and I-V measurements. At a reserve bias of 10V, the dark current is less than 5nA and capacitance is about 0.4pF. The calculated bandwidth using the measured series resistance and capacitance is about 4.23GHz.

• 한국철도학회논문집
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• 제10권4호
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• pp.438-443
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• 2007

This paper proposes an integrated SE process for the development of railway systems with safety assessment included. Although the safety assessment process must be performed with SE process properly with good coordination, the interfaces between the two processes have not been clear. Thus, in many of safety critical system developments in Korea, it is difficult to assess safety in proper development phase. The process model proposed in this paper is based on both the concept of system life cycle and the repetitive use of SE process. In each of development phases, appropriate safety assessment methods are described. Also the evaluation of the integrated system incorporating safety factors is described. The resultant process model is expressed by the Enhanced Functional Flow Block Diagram (EFFBD) using a CASE tool. The model also allows timeline analysis for identifying activity flow and data flow, resulting in the effective management of process. In conclusion, the integrated process enable both the SE process and safety assessment process to cooperate with each other from early development phase throughout the whole system life cycle.

• ETRI Journal
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• 제34권2호
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• pp.190-198
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• 2012

An adaptive correlation noise model (CNM) construction algorithm is proposed in this paper to increase the efficiency of parity bits for correcting errors of the side information in transform domain Wyner-Ziv (WZ) video coding. The proposed algorithm introduces two techniques to improve the accuracy of the CNM. First, it calculates the mean of direct current (DC) coefficients of the original WZ frame at the encoder and uses it to assist the decoder to calculate the CNM parameters. Second, by considering the statistical property of the transform domain correlation noise and the motion characteristic of the frame, the algorithm adaptively models the DC coefficients of the correlation noise with the Gaussian distribution for the low motion frames and the Laplacian distribution for the high motion frames, respectively. With these techniques, the proposed algorithm is able to make a more accurate approximation to the real distribution of the correlation noise at the expense of a very slight increment to the coding complexity. The simulation results show that the proposed algorithm can improve the average peak signal-to-noise ratio of the decoded WZ frames by 0.5 dB to 1.5 dB.

• 한국융합학회논문지
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• 제8권12호
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• pp.291-298
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• 2017

최근 차량내부에서는 운전과 직접적인 관련이 적은 다양한 편의장치들이 도입되고 있으며, 이러한 장치들의 조작환경을 하나로 통합하려는 노력이 시도되고 있다. 본 논문은 자동차 내의 다양한 편의장치에 대한 통합 조작환경을 구축하기 위해 자기유변유체(magnetorheological fluid; MR 유체)를 이용한 햅틱장치를 제안하고자 한다. 이를 위해 먼저 차량 편의 조작장치들이 갖는 회전과 상하 수직 운동을 동시에 구현할 수 있는 메커니즘을 고안하고 햅틱 기능을 부여하기 위해 MR 유체를 도입함으로써 하나의 장치로 다기능 조작이 가능한 햅틱 장치를 고안한다. 장치에서 발생하는 반향력에 대한 모델링에 근거하여 MR 햅틱 장치의 자료를 설계하고 시작품을 제작한다. 그리고 완성된 장치의 회전 및 수직 운동에 대한 응답 성능시험을 수행하여 제안된 모델을 검정한다. 또한 힘 반향 성능을 구현하기 위해 장치의 반향력 모델을 이용한 역모델 보상기(inverse model compensator)를 설계한다. 마지막으로 실제 자동차의 여러 편의 기능의 작동과정을 고려하여 햅틱 반향력 맵을 구축하고 제어기와 연동하여 제작된 햅틱 장치의 힘반향(force-feedback) 제어 성능을 평가한다.

• 천문학회보
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• 제41권1호
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• pp.40.2-41
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• 2016

To understand the observed kinematics in the narrow-line region (NLR) of type 2 AGNs, we construct a model of 3-D biconical outflow combined with a thin dust plane. The model consists of two identical cones whose apex is located at the nucleus, and the cones are axisymmetric with respect to the bicone axis. After we define the properties of the bicone and the dust plane, we calculate a spatially integrated velocity and velocity dispersion along the line-of-sight using various physical parameters. As we test the effect of model parameters, we find three key parameters determining the integrated kinematics: intrinsic outflow velocity, bicone inclination, and the amount of dust extinction. The velocity dispersion increases as the intrinsic outflow velocity or the bicone inclination increases, while the velocity shift increases as the amount of dust extinction increases. We confirm that the integrated velocity dispersion can be a good indicator of the intrinsic outflow velocity unless dust extinction is not very strong (>~80%), while the effect of dust extinction can be alleviated by combining the integrated velocity and the velocity dispersion. Based on the simulated velocity distributions using the 3-D models, the variety of the observed [O $_{III}$] line profiles of type 2 AGNs can be well reproduced. In addition, we perform Monte Carlo simulations based on the different sets of model parameters. By comparing the model results with the observed [O $_{III}$] kinematics of ~39,000 SDSS type 2 AGNs (Woo et al. 2016), we find that the observed [O $_{III}$] velocity-velocity dispersion distribution is well reproduced by the biconical outflow model, enabling us to constrain the intrinsic physical parameters of outflows.

• 정보보호학회논문지
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• 제22권3호
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• pp.575-584
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• 2012

군의 정보화, 과학화 추진에 따른 환경 변화에 따라 기존 수작업, 오프라인 중심의 제반 군사보안 업무도 효율적이고 체계적인 업무 수행을 지원할 수 있도록 변화와 발전이 필요하다. 이에 본 연구에서는 주요 군사보안 업무 분야에 대한 실태 및 문제점 분석과 미국, 영국 등의 사례 분석을 기반으로, 주요 군사보안 업무를 자동화, 정보화하기 위한 국방통합보안시스템 구축 표준 Model을 제시하였다. 표준 Model은 통합보안체계, 비밀관리시스템, 인원출입 시스템, 차량출입시스템, 첨단경계시스템, 테러 예방시스템 및 보안사고분석시스템 등의 단위 시스템으로 구성되며, 현재 가용한 기술 및 시스템을 기반으로 제안하였는데, 이를 각급부대에 적용할 경우 군사보안 발전에 기여할 것으로 기대된다.

• 한국산학기술학회논문지
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• 제15권1호
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• pp.449-459
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• 2014

시각적인 클래스 모델로 기 제시된 2+1 View 통합 메타모델은 비정형적인 명세에 기인하여 명확하게 모델의 구문을 표현하지 못하고 있으며, 또한 그 모델의 정확성을 보장할 수 없다. 본 논문은 Z와 Object-Z를 사용해서 2+1 View 통합 메타모델의 구문적 의미를 정형적으로 명세하고, Z/Eves 툴을 통해 메타모델의 정확성을 검사하는 것이다. 정형 명세는 클래스 모델과 Z/Object-Z간의 변환규칙을 적용해서 2+1 View 통합 메타모델의 구문과 정적 시멘틱에 대해 Z와 Object-Z 스키마로 각각 표현한다. 메타모델의 검사는 Z 스키마 명세에 대해 Z/Eves 도구를 사용하여 구문, 타입 검사 그리고 도메인 검사를 수행하여 메타모델의 정확성을 입증한다. 이로서, 2+1 View 통합 메타모델 메타모델의 Z/Object-Z 변환을 통해 구조물의 구문적 의미를 명확하게 표현할 수 있으며, 또한 그 메타모델의 정확성을 검사할 수 있다.