• 한국영양학회:학술대회논문집
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• 한국영양학회 2002년도 춘계 심포지움초록
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• pp.598-603
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• 2002

While the sequencing of several genomes was underway, several advanced techniques in genetics, molecular biology and protein chemistry emerged. Within the notritional sciences, while the focus on nutrition education, epidemiology and public health aspects remains essential; it is crucial to incorporate the new advances in gene and protein discovery in nutritional studies. Nutrition is a discipline that has always integrated social, biochemical and physiological sciences from the studies at the molecule level to studies at the population level. for this reason, nutritionists are in a prime position to readily incorporate the current genomics approaches in nutrition research. All the available analytical techniques can and should be used in modem nutritional sciences. These include genetics, genomics, proteomics and metabolomics which also require integration and use of bioinformatics and computational methods for data analysis and management. These applications will be briefly reviewed with a primary focus on what the genomics and genetics approaches offer to nutritionists. We will use one of our research focus areas to illustrate uses of some of these applications in obesity-hypertension research. Our central hypothesis is that adipose tissue is an endocrine organ that plays a major role in obesity and related hypertension. We are primarily studying the renin angiotensin system (RAS). We provide evidence from our own studies and others for the paracrine as well as endocrine role of adipocyte-derived angiotensin II in adipocyte gene expression, adiposity and blood pressure regulation. Both cell culture studies as well as knockout and transgenic mice models are used to test our hypothesis. Genomics and proteomics technologies are currently developed to complement our physiological and molecular studies on the RAS and for a fine analysis of this system and its function in health and disease.

• Asian Pacific Journal of Cancer Prevention
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• 제17권12호
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• pp.5075-5080
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• 2016

Purpose: Factors associated with ever-use and differences between ever-users and non-users of tobacco among adolescent school students from low income families in Mumbai were assessed. Materials and Methods: A self-administered questionnaire, completed by 1918 students from grades 7, 8 and 9 in 12 schools managed by the city municipal corporation in July 2015, gathered data on socio-demographic characteristics, tobacco use and tobacco-related knowledge, attitudes and beliefs. Results: Although only 1% of respondents thought tobacco was cool, nearly 35% were unaware of associations between tobacco use and health problems. Male students were almost twice as likely (OR=2.5, P <= 0.05) to have ever used tobacco compared to females and Supari (areca nut) users were eight times more likely (OR=8.99, P < 0.001) than Supari non -users. Tobacco-users were more likely to agree with statements: 'People who use tobacco have more friends' (OR=2.8, P = 0.004), 'Smoking relieves stress' (OR=5.6, P = 0.002) and 'It is possible to purchase any tobacco product within 100 yards of school' (OR=10.8, P < 0.001). Conclusion: This study highlights the gains made by tobacco prevention campaigns in that almost all students did not consider tobacco as cool or a stress reliever. However, they still need education about health consequences of tobacco-use. In addition, Supari use has to be addressed in school-based tobacco prevention and cessation initiatives. Furthermore, programs must also address perceptions and norms related to peers and tobacco use and ensure active implementation of existing laws. Such integrated measures will help ensure tobacco-free spaces around schools.

• 디지털융복합연구
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• 제13권7호
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• pp.393-402
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• 2015

본 연구는 대전, 세종, 충 남북 지역에 거주하는 개인회생제도 이용자 236명을 조사대상자로 하여 그들의 스트레스 요인이 우울에 미치는 영향을 조사하였으며, 이 관계에서 희망의 조절효과를 검증하였다. 본 연구에서는 자료분석을 위하여 PASW Statistics 18.0을 이용하였다. 주요 연구결과는 다음과 같다. 첫째, 조사대상자의 우울 수준은 보통수준보다 높은 것으로 나타났다. 둘째, 우울은 연령, 거주 지역, 학력, 사회활동의 참여 여부에 따라 집단별로 유의미한 차이가 나타났다. 셋째, 우울에 영향을 미치는 요인은 거주 지역, 사회활동의 참여 여부, 스트레스 요인에서의 건강 경제 가족문제, 희망 등으로 나타났다. 넷째, 희망은 건강 경제 가족 등의 스트레스의 요인과 우울과의 관계에서 조절효과를 갖는 것으로 나타났다. 이러한 실증적 연구결과에 기초하여 개인회생제도 이용자들의 우울을 방지하기 위한 실질적이고 통합적인 방안을 제시하였다. 또한, 개인회생제도 이용자에 대한 실천영역에서의 최초의 분석결과를 제시함으로써 제도의 본래 목적을 달성하는데 기초자료를 제공했다는 점에서 본 연구의 의의를 찾을 수 있다.

• 대한간호학회지
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• 제54권2호
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• pp.193-210
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• 2024

Purpose: The objective of this study was to develop a predictive model for the sexual experiences of adolescents using the random forest method and to identify the "variable importance." Methods: The study utilized data from the 2019 to 2021 Korea Youth Risk Behavior Web-based Survey, which included 86,595 man and 80,504 woman participants. The number of independent variables stood at 44. SPSS was used to conduct Rao-Scott χ² tests and complex sample t-tests. Modeling was performed using the random forest algorithm in Python. Performance evaluation of each model included assessments of precision, recall, F1-score, receiver operating characteristics curve, and area under the curve calculations derived from the confusion matrix. Results: The prevalence of sexual experiences initially decreased during the COVID-19 pandemic, but later increased. "Variable importance" for predicting sexual experiences, ranked in the top six, included week and weekday sedentary time and internet usage time, followed by ease of cigarette purchase, age at first alcohol consumption, smoking initiation, breakfast consumption, and difficulty purchasing alcohol. Conclusion: Education and support programs for promoting adolescent sexual health, based on the top-ranking important variables, should be integrated with health behavior intervention programs addressing internet usage, smoking, and alcohol consumption. We recommend active utilization of the random forest analysis method to develop high-performance predictive models for effective disease prevention, treatment, and nursing care.

• Asian Pacific Journal of Cancer Prevention
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• 제15권13호
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• pp.5487-5492
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• 2014

Ultrasonography is non-invasive and can give useful clues in the diagnosis of cervical lymphadenopathy, However, differential diagnosis is difficult in some situations even combined with color Doppler imaging. The present study was conducted to evaluate the clinical value of real time elastography in patients with unexplained cervical lymphadenopathy using a quantitative method. From May 2011 to February 2012, 39 enlarged lymph nodes from 39 patients with unexplained cervical lymphadenopathy were assessed. All the patients were examined by both B-mode ultrasound, color Doppler flow imaging and elastography. The method of analyzing elasto-graphic data was the calculation of the 10 parametres ("mean", "sd", "area%", "com", "kur", "ske", "con", "ent", "idm", "asm") offered by the software integrated into the Hitachi system. The findings were then correlated with the definitive tissue diagnosis obtained by lymph node dissection or biopsy. Final histology revealed 10 cases of metastatic lymph nodes, 11 cases of lymphoma, 12 cases of tuberculosis and 6 cases of nonspecific lymphadenitis. The significant distinguishing features for conventional ultrasound were the maximum short diameter (p=0.007) and absent of echogenic hilum (p=0.0293). The diagnostic accuracy was 43.6% (17/39 cases) and there were 17 patients with equivocal diagnosis. For elastography, "mean" (p=0.003), "area%" (p=0.009), "kurt" (p=0.0291), "skew" (p=0.014) and "cont" (p=0.012) demonstrated significant differences between groups. With 9 of the 17 patients with previous equivocal diagnoses (52.9%) definite and correct diagnoses could be obtained. The diagnostic accuracy for conventional ultrasound combined elastography was 69.2% (27/39 cases). There were differences in the diagnostic sensitivity of the two methods (p=0.0224). Ultrasound combined with elastography demonstrated higher rates of conclusive and accurate diagnoses in patients with unexplained cervical lymphadenopathy than conventional ultrasound. The quantitative program showed good correlation with the pathology of different lymph node diseases.

• Parasites, Hosts and Diseases
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• 제57권3호
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• pp.303-308
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• 2019

Toxoplasma gondii is an apicomplexan parasite that can cause toxoplasmosis in a wide range of warm-blooded animals including humans. In this study, we analyzed seroprevalence of T. gondii among 467 school children living in the rural areas of Pyin Oo Lwin and Naung Cho, Myanmar. The overall seroprevalence of T. gondii among school children was 23.5%; 22.5% of children were positive for T. gondii IgG, 0.4% of children were positive for T. gondii IgM, and 0.6% of children were positive for both T. gondii IgG and IgM. Geographical factors did not significantly affect the seroprevalence frequency between Pyin Oo Lwin and Naung Cho, Myanmar. No significant difference was found between males (22.2%) and females (25.0%). The overall seroprevalence among school children differed by ages (10 years old [13.6%], 11-12 years old [19.8%], 13-14 years old [24.6%], and 15-16 years old [28.0%]), however, the result was not significant. Polymerase chain reaction analysis for T. gondii B1 gene for IgG-positive and IgM-positive blood samples were negative, indicating no direct evidence of active infection. These results collectively suggest that T. gondii infection among school children in Myanmar was relatively high. Integrated and improved strategies including reinforced education on toxoplasmosis should be implemented to prevent and control T. gondii infection among school children in Myanmar.

• 한국콘텐츠학회논문지
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• 제5권1호
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• pp.27-35
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• 2005

최근 의료 및 보건 분야의 정보화가 급격히 진행됨에도 불구하고 보건 분야 중의 전문방사선사와 관련된 의료 및 교육 컨텐츠 개발에 해당하는 시험문제 개발이나 관리가 여전히 수작업이나 문서편집기를 이용한 오프라인 방식에 머무르고 있다. 따라서 본 연구에서는 CT 방사선사 전문자격증 취득 및 보수교육의 효율성을 향상시키기 위해 다양한 종류의 문항들을 시간과 공간의 제약 없이 언제 어디서든지 효율적으로 문항을 출제하고 관리할 수 있는 웹기반 문항 관리 시스템을 설계 및 구현한다. 제안하는 시스템은 관리자 모듈과 사용자 모듈로 구성되어 있으며, 관리자 모듈 내에서는 관련 있는 문항들을 그룹핑할 수 있는 분류관리와 문항출제 및 사용자관리, 난이도조절등과 같은 기능이 있으며, 사용자 모듈에서는 시험응시, 문항검색, 개인성적 조회, 해설듣기 등과 같은 기능을 포함하고 있다. 아울러 구현된 문항관리시스템은 CT전문방사선사 자격시험을 준비하는 방사선사들에게 정보교류, 의료컨텐츠 제공 및 학습능력 배양시킬 뿐만 아니라, 테스트 후 성적결과의 분석 및 문제해설까지 제공하는 활용가치가 높은 시스템으로 기대된다.

• 한국운동역학회지
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• 제25권3호
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• pp.323-333
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• 2015

Objective : The purpose of this study was to investigate the changes of gait patterns and muscle activations with increased loads during stair walking. Also, it can be used as descriptive data about continuous stair walking in a real life setting. Method : Twelve sedentary young male adults(Age: $27.0{\pm}1.8yrs$, Weight: $65.8{\pm}9.9kg$) without any lower extremity injuries participated in this study. Participants performed stair walking up 7 floors and their ascending and descending motion on each floor was analyzed. A wireless electromyography(EMG) were attached on the Rectus Femoris(RF), Biceps Femoris(BF), Gastrocnemius(GN), Tibialis Anterior(TA) muscle to calculate integrated EMG(iEMG), median frequency(MDF) and co-contraction index(CI). Chest and left heel accelerometer signal were recorded by wireless accelerometer and those were used to calculate approximate entropy(ApEn) for analyzing gait pattern. All analyses were performed with SPSS 21.0 and for repeated measured ANOVA and Post-hoc was LSD. Results : During ascending stairs, there were a statistically significant difference in Walking time between 1-2nd and other floors(p=.000), GN iEMG between 2-3th and 6-7th(p=.043) floor, TA MDF between 1-2nd and 5-6th(p=.030), 6-7th(p=.015) floor and TA/GN CI between 2-3th and 6-7th(p=.038) floor and ApEn between 1-2nd and 6-7th(x: p=.003, y: p=.005, z: p=.006) floor. During descending stairs, there were a statistically significant difference in TA iEMG between the 6-5th and 3-2nd(p=.026) floor, and for the ApEn between the 1-2nd and 6-7th(x: p=.037, y: p=.000, z: p=.000) floor. Conclusion : Subjects showed more regular pattern and muscle activation response caused by regularity during ascending stairs. Regularity during the first part of stair-descending could be a sign of adaptation; however, complexity during the second part could be a strategy to decrease the impact.

• 생태와환경
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• 제55권3호
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• pp.231-243
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• 2022

인위적 교란은 담수 생태계에서 어류 군집의 생물다양성을 저하시키는 것으로 알려져 있다. 본 연구에서는 교량건설이 어류 군집에 미치는 영향을 파악하기 위해, 단장천과 동천 내 총 8개 지점에서 2021년 6월부터 11월까지 어류조사를 총 5회 실시하였다. 조사 결과, 총 10과 23종 782개체가 채집되었으며, 우점종은 참갈겨니 (Zacco Koreanus)로 상대풍부도(Relative Abundance)는 50.89%로 나타났다. 유사도 지수와 UPGMA 결과, St. 3은 공사로 인해 정수역이 형성되고 하류 지점과 하상이 유사해졌음을 유추할 수 있다. 생활상에 따라 어류를 저서성(demersal)과 중층성(benthopelagic)으로 나누었을 때, 중층성 어류인 참갈겨니의 건강도가 공사지점 기준 상류지점보다 하류지점에서 낮게 나타났으며, 저서성 어류의 상대밀도는 과거에 비해 상류지점, 하류지점 모두 감소한 것으로 나타났다. 이는 교량 건설이 어류의 서식지에 부정적인 영향을 미치며, 특히 저서성 어류의 서식환경에 부정적인 영향을 미치는 것으로 판단된다. 공사에 의한 서식지 단편화, 미소서식처 파괴와 같은 교란을 완화하기 위해서는 하천의 저질상태, 유속 등을 고려한 오탁방지막과 침사지 설치와 같은 보전 방안이 필요한 것으로 사료된다.

• 한국산학기술학회논문지
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• 제19권6호
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• pp.324-333
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• 2018

본 연구의 목적은 만성질환인 고혈압, 이상지질혈증, 관절염, 갑상선 질환, 우울증, 아토피, 알레르기, 당뇨병 등의 잠재계층이 어떻게 구성되어 있는지와 유형화된 만성질환의 예측요인을 살펴보고자 하는 것이다. 연구대상은 2014년 국민건강영양조사에 참여한 대한민국 국민으로, 표본추출방법은 층화집락표본추출방법을 사용하였으며 표본 수는 총 7,550명이고, 이를 대상으로 잠재계층분석을 적용하였다. 결과적으로 1 class 유형은 고혈압, 당뇨 그룹으로 고혈압을 앓고 있을 확률이 78.6%이고 당뇨병을 앓고 있을 확률이 34.6%이었다. 2 class 유형은 아토피, 알레르기 그룹으로 아토피를 앓고 있을 확률이 20.3%이고 알레르기를 앓고 있을 확률이 42.2%이었다. 3 class 유형은 이상지질, 관절염, 갑상선질환, 우울증 그룹으로 이상지질 56.1%, 관절염 50.9%, 갑상선 질환 19.4%, 우울증 28.75%로 나타날 확률을 지닌 집단이었다. 4 class 유형은 만성질환을 갖고 있지 않은 정상집단으로 나타났다. 준거변수인 4 class와 1 class를 비교하였을 때, 연령, 운동능력, 자기관리, 비만, 고콜레스테롤 유병여부 등이 유의하게 나타났고, 2 class와 비교하였을 때, 성별, 연령, 교육수준 등이 유의하게 나타났으며, 3 class와 비교하였을 때, 성별, 연령, 통증 및 불편, 고 콜레스테롤 등이 유의하게 나타났다. 결과적으로 세 유형 모두 연령은 복합적인 만성질환을 일으킬 수 있는 요인으로 나타났는데, 이는 질환을 일으킬 수 있는 결정적인 시기가 오기 전에 예방이 중요하다는 것을 의미한다. 따라서 연령에 따른 질병의 유병율 발생 시기를 파악하여 이에 적절한 예방적 노력이 필요하다.