• Asian Pacific Journal of Cancer Prevention
• /
• 제17권3호
• /
• pp.1003-1008
• /
• 2016

Breast cancer is now the leading cause of cancer death in women worldwide. Cancer progression is driven not only by cancer cell intrinsic alterations and interactions with tumor microenvironment, but also by systemic effects. Integration of multiple profiling data may provide insights into the underlying molecular mechanisms of complex systemic processes. We performed a bioinformatic analysis of two public available microarray datasets for breast tumor stroma and peripheral blood mononuclear cells, featuring integrated transcriptomics data, protein-protein interactions (PPIs) and protein subcellular localization, to identify genes and biological pathways that contribute to dialogue between tumor stroma and the peripheral circulation. Genes of the integrin family as well as CXCR4 proved to be hub nodes of the crosstalk network and may play an important role in response to stroma-derived chemoattractants. This study pointed to potential for development of therapeutic strategies that target systemic signals travelling through the circulation and interdict tumor cell recruitment.

• 생약학회지
• /
• 제42권1호
• /
• pp.46-53
• /
• 2011

Advanced glycation end products (AGEs) have been postulated to play a central role in the development of diabetic complications. A variety of different agents that inhibit AGEs have been under investigation. In this study, 66 herbal medicines from China have been investigated with an in vitro evaluation system using AGEs formation inhibitory activity. Of these, 31 herbal medicines ($IC_{50}$ < $50\;{\mu}g/ml$) were found to have significant AGEs formation inhibitory activity. Particularly, 5 herbal medicines, Camptotheca acuminata (branches and leaves), Quercus franchetii (branches), Camellia pitardii (leaves, branches, and fruits), Antidesma bunius (whole plants), and Loranthus parasiticus (whole plants) showed more potent inhibitory activity (approximately 6-20 fold) than the positive control aminoguanidine ($IC_{50}=52.96\;{\mu}g/ml$).

• 생약학회지
• /
• 제42권2호
• /
• pp.161-168
• /
• 2011

Advanced glycation end products (AGEs) has been shown to play an important role in the development of the diabetic complications. The AGEs inhibitors or cross-link breakers attenuate various functional and structural manifestations of diabetic complications. In this study, 69 China herbal medicines have been investigated with an in vitro evaluation system using AGEs inhibitory activity. Of these, 28 herbal medicines $IC_{50}$=<50 ${\mu}g/ml$) were found to have stronger AGEs inhibitory activity compared with aminoguanidine ($IC_{50}$=59.77 ${\mu}g/ml$). Particularly, 5 herbal medicines, Camptotheca acuminata (stem, leaf), Eurya groffii (stem, leaf), Cornus Capitata (leaf), Mucuna birdwoodiana (root), Nelumbo nucifera (fruit, seed) showed more potent inhibitory activity (approximately 6-27 fold) than the positive control aminoguanidine.

• 대한안전경영과학회지
• /
• 제14권4호
• /
• pp.107-116
• /
• 2012

The issues raised so far in the development of safety-critical systems have centered on how effectively the safety requirements are met in systems design. The systems are becoming more complex due to the increasing demand on the functionality and performance. As such, the integration of both the systems design and systems safety processes becomes more important and at the same time quite difficult to carry out. In this paper, an approach to solving the problem is presented, which is based on an integrated data model. To do so, the data generated from the inputs and outputs of the systems design and systems safety processes are analyzed first. The results of analysis are used to extract common attributes among the data, thereby making it possible to define classes. The classes then become the cores of the interface data model through which the interaction between the two processes under study can be modeled and interpreted. The approach taken has also been applied in a design case to demonstrate its value. It is expected that the results of the study could play a role of the stepping stone in extending to the architecture development of the integrated process.

• International Journal of Knowledge Content Development & Technology
• /
• 제12권2호
• /
• pp.57-75
• /
• 2022

Currently, it is not easy for most domestic public libraries to collect and provide reliable health information services on their own. Health information is distributed or professional, making it inconvenient for users to use. Based on the implications derived from the case study, the Library Health Information Integration Service Model was proposed as a specialized information service. The model consists of a composition shared by librarians, health and medical experts, and users, focusing on library websites that provide integrated health information integration services, and has the following features. First, it provides health and medical information on a specialized subject. Second, it provides integrated health and medical information services provided in various ways. Third, librarians and health and medical experts work together to provide information services. Fourth, users can freely use health information integration services online and offline. The model presented in this study means that libraries can play a leading role in health information integration services to increase the utilization rate of public libraries and further contribute to librarians serving as experts in health information services.

• 한국정밀공학회:학술대회논문집
• /
• 한국정밀공학회 1997년도 춘계학술대회 논문집
• /
• pp.395-399
• /
• 1997

An international standard for the product model data, STEP, and a standard for the distributed object technology. CORBA, will play a very important role in the future manufacturing environment. These two technologies provide background for the sharing of product data and the integration of applications on the network. This paper describes a prototype CAD/CAE enviroment that is integrated on the network by STEP and CORBA. Several application servers and client software were developed to verify the proposed concept.

• 한국전자거래학회:학술대회논문집
• /
• 한국전자거래학회 2005년도 종합학술대회
• /
• pp.118-123
• /
• 2005

Nowadays, ebXML and Web Services are two major e-business frameworks, and ebXML Registry and UDDI play important roles in publishing and inquiring business partners' meta information. These two types of registries should be interoperated in order to interoperate two frameworks. In this paper we propose interoperation procedures for each case of interoperation, i.e. ebXML-based, WS-based, or Integrated Model-based Interoperation.

• 대한전자공학회논문지TC
• /
• 제43권5호
• /
• pp.7-16
• /
• 2006

IPTV는 하나의 셋톱박스로 TV와 연결, DSL망이나 광가입자망(FTTH)나 광동축혼합망(HFC)을 통해 초고속인터넷 방송 데이터서비스 전자상거래 등을 제공하는 서비스를 말한다. 최근 IPTV에 대한 사회적 분위기가 무르익으면서 통신사업자들 사이에서는 더 이상 IPTV 투자계획을 미룰 수 없다는 절박함과 함께 네트워크 고도화 전략이 IPTV 서비스의 승부처로 부각되고 있다. 인터넷 IPTV 인터넷전화 등 트리플플레이서비스(TPS)를 제공하기 위해서는 광케이블을 이용한 FTTH 구축이 필수적이다. IPTV를 염두에 둔 통신사들의 네트워크 전략은 특히 현재의 초고속인터넷망 주류인 xDSL이나 케이블모뎀 망(HFC)이 광랜이나 광가입자망(FTTH) 등 100Mbps급으로 바뀌는 촉매제 역할을 할 것으로 예상된다. 대용량 멀티미디어, 즉 TV프로그램도 실시간으로 전송할 수 있는 초고속인터넷 가입자망의 진화에 따라 등장한 IPTV는 방송법상의 종합유선방송(케이블TV)과 사실상 동일한 서비스를 제공할 수 있다. IPTV는 케이블TV업계의 존립을 흔들 수 있는 위협적인 존재가 아닐 수 없다. 비즈니스 모델이 똑같기 때문입니다. 시장 정체에 빠진 유선 통신사업자는 케이블TV방송사(SO)에 대응해 초고속인터넷 시장을 지키기 위해서라도 반드시 방송부문의 협력이 필요한 상황이다. 분명한 것은 IPTV가 컨버전스 시대의 신규 서비스로, 소비자에게 다양한 서비스의 선택권을 제공해 국민의 편의를 높일 것이다. 이에 따른 통신 업체의 정부의 역할에 대하여 논의한다.

• 대한한의학회지
• /
• 제34권2호
• /
• pp.41-50
• /
• 2013

Objectives: As a newcomer to the medical tourism industry, Korea needs to differentiate itself from the leading competing countries to vitalize its early-stage medical tourism industry. This study aims to introduce a strategic plan to vitalize the Korean integrated medical tourism so that Korea can differentiate itself from competing countries and create high added value. Methods: The concept and actual conditions of medical tourism and Oriental medical tourism were examined. A plan to differentiate Korea from the competing countries in the medical tourism industry was studied to create high added-value through strategic vitalization of its medical tourism industry. Results: Korean integrated medical tourism must be developed differently from those of other South-East Asian countries in order to strategically promote the cash-cow medical tourism industry. In order to develop such medical tourism, Korean medical practice, which integrates Western and Oriental medicine, is to be developed through mutual understanding and fusion of other disciplines among medical doctors and Oriental medical doctors who are working in local healthcare for health promotion of local residents and disease prevention and control. This will play a key role in developing a unique medical tourism product of Korea by means of strategic alliances as an integrated medicine. Manpower specialized for integrated medicine is to be specially supplied for Oriental medicine-related business lines at city, county and borough levels, among local governments, that are enthusiastically carrying forward Oriental medical tourism with an interest to promoting more active and strategic business development and raise the effectiveness and efficiency of public health centers handling related medical tourism. Manpower specialized for Korean integrated medical tourism is to be specially supplied for the Ministry of Culture, Health and Tourism, a policy control tower to develop and vitalize high value-added fusion (theme) tourism products such as the Korean integrated medical tourism, in order to discover, promote and support Korean integrated medical tourism's differences from existing medical tourism. Conclusions: The differentiated integrated medical tourism that only Korea can offer in a variety of forms, in order to create a key area of high value-added medical tourism, should be strategically vitalized through a liaison between integrated medicine and tourism and the realization of patient-centered health care services with medical technology developed based on mutual understanding of Western and Oriental medicine.

• 한국정보통신학회논문지
• /
• 제13권1호
• /
• pp.45-52
• /
• 2009

최근 들어 통방융합이 진행되고 있는데, 이는 방송, 통신, 전화 서비스가 통합된 TPS(Triple Play Service)를 제공하는 IPTV(Internet Protocol TV) 서비스를 등장시켰다. IPTV는 방송 서비스와 VOD(Video on Demand) 서비스를 제공하며, 이에 대한 보안을 위해 IPTV 포럼에서 CAS(Conditional Access System)와 DRM(Digital Rights Management) 보안 솔루션 인터 페이스 표준화를 진행 중에 있다. CAS는 실시간 방송 보안에 적합하고, DRM은 VOD 서비스 보안에 적합하다. 그러나 이 보안 시스템들은 제작자에 따라 권한정보의 표현 및 관리가 서로 상이하여 상호운용 부재를 야기한다. 또한 CAS와 DRM의 인터페이스 표준화 작업이 완료되면 표준 인터페이스를 기반으로 이기종 보안 시스템간의 통합 운용 요구가 발생할 것으로 사료된다. 이는 보안 시스템과 플랫폼에 독립적으로 상호 운용 가능한 권한 정보 관리 시스템의 필요성을 의미한다. 이에 본 논문에서는 멀티미디어 디지털 콘텐츠의 보호와 유연한 IPTV 서비스를 위해 CAS와 DRM을 연계하여 권한 정보를 관리하는 수신권한 관리 시스템을 설계 및 구현하였다.