• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
• /
• v.29 no.2
• /
• pp.12-32
• /
• 2016

Objectives : The objective of this study is to develop the strategies of the psoriasis clinical trials guideline on Korean medicine by comparison between Clinical guidelines and domestic and foreign clinical trials papers of psoriasis on Korean medicine. Methods : This study is based on analysis of papers on Clinical trials guidelines, Clinical practice guideline and clinical trials about Korean medicine. The papers were searched from Pubmed, Medline, Oasis(Oriental Medicine Advanced Searching Integrated System), Korean Traditional Knowledge Portal and Google portal database. Results : A total 8 Clinical practice guidelines and 2 Clinical trials guidelines were found. Moreover, there were 15 foreign papers about clinical trials and 29 internal articles about case studies. They suggested the diagnostic strategy, classification, effective outcome measure, severity measure, precaution of combination therapy, precaution and treatment period of clinical trials, safety evaluation, patterns of Korean Medicine, clinical specific features on psoriasis.Conclusions : The criteria of every item to provide the clinical trials guideline using Korean medicine on psoriasis were developed by apply the results. If we accumulate the more clinical articles on Korean medicine, it will be great help to develop the reliable standard of that guideline.

• Journal of the Korean association of regional geographers
• /
• v.12 no.4
• /
• pp.508-521
• /
• 2006

The results of environmental equity analysis vary dramatically depending on different methods used. The information and data available to the researcher are also often uncertain and imprecise in empirical studies. A sensitivity analysis approach was used too handle uncertainties and methodological inconsistencies in environmental equity analysis. This paper explores the sensitivity of environmental equity analysis to two spatial measures such as proximity and scale. Two experiments were implemented to evaluate the effects of two spatial measures on the environmental equity analysis using a combination of control and experimental factors. Fulton County, Georgia was selected as a case study area for these experiments. Two major data sets including demographic characteristics and toxic release inventory (TRI) database for the study area in 1990 were integrated into a GIS environment. Two statistical analyses such as independent samples t-test and coefficient of variation were performed to determine the environmental equity in the study area and to compare the relative variability in the socioeconomic characteristics of populations over different spatial measures. The findings from two experiments indicate that the outcomes of environmental equity analysis are slightly sensitive to the buffer distance used to determine the impact zones of TRI facilities, but not to the geographic scale used in the analysis. The findings also suggest that the consequences of these choices can alter spatially and statistically the results in environmental equity analysis.

• Journal of Veterinary Clinics
• /
• v.33 no.5
• /
• pp.278-285
• /
• 2016

Epidemiological studies have shown the association between transportation of live animals and the potential transmission of infectious disease between premises. This finding was also observed in the 2014-2015 foot-and-mouth disease (FMD) outbreak in Korea. Furthermore, slaughterhouses played a key role in the global spread of the FMD virus during the epidemic. In this context, in-depth knowledge of the structure of direct and indirect contact between slaughterhouses is paramount for understanding the dynamics of FMD transmission. But the social network structure of vehicle movements to slaughterhouses in Korea remains unclear. Hence, the aim of this study was to configure a social network topology of vehicle movements between slaughterhouses for a better understanding of how they are potentially connected, and to explore whether FMD outbreaks can be explained by the network properties constructed in the study. We created five monthly directed networks based on the frequency and chronology of on- and off-slaughterhouse vehicle movements. For the monthly network, a node represented a slaughterhouse, and an edge (or link) denoted vehicle movement between two slaughterhouses. Movement data were retrieved from the national Korean Animal Health Integrated System (KAHIS) database, which tracks the routes of individual vehicle movements using a global positioning system (GPS). Electronic registration of livestock movements has been a mandatory requirement since 2013 to ensure traceability of such movements. For each of the five studied networks, the network structures were characterized by small-world properties, with a short mean distance, a high clustering coefficient, and a short diameter. In addition, a strongly connected component was observed in each of the created networks, and this giant component included 94.4% to 100% of all network nodes. The characteristic hub-and-spoke type of structure was not identified. Such a structural vulnerability in the network suggests that once an infectious disease (such as FMD) is introduced in a random slaughterhouse within the cohesive component, it can spread to every other slaughterhouse in the component. From an epidemiological perspective, for disease management, empirically derived small-world networks could inform decision-makers on the higher potential for a large FMD epidemic within the livestock industry, and could provide insights into the rapid-transmission dynamics of the disease across long distances, despite a standstill of animal movements during the epidemic, given a single incursion of infection in any slaughterhouse in the country.

• The KIPS Transactions:PartD
• /
• v.10D no.2
• /
• pp.247-260
• /
• 2003

To share and standardize information, especially in the database environments, MDR (Metadata Registry) can be used to integrate various heterogeneous databases within a particular domain. But due to the discrepancies of data element representation between organizations, global information integration is not so easy. And users who are searching integrated information on the Web have limitation to obtain schema information for the underlying source databases. To solve those problems, in this paper, we present a 3-layered Information Integration System (LI2S) based on MDRs and Ontology. The purpose of proposed architecture is to define information integration model, which combine both of the nature of MDRs standard specification and functionality of ontology for the concept and relation. Adopting agent technology to the proposed model plays a key role to support the hierarchical and independent information integration architecture. Ontology is used as for a role of semantic network from which it extracts concept from the user query and the establishment of relationship between MDRs for the data element. (MDR and Knowledge Base are used as for the solution of discrepancies of data element representation between MDRs. Based on this architectural concept, LI2S was designed and implemented.

• Korean Journal of Clinical Laboratory Science
• /
• v.53 no.4
• /
• pp.353-362
• /
• 2021

Cancer is a global health problem. There are diverse types of cancers, but there are several common pathways which lead to the development of cancer. Changes in gene expression might be the most common similarity found in almost all cancers. An understanding of the underlying changes in gene expression during cancer progression could lay a valuable foundation for the development of cancer therapeutics and even cancer vaccines. In this study, a well-known carcinogen, N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), was employed to induce changes in gene expression in normal stomach cells. MNNG is known to cause cancer by inducing damage to DNA in MNNG-treated mammalian cells and animals fed with this carcinogen. An analysis was performed by comparing the differentially expressed genes (DEGs) caused by MNNG treatment with DEGs in stomach cancer cell lines. To this end, methods of analysis for functional categorization and protein-protein interaction networks, such as gene ontology (GO), the database for annotation, visualization, and integrated discovery (DAVID), Kyoto encyclopedia of genes and genomics (KEGG) and search tool for the retrieval of interacting genes/proteins (STRING), were used. As a result of these analyses, MNNG-regulated specific genes and interaction networks of their protein products that contributed to stomach cancer were identified.

• Korean Journal of Ecology and Environment
• /
• v.54 no.3
• /
• pp.151-155
• /
• 2021

The application of environmental DNA in the domestic ecosystem is also accelerating, but the processing and analysis of the produced data is limited, and doubts are raised about the reliability of the analyzed and produced biological taxa identification data, and the sample medium (target sample, water, air, sediment, Gastric contents, feces, etc.) and quantification and improvement of analysis methods are also needed. Therefore, in order to secure the reliability and accuracy of biodiversity research using the environmental DNA of the domestic ecosystem, it is a process of actively using the database accumulated through ecological taxonomy and undergoing verification procedures, and experts verifying the resolution of the data increased by gene sequence analysis. This is absolutely necessary. Environmental DNA research cannot be solved only by applying molecular biology technology, and interdisciplinary research cooperation such as ecology-taxa identification-genetics-informatics is important to secure the reliability of the produced data, and researchers dealing with various media can approach it together. It is an area in desperate need of an information sharing platform that can do this, and the speed of development will proceed rapidly, and the accumulated data is expected to grow as big data within a few years.

• Journal of Korean Medicine Rehabilitation
• /
• v.29 no.3
• /
• pp.75-85
• /
• 2019

Objectives This study was perfomed to assess the adherance to CARE (CAse REport) guideline of case reports in the Journal of Korean Medicine Rehabilitation Methods We searched the case reports published in the Journal of Korean Medicine Rehabilitation from January 2016 to April 2019 in the database of oriental medicine advanced searching integrated system (OASIS). Then we evaluated the quality of the searched case reports based on the CARE guideline. Results Totally 31 papers were selected after the screening the case reports by the inclusion and exclusion criteria. The report rate of the sub-items of the CARE guideline was 78.26% at the maximum, 60.87% at the maximum, and 70.97% on the average. The following items were reported only in less than 50% of them; 'Timeline', 'Diagnostic challenges', 'Diagnostic reasoning including other diagnoses considered' 'Prognostic characteristics', 'Follow-up and Outcomes', 'Patient Perspective', 'Informed Consent' Conclusions This study is expected to contribute to the overall improvement of the level of case reports in the Journal of Korean Medicine Rehabilitation.

• The Journal of Internal Korean Medicine
• /
• v.40 no.3
• /
• pp.409-424
• /
• 2019

Objectives: This research aimed to confirm the efficacy of oriental medicine in sixth cranial nerve palsy and to evaluate the quality of the studies. Methods: Using the medical subject heading (MeSH) keywords "abducens nerve palsy", "abducens nerve paralysis", "sixth nerve palsy", "herbal medicine", "Chinese medicine", "oriental medicine" and "acupuncture", we collected the research papers through an electronic database search in Oriental Medicine Advanced Searching Integrated System (OASIS), National Discovery for Science Leaders (NDSL), PubMed, Cochran Library, and China National Knowledge Infrastructure (CNKI). Results: A total of 136 papers were searched from the databases. Among these, 15 case reports and 8 randomized controlled trials (RCTs) met our criteria. 17 articles were found on the use of acupuncture as the main intervention, 11 on the use of herbal medicine as the main intervention, and 9 on the use of electroacupuncture as the main intervention. The frequently used acupoints were LI4, EX-HN5, GB1, BL2, TE23, LR3, BL1, ST2, GB20, and ST36. All 23 studies confirmed the efficacy of Korean medicine. According to the assessment using the risk of bias, the overall quality of the RCTs was low. Conclusions: Twenty-three papers suggested that Korean medicine treatment for abducens nerve palsy was effective in many cases. Analyzing the potential bias was difficult.

• Journal of Trauma and Injury
• /
• v.32 no.3
• /
• pp.143-149
• /
• 2019

Purpose: No previous study has assessed elderly pedestrian traffic accidents based on a nationwide database. This study aimed to help primary physicians who examine patients in emergency departments to determine and make prompt and accurate treatment decisions. Methods: This study used data from the Emergency Department-based Injury Indepth Surveillance from 2013 to 2017, managed by the Korea Centers for Disease Control and Prevention. Pedestrians aged ${\geq}65years$ were included, and using multivariate logistic regression multiple factors were analyzed to determine their relationship with injury severity. Results: Of 227,695 subjects, 6,498 were included, of whom 2,065 (31.8%) were severely injured. There were more female than male patients in all severity groups. Most accidents occurred in the afternoon and on general roads. In the multivariate analysis, the odds ratio (OR) of injury severity for male pedestrians was 1.165 (95% confidence interval: 1.034-1.313, p=0.012). Older age of patients and the use of ambulances were associated with greater injury severity. The accident time affected the degree of injury severity; i.e., compared to dawn, injury severity increased in the morning (OR: 1.246, p=0.047) and decreased at night (OR: 0.678, p<0.001). A significant difference was noted in the correlation between the type of vehicle causing the accident and the accident severity; i.e., motorcycle accidents had lower severity than bicycle accidents (OR: 0.582, p=0.047). Conclusions: Injury severity was correlated with sex, age, transportation to the ED, TA onset time, and type of vehicle. The study results suggest that injury severity may be positively reflected in initial assessments and overall integrated treatments by physicians and in the related policies.

• The Korean Journal of Archival Studies
• /
• no.1
• /
• pp.137-188
• /
• 2000

Korea was highly successful in maintaining a strong tradition of record preservation. However, Japanese imperialism and the Korean war over this century has seen a huge quantity of these once plentiful records either destroyed or relocated overseas. Many of Korea records remain in the custody of foreign archival institutions. Additionally, many records of foreign states concerned with korean affairs, for example, records of the Department of state, in the U.S.A., are of great relevance to Korean modern history. These records which exist in foreign countries are a necessary and invaluable resource in the advancement of Korea studies. After the 1980s, as research interest in Korean modern history increased gradually, much historical material related to Korea was extensively introduced, removed, collected from the U.S.A., Japan, Russia and China etc. by the efforts of pioneering scholars and institutions. Several attempts at collating and publishing this material have been made. Despite this encouraging result, individual scholars and institutions's efforts face problems in relation to removal of records. Firstly, it is repeated nonproductively to remove and collect the same records, for we didn't establish a comprehensive information system, through which the condition of foreign record removal and management is able to be administrated. Secondly, there is no system for arrangement, preservation, use of removed records. For example, finding aids, such as inventory, register, description, isn't prepared for user. A user may usually not understand an accurate context of their creation, preservation removal. Thirdly, almost institution has arranged the removed records among other materials and books. Each institution has a different classification criteria, too. These conditions seem to make a difficulty in national management. This study investigated how the materials for Korea history which has been removed from foreign countries should be managed for effective preservation and use. For these purpose, we investigated the present conditions of removal and management of these materials. Also, we investigated examples of the foreign state, U.S.A. and Japan to have a idea for removal and management policy. Then, This study propose a establishment of information network system as management policy. To administrate removing and managing records effectively, an idea that records belong to the public should be accepted commonly. The policy for management of the record is followings. Firstly, unification of classification is necessary. The records which were removed from foreign countries had better to be classified according to their origins of states and institutions. Secondly, Finding aids should be prepared for user. There are many accession aids such as catalog, register, inventory for user in archives. This will be a efficient method for management. When a record is removed, a card for description of contents must be composed. Thirdly, a digital input and network system establishment is necessary. It will help to manage a condition of removed records. A digital input and management system establishment is not just a project of digitalizing records. At present, various finding aids need to be introduced to make a database for records and archives. An search using only 'search engine' may make a difficulty in finding materials because such method is apt to have too much or little result. So, classification, arrangement, description, response-service should be integrated in these system. The recent technical advancement give a opportunity to realize this idea. Above all, these procedure should be archival process.