• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
• /
• v.16 no.2
• /
• pp.291-297
• /
• 1998

In order to accomplish the digital map production I/O devices should be used which are used for data input procedure to convert original paper map(hardcopy) data into computer compatible digital map data, and for the mapsheet output procedure of worked out data. For the input device, digitizer and scanner are most frequently used. Digitizer has possibility of direct production of digital data, and are mainly used for input procedure of partly plotted source map. In contrary, scanner is rather easy to operate the instrument, so that is widely used for the input procedure of original sheet map. In this study, to extract the input device characteristics, some kinds of digitizers and scanners were cheesed and used for the positional error analysis through the operational method and types of instruments. Also for the output device characteristics, some kinds of plotter and materials are used and compared to analyze the positional error through the instrumental types and output sheet materials.

• Journal of Pharmaceutical Investigation
• /
• v.23 no.1
• /
• pp.11-18
• /
• 1993

Inclusion complex of ibuprofen with $2-Hydroxypropyl-{\beta}-cyclodextrin\;(HP-{\beta}-CD)$ in aqueous solution and in the solid state was evaluated by the solubility method and the instrumental analysis such as infrared spectroscopy, thermal analysis and x-ray diffractometry. The aqueous solubility of ibuprofen was increased linearly with the increase in the concentration of $HP-{\beta}-CD$, showing an $A_L$ type phase solubility diagram. The results showed that the dissolution rate of ibuprofen was significantly increased by complexation with $HP-{\beta}-CD$. $Ibuprofen-HP-{\beta}-CD$ complex enhanced the mean plasma concentration levels and the area under plasma concentration-time curve after oral administration compared to those of the drug alone. It is concluded that the complex of ibuprofen with $HP-{\beta}-CD$ increases the dissolution rate and improves the bioavailability of the ibuprofen by the formation of a water-soluble complex.

• Earthquakes and Structures
• /
• v.17 no.4
• /
• pp.365-372
• /
• 2019

Post-earthquake crisis management is a key capability for a country to be able to recover after a major seismic event. Instrumental seismic data transmitted and processed in a very short time can contribute to better management of the emergency and can give insights on the earthquake's impact on a specific area. Romania is a country with a high seismic hazard, mostly due to the Vrancea intermediate-depth earthquakes. The elastic acceleration response spectrum of a seismic motion provides important information on the level of maximum acceleration the buildings were subjected to. Based on new data analysis and knowledge advancements, the acceleration elastic response spectrum for horizontal ground components recommended by the Romanian seismic codes has been evolving over the last six decades. This study aims to propose a framework for post-earthquake warning based on code spectrum exceedances. A comprehensive background analysis was undertaken using strong motion data from previous earthquakes corroborated with observational damage, to prove the method's applicability. Moreover, a case-study for two densely populated Romanian cities (Focsani and Bucharest) is presented, using data from a $5.5M_W$ earthquake (October 28, 2018) and considering the evolution of the three generations of code-based spectral levels for the two cities. Data recorded in free-field and in buildings were analyzed and has confirmed that no structural damage occurred within the two cities. For future strong seismic events, this tool can provide useful information on the effect of the earthquake on structures in the most exposed areas.

• Korean Institute of Interior Design Journal
• /
• v.18 no.2
• /
• pp.80-92
• /
• 2009

Natural history museums preserve and manage the creatures living in each country, so they play unique roles for bio-diversity, and in fact, their roles are really instrumental for the collection, preservation, research, exhibition and education of creatures in the 21st century. Therefore, this research has the purpose to survey the status of our country's existing natural history museums, analyze their visual perception space structural characteristics, and ultimately utilize their characteristics as basic data in planning out and designing spaces of natural history museums to be established later on. As for the research scope, the research selected as research subjects 7 natural history museums that currently have composite set of open type and mixed type and have been accommodating comparatively active exhibitions since 2000 among 10 or so natural history museums in our country. Research method is that the research analyzed the exhibition spaces of 7 natural history museums by using depthmap program which can analyze space with visual graph analysis function, and analyzed the visibility among unit areas by each natural history museum integration and exhibition contents composition. In such analysis method, the research was able to quantitatively analyze the visual characteristics of exhibition space that induces and adjusts the motion of audience. Visual perception quantitative analysis as in this research will enhance exhibition design by considering the correlation between audience and exhibited items when planning out natural history museums space to be established later on.

• Korean Journal of Medicinal Crop Science
• /
• v.3 no.3
• /
• pp.226-232
• /
• 1995

Extraction methods and instrumental analytical conditions were compared to establish a fast and appropriate analytical method to determine saikosaponins in Bupleurum falcatum. Using HPLC, analysis of diene-saikosaponin treated with 2% acid was faster than that of saikosaponin itself. Among various extraction methods, extraction by standing in methanol at room temperature showed highest efficieny, and extraction with boiling methanol was shorter in analytical time and showed good chromatogram. And we could analyze many samples faster using HPTLC but the analytical accuracy was low. In extraction and analysis of saikosaponins, extraction with boiling methanol and acidic treatment was fast and easy analytical method. And for selecting useful lines in component breeding, we think TLC method was better.

• The Korean Journal of Community Living Science
• /
• v.23 no.3
• /
• pp.255-263
• /
• 2012

Polybrominated diphenyl ethers (PBDEs) are a group of brominated flame retardants (BFRs), which are used in a variety of consumer products. Several of those are produced in large quantities. Their chemical structure similarities to polychlorinated dibenzo-p-dioxins and polychlorinated biphenyls (PCBs), as well as their toxicity, has been studied. PBDEs are persistent and lipophilic, which results in their bioaccumulation in the fatty tissues of organisms and enrichment throughout food chains. In addition, a number of studies also reported high levels of PBDEs in animals and food resulting from the use of contaminated animal feed Public concern about PBDEs levels in animals and food has been raised. Feed contamination by toxic chemicals has been the cause of the contamination of poultry products. The purpose of this study was to evaluate PBDEs in pig feed to search the origin chase of POPs in pigs. Feed samples were obtained wheat from East Europe, corn from South America and America, soybean meal from Korea, America, South America and India and tallow from Korea. The preparation of samples was based on the EPA method 1614. Instrumental analysis was based on the use of high resolution gas chromatography coupled to high resolution mass spectrometry (HRGC/HRMS). Quantification was carried out by the isotopic dilution method. The analysis of ${\Sigma}PBDEs$ involved 22 PBDE congeners, including BDE-17, 28, 47, 49, 66, 71, 77, 85, 99, 100, 119, 126, 138, 153, 154, 156, 183, 184, 190, 191, 196 and 197.

• Proceedings of the Korean Society of Toxicology Conference
• /
• 2006.11a
• /
• pp.65-74
• /
• 2006

Modem drug discovery requires rapid pharmacokinetic evaluation of chemically diverse compounds for early candidate selection. This demands the development of analytical methods that offer high-throughput of samples. Naturally, liquid chromatography / tandem mass spectrometry (LC-MS/MS) is choice of the analytical method because of its superior sensitivity and selectivity. As a result of the short analysis time(typically 3-5min) by LC-MS/MS, sample preparation has become the rate- determining step in the whole analytical cycle. Consequently tremendous efforts are being made to speed up and automate this step. In a typical automated 96-well SPE(solid-phase extraction) procedure, plasma samples are transferred to the 96-well SPE plate, internal standard and aqueous buffer solutions are added and then vacuum is applied using the robotic liquid handling system. It takes only 20-90 min to process 96 samples by automated SPE and the analyst is physically occupied for only approximately 10 min. Recently, the ultra-high flow rate liquid chromatography (turbulent-flow chromatography)has sparked a huge interest for rapid and direct quantitation of drugs in plasma. There is no sample preparation except for sample aliquotting, internal standard addition and centrifugation. This type of analysis is achieved by using a small diameter column with a large particle size(30-5O ${\mu}$m) and a high flow rate, typically between 3-5 ml/min. Silica-based monolithic HPLC columns contain a novel chromatographic support in which the traditional particulate packing has been replaced with a single, continuous network (monolith) of pcrous silica. The main advantage of such a network is decreased backpressure due to macropores (2 ${\mu}$m) throughout the network. This allows high flow rates, and hence fast analyses that are unattainable with traditional particulate columns. The reduction of particle diameter in HPLC results in increased column efficiency. use of small particles (<2 urn), however, requires p.essu.es beyond the traditional 6,000 psi of conventional pumping devices. Instrumental development in recent years has resulted in pumping devices capable of handling the requirements of columns packed with small particles. The staggered parallel HPLC system consists of four fully independent binary HPLC pumps, a modified auto sampler, and a series of switching and selector valves all controlled by a single computer program. The system improves sample throughput without sacrificing chromatographic separation or data quality. Sample throughput can be increased nearly four-fold without requiring significant changes in current analytical procedures. The process of Bioanalytical Method Validation is required by the FDA to assess and verify the performance of a chronlatographic method prior to its application in sample analysis. The validation should address the selectivity, linearity, accuracy, precision and stability of the method. This presentation will provide all overview of the work required to accomplish a full validation and show how a chromatographic method is suitable for toxirokinetic sample analysis. A liquid chromatography/tandem mass spectrometry (LC-MS/MS) method developed to quantitate drug levels in dog plasma will be used as an example of tile process.

• Journal of Food Hygiene and Safety
• /
• v.5 no.3
• /
• pp.159-164
• /
• 1990

To detect and quantitation residual antibiotics and antibacterial agents in meats, we performed a biological assay employing the three microorganisms Bacillus subtilis ATCC 6633, Micrococcus luteus ATCC 9341, and Bacillus cereus var. mycoides ATCC 11778 for the screening purpose and developed a Gas Chromatography-mass Spectrometry(GC/MS) analysis for the confirmation and quantiation. In the biological assay (paper disk method), three test solution are used depending on the character of the residual antibiotics and antibacterial agents, follow by a simple clean up procedure which includes homogenization with Mcilvaine buffer, defatting with includes homogenization with Mcilvaine buffer, defatting with hexane, extraction with chloroform, clean-up by Sep-Pak $C_{18}$ and Bakerbond SPE carboxylic acid column. The chloroform layer is used for the analysis of sulfa agents. macrolides antibiotics and antibacterial agents, Adsorbed materials in the Sep-Pak $C_{18}$ were also employed for th analysis of penicillins and tetracyclines. Effluents from the Sep-Pak $C_{18}$ were cleaned-up one more by Bakerbond 10 SPE COOH column and employed for the analysis of aminoglycosides. In the instrumental analysis by using the GC/MSD, residual antibiotics and antibacterial agent were quantitated by selected ion monitoring (SIM) mode after derivatization. A simultaneous analysis of six residual antibiotic and antibacterial agent such as oxytetracycline, penicillin, ampicillin, choliraphenicol and thiamphenicol was developed with simple cleanup procedures revealing good recovery and reproducibility. Also, simultaneous detection of macrolides antibiotics such as erythromycin, spiramycin, and oleandomycin was developed after acid hydrolysis due to their large molecular structures. Because of the high reproducibility and selectivity of these two methods, it is very desirable that the combination of the two methods be used in the bioassay for the screening of residual antibiotics and antibacterial agent and that GC/MSD analysis be used for the confirmation and quantitation.

• The Korean Journal of Pesticide Science
• /
• v.19 no.3
• /
• pp.185-194
• /
• 2015

This study was performed to establish a single residue analytical method for determining fungicide carpropamid residues in various agricultural commodities. Korean cabbage, apple, brown rice and green pepper were selected as representative crops. Samples were homogenized, extracted with acetone and purified by liquid-liquid partition and Florisil column chromatography. Carpropamid residues were analyzed at 220 nm with reversed phase HPLC equipped octylsilyl and octadecylsilyl column and confirmed using mass spectrometry. ILOQ (Instrumental limit of quantitation) of carpropamid was 2 ng and MLOQ (Method LOQ) was 0.02 mg/kg. Mean recoveries from four kinds of crop samples fortified at three levels (MLOQ, 10LOQ, 100LOQ) in triplicate were in the range of 84~112%. Relative standard deviations of the analytical method were all less than 10%, irrespective of crop types.

• Korean Journal of Soil Science and Fertilizer
• /
• v.32 no.3
• /
• pp.268-273
• /
• 1999

To measure the precision of Soiltek$^{(R)}$ KA-1 spectrophotometric measurement of soil available phosphate, standard deviation, C;V, and relative sensitivity were investigated, comparing to Lancaster method. Available phosphate concentration measured by Soiltek$^{(R)}$ KA-1 spectrophotometric method was highly correlated with Lancaster method($r=0.998^{***}$) and the slop of regression equation was close to 1.0. There were no differences in standard deviation. CV, and relative sensitivity for soil available phosphate concentrations measured by two methods. Regarding to convenience of experimental procedure and instrumental operation, and time saving analysis, Soiltek$^{(R)}$ KA-1 spectrophotometric measurement for soil available phosphate is highly recommended.