• Molecules and Cells
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• v.46 no.6
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• pp.360-373
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• 2023

Papillary thyroid carcinoma (PTC) is the most common subtype of thyroid carcinoma. Despite a good prognosis, approximately a quarter of PTC patients are likely to relapse. Previous reports suggest an association between S-phase kinase-associated protein 2 (SKP2) and the prognosis of thyroid cancer. SKP1 is related to apoptosis of PTC cells; however, its role in PTC remains largely elusive. This study aimed to understand the expression and molecular mechanism of SKP2 in PTC. SKP2 expression was upregulated in PTC tissues and closely associated with clinical diagnosis. In vitro and in vivo knockdown of SKP2 expression in PTC cells suppressed cell growth and proliferation and induced apoptosis. SKP2 depletion promoted cell autophagy under glucose deprivation. SKP2 interacted with PH domain leucine-rich repeat protein phosphatase-1 (PHLPP1), triggering its degradation by ubiquitination. Furthermore, SKP2 activates the AKT-related pathways via PHLPP1, which leads to the cytoplasmic translocation of SKP2, indicating a reciprocal regulation between SKP2 and AKT. In conclusion, the upregulation of SKP2 leads to PTC proliferation and survival, and the regulatory network among SKP2, PHLPP1, and AKT provides novel insight into the molecular basis of SKP2 in tumor progression.

• Journal of Korean Tunnelling and Underground Space Association
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• v.11 no.3
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• pp.303-314
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• 2009

Image analyses for sheared joint specimens are performed to study asperity degradation characteristics with respect to the roughness mobilization of rock joints. Four different types of joint specimens, which are made of high-strength gypsum materials, are prepared by replicating the three-dimensional roughness of rock joints. About twenty jointed rock shear tests are performed at various normal stress levels. The characteristic and scale of asperity degradation on the sheared joint specimens are analyzed using the digital image analysis technique. The results show that the asperity degradation characteristic mainly depends on the normal stress level and can be defined by asperity failure and wear. The asperity degradation develops significantly around the peak shear displacement and the average amount of degraded asperities remains constant with further displacement because of new degradation of small scale asperities. The shear strength results using high-strength gypsum materials can not fully represent physical properties of each mineral particles of asperities on the natural rock joint surface. However the results of this quantitative estimation for the relationship between the peak shear displacement and the asperity degradation suggest that the characterization of asperity degradation provides an important insight into mechanical characteristics and shear models of rock joints.

• Convergence Security Journal
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• v.22 no.4
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• pp.161-168
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• 2022

After the corona virus, as non-face-to-face services are activated, domain services that guarantee integrity by embedding sensing information of the Internet of Things (IoT) with block chain technology are expanding. For example, in areas such as safety and security using CCTV, a process is required to safely update firmware in real time and to confirm that there is no malicious intrusion. In the existing safe security processing procedures, in many cases, the person in charge performing official duties carried a USB device and directly updated the firmware. However, when private blockchain technology such as Hyperledger is used, the convenience and work efficiency of the Internet of Things environment can be expected to increase. This article describes scenarios in how to prevent vulnerabilities in the operating environment of various customers such as firmware updates and device changes in a non-face-to-face environment. In particular, we introduced the optimal blockchain technique for the Internet of Things (IoT), which is easily exposed to malicious security risks such as hacking and information leakage. In this article, we tried to present the necessity and implications of security management that guarantees integrity through operation applying block chain technology in the increasingly expanding Internet of Things environment. If this is used, it is expected to gain insight into how to apply the blockchain technique to guidelines for strengthening the security of the IoT environment in the future.

• The Journal of Bigdata
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• v.7 no.2
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• pp.235-244
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• 2022

The rental history data of public bicycles in Seoul were analyzed to examine how pandemic phenomena such as COVID-19 caused changes in people's micro mobility. Data for 2019 and 2021 were compared and analyzed by dividing them before and after COVID-19. Data were collected from public data portal sites, and data marts were created for in-depth analysis. In order to compare the changes in the two periods, the riding direction type dimension and the rental station type dimension were added, and the derived variables (rotation rate per unit, riding speed) were newly created. There is no significant difference in the average rental time before and after COVID-19, but the average rental distance and average usage speed decreased. Even in the mobility of Ttareungi, you can see the slow rhythm of daily life. On weekdays, the usage rate was the highest during commuting hours even before COVID-19, but it increased rapidly after COVID-19. It can be interpreted that people who are concerned about infection prefer Ttareungi to village buses as a means of micro-mobility. The results of data mart-based visualization and analysis proposed in this study will be able to provide insight into public bicycle operation and policy development. In future studies, it is necessary to combine SNS data such as Twitter and Instagram with public bicycle rental history data. It is expected that the value of related research can be improved by examining the behavior of bike users in various places.

• Journal of the Korean Institute of Landscape Architecture
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• v.51 no.3
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• pp.122-138
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• 2023

Today, fishing villages are on the verge of extinction due to severe aging within the population and outward migration. Recent projects and studies targeting fishing villages viewed the fishing villages from an outsider-centered perspective, without a local-centered understanding of the village as a daily living space. Therefore, to understand the settlement environment of fishing villages, this study analyzed empirical data on the usage behavior of fishing village residents to gain insight into the characteristics of the outdoor space uses of residents in fishing villages. In this regard, a face-to-face survey was conducted among residents, and a village map drawn by the villagers showedthe spatial perception of the villagers. Empirical data on the behavior of fishing villagers using the village space was collected and analyzed through GPS. The study results suggested that residents of fishing villages tend to focus on productive activities, such as fishing, leading to a lack of awareness of other leisure activities and spaces. This monotonous pattern of space utilization within the village appears to stem from an absolute lack of available facilities within the target area. Therefore, in future village regeneration projects aimed at improving the quality of life for residents in fishing villages, it is essential to consider the residents' perception and utilization of space as a priority. The results of this study can be considered valuable foundational data for understanding the utilization of spaces within fishing villages and can be effectively utilized in planning initiatives to enhance quality of life.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.28 no.4B
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• pp.383-392
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• 2008

It is not always easy to estimate the parameters in hydrologic models due to insufficient hydrologic data when hydraulic structures are designed or water resources plan are established. Therefore, uncertainty analysis are inevitably needed to examine reliability for the estimated results. With regard to this point, this study applies a Bayesian Markov Chain Monte Carlo scheme to the NWS-PC rainfall-runoff model that has been widely used, and a case study is performed in Soyang Dam watershed in Korea. The NWS-PC model is calibrated against observed daily runoff, and thirteen parameters in the model are optimized as well as posterior distributions associated with each parameter are derived. The Bayesian Markov Chain Monte Carlo shows a improved result in terms of statistical performance measures and graphical examination. The patterns of runoff can be influenced by various factors and the Bayesian approaches are capable of translating the uncertainties into parameter uncertainties. One could provide against an unexpected runoff event by utilizing information driven by Bayesian methods. Therefore, the rainfall-runoff analysis coupled with the uncertainty analysis can give us an insight in evaluating flood risk and dam size in a reasonable way.

• Journal of Korea Entertainment Industry Association
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• v.13 no.7
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• pp.193-203
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• 2019

Family films with insight of the society are now recognized as significant texts to communicate with audience from the beginning of the history of film and to reflect various viewpoints on changes of the times and socio-cultural context. In such aspect, the films of Hirokazu Kore-eda are very significant in that they suggest very sharp view on modern society through family narrative. His family narratives not only presented a profound reflection on the modern society and human relations through themes on death, loss, severance, and alienation, but also formed a public sympathy based on success in the box-office numbers despite his heavy subjects. His such achievement is closely related to the format of spatial representation to record 'time' and 'daily life' as well as the family film as a narrative form to draw the meaning of a family. Therefore, this study analyzes the family narrative and the format of spatial representation in the films of Hirokazu Kore-eda, and could find the film form where life and space closely communicate each other to reach the topic. This study, concentrating on the spatial representation and the roles and meanings of formal factors in family narrative, can find its own value in its expansion out of the previous studies which adopted macro perspectives on the trend of the times.

• Animal Bioscience
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• v.35 no.9
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• pp.1340-1350
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• 2022

Objective: Luxi Black Head sheep (LBH) is the first crossbreed specialized for meat production and was developed by crossbreeding Black Head Dorper sheep (DP) and Small Tailed Han sheep (STH) in the farming areas of northern China. Research on the genomic variations and selection signatures of LBH caused by continuous artificial selection is of great significance for identifying the genetic mechanisms of important traits of sheep and for the continuous breeding of LBH. Methods: We explored the genetic relationships of LBH, DP, and several Mongolian sheep breeds by constructing phylogenetic tree, principal component analysis and linkage disequilibrium analysis. In addition, we analysed 29 whole genomes of sheep. The genome-wide selection signatures have been scanned with four methods: heterozygosity (H_P), fixation index (F_ST), cross-population extended haplotype homozygosity (XP-EHH) and the nucleotide diversity (𝜃_π) ratio. Results: The genetic relationships analysis showed that LBH appeared to be an independent cluster closer to DP. The candidate signatures of positive selection in sheep genome revealed candidate genes for developmental process (HoxA gene cluster, BCL2L11, TSHR), immunity (CXCL6, CXCL1, SKAP2, PTK6, MST1R), growth (PDGFD, FGF18, SRF, SOCS2), and reproduction (BCAS3, TRIM24, ASTL, FNDC3A). Moreover, two signalling pathways closely related to reproduction, the thyroid hormone signalling pathway and the oxytocin signalling pathway, were detected. Conclusion: The selective sweep analysis of LBH genome revealed candidate genes and signalling pathways associated with developmental process, immunity, growth, and reproduction. Our findings provide a valuable resource for sheep breeding and insight into the mechanisms of artificial selection.

• The Journal of Korean Philosophical History
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• no.29
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• pp.281-309
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• 2010

The aim of this paper is to investigate the origin of prajñāpāramitā thought in Platform-Sutra, because the practices such as No-thought(無念)·No-image(無相)·No-staying(無住), Samadhi for one act(一行三昧), Seating meditation(坐禪) and Non- distinction of calmness and wisdom(定慧一體) are consolidated into the practice of prajñāpāramitā. The practice of No-thought, No-image and No-staying means an absolute stage which cannot be described in words. It is another expression of prajñā-samadhi or practice of prajñā -pāramitā whose concepts originate from Diamond-Sūtra, Vimalakīrtinirdeśa-sūtra, Mahāparinibbāna-sūtra, and Mahāprajñā-pāramitā-Sūtra. Samadhi for one act is to have an insight into the original nature in everyday life, which is a new development of practicing prajñāpāramitā. Seating meditation is another form of expression of Sudden Enlightenment to see into one's original nature(頓悟見性) through practicing prajñāpāramitā. This can be said a new kind of mixture of Buddhadhātu thought and prajñāpāramitā thought. Therefore prajñāpāramitā thought in Platform Sutra comes from Buddhadhātu thought and prajñāpāramitā thought. Those two thoughts consolidated in Platform Sutra, made the starting point of Zen Buddhism. At the same time, they further continued to be systemized into the thought of Zen Buddhism and eventually into the conclusion of Zen sect of Chinese Buddhism.

• 한국노년학
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• v.31 no.2
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• pp.277-290
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• 2011

The present study examined the impact of work stress and job satisfaction on intention to leave among staff including social workers, nurses, and care workers. The study subject included 235 staff in a welfare organization that provides long-term care services. Data was analyzed using multiple linear regression. The findings of the study show that work stress and job satisfaction affect intention to leave in the context of welfare organizations. Demographic variables were not the main focus of this study and thus these results are incidental. Staff with higher levels of work stress were more likely to think about leaving, while those with grater job satisfaction were less likely. There were several limitations in this study. Generalizability of the findings are limited to staff working in the province of Jeonnam. The results have important implications for the development of strategies to minimize turnover intention in long-term care. Reducing the intent to leave is desirable for issues of both cost reduction and quality of care. Managers could perhaps start to consider decreasing work overload assigned to staff. This study also provides some insight into the work status of new staff. Clearly this finding needs to be explored in further research studies. A more comprehensive model is likely required to adequately explain intention to leave the job.