• Tuberculosis and Respiratory Diseases
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• v.39 no.3
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• pp.242-247
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• 1992

Background: The ability to precisely measure specific mRNA levels by hybridization to complementary DNA probes is an important tool for analyzing the regulation of gene expression. Surfactant proteins have important roles in regulating surfactant metabolism as well as in determing its physical properties. Method: The complete coding regions for rat surfactant protein complementary DNA of surfactant protein B were subcloned into pGem 3Z or 4Z such that either antisense or sense transcripts were obtained by using SP 6 RNA polymerase. Surfactant protein B mRNA was measured by filter hybridization. Results: Equation of standard curve between counts per minute (Y) and surfactant protein B mRNA transcript input (X) was Y=2034.9 X+159.1. Correlation coefficient was 1.0. Couclusions: Filter hybridization assay is suited to situation when rapid, accurate quantitation of multiple samples is required.

• Journal of the Korean Institute of Intelligent Systems
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• v.15 no.1
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• pp.110-115
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• 2005

This paper proposes the method to detect contours of a face, eyes and a mouth in a color image for making an avatar automatically. First, we use the HSI color model to exclude the effect of various light condition, and we find skin regions in an input image by using the skin color is defined on HS-plane. And then, we use deformable templates and Genetic Algorithm(GA) to detect contours of a face, eyes and a mouth. Deformable templates consist of B-spline curves and control point vectors. Those can represent various shape of a face, eyes and a mouth. And GA is very useful search procedure based on the mechanics of natural selection and natural genetics. Second, an avatar is created automatically by using contours and Fuzzy C-means clustering(FCM). FCM is used to reduce the number of face color As a result, we could create avatars like handmade caricatures which can represent the user's identity, differing from ones generated by the existing methods.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.29 no.5C
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• pp.726-736
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• 2004

In this paper, we proposed a new scalar multiplier structure needed for an elliptic curve cryptosystem(ECC) over the standard basis in GF(2$^{163}$ ). It consists of a bit-serial multiplier and a divider with control logics, and the divider consumes most of the processing time. To speed up the division processing, we developed a new division algorithm based on the extended Euclid algorithm. Dynamic data dependency of the Euclid algorithm has been transformed to static and fixed data flow by a localization technique, to make it independent of the input and field polynomial. Compared to other existing scalar multipliers, the new scalar multiplier requires smaller gate counts with improved processor performance. It has been synthesized using Samsung 0.18 um CMOS technology, and the maximum operating frequency is estimated 250 MHz. The resulting performance is 148 kbps, that is, it takes 1.1 msec to process a 163-bit data frame. We assure that this performance is enough to be used for digital signature, encryption/decryption, and key exchanges in real time environments.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.29 no.5
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• pp.413-419
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• 2016

Damage of infrastructures by an earthquake causes the secondary damage through the world at large more than the damage of the structures themselves. Amomg them, underground utility tunnel structures comes under the special life line: communication, gas, electricity and etc. and it has a need to evaluate its fragility to an earthquake exactly. Therefore, the destruction ability according to peak ground acceleration of earthquakes for the underground utility tunnels is evaluated in this paper. As an input ground motion for evaluating seismic fragilities, real earthquakes and artificial seismic waves which could be generated in the Korean peninsula are used. And as a seismic analysis method, response displacement method and time history analyzing method are used. An limit state which determines whether destruction is based on the bending moment and shear deformation. A method used to deduct seismic fragility curve is method of maximum likelihood and the distribution function is assumed to the log normal distribution. It could evaluate the damage of underground utility tunnels to an earthquake and could be applied as basic data for seismic design of underground utility tunnel structures.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.13
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• pp.5349-5353
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• 2014

Statistical methods to analyze and predict the related risk factors of nosocomial infection in lung cancer patients are various, but the results are inconsistent. A total of 609 patients with lung cancer were enrolled to allow factor comparison using Student's t-test or the Mann-Whitney test or the Chi-square test. Variables that were significantly related to the presence of nosocomial infection were selected as candidates for input into the final ANN model. The area under the receiver operating characteristic (ROC) curve (AUC) was used to evaluate the performance of the artificial neural network (ANN) model and logistic regression (LR) model. The prevalence of nosocomial infection from lung cancer in this entire study population was 20.1% (165/609), nosocomial infections occurring in sputum specimens (85.5%), followed by blood (6.73%), urine (6.0%) and pleural effusions (1.82%). It was shown that long term hospitalization (${\geq}22days$, P= 0.000), poor clinical stage (IIIb and IV stage, P=0.002), older age (${\geq}61days$ old, P=0.023), and use the hormones were linked to nosocomial infection and the ANN model consisted of these four factors. The artificial neural network model with variables consisting of age, clinical stage, time of hospitalization, and use of hormones should be useful for predicting nosocomial infection in lung cancer cases.

• Smart Structures and Systems
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• v.19 no.5
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• pp.487-497
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• 2017

Semi-active devices use the building's own motion to produce resistive forces and are thus strictly dissipative and require little power. Devices that independently control the binary open/closed valve state can enable novel device hysteresis loops that were not previously possible. However, some device hysteresis loops cannot be obtained without active analog valve control allowing slower, controlled release of stored energy, and is presents an ongoing limitation in obtaining the full range of possibilities offered by these devices. This in silico study develops a proportional-derivative feedback control law using a validated nonlinear device model to track an ideal diamond-shaped force-displacement response profile using active analog valve control. It is validated by comparison to the ideal shape for both sinusoidal and random seismic input motions. Structural application specific spectral analysis compares the performance for the non-linear, actively controlled case to those obtained with an ideal, linear model to validate that the potential performance will be retained when considering realistic nonlinear behaviour and the designed valve control approach. Results show tracking of the device force-displacement loop to within 3-5% of the desired ideal curve. Valve delay, rather than control law design, is the primary limiting factor, and analysis indicates a ratio of valve delay to structural period must be 1/10 or smaller to ensure adequate tracking, relating valve performance to structural period and overall device performance under control. Overall, the results show that active analog feedback control of energy release in these devices can significantly increase the range of resetable, valve-controlled semi-active device performance and hysteresis loops, in turn increasing their performance envelop and application space.

• Structural Engineering and Mechanics
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• v.72 no.6
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• pp.747-762
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• 2019

Based on the ball-screw mechanism, a tuned viscous mass damper (TVMD) has been proposed, which has functions of amplifying physical mass of the system and frequency tuning. Considering the sensitivity of a single TVMD's effectiveness to frequency mistuning like that of the conventional tuned mass damper (TMD) and according to the concept of the conventional multiple tuned mass damper (MTMD), in the present paper, multiple tuned mass viscous dampers (MTVMD) consisting of many tuned mass dampers (TVMD) with a uniform distribution of natural frequencies are considered for attenuating undesirable vibration of a structure. The MTVMD is manufactured by keeping the stiffness and damping constant and varying the mass associated with the lead of the ball-screw type inerter element in the damper. The structure is represented by its mode-generalized system in a specific vibration mode controlled using the mode reduced-order method. Modal properties and fundamental characteristics of the MTVMD-structure system are investigated analytically with the parameters, i.e., the frequency band, the average damping ratio, the tuning frequency ratio, the total number of TVMD and the total mass ratio. It is found that there exists an optimum set of the parameters that makes the frequency response curve of the structure flattened with smaller amplitudes in a wider input frequency range. The effectiveness and robustness of the MTVMD are also discussed in comparison with those of the usual single TVMD (STVMD) and the results shows that the MTVMD is more effective and robust with the same level of total mass.

• Journal of Korean Society on Water Environment
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• v.31 no.6
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• pp.653-664
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• 2015

TPLMS (Total water pollutant load management system) that is the most powerful water-quality protection program have been implemented since 2004. In the implementation of TPLMS, target water-quality and permissible discharged load from each unit watershed can be decided by water-quality modeling. And NPS (Non-point sources) discharge coefficients associated with certain (standard) flow are used on estimation of input data for model. National Institute of Environmental Research (NIER) recommend NPS discharge coefficients as 0.15 (Q₂₇₅) and 0.50 (Q₁₈₅) in common for whole watershed in Korea. But, uniform coefficient is difficult to reflect various NPS characteristics of individual watershed. Monthly NPS discharge coefficients were predicted and estimated using surface flow and water-quality from HSPF watershed model in this study. Those coefficients were plotted in flow duration curve of study area (Palger stream and Geumho C watershed) with monthly average flow. Linear regression analysis was performed about NPS discharge coefficients of BOD, T-N and T-P associated with flow, and R² of regression were distributed in 0.893~0.930 (Palger stream) and 0.939~0.959 (Geumho C). NPS Discharge coefficient through regression can be estimated flexibly according to flow, and be considered characteristics of watershed with watershed model.

• Journal of Technology Innovation
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• v.23 no.1
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• pp.87-105
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• 2015

This research confirms a non-linear relationship between R&D investment and performance of small and medium-sized enterprises and measures the adequate level as threshold value. Although previous studies did not consider the time lag and estimated indirectly the level using the R&D investment squared term, this study assumes 2 years time lag and uses the threshold estimation model to measure directly. We find that there is the S-curve relationship between the profit rate as R&D output and R&D intensity and the ratio of researchers to employees as R&D input. Also, we estimate the adequate levels of R&D investment, 6.4% for R&D intensity and 13% for the ratio of researchers to employees. This relationship and measurement of the level can offer basic facts and implications about R&D policy and strategy.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.43 no.3
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• pp.213-223
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• 2015

The helicopter initial design model was established by using the latest weight estimation equations based on the Tishchenko's methodology through the study existing initial design tools. The sequential decomposition method is used to reduce analysis time in the sizing. Empirical parameters of the weight estimation equation were also extracted from numerical and regression analysis for a helicopter database. Design input and output values were compared with the RISPECT design tool. Finally, comparison of the re-design resulting for several existing helicopters was presented and showed the good agreement within less than 5% in the weight estimation and main rotor sizing. Established initial design model was proved to be effectively used as initial design tool.