• Korean Journal of Microbiology
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• v.38 no.4
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• pp.203-203
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• 2002

Cytomegalovirus (CMV), a beta-herpesvirus with worldwide distribution, exhibits host persistence, a distinguishing characteristic of all herpesviruses. This persistence is dependent upon restricted gene expression in infected cells as well as the ability of productively infected cells to escape from normal cell-mediated anti-viral immunosurveillance. Type I (IFN-α/β) and type II (IFN-γ) interferons are major components of the innate defense system against viral infection. They are potent inducers of MHC class I and II antigens and of antigen processing proteins. Additionally, IFNS mediate direct antiviral effects through induction effector molecules that block viral infection and replications such as 2′, 5-oligoadenylate synthetase (2, 5-OAS). IFNS function through activation of well-defined signal transduction pathways that involve phosphorylation of constituent proteins and ultimate formation of active transcription factors. Recent studies have shown that a number of diverse viruses, including CMV, EBV, HPV mumps and Ebola, are capable of inhibiting IFN-mediated signal transduction through a variety of mechanisms. As an example, CMV infection inhibits the ability of infected cells Is transcribe HLA class I and II antigens as well as the antiviral effector molecules 2, 5-OAS and MxA I. EMSA studies have shown that IFN-α and IFN-γ are unable to induce complete signal transduction in the presence of CMV infection, phenomena that are associated with specific decreases in JAKl and p48. Viral inhibition of IFN signal transduction represents a new mechanistic paradigm for increased viral survival, a paradigm predicting widespread consequences in the case of signal transduction factors common to multiple cytokine pathways.

• Journal of Korea Technology Innovation Society
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• v.17 no.3
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• pp.467-489
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• 2014

The purpose of this study is to explore the suitable creative class in korea as the core capital of creative urban growth under creative economy era. We are test to find it for two types of creative class. One is Richard Florida(2002)'s creative class, the other is Mcgranahan & Wojan(2007)'s recasting creative class. Data on 2010 for this paper are generated from Statistics Korea. As a result, we find that the economic geography of creative class is highly concentrated. Furthermore, the geography of creative class is strongly associated with innovation index and high-technology industry location. And Mcgranahan & Wojan(2007)'s creative class is more strong relationship between all dependent variables than Florida's. We also find that it has better power of explanation than Florida's with all of them in regression analysis. According to the results, this study suggests some solutions. First, this study can be provided to government and local policy makers as basis data and practical policy guide to attract creative class. Second, this paper presents standard about a diversity of definitions for creative class in Korea. Third, this research also facilitates follow-up studies about regional economic growth and creative climates.

• Cross-Cultural Studies
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• v.26
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• pp.73-94
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• 2012

In the present context of systemic global crisis, this paper focuses on a sustainable society. Throughout the World there are vast members of the unemployes. A secure job lasting a lifetime has become more and more rare. Nowadays majority of jobs are part-time or temporary. $Andr{\acute{e}}$ Gorz found a solution in a policy of the progessive reduction in labor time. This is the potential which automated production opens up for a culture society. Nevertheless, Gorz's proposal is based on utopion ideals. This paper focuses on a dynamic force for a culture society, especially art, learning and the third sector. Adrienne Goehler underlines that a culture in the broad sense of the word produces economical and social productivity. In this connection Goehler give attention to 'Cultrual Creatives' and the Creative Class. Cultural creatives are comprised of people who have participated in the process of creating a new culture with enlightened creativity. The Creative Class is a class of workers whose job is to create economic growth through innovation. Creativity is important for a sustainable society. Gore and Rifkin both come close to the ecological thinking. Gore claims that ecosystem of nature have a self-organizing capacity. In this context tried to prove this article that ecosystem is closely connected with a creative environment.

• Journal of Engineering Education Research
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• v.22 no.1
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• pp.22-28
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• 2019

The purpose of this study is to develop instructional design model of flipped learning suitable for engineering education field and to draw out effects and improvements by applying it to actual lessons for engineering college students. Literature review and case studies were conducted to achieve the purpose of the study. For a case study, flipped learning was applied to 'creative problem solving methodology' which is a liberal arts course of engineering college at D university in Gyeonggi-do. As a result of the literature review, the PARTNER model was applied and weekly instructional guide was presented by each stage. In addition, the results of analysis on the reflection journal showed that the students were more able to achieve the deepening learning stage through active participation in class than the existing class, and found that they had a more challenging plan after the class.

• The Journal of Society for e-Business Studies
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• v.3 no.2
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• pp.179-202
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• 1998

This study reviews the concept of Integrated Logistic Support(ILS), ILS standards, ILS elements, and the processes of developing ILS elements and Logistics Support Analysis(LSA). It also examines the potentials of applying ILS development process to building CALS systems in commercial sectors in order to accomplish business process innovation and achieve life-cycle cost savings in product and equipment management. In order to utilize the ILS approach for commercial industries, we need customizing the process of Logistics Support Analysis defined in MIL-STD-1388-lA. The success of ILS implementation depends on the determination of the range of ILS elements in relation with the application environment, and the appropriate development of those elements. During the development process, in order to analyze and design logistics flow processes and supporting activities, we suggest the object-oriented logistics process modeling approach with basic concepts and constructs embedded in objects. Several diagrams including Class Diagram, Class-Instance Diagram, and Integrated Instance Diagram, are provided. Simple Steps to follow are suggested for the analysis and design of inter-organizational logistics flow and support processes. The outcomes of the study are expected to contribute to stimulating the utilization of ILS concepts and development process during building commercial CALS systems.

• Journal of Engineering Education Research
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• v.26 no.4
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• pp.11-21
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• 2023

In engineering education, stimulating students' questions and encouraging learning participation are crucial for achieving higher-order thinking abilities. This study aims to investigate the use and effect of an online communication channel in fostering engineering students' questioning abilities. Consequently, in this research, we gauged students' satisfaction with an engineering class that implemented a communication channel, and scrutinized the changes in their perceptions regarding the significance of questions, their engagement in learning, and their academic self-efficacy. In addition, we interviewed the students who participated in the class. The outcomes are as follows: Firstly, student satisfaction improved compared to the previous semester's class where the communication channel was not utilized. Secondly, learners' understanding of the importance of asking questions positively escalated, alongside their actual frequency of posing questions. Thirdly, there was an improvement in learners' active engagement in their studies and their academic self-confidence. The findings of this research suggest that communication channels should be employed to motivate learners to pose questions and involve students in effective learning.

• Journal of Korea Technology Innovation Society
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• v.20 no.1
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• pp.205-238
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• 2017

Display industry in Korea has been rapidly developing over 20 years, now taking the top-class leading position in the world. Nevertheless, many previous studies have mainly focused on major panel set makers. To overcome the drawbacks, this study focuses on supplier companies in the upstream of display industry such as materials, components, and equipments sectors. The research method used in this study is an industry value chain perspective combined with architectural innovation approach. Display panel is produced through fabrication process and modular process, each having a different characteristics of process architecture. This research figured out that there are quite a different development characteristics between materials and components suppliers and equipment suppliers. The number and revenue of materials and components suppliers were quite larger than equipments suppliers. However, the former has been growing mainly in the field of modular process, having a very weak position in the field of fabrication process. On the contrary, equipments suppliers have been showing a continuously growing pattern in the field of fabrication process. The R&D expenditures between these two kinds of suppliers showed a similar pattern. The fabrication process of display panel production is characterized as a highly integral architecture characteristics, so as to be a strong barriers to local suppliers, resulting less development of materials and components suppliers in Korea.

• Journal of the Korean Society for Library and Information Science
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• v.25
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• pp.343-388
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• 1993

The ability of any organization to innovate itself in a rapid change of environment means the existence of the organization. Innovative activity is achieved in different ways according to the objectives of organization. the characteristics of external environmental factors. and various attributes in organization. In the present study. all the existing approaches to the innovative nature of organization were synthetically compared to each other and evaluated: then. for a more rational approach. a research model was built and suggested by establishing the inclusive variables of the innovative nature of library organization and categorizing the types of such nature. Additionally. an empirical. analytical study on such a model was done. That is. paying regard to the fact that innovation has basically a close relation with the circumstantial factors of organization. synthetic, circumstantial relations were clarified. considering the external environmental factors and internal characteristics of organization. In the study. the innovation of library organization was seen in two parts i.e .. the feasible degree of technical innovation and the feasible degree of administrative innovation. Regarding the types of innovative implementation. according to the feasible degree of innovation, four types such as a stationary type. technic-oriented type, organization-oriented type. and technical-socio systematic type were classified. There were nine independent variables-i.e., the scale of organization. available resources of the organization, formalization, differentiation, specialization. decentralization, recognizant degree of the technical attribute. degree of response to the change of technical environment, and professional activities. There were three subordinate variables - i.e., technical innovation, administrative innovation. and the performance of organization. Through establishment of such variables, the factors which might influence the innovation of library organization were understood, and with the types of the innovative implementation of library organization being classified according to the feasible degree of innovation. the characteristics of library organization were reviewed in the light of each type. Also. the performance of library organization according to the types of the innovative implementation of library organization was analyzed. and the relations between the types of innovative implementation according to circumstantial variables and the performance of library organization were clarified. In order to clarify the adequacy of the research model in the methodology of empirical study, data were collected from 72 university libraries and 38 special libraries. and for a hypothetical test of the research model. an analysis of correlations, a stepwise regression analysis. and One Way ANOVA were utilized. The following are the major results or findings from the study 1) It appeared there is a trend that the bigger the scale of organization and available resources are, the more active the professional activity of the managerial class is, and the higher the recognizant degree of technical environment (recognizant degree of technical attributes and the degree of response t9 the change of technical environment) is, the higher the feasible degree of innovation becomes. 2) It appeared that among the variables influencing the feasible degree of technical innovation, the order from the variable influencing most was first, the recognizant degree of technical innovation: second, the available resources of organization: and third, professional activity. Regarding the variables influencing the feasible degree of administrative innovation from the most influential variable, it appeared they were the available resources of organization, the differentiation of organization. and the degree of response to the change of technical environment. 3) It appeared that the higher the educational level of the managerial class is, the more active the professional activity becomes. It seemed there is a trend that the group of library managers whose experience as a librarian was at the middle level(three years to six years of experience) was more active in research activity than the group of library managers whose experience as a librarian was at a higher level(more than ten years). Also, it appeared there is a trend that the lower the age of library managers is, the higher the recognizant degree of technical attributes becomes. and the group of library managers whose experience as a librarian was at the middle level (three years to six years of experience) recognized more affirmatively the technical aspect than the group of library managers whose experience as a librarian was at a higher level(more than 10 years). Also, it appeared that, when the activity of the professional association and research activity are active, the recognizant degree of technology becomes higher, and as a result. it influences the innovative nature of organization(the feasible degree of technical innovation and the feasible degree of administrative innovation). 4) As a result of the comparison and analysis of the characteristics of library organization according to the types of innovative implementation of library organization. it was indicated there is a trend that the larger the available resources of library organization, the higher the organic nature of organization such as differentiation. decentralization, etc., and the higher the level of the operation of system development, the more the type of the innovative implementation of library organization becomes the technical-socio systematic type which is higher both in the practical degrees of technical innovation and administrative innovation. 5) As a result of the comparison and analysis of the relations between the types of innovative implementation and the performance of organization, it appeared that the order from the highest performance of organization is the technical-socio systematic type, then the technic-oriented type, the organization­oriented type, and finally the stationary type which is lowest in such performance. That is, it demonstrated that, since the performance of library organization is highest in the library of the technical-socio systematic type while it is lowest in the library whose practical degrees in both technical innovation and administrative innovation are low, the performance of library organization differs significantly according to the types of innovative implementation of library organization. The present study has extracted the factors influencing innovation, classified systematically the types of innovative implementation, and inferred the synthetical, circumstantial correlations between the types and the performance of organization, and empirically inspected those factors. However, due to the present study's restrictive matters and the limit of the research design, results from the study should be more prudently interpreted. Also, the present study, as an investigative study of the types of innovative implementation, with few preceding studies, requires more complete hypothetical inference based on the results of the present study. In other words, if more systematical studies are given to understanding the relations, it will devote the suggestion and demonstration of a more useful theory.

• IEIE Transactions on Smart Processing and Computing
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• v.2 no.6
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• pp.323-331
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• 2013

An extreme learning machine (ELM) is an efficient learning algorithm that is based on the generalized single, hidden-layer feed-forward networks (SLFNs), which perform well in classification applications. Many studies have demonstrated its superiority over the existing classical algorithms: support vector machine (SVM) and BP neural network. This paper presents a novel face recognition approach based on a multi-class project extreme learning machine (MPELM) classifier and 2D Gabor transform. First, all face image features were extracted using 2D Gabor filters, and the MPELM classifier was used to determine the final face classification. Two well-known face databases (CMU-PIE and ORL) were used to evaluate the performance. The experimental results showed that the MPELM-based method outperformed the ELM-based method as well as other methods.

• Journal of Industrial Convergence
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• v.20 no.1
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• pp.23-33
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• 2022

The study was conducted to develop an implementation model for digital transformation (DX) of manufacturing companies. To this end, previous studies on the process of management innovation and digital transformation were reviewed. The DX process model was derived based on the NEBIC theory and innovation theory applied in the innovation process of the Internet business. In addition, a research model including the factors of the will of the top management class (TMT) was constructed and confirmed through empirical data. The research hypothesis were verified based on data collected from members of mid-sized manufacturing companies promoting digital transformation. Through regression analysis, the influence relationship of each stage of the research model (technical knowledge, TK → opportunity perception, OR → performace expectation, PE and → Intention to execute, IE) was confirmed. Hierarchical regression analysis was conducted to understand the mediating effect of the members' perception of the top management's willingness to promote DX in the process. As a result of checking the Sobel test, it was confirmed that the management's perception of DX promotion partially mediated the relationship at each stage. This study is meaningful in that it presented a model applicable to the digital transformation of the mid-sized manufacturing industry. It is also valuable in providing an empirical basis for innovative research and NEBIC expansion. Longitudinal studies are required to overcome the limitations of empirical data for process models with dynamic characteristics whereas extended empirical studies are required in various fields other than manufacturing to generalize research results.