• Title/Summary/Keyword: Innovation School

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Anti-Mycobacterial Activity of Tamoxifen Against Drug-Resistant and Intra-Macrophage Mycobacterium tuberculosis

  • Jang, Woong Sik;Kim, Sukyung;Podder, Biswajit;Jyoti, Md. Anirban;Nam, Kung-Woo;Lee, Byung-Eui;Song, Ho-Yeon
    • Journal of Microbiology and Biotechnology
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    • v.25 no.6
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    • pp.946-950
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    • 2015
  • Recently, it has become a struggle to treat tuberculosis with the current commercial antituberculosis drugs because of the increasing emergence of multidrug-resistant (MDR) tuberculosis and extensively drug-resistant (XDR) tuberculosis. We evaluated here the antimycobacterial activity of tamoxifen, known as a synthetic anti-estrogen, against eight drugsensitive or resistant strains of Mycobacterium tuberculosis (TB), and the active intracellular killing of tamoxifen on TB in macrophages. The results showed that tamoxifen had antituberculosis activity against drug-sensitive strains (MIC, 3.125-6.25 µg/ml) as well as drugresistant strains (MIC, 6.25 to 12.5 µg/ml). In addition, tamoxifen profoundly decreased the number of intracellular TB in macrophages in a dose-dependent manner.

Energy-Connectivity Tradeoff through Topology Control in Wireless Ad Hoc Networks

  • Xu, Mengmeng;Yang, Qinghai;Kwak, Kyung Sup
    • ETRI Journal
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    • v.39 no.1
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    • pp.30-40
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    • 2017
  • In this study, we investigate topology control as a means of obtaining the best possible compromise between the conflicting requirements of reducing energy consumption and improving network connectivity. A topology design algorithm capable of producing network topologies that minimize energy consumption under a minimum-connectivity constraint is presented. To this end, we define a new topology metric, called connectivity efficiency, which is a function of both algebraic connectivity and the transmit power level. Based on this metric, links that require a high transmit power but only contribute to a small fraction of the network connectivity are chosen to be removed. A connectivity-efficiency-based topology control (CETC) algorithm then assigns a transmit power level to each node. The network topology derived by the proposed CETC heuristic algorithm is shown to attain a better tradeoff between energy consumption and network connectivity than existing algorithms. Simulation results demonstrate the efficiency of the CECT algorithm.

A Comparative Study on the Industrial Cluster Cases for Job Creation from the Viewpoint of Sustainability and Open Innovation (SW일자리 창출을 위한 지속가능성과 개방형 관점에서의 산업클러스터 사례 비교 분석)

  • Lim, Gyoo Gun;Lee, Ji Yoon;Choi, Jinho
    • Korean Management Science Review
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    • v.34 no.2
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    • pp.85-101
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    • 2017
  • Currently, the SW industry is the center of digital economy and it is very important industry in terms of market scale and ripple effect. Due to the suffering from poor working environment of the SW industry and the disproportion of manpower supply due to the lack of experienced SW manpower, it is hard to create jobs of high quality for the SW professionals who can be applied to various convergence industries. In this study, we try to analyze the benchmarking cases of successful foreign industrial innovative clusters in order to promote sustainable development direction of SW industry and to create high quality SW jobs. First, the comparison criteria are derived from the viewpoint of creation of high quality SW jobs through an analysis of SW environment by using expert FGI (Focus Group Interview) technique. The critical success factors (CSFs) are derived by comparing and analyzing each industrial cluster cases in terms of SW job creation. This article presents the desirable implications of the cluster of SW industry that can generate SW jobs continuously from the viewpoint of ecosystem environment infrastructure. Through this study, we propose a meaningful direction of SW clusters for job creation, and solve the business inconsistency and suggest ways to increase the sustainability of core competence manpower.

The External Benefits of Research and Development Investment in Waste-to-Energy Technology in Korea

  • Lim, Seul-Ye;Kim, Hyo-Jin;Yoo, Seung-Hoon
    • Asian Journal of Innovation and Policy
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    • v.5 no.2
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    • pp.208-224
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    • 2016
  • The Korean government considers expanding the WtE share of total energy from 1% to 5% by 2020 through research and development (R&D) in waste-to-energy (WtE) technologies. This study attempts to measure the external benefits of investing in R&D in these technologies. To this end, a contingent valuation (CV) is employed. More specifically, a 2016 national survey of randomly selected 1,000 households was carried out across the nation to gauge the willingness to pay (WTP) for the investment. One-and-one-half-bounded dichotomous choice question was used in the CV survey, and the spike model was applied to dealing with zero WTP responses. The mean yearly WTP is estimated to be KRW 4,175 (USD 3.57) per household, which is statistically significant at the 1% level. Expanding the value to the entire nation translates into an investment of about KRW 79.1 billion (USD 67.6 million), which can be interpreted as the annual external benefit of the R&D investment in WtE technology.

The Role of Economic Cluster Perspectives in Regional Economic Development

  • Haak, Robert;Vora, Gautam;Walsh, Steven T.;White, Craig G.
    • World Technopolis Review
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    • v.3 no.1
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    • pp.17-29
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    • 2014
  • The importance of science and technology as the root of exceptional regional economic development has been extolled since the time of Schumpeter. Today emerging technologies are signaling the start of a new economic cycle where regions that are effective in technology translation will gain advantage. The will of policymakers to translate technology into regional job and wealth creation seems to be at an all-time high. Yet an improved process for translating technical development into regional prosperity has proved elusive. If there are no processes other than applying techniques that have worked in the past for other regions to a new region then there is cause for concern. Here the authors seek to add to this field of knowledge by applying elements of the varied cluster theories to provide a basis for policy for regional economic development by turning science and technology into commercial innovation. We provide a review of current cluster theories and discuss the positive and negative issues associated with each. We propose a model that allows interested professionals to utilize aspects of each cluster perspective geared to the realities of their specific area.

Study of Characterization of Activated Carbon from Coconut Shells on Various Particle Scales as Filler Agent in Composite Materials

  • DUNGANI, Rudi;MUNAWAR, Sasa Sofyan;KARLIATI, Tati;MALIK, Jamaludin;ADITIAWATI, Pingkan;SULISTYONO, SULISTYONO
    • Journal of the Korean Wood Science and Technology
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    • v.50 no.4
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    • pp.256-271
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    • 2022
  • Activated carbon (AC) derived from coconut shells (CS-AC) was obtained through pyrolysis at 700℃ and subsequently activated with H3PO4. AC was ground in a Wiley mill several times to form powder particles at particle scales of 80, 100, and 200 meshes. The characterization of the AC was studied using scanning electron microscopy (SEM), X-ray diffraction analysis (XRD), Fourier-transform infrared spectroscopy (FT-IR), and surface area analysis (SBET). The CS-AC-200 mesh resulted in a higher percentage of mesopores and surface area. This particle size had a larger surface area with angular, irregular, and crushed shapes in the SEM view. The smaller particles had smoother surfaces, less wear, and increased curing depth and ratio of the hardness of the resin composite. Based on the characterization results of the AC, it is evident that CS-AC with a 200 mesh particle size has the potential to be used as a filler in biocomposites.

Lightweight high-precision pedestrian tracking algorithm in complex occlusion scenarios

  • Qiang Gao;Zhicheng He;Xu Jia;Yinghong Xie;Xiaowei Han
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • v.17 no.3
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    • pp.840-860
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    • 2023
  • Aiming at the serious occlusion and slow tracking speed in pedestrian target tracking and recognition in complex scenes, a target tracking method based on improved YOLO v5 combined with Deep SORT is proposed. By merging the attention mechanism ECA-Net with the Neck part of the YOLO v5 network, using the CIoU loss function and the method of CIoU non-maximum value suppression, connecting the Deep SORT model using Shuffle Net V2 as the appearance feature extraction network to achieve lightweight and fast speed tracking and the purpose of improving tracking under occlusion. A large number of experiments show that the improved YOLO v5 increases the average precision by 1.3% compared with other algorithms. The improved tracking model, MOTA reaches 54.3% on the MOT17 pedestrian tracking data, and the tracking accuracy is 3.7% higher than the related algorithms and The model presented in this paper improves the FPS by nearly 5 on the fps indicator.

Analyzing Effective Factors on Hydrogen Release Based on Response Surface Method and Analysis of Variance (반응표면법과 ANOVA 기반의 수소 누출에 대한 유효인자 분석)

  • JUNSEO LEE;SEHYEON OH;SEUNGHYO AN;EUNHEE KIM;BYUNGCHOL MA
    • Journal of Hydrogen and New Energy
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    • v.34 no.6
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    • pp.712-721
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    • 2023
  • While hydrogen is widely used, it has a low minimum ignition energy, raising safety concerns when using it. This research studied which parameters are the key variables in the hydrogen release and diffusion. These parameters were divided into six process variables in the initial release and two environmental variables in the dispersion. One hundred and twenty cases were selected through design of experiment, and the end-point in each case were analyzed using PHAST. Afterwards, an end-point prediction model was developed using RSM and ANOVA, and the impact of each variable on the endpoint was analyzed. As a result, the influence of eight variables was graded. The nozzle diameter had the greatest influence on the end-point, while the pipe roughness coefficient had no effect on the end-point. It is expected that these results will be used as basic data to improve safety across all fields of hydrogen handling facilities.

Digital Orientation for Emerging Multinationals and the Location Strategies in Internationalization: The Chinese Experience

  • Xinyue Zhang;Bo Kyung Kim;Jooyoung Kwak
    • Asia-Pacific Journal of Business
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    • v.14 no.3
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    • pp.1-16
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    • 2023
  • Purpose Despite the ongoing digital transformation, it is not clear whether emerging market firms follow their manufacturing FDI path in the emerging digital industries. This paper examines how digital orientation affects the location strategies in internationalization and how the existing innovation capacities moderate the link between digital orientation and the location strategies. Design/methodology/approach This study chooses the Chinese setting for research design because digital transformation is already prevalent in the society and the cases of outward expansion are salient among the emerging markets. It uses the panel dataset of 976 Chinese listed firms that consists of 6,648 observations spanning from 2007 to 2017. Ordinary least square regression is used for the statistical approach with a one-year lag in the model. Findings Digital orientation increases a likelihood of emerging multinationals' entries in developed countries, and a high level of innovative capacities strengthens the link. Two groups seem to prefer entries in developed countries: firms with a high level of digital orientation with a high level of innovative capacities and firms with a low level of digital orientation, if with a low level of innovative capacities. The former reflects the context of digital transformation and the latter hints at the tax avoidance or interests in real estate. Research implications or originality While emerging multinationals are known to prefer entries in developing countries for capacity arbitrage, our results forecast that their FDI strategies may have a drastic change as digital transformation deepens.

A Comparative Analysis Between <Leonardo.Ai> and <Meshy> as AI Texture Generation Tools

  • Pingjian Jie;Xinyi Shan;Jeanhun Chung
    • International Journal of Advanced Culture Technology
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    • v.11 no.4
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    • pp.333-339
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    • 2023
  • In three-dimensional(3D) modeling, texturing plays a crucial role as a visual element, imparting detail and realism to models. In contrast to traditional texturing methods, the current trend involves utilizing AI tools such as Leonardo.Ai and Meshy to create textures for 3D models in a more efficient and precise manner. This paper focuses on 3D texturing, conducting a comprehensive comparative study of AI tools, specifically Leonardo.Ai and Meshy. By delving into the performance, functional differences, and respective application scopes of these two tools in the generation of 3D textures, we highlight potential applications and development trends within the realm of 3D texturing. The efficient use of AI tools in texture creation also has the potential to drive innovation and enhancement in the field of 3D modeling. In conclusion, this research aims to provide a comprehensive perspective for researchers, practitioners, and enthusiasts in related fields, fostering further innovation and development in this domain.